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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:endotoxin shock
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Accession:DOID:9007601 term browser browse the term
Definition:When endotoxemia, a condition characterized by the presence of endotoxins (bacterial lipopolysacharrides) in the blood is accompanied by hypotension despite adequate fluid infusion, it is called endotoxin shock. On lysis of, or secretion by gram-negative bacteria, bacterial lipopolysacharride (LPS) enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
Synonyms:exact_synonym: endotoxic shock
 broad_synonym: septic shock
 xref: EFO:0006834

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endotoxin shock term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCH1 GTP cyclohydrolase 1 treatment ISO RGD PMID:8602831 RGD:329961578 NCBI chr24:32,029,997...32,079,656
Ensembl chr24:32,027,648...32,079,490 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A treatment ISO RGD PMID:19318092 RGD:401901206 NCBI chr 3:24,820,029...24,884,472
Ensembl chr 3:24,820,035...24,883,432 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15274
    disease by infectious agent 2055
      Bacterial Infections and Mycoses 979
        Toxemia 150
          Endotoxemia 150
            endotoxin shock 2
Path 2
Term Annotations click to browse term
  disease 15274
    disease of anatomical entity 14909
      Immune & Inflammatory Diseases 4951
        Inflammation 2379
          Systemic Inflammatory Response Syndrome 369
            Sepsis 367
              bacterial sepsis 165
                Bacteremia 165
                  Endotoxemia 150
                    endotoxin shock 2
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