RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: secondary hyperparathyroidism
Accession: DOID:12466
browse the term
Definition: Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.
Synonyms: exact_synonym: secondary hyperparathyroidisms
primary_id: MESH:D006962
xref: EFO:1001173 ; NCI:C113335
For additional species annotation, visit the
Alliance of Genome Resources .
G
ABCG2
ATP binding cassette subfamily G member 2 (JR blood group)
treatment
ISO
RGD
PMID:27988213
RGD:13450940
NCBI chr 4:80,379,108...80,446,641
Ensembl chr 4:91,101,321...91,170,157
G
ACP5
acid phosphatase 5, tartrate resistant
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21985997 PMID:22373954
NCBI chr19:11,120,451...11,125,167
Ensembl chr19:11,832,575...11,835,203
G
ALPL
alkaline phosphatase, biomineralization associated
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22373954
NCBI chr 1:20,702,509...20,772,301
Ensembl chr 1:21,667,732...21,736,688
G
CASR
calcium sensing receptor
severity
ISO
associated with Kidney Failure, Chronic;DNA:missense mutations:cds:p.R990G, p.Q1011E (human) protein:decreased expression:parathyroid gland (human)
RGD
PMID:11044218 PMID:19640368
RGD:7205505 RGD:7205664
NCBI chr 3:119,278,071...119,383,901
Ensembl chr 3:126,252,765...126,285,268
G
CRP
C-reactive protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21350317
NCBI chr 1:135,062,102...135,064,402
G
ENG
endoglin
ISO
associated with Renal Insufficiency, Chronic; protein:increased expression:parathyroid gland, vasculature (human)
RGD
PMID:18398016
RGD:7248778
NCBI chr 9:98,934,080...98,973,862
Ensembl chr 9:127,605,608...127,644,641
G
IL6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21350317
NCBI chr 7:23,415,922...23,420,767
G
KL
klotho
ISO
associated with Uremia;mRNA,protein:increased expression:parathyroid gland:
RGD
PMID:20631679
RGD:10403078
NCBI chr13:14,272,463...14,321,122
Ensembl chr13:32,702,336...32,751,458
G
PIN1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
ISO
associated with Kidney Failure, Chronic
RGD
PMID:19770516
RGD:8693427
NCBI chr19:9,389,829...9,404,099
Ensembl chr19:10,053,254...10,066,853
G
PTGS2
prostaglandin-endoperoxide synthase 2
ISO
associated with kidney failure, chronic: protein:increased expression:parathyroid gland associated with Uremia
RGD
PMID:21335517
RGD:5135046
NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
G
PTH
parathyroid hormone
treatment
ISO
CTD Direct Evidence: marker/mechanism associated with Renal Insufficiency, Chronic; protein:increased expression:serum (human) associated with Kidney Failure, Chronic associated with Renal Insufficiency, Chronic; DNA:snp:exon:g.350C>A (rs6256) (human) associated with Uremia
CTD RGD
PMID:12046039 PMID:21335517 PMID:21350317 PMID:22118402 PMID:22373954 PMID:23121374 PMID:23499504 PMID:23529273 More...
RGD:5135046 RGD:7242411 RGD:7242414 RGD:7242728 RGD:7242750
NCBI chr11:13,653,777...13,657,901
Ensembl chr11:13,347,838...13,351,802
G
TNFRSF11B
TNF receptor superfamily member 11b
treatment
ISO
associated with Kidney Failure, Chronic
RGD
PMID:22156488
RGD:7205487
NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422
G
VDR
vitamin D receptor
treatment
ISO
associated with Kidney Failure, Chronic
RGD
PMID:8807569
RGD:8158085
NCBI chr12:40,828,413...40,891,700
Ensembl chr12:41,702,742...41,766,192
G
PTH
parathyroid hormone
ISO
associated with Kidney Failure, Chronic; protein:decreased expression:serum (human)
RGD
PMID:18480316
RGD:7242687
NCBI chr11:13,653,777...13,657,901
Ensembl chr11:13,347,838...13,351,802
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