Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:nephrotoxicity
go back to main search page
Accession:DOID:9006956 term browser browse the term
Definition:This is toxicity that causes injury to the kidney or damages its function. It is a poisonous effect of some substances, both toxic chemicals and medications.
Synonyms:exact_synonym: kidney toxicity;   renal toxicity
 xref: EFO:0011056


show annotations for term's descendants           Sort by:
nephrotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor ameliorates ISO RGD PMID:32112355 RGD:407419877 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G treatment ISO RGD PMID:37244046 RGD:329853759 NCBI chr12:26,838,633...26,912,344
Ensembl chr12:26,844,079...26,912,110 		JBrowse link
G CACNA1S calcium voltage-gated channel subunit alpha1 S treatment ISO RGD PMID:37244046 RGD:329853759 NCBI chr10:23,503,701...23,567,797
Ensembl chr10:23,502,898...23,568,058 		JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha treatment ISO RGD PMID:37244046 RGD:329853759 NCBI chr 2:151,248,356...151,353,907
Ensembl chr 2:151,248,358...151,308,706 		JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 treatment ISO RGD PMID:37244046 RGD:329853759 NCBI chr17:55,110,546...55,130,328
Ensembl chr17:55,110,590...55,130,363 		JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 treatment ISO RGD PMID:37244046 RGD:329853759 NCBI chr 5:23,053,129...23,058,865
Ensembl chr 5:23,053,892...23,058,470 		JBrowse link
G GATM glycine amidinotransferase ISO RGD PMID:15462098 PMID:19664912 RGD:329961309 RGD:329961312 NCBI chr 1:126,361,968...126,378,705
Ensembl chr 1:126,361,945...126,380,871 		JBrowse link
G GC GC vitamin D binding protein treatment ISO RGD PMID:37244046 RGD:329853759 NCBI chr 8:68,326,293...68,360,262
Ensembl chr 8:68,326,299...68,360,262 		JBrowse link
G GPX3 glutathione peroxidase 3 treatment ISO RGD PMID:22115772 PMID:23662110 PMID:27412471 RGD:401827919 RGD:401827924 RGD:401827925 NCBI chr16:71,980,467...71,989,011
Ensembl chr16:71,980,475...71,989,026 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 treatment ISO RGD PMID:37244046 RGD:329853759 NCBI chr16:66,162,318...66,208,868 JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 treatment ISO RGD PMID:37244046 RGD:329853759 NCBI chr13:61,068,131...61,398,918
Ensembl chr13:61,068,126...61,398,912 		JBrowse link
G NOS2 nitric oxide synthase 2 treatment ISO RGD PMID:37244046 RGD:329853759 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G RYR1 ryanodine receptor 1 treatment ISO RGD PMID:37244046 RGD:329853759 NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458 		JBrowse link
G S100A1 S100 calcium binding protein A1 treatment ISO RGD PMID:37244046 RGD:329853759 NCBI chr 4:96,007,026...96,012,305
Ensembl chr 4:96,007,028...96,012,310 		JBrowse link
G S100B S100 calcium binding protein B treatment ISO RGD PMID:37244046 RGD:329853759
G TGFB1 transforming growth factor beta 1 treatment ISO RGD PMID:37244046 RGD:329853759 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046 		JBrowse link
G VDR vitamin D receptor treatment ISO RGD PMID:37244046 RGD:329853759 NCBI chr 5:78,205,807...78,266,505
Ensembl chr 5:78,205,810...78,266,475 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15426
    Pathological Conditions, Signs and Symptoms 12090
      Pathologic Processes 7676
        nephrotoxicity 17
Path 2
Term Annotations click to browse term
  disease 15426
    disease of anatomical entity 15095
      Urogenital Diseases 4851
        urinary system disease 2387
          kidney disease 2146
            nephrotoxicity 17
paths to the root