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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
cyclopentenone results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:18383863 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO |
cyclopentenone results in increased expression of CDKN1B |
CTD |
PMID:16061222 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation |
ISO |
cyclopentenone results in decreased phosphorylation of RB1 protein |
CTD |
PMID:16061222 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
4-phenyl-3-furoxancarbonitrile results in increased expression of GCLC mRNA 4-phenyl-3-furoxancarbonitrile analog results in increased expression of GCLC mRNA |
CTD |
PMID:22851183 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
4-phenyl-3-furoxancarbonitrile results in increased expression of GCLM mRNA |
CTD |
PMID:22851183 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
4-phenyl-3-furoxancarbonitrile results in increased expression of NQO1 mRNA |
CTD |
PMID:22851183 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
increases expression |
ISO |
bryostatin 1 results in increased expression of BIRC3 mRNA |
CTD |
PMID:14527959 |
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Cd22 |
CD22 molecule |
increases expression |
ISO |
bryostatin 1 results in increased expression of CD22 protein |
CTD |
PMID:10741703 |
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NCBI chr 1:86,116,376...86,132,782
Ensembl chr 1:86,117,459...86,132,322
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G |
Cdk1 |
cyclin-dependent kinase 1 |
multiple interactions |
ISO |
bryostatin 1 inhibits the reaction [Paclitaxel results in increased activity of CDK1 protein] |
CTD |
PMID:10516758 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
F3 |
coagulation factor III, tissue factor |
increases expression |
ISO |
bryostatin 1 results in increased expression of F3 protein |
CTD |
PMID:25569083 |
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NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Il10 |
interleukin 10 |
decreases expression |
ISO |
bryostatin 1 analog results in decreased expression of IL10 mRNA; bryostatin 1 results in decreased expression of IL10 mRNA |
CTD |
PMID:15614042 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12b |
interleukin 12B |
decreases expression increases expression |
ISO |
bryostatin 1 analog results in decreased expression of IL12B mRNA bryostatin 1 results in increased expression of IL12B mRNA |
CTD |
PMID:15614042 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Itgax |
integrin subunit alpha X |
increases expression |
ISO |
bryostatin 1 results in increased expression of ITGAX protein |
CTD |
PMID:10741703 |
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NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
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G |
Prkca |
protein kinase C, alpha |
multiple interactions decreases expression |
ISO |
[bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCA protein bryostatin 1 results in decreased expression of PRKCA protein |
CTD |
PMID:8892972 |
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NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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G |
Prkcb |
protein kinase C, beta |
multiple interactions decreases expression |
ISO |
[bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein; [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein alternative form bryostatin 1 results in decreased expression of PRKCB protein; bryostatin 1 results in decreased expression of PRKCB protein alternative form |
CTD |
PMID:8892972 |
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NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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G |
Prkcg |
protein kinase C, gamma |
multiple interactions decreases expression |
ISO |
[bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCG protein bryostatin 1 results in decreased expression of PRKCG protein |
CTD |
PMID:8892972 |
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NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
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G |
Atg5 |
autophagy related 5 |
multiple interactions |
ISO |
N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of ATG5 mRNA] |
CTD |
PMID:31369747 |
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NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Becn1 |
beclin 1 |
multiple interactions |
ISO |
N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of BECN1 mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of BECN1 protein] |
CTD |
PMID:31369747 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of MAP1LC3B mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of MAP1LC3B protein] |
CTD |
PMID:31369747 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
ISO |
N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in increased expression of SQSTM1 mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in increased expression of SQSTM1 protein] |
CTD |
PMID:31369747 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Mttp |
microsomal triglyceride transfer protein |
multiple interactions |
ISO |
CDN1163 inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MTTP protein] |
CTD |
PMID:34516972 |
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NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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G |
Nanog |
Nanog homeobox |
decreases expression |
ISO |
Chir 98014 results in decreased expression of NANOG mRNA |
CTD |
PMID:22723015 |
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NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
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G |
Otx2 |
orthodenticle homeobox 2 |
decreases expression |
ISO |
Chir 98014 results in decreased expression of OTX2 mRNA |
CTD |
PMID:22723015 |
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NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416
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G |
Pax6 |
paired box 6 |
decreases expression |
ISO |
Chir 98014 results in decreased expression of PAX6 mRNA |
CTD |
PMID:22723015 |
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NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
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G |
Gucy1a1 |
guanylate cyclase 1 soluble subunit alpha 1 |
multiple interactions |
ISO EXP |
[BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; dicyanocobinamide promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]] 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] |
CTD |
PMID:19466990 PMID:22171090 |
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NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
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G |
Gucy1b1 |
guanylate cyclase 1 soluble subunit beta 1 |
multiple interactions affects binding |
EXP ISO |
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [BAY 58-2667 binds to GUCY1B1 protein]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] [BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; dicyanocobinamide promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]] |
CTD |
PMID:19466990 PMID:22171090 |
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NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
BAY 58-2667 inhibits the reaction [Isoproterenol results in increased expression of PTGS2 mRNA] |
