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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Retrograde Degeneration
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Accession:DOID:9005908 term browser browse the term
Definition:Pathologic changes that occur in the axon and cell body of a neuron proximal to an axonal lesion. The process is characterized by central chromatolysis which features flattening and displacement of the nucleus, loss of Nissl bodies, and cellular edema. Central chromatolysis primarily occurs in lower motor neurons.
Synonyms:exact_synonym: Axon Reaction;   Axon Reactions;   Axonal Reaction;   Axonal Reactions;   Nissl Degeneration;   Retrograde Degenerations;   Trans Synaptic Degeneration;   Trans-Synaptic Degenerations;   Transneuronal Retrograde Degeneration;   Transneuronal Retrograde Degenerations
 primary_id: MESH:D012183;   RDO:0006484


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Retrograde Degeneration term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qb complement C1q B chain IEP mRNA:increased expression RGD PMID:16934480 RGD:1599508 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G Ngf nerve growth factor IMP RGD PMID:29609077 RGD:402463965 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor IEP protein:decreased expression:forebrain RGD PMID:29609077 RGD:402463965 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 IEP protein:decreased expression:forebrain RGD PMID:29609077 RGD:402463965 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19099
    Pathological Conditions, Signs and Symptoms 13604
      Pathologic Processes 8255
        Nerve Degeneration 136
          Retrograde Degeneration 4
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