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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flucytosine
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Accession:CHEBI:5100 term browser browse the term
Definition:An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Synonyms:exact_synonym: 4-amino-5-fluoropyrimidin-2(1H)-one
 related_synonym: 5-FC;   5-Fluorocystosine;   5-Fluorocytosine;   Ancobon (TN);   Ancotil;   Formula=C4H4FN3O;   InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9);   InChIKey=XRECTZIEBJDKEO-UHFFFAOYSA-N;   SMILES=Nc1nc(=O)[nH]cc1F;   flucytosina;   flucytosinum
 xref: CAS:2022-85-7;   DrugBank:DB01099;   Drug_Central:1188;   HMDB:HMDB0015231;   KEGG:D00323;   LINCS:LSM-5878
 xref_mesh: MESH:D005437
 xref: PDBeChem:1LD;   PMID:11519290;   PMID:14871609;   PMID:18731030;   PMID:23576540;   PMID:25649231;   PMID:26201447;   PMID:28166217;   Patent:US2802005;   Patent:US2945038;   Patent:US3040026;   Wikipedia:Flucytosine



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flucytosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Flucytosine results in decreased expression of BCL2 protein CTD PMID:15592511 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Flucytosine results in increased expression of MDM2 protein CTD PMID:15592511 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Flucytosine results in increased expression of TP53 protein CTD PMID:15592511 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19860
    role 19832
      application 19675
        pro-agent 11550
          prodrug 11310
            flucytosine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    main group molecular entity 19804
                      s-block molecular entity 19637
                        hydrogen molecular entity 19618
                          hydrides 19124
                            inorganic hydride 18133
                              pnictogen hydride 18122
                                nitrogen hydride 18030
                                  azane 17837
                                    ammonia 17836
                                      organic amino compound 17836
                                        aromatic amine 15490
                                          aminopyrimidine 1931
                                            cytosine 1372
                                              flucytosine 3
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