CTD |
PMID:19667237 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
BAY 58-2667 inhibits the reaction [Isoproterenol results in increased expression of TGFB1 mRNA] |
CTD |
PMID:19667237 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Il13 |
interleukin 13 |
decreases expression decreases secretion |
ISO |
Etazolate results in decreased expression of IL13 mRNA Etazolate results in decreased secretion of IL13 protein |
CTD |
PMID:16083514 |
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NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Ltc4s |
leukotriene C4 synthase |
decreases secretion |
ISO |
Etazolate results in decreased secretion of LTC4S protein |
CTD |
PMID:16083514 |
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NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression multiple interactions |
ISO |
Ethoxyquin results in increased expression of ABCC2 mRNA [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA |
CTD |
PMID:15833929 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
increases expression multiple interactions |
ISO |
Ethoxyquin results in increased expression of ABCC3 mRNA [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA |
CTD |
PMID:15833929 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
increases expression multiple interactions |
ISO |
Ethoxyquin results in increased expression of ABCC4 mRNA [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA |
CTD |
PMID:15833929 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
multiple interactions increases expression |
ISO |
[Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA Ethoxyquin results in increased expression of ABCC5 mRNA |
CTD |
PMID:15833929 |
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NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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G |
Abcc6 |
ATP binding cassette subfamily C member 6 |
increases expression multiple interactions |
ISO |
Ethoxyquin results in increased expression of ABCC6 mRNA [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA |
CTD |
PMID:15833929 |
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NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
increases expression multiple interactions |
ISO |
Ethoxyquin results in increased expression of AKR1B10 mRNA NFE2L2 protein promotes the reaction [Ethoxyquin results in increased expression of AKR1B10 mRNA] |
CTD |
PMID:21277289 |
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NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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G |
Akr7a3 |
aldo-keto reductase family 7 member A3 |
increases activity increases expression |
EXP |
Ethoxyquin results in increased activity of AKR7A3 protein Ethoxyquin results in increased expression of AKR7A3 mRNA; Ethoxyquin results in increased expression of AKR7A3 protein |
CTD |
PMID:8198522 PMID:8395332 PMID:9328168 PMID:19695238 |
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NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
ISO EXP |
Ethoxyquin results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:17998271 PMID:19695238 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldh1b1 |
aldehyde dehydrogenase 1 family, member B1 |
increases expression |
ISO |
Ethoxyquin results in increased expression of ALDH1B1 mRNA |
CTD |
PMID:17998271 |
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NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
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G |
Alox5 |
arachidonate 5-lipoxygenase |
decreases activity |
EXP |
Ethoxyquin results in decreased activity of ALOX5 protein |
CTD |
PMID:3928952 |
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NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Dihydrotestosterone inhibits the reaction [Ethoxyquin results in increased activity of AR protein]; Ethoxyquin inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA] |
CTD |
PMID:15064155 PMID:21310686 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Ces2c |
carboxylesterase 2C |
increases expression |
ISO |
Ethoxyquin results in increased expression of CES2C mRNA |
CTD |
PMID:22429928 |
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NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases activity increases expression |
EXP |
Ethoxyquin inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein] Ethoxyquin results in increased activity of CYP1A1 protein Ethoxyquin results in increased expression of CYP1A1 mRNA |
CTD |
PMID:16906435 PMID:19695238 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP |
Ethoxyquin results in increased expression of CYP1A2 mRNA |
CTD |
PMID:19695238 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
EXP |
Ethoxyquin results in increased expression of CYP1B1 mRNA |
CTD |
PMID:19695238 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2b15 |
cytochrome P450, family 2, subfamily b, polypeptide 15 |
increases expression |
EXP |
Ethoxyquin results in increased expression of CYP2B15 mRNA |
CTD |
PMID:19695238 |
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NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases expression |
ISO |
Ethoxyquin results in increased expression of CYP2B10 mRNA |
CTD |
PMID:17627975 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp3a18 |
cytochrome P450, family 3, subfamily a, polypeptide 18 |
increases expression |
EXP |
Ethoxyquin results in increased expression of CYP3A18 mRNA |
CTD |
PMID:19695238 |
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NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
increases expression |
EXP |
Ethoxyquin results in increased expression of CYP3A23-3A1 mRNA |
CTD |
PMID:19695238 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
Ethoxyquin results in increased expression of EPHX1 mRNA |
CTD |
PMID:19695238 |
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NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
EXP ISO |
Ethoxyquin results in increased expression of GSTA2 mRNA Ethoxyquin results in increased expression of GSTA2 protein |
CTD |
PMID:11309284 PMID:19695238 |
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NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gsta3 |
glutathione S-transferase alpha 3 |
increases expression |
EXP |
Ethoxyquin results in increased expression of GSTA3 protein |
CTD |
PMID:8198522 PMID:9794803 |
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NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
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G |
Gsta4 |
glutathione S-transferase alpha 4 |
increases expression |
EXP |
Ethoxyquin results in increased expression of GSTA4 mRNA; Ethoxyquin results in increased expression of GSTA4 protein |
CTD |
PMID:9794803 PMID:19695238 |
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NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
multiple interactions increases expression increases activity |
EXP ISO |
Ethoxyquin promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Ethoxyquin results in increased expression of and results in increased activity of GSTA5 protein Ethoxyquin results in increased expression of GSTA1 protein Ethoxyquin results in increased expression of GSTA5 mRNA; Ethoxyquin results in increased expression of GSTA5 protein Ethoxyquin results in increased activity of GSTA5 protein |
CTD |
PMID:1637297 PMID:8198522 PMID:9328168 PMID:9794803 PMID:11309284 PMID:19695238 More...
