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ONTOLOGY REPORT - ANNOTATIONS


Term:cinaciguat
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Accession:CHEBI:142433 term browser browse the term
Definition:A benzoic acid that is 4-(aminomethyl)benzoic acid in which the amino group is substituted by 4-carboxybutyl and 2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl groups. It is a soluble guanylate cyclase activator, used for the treatment of acute decompensated heart failure.
Synonyms:exact_synonym: 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid
 related_synonym: BAY 58-2667;   BAY582667;   Formula=C36H39NO5;   InChI=1S/C36H39NO5/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41);   InChIKey=WPYWMXNXEZFMAK-UHFFFAOYSA-N;   SMILES=C=1C=CC=C(C1)CCC2=CC=C(C=C2)COC3=C(C=CC=C3)CCN(CCCCC(O)=O)CC4=CC=C(C=C4)C(O)=O;   cinaciguatum
 xref: CAS:329773-35-5 "ChemIDplus";   CAS:329773-35-5 "KEGG DRUG";   KEGG:D07577
 xref_mesh: MESH:C480588
 xref: PDBeChem:Z90;   PMID:18779378 "Europe PMC";   PMID:20067336 "Europe PMC";   PMID:20463019 "Europe PMC";   PMID:20730699 "Europe PMC";   PMID:21856817 "Europe PMC";   PMID:21868716 "Europe PMC";   PMID:22474005 "Europe PMC";   PMID:22713287 "Europe PMC";   PMID:23144773 "Europe PMC";   PMID:24090476 "Europe PMC";   PMID:25200007 "Europe PMC";   PMID:26520063 "Europe PMC";   PMID:27122537 "Europe PMC";   PMID:27853261 "Europe PMC";   PMID:28894114 "Europe PMC";   PMID:29138269 "Europe PMC";   PMID:29653192 "Europe PMC";   Patent:US2012010292;   Reaxys:9676935 "Reaxys";   Wikipedia:Cinaciguat


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cinaciguat term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 JBrowse link 2 181,045,694 181,103,321 RGD:6480464
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 JBrowse link 2 180,976,939 181,026,001 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19734
    role 19680
      biological role 19678
        biochemical role 19177
          effector 102
            soluble guanylate cyclase activator 6
              cinaciguat 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic group 18414
                              organic divalent group 18406
                                organodiyl group 18406
                                  carbonyl group 18295
                                    carbonyl compound 18295
                                      carboxylic acid 17963
                                        aromatic carboxylic acid 10743
                                          benzoic acids 10709
                                            cinaciguat 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.