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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:deoxypodophyllotoxin
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Accession:CHEBI:4429 term browser browse the term
Definition:A member of the class of furonaphthodioxoles that is (5R,5aR,8aR)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one substituted at position 5 by a 3,4,5-trimethoxyphenyl group.
Synonyms:exact_synonym: (5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
 related_synonym: 4-Deoxypodophyllotoxin;   Anthricin;   Desoxypodophyllotoxin;   Formula=C22H22O7;   Hernandin;   Hernandion;   InChI=1S/C22H22O7/c1-24-17-6-12(7-18(25-2)21(17)26-3)19-14-8-16-15(28-10-29-16)5-11(14)4-13-9-27-22(23)20(13)19/h5-8,13,19-20H,4,9-10H2,1-3H3/t13-,19+,20-/m0/s1;   InChIKey=ZGLXUQQMLLIKAN-SVIJTADQSA-N;   SMILES=[C@H]1(C2=C(C[C@@]3([C@@]1(C(OC3)=O)[H])[H])C=C4OCOC4=C2)C5=CC(=C(OC)C(=C5)OC)OC;   Silicicolin
 xref: CAS:19186-35-7;   KEGG:C10556;   KNApSAcK:C00002597
 xref_mesh: MESH:C014451
 xref: MetaCyc:CPD-8958;   PMID:24176745;   PMID:24913660;   PMID:25608854;   PMID:25712646;   PMID:25720974;   PMID:26470595;   PMID:26573436;   PMID:26683770;   Reaxys:98060



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deoxypodophyllotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation
multiple interactions
ISO deoxypodophyllotoxin results in increased phosphorylation of ACACA protein
deoxypodophyllotoxin inhibits the reaction [Dietary Fats results in decreased phosphorylation of ACACA protein]
deoxypodophyllotoxin inhibits the reaction [T0901317 results in increased expression of ACACA mRNA]
CTD PMID:30148990 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO deoxypodophyllotoxin inhibits the reaction [T0901317 results in increased expression of FASN mRNA] CTD PMID:30148990 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO deoxypodophyllotoxin inhibits the reaction [Dietary Fats results in increased activity of GPT protein] CTD PMID:30148990 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO deoxypodophyllotoxin inhibits the reaction [T0901317 results in increased expression of SCD mRNA] CTD PMID:30148990 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO deoxypodophyllotoxin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]
deoxypodophyllotoxin inhibits the reaction [T0901317 results in increased expression of SREBF1 mRNA]; deoxypodophyllotoxin inhibits the reaction [T0901317 results in increased expression of SREBF1 protein]; dorsomorphin inhibits the reaction [deoxypodophyllotoxin inhibits the reaction [T0901317 results in increased expression of SREBF1 protein]]
CTD PMID:30148990 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO deoxypodophyllotoxin results in increased phosphorylation of STK11 protein CTD PMID:30148990 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      biological role 19633
        biochemical role 19388
          apoptosis inducer 13431
            deoxypodophyllotoxin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic group 18752
                              organic divalent group 18771
                                organodiyl group 18737
                                  carbonyl group 18704
                                    carbonyl compound 18738
                                      carboxylic ester 15889
                                        lactone 11266
                                          gamma-lactone 6788
                                            deoxypodophyllotoxin 6
paths to the root