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NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
ISO EXP |
Ethoxyquin results in increased expression of GSTM1 mRNA; Ethoxyquin results in increased expression of GSTM1 protein; Ethoxyquin results in increased expression of GSTM5 protein |
CTD |
PMID:8198522 PMID:11309284 PMID:18723825 PMID:19695238 |
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NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstm2 |
glutathione S-transferase mu 2 |
increases expression |
EXP ISO |
Ethoxyquin results in increased expression of GSTM2 mRNA |
CTD |
PMID:18723825 PMID:19695238 |
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NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstm4 |
glutathione S-transferase mu 4 |
increases expression |
ISO |
Ethoxyquin results in increased expression of GSTM4 mRNA |
CTD |
PMID:18723825 |
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NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
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G |
Gstm5 |
glutathione S-transferase, mu 5 |
increases expression |
ISO EXP |
Ethoxyquin results in increased expression of GSTM3 mRNA Ethoxyquin results in increased expression of GSTM3 protein |
CTD |
PMID:9794803 PMID:18723825 |
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NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
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G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
EXP |
Ethoxyquin results in increased expression of GSTP1 mRNA; Ethoxyquin results in increased expression of GSTP1 protein |
CTD |
PMID:8198522 PMID:9794803 PMID:19695238 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gstt1 |
glutathione S-transferase theta 1 |
increases expression |
ISO EXP |
Ethoxyquin results in increased expression of GSTT1 mRNA Ethoxyquin results in increased expression of GSTT1 mRNA; Ethoxyquin results in increased expression of GSTT1 protein |
CTD |
PMID:9794803 PMID:18723825 |
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NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
Ethoxyquin results in increased expression of HMOX1 mRNA; Ethoxyquin results in increased expression of HMOX1 protein |
CTD |
PMID:25690736 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
[Ethoxyquin results in increased expression of PRDX1 protein] which results in increased phosphorylation of MAPK14 protein |
CTD |
PMID:16880205 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mgst1 |
microsomal glutathione S-transferase 1 |
increases expression |
ISO |
Ethoxyquin results in increased expression of MGST1 mRNA |
CTD |
PMID:18723825 |
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NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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Mgst3 |
microsomal glutathione S-transferase 3 |
increases expression |
ISO |
Ethoxyquin results in increased expression of MGST3 mRNA |
CTD |
PMID:18723825 |
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NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
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Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions affects activity |
ISO |
NFE2L2 protein promotes the reaction [Ethoxyquin results in increased expression of AKR1B10 mRNA] Ethoxyquin affects the activity of NFE2L2 protein [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA; [Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA; Ethoxyquin binds to and results in increased activity of NFE2L2 protein |
CTD |
PMID:11309284 PMID:15833929 PMID:15919853 PMID:21277289 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nox4 |
NADPH oxidase 4 |
increases expression |
EXP |
Ethoxyquin results in increased expression of NOX4 mRNA |
CTD |
PMID:19695238 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions increases activity |
ISO EXP |
Ethoxyquin results in increased expression of NQO1 mRNA; Ethoxyquin results in increased expression of NQO1 protein Ethoxyquin promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Ethoxyquin results in increased activity of NQO1 protein] |
CTD |
PMID:11309284 PMID:15919853 PMID:16045903 PMID:16906435 PMID:17627975 PMID:19144771 PMID:19695238 More...
