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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:deoxypodophyllotoxin
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Accession:CHEBI:4429 term browser browse the term
Definition:A member of the class of furonaphthodioxoles that is (5R,5aR,8aR)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one substituted at position 5 by a 3,4,5-trimethoxyphenyl group.
Synonyms:exact_synonym: (5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
 related_synonym: 4-Deoxypodophyllotoxin;   Anthricin;   Desoxypodophyllotoxin;   Formula=C22H22O7;   Hernandin;   Hernandion;   InChI=1S/C22H22O7/c1-24-17-6-12(7-18(25-2)21(17)26-3)19-14-8-16-15(28-10-29-16)5-11(14)4-13-9-27-22(23)20(13)19/h5-8,13,19-20H,4,9-10H2,1-3H3/t13-,19+,20-/m0/s1;   InChIKey=ZGLXUQQMLLIKAN-SVIJTADQSA-N;   SMILES=[C@H]1(C2=C(C[C@@]3([C@@]1(C(OC3)=O)[H])[H])C=C4OCOC4=C2)C5=CC(=C(OC)C(=C5)OC)OC;   Silicicolin
 xref: CAS:19186-35-7;   KEGG:C10556;   KNApSAcK:C00002597
 xref_mesh: MESH:C014451
 xref: MetaCyc:CPD-8958;   PMID:24176745;   PMID:24913660;   PMID:25608854;   PMID:25712646;   PMID:25720974;   PMID:26470595;   PMID:26573436;   PMID:26683770;   Reaxys:98060



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deoxypodophyllotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation
multiple interactions
ISO deoxypodophyllotoxin results in increased phosphorylation of ACACA protein
deoxypodophyllotoxin inhibits the reaction [T0901317 results in increased expression of ACACA mRNA]
deoxypodophyllotoxin inhibits the reaction [Dietary Fats results in decreased phosphorylation of ACACA protein]
CTD PMID:30148990 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO deoxypodophyllotoxin inhibits the reaction [T0901317 results in increased expression of FASN mRNA] CTD PMID:30148990 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO deoxypodophyllotoxin inhibits the reaction [Dietary Fats results in increased activity of GPT protein] CTD PMID:30148990 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO deoxypodophyllotoxin inhibits the reaction [T0901317 results in increased expression of SCD mRNA] CTD PMID:30148990 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO deoxypodophyllotoxin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]
deoxypodophyllotoxin inhibits the reaction [T0901317 results in increased expression of SREBF1 mRNA]; deoxypodophyllotoxin inhibits the reaction [T0901317 results in increased expression of SREBF1 protein]; dorsomorphin inhibits the reaction [deoxypodophyllotoxin inhibits the reaction [T0901317 results in increased expression of SREBF1 protein]]
CTD PMID:30148990 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO deoxypodophyllotoxin results in increased phosphorylation of STK11 protein CTD PMID:30148990 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        biochemical role 19515
          apoptosis inducer 13628
            deoxypodophyllotoxin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  ester 17270
                                    carboxylic ester 16587
                                      lactone 12526
                                        gamma-lactone 6863
                                          deoxypodophyllotoxin 6
paths to the root