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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:trachoma
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Accession:DOID:11265 term browser browse the term
Definition:A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea. (DO)
Synonyms:exact_synonym: Egyptian ophthalmia;   active stage trachoma;   trachoma dubium;   trachomas
 primary_id: MESH:D014141
 xref: GARD:10374;   ICD10CM:A71;   ICD10CM:A71.0;   ICD10CM:A71.1;   ICD9CM:076;   ICD9CM:076.0;   ICD9CM:076.1
For additional species annotation, visit the Alliance of Genome Resources.

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show annotations for term's descendants           Sort by:
trachoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl8 C-X-C motif chemokine ligand 8 susceptibility ISO DNA:SNP:promoter:g.-251A>T (rs4073) (human) RGD PMID:20015396 RGD:150520200 NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643 		JBrowse link
G Il10 interleukin 10 severity
no_association		 ISO DNA:haplotype: :
DNA:SNP:promoter:−819T>C, −592A>C (human)
protein:increased expression:tear
DNA:SNP:promoter:−1082G>A (human)
DNA:SNP, haplotype:promoter:−1082G>A (human)		 RGD PMID:11023480 PMID:15789056 PMID:17947295 PMID:18628987 RGD:7365037 RGD:7365053 RGD:7365072 RGD:7365085 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779 		JBrowse link
G Il17a interleukin 17A ISO mRNA:increased expression:conjunctiva (human) RGD PMID:21911461 RGD:9068420 NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962 		JBrowse link
G Tnf tumor necrosis factor ISO DNA:SNP, haplotypes:promoter:−308G>A (human) RGD PMID:17330135 RGD:8548830 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
Trachomatous Trichiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain ISO mRNA:decreased expression:tarsal conjunctiva (human) RGD PMID:20375326 RGD:8552676 NCBI chrNW_004955451:11,468,156...11,484,410
Ensembl chrNW_004955451:11,468,290...11,483,073 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    sensory system disease 6168
      eye disease 3170
        corneal disease 208
          trachoma 5
            Trachomatous Trichiasis 1
Path 2
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13822
      nervous system disease 12089
        Neurologic Manifestations 8846
          sensory system disease 6168
            eye disease 3170
              Eye Infections 50
                Bacterial Eye Infections 20
                  bacterial conjunctivitis 6
                    trachoma 5
                      Trachomatous Trichiasis 1
paths to the root