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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tolnaftate
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Accession:CHEBI:9620 term browser browse the term
Definition:A monothiocarbamic ester that is the methyl(3-tolyl)carbamothioate ester of 2-naphthol. A synthetic anti-fungal agent used to treat jock itch, athlete's foot and ringworm.
Synonyms:exact_synonym: O-2-naphthyl methyl(3-methylphenyl)carbamothioate
 related_synonym: 2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate;   Formula=C19H17NOS;   InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3;   InChIKey=FUSNMLFNXJSCDI-UHFFFAOYSA-N;   Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester;   N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide;   O-2-Naphthyl m,N-dimethylthiocarbanilate;   SMILES=CN(C(=S)Oc1ccc2ccccc2c1)c1cccc(C)c1;   Separin;   Tinactin;   Tolnaphthate;   m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester;   tolnaftato;   tolnaftatum
 xref: CAS:2398-96-1;   DrugBank:DB00525;   Drug_Central:3617;   HMDB:HMDB0005005;   KEGG:D00381;   LINCS:LSM-5554
 xref_mesh: MESH:D014047
 xref: PMID:20347664;   PMID:2061794;   PMID:20635527;   PMID:21565546;   PMID:22125963;   PMID:24706116;   PMID:3509341;   PMID:4568708;   PMID:5319027;   PMID:5705341;   PMID:5745067;   PMID:5847820;   PMID:5856396;   PMID:5952516;   PMID:697362;   Patent:US2010035939;   Patent:WO2010037089;   Reaxys:2752620;   Wikipedia:Tolnaftate


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tolnaftate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli1 GLI family zinc finger 1 multiple interactions ISO Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Tolnaftate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
decreases secretion
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein] CTD PMID:11886533, PMID:15284827 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions
decreases secretion
decreases expression
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein] CTD PMID:11886533, PMID:15284827 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          genotoxin 16978
            2-naphthol 37
              tolnaftate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  cyclic hydrocarbon 17075
                                    arene 17071
                                      polycyclic arene 16889
                                        ortho-fused polycyclic arene 9650
                                          ortho-fused bicyclic arene 2401
                                            naphthalene 2348
                                              naphthol 190
                                                2-naphthol 37
                                                  tolnaftate 5
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