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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chronic Relapsing Experimental Autoimmune Encephalomyelitis
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Accession:DOID:9007752 term browser browse the term
Definition:A chronic relapsing-remitting version of EAE, an experimental animal model for central nervous system demyelinating disease in which demyelination is extensive.
Synonyms:exact_synonym: CR-EAE;   CREAE;   chronic relapsing EAE;   chronic relapsing experimental allergic encephalomyelitis;   chronic relapsing-remitting EAE
 primary_id: RDO:9000096


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Chronic Relapsing Experimental Autoimmune Encephalomyelitis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 IEP mRNA:increased expression:spinal cord (rat) RGD PMID:12098510 RGD:8655962 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Nefh neurofilament heavy chain ISO protein:decreased expression:spinal cord: RGD PMID:12742652 RGD:27226817 NCBI chr14:84,044,428...84,054,413
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Plp1 proteolipid protein 1 ISO human sequence peptide in a mouse model; associated with Herpesviridae infections RGD PMID:12811845 RGD:30296670 NCBI chr  X:104,933,921...104,993,317
Ensembl chr  X:100,185,767...100,201,032 		JBrowse link
G Serpine1 serpin family E member 1 ISO RGD PMID:17983428 RGD:13208507 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19142
    Animal Diseases 1793
      Animal Disease Models 1741
        Experimental Nervous System Autoimmune Disease 278
          Experimental Autoimmune Encephalomyelitis 235
            Chronic Relapsing Experimental Autoimmune Encephalomyelitis 4
Path 2
Term Annotations click to browse term
  disease 19142
    disease of anatomical entity 18455
      Immune & Inflammatory Diseases 5753
        immune system disease 5035
          primary immunodeficiency disease 4438
            autoimmune disease 2376
              autoimmune disease of the nervous system 714
                autoimmune disease of central nervous system 393
                  Demyelinating Autoimmune Diseases, CNS 386
                    Experimental Autoimmune Encephalomyelitis 235
                      Chronic Relapsing Experimental Autoimmune Encephalomyelitis 4
paths to the root