The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A benzoic acid that is 4-(aminomethyl)benzoic acid in which the amino group is substituted by 4-carboxybutyl and 2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl groups. It is a soluble guanylate cyclase activator, used for the treatment of acute decompensated heart failure.
[BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; dicyanocobinamide promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]] 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [BAY 58-2667 binds to GUCY1B1 protein]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] [BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; dicyanocobinamide promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]
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