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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:MPTP Poisoning
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Accession:DOID:9006854 term browser browse the term
Definition:A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
Synonyms:exact_synonym: MPTP Induced Degeneration of the Striatum;   MPTP Induced Parkinsonism;   MPTP Neurotoxicity Syndrome;   MPTP Neurotoxicity Syndromes;   Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
 primary_id: MESH:D020267


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MPTP Poisoning term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP9 aquaporin 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29566083 NCBI chr 1:113,798,380...113,848,452
Ensembl chr 1:113,794,040...113,848,683 		JBrowse link
G IL17A interleukin 17A ISO CTD Direct Evidence: marker/mechanism CTD PMID:31351185 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153 		JBrowse link
G INS insulin ISO CTD Direct Evidence: therapeutic CTD PMID:26364587 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15390
    syndrome 10317
      toxic encephalopathy 203
        MPTP Poisoning 3
Path 2
Term Annotations click to browse term
  disease 15390
    disease of anatomical entity 15084
      nervous system disease 13224
        central nervous system disease 11810
          brain disease 11093
            movement disease 2501
              Parkinsonism 431
                secondary Parkinson disease 18
                  MPTP Poisoning 3
paths to the root