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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flucytosine
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Accession:CHEBI:5100 term browser browse the term
Definition:An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Synonyms:exact_synonym: 4-amino-5-fluoropyrimidin-2(1H)-one
 related_synonym: 5-FC;   5-Fluorocystosine;   5-Fluorocytosine;   Ancobon (TN);   Ancotil;   Formula=C4H4FN3O;   InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9);   InChIKey=XRECTZIEBJDKEO-UHFFFAOYSA-N;   SMILES=Nc1nc(=O)[nH]cc1F;   flucytosina;   flucytosinum
 xref: CAS:2022-85-7;   DrugBank:DB01099;   Drug_Central:1188;   HMDB:HMDB0015231;   KEGG:D00323;   LINCS:LSM-5878
 xref_mesh: MESH:D005437
 xref: PDBeChem:1LD;   PMID:11519290;   PMID:14871609;   PMID:18731030;   PMID:23576540;   PMID:25649231;   PMID:26201447;   PMID:28166217;   Patent:US2802005;   Patent:US2945038;   Patent:US3040026;   Wikipedia:Flucytosine



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flucytosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Flucytosine results in decreased expression of BCL2 protein CTD PMID:15592511 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Flucytosine results in increased expression of MDM2 protein CTD PMID:15592511 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Flucytosine results in increased expression of TP53 protein CTD PMID:15592511 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        pro-agent 10144
          prodrug 9948
            flucytosine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            inorganic hydride 17882
                              pnictogen hydride 17865
                                nitrogen hydride 17754
                                  azane 17503
                                    ammonia 17502
                                      organic amino compound 17502
                                        aromatic amine 14911
                                          aminopyrimidine 1686
                                            cytosine 1146
                                              flucytosine 3
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