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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:renal osteodystrophy
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Accession:DOID:13068 term browser browse the term
Definition:Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.
Synonyms:exact_synonym: CKD-MBD;   Chronic kidney disease-mineral and bone disorder;   renal osteodystrophies;   renal rickets
 primary_id: MESH:D012080
 xref: EFO:1001152;   ICD10CM:N25.0;   ICD9CM:588.0;   NCI:C114827
For additional species annotation, visit the Alliance of Genome Resources.


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renal osteodystrophy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pth parathyroid hormone ISO associated with Kidney Failure, Chronic; protein:decreased expression:serum (human) RGD PMID:18480316 RGD:7242687 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21108
    disease of anatomical entity 18147
      Urogenital Diseases 5119
        urinary system disease 2751
          kidney disease 2524
            renal osteodystrophy 1
Path 2
Term Annotations click to browse term
  disease 21108
    Nutritional and Metabolic Diseases 8116
      disease of metabolism 8116
        acquired metabolic disease 2510
          nutrition disease 1072
            Malnutrition 333
              nutritional deficiency disease 317
                Avitaminosis 207
                  Vitamin D Deficiency 34
                    rickets 29
                      renal osteodystrophy 1
paths to the root