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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Meningeal Tuberculosis
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Accession:DOID:9004501 term browser browse the term
Definition:A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)
Synonyms:exact_synonym: TB Meningitides;   TB Meningitis;   Tubercular Meningitides;   Tubercular Meningitis;   Tuberculosis Meningitides;   Tuberculosis Meningitis;   Tuberculous Hypertrophic Pachymeningitides;   Tuberculous Hypertrophic Pachymeningitis;   Tuberculous Meningitides;   meningeal tuberculoses;   tuberculous meningitis
 primary_id: MESH:D014390
 xref: EFO:1000039


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Meningeal Tuberculosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4r interleukin 4 receptor ISO protein:decreased expression:serum RGD PMID:21251883 RGD:5128510 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Tnf tumor necrosis factor ISO RGD PMID:10318940 RGD:10449456 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18970
    disease by infectious agent 2216
      Bacterial Infections and Mycoses 1073
        Central Nervous System Infections 296
          Central Nervous System Bacterial Infections 48
            central nervous system tuberculosis 2
              Meningeal Tuberculosis 2
Path 2
Term Annotations click to browse term
  disease 18970
    disease by infectious agent 2216
      Bacterial Infections and Mycoses 1073
        bacterial infectious disease 824
          Gram-Positive Bacterial Infections 395
            Actinomycetales Infections 320
              Mycobacterium Infections 319
                tuberculosis 130
                  extrapulmonary tuberculosis 18
                    central nervous system tuberculosis 2
                      Meningeal Tuberculosis 2
paths to the root