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases activity |
ISO |
Ethoxyquin binds to and results in increased activity of NR1I2 protein Ethoxyquin results in increased activity of NR1I2 protein |
CTD |
PMID:21115097 PMID:25455453 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Prdx1 |
peroxiredoxin 1 |
increases expression multiple interactions |
ISO |
Ethoxyquin results in increased expression of PRDX1 protein [Ethoxyquin results in increased expression of PRDX1 protein] which results in increased phosphorylation of MAPK14 protein |
CTD |
PMID:16880205 |
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NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
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Slco2b1 |
solute carrier organic anion transporter family, member 2b1 |
increases expression |
ISO |
Ethoxyquin results in increased expression of SLCO2B1 mRNA |
CTD |
PMID:15919853 |
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NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression |
EXP ISO |
Ethoxyquin results in increased expression of UGT1A1 mRNA |
CTD |
PMID:19144771 PMID:19695238 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
increases expression |
ISO |
Ethoxyquin results in increased expression of UGT1A5 mRNA |
CTD |
PMID:19144771 |
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NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Acta1 |
actin, alpha 1, skeletal muscle |
decreases expression |
EXP |
GSK2181236A decreases expression of Acta1 mRNA in rat myocardium |
RGD |
PMID:22783192 |
RGD:25824851 |
NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
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Nppa |
natriuretic peptide A |
decreases expression |
EXP |
GSK2181236A decreases expression of Nppa mRNA in rat myocardium |
RGD |
PMID:22783192 |
RGD:25824851 |
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases metabolic processing |
ISO |
CYP1A1 protein results in increased metabolism of riociguat |
CTD |
PMID:30950278 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Kcnk3 |
potassium two pore domain channel subfamily K member 3 |
decreases response to substance increases activity |
ISO |
KCNK3 protein mutant form results in decreased susceptibility to riociguat riociguat results in increased activity of KCNK3 protein |
CTD |
PMID:30365877 |
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NCBI chr 6:25,761,487...25,799,153
Ensembl chr 6:25,763,228...25,799,153
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G |
Ctnnb1 |
catenin beta 1 |
affects localization |
ISO |
sporidesmin affects the localization of CTNNB1 protein |
CTD |
PMID:28193462 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
affects expression |
ISO |
sporidesmin affects the expression of CYP1A2 mRNA |
CTD |
PMID:28193462 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
increases expression multiple interactions |
ISO |
sporidesmin results in increased expression of CYP2C18 mRNA; sporidesmin results in increased expression of CYP2C18 protein MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA] |
CTD |
PMID:28193462 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
affects expression multiple interactions |
ISO |
sporidesmin affects the expression of CYP2C8 mRNA MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA] |
CTD |
PMID:28193462 |
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Dkk3 |
dickkopf WNT signaling pathway inhibitor 3 |
decreases expression |
ISO |
sporidesmin results in decreased expression of DKK3 mRNA |
CTD |
PMID:28193462 |
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NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590
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Mir132 |
microRNA 132 |
increases expression |
ISO |
sporidesmin results in increased expression of MIR132 mRNA |
CTD |
PMID:28193462 |
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NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
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G |
Mir138-2 |
microRNA 138-2 |
increases expression |
ISO |
sporidesmin results in increased expression of MIR138-2 mRNA alternative form |
CTD |
PMID:28193462 |
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NCBI chr19:10,674,193...10,674,274
Ensembl chr19:10,674,193...10,674,274
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Mir139 |
microRNA 139 |
increases expression |
ISO |
sporidesmin results in increased expression of MIR139 mRNA |
CTD |
PMID:28193462 |
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NCBI chr 1:155,878,828...155,878,895
Ensembl chr 1:155,878,825...155,878,902
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Mir150 |
microRNA 150 |
increases expression |
ISO |
sporidesmin results in increased expression of MIR150 mRNA |
CTD |
PMID:28193462 |
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NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108
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G |
Mir184 |
microRNA 184 |
increases expression |
ISO |
sporidesmin results in increased expression of MIR184 mRNA |
CTD |
PMID:28193462 |
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NCBI chr 8:90,343,134...90,343,210
Ensembl chr 8:90,343,134...90,343,210
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G |
Mir21 |
microRNA 21 |
increases expression multiple interactions |
ISO |
sporidesmin results in increased expression of MIR21 mRNA MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]; MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA] |
CTD |
PMID:28193462 |
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NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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G |
Mir293 |
microRNA 293 |
increases expression |
ISO |
sporidesmin results in increased expression of MIR371A mRNA |
CTD |
PMID:28193462 |
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NCBI chr 1:65,963,050...65,963,121
Ensembl chr 1:65,963,050...65,963,121
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G |
Mir295-1 |
microRNA 295-1 |
increases expression |
ISO |
sporidesmin results in increased expression of MIR372 mRNA |
CTD |
PMID:28193462 |
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NCBI chr 1:65,962,566...65,962,646
Ensembl chr 1:65,962,566...65,962,646
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Mir31 |
microRNA 31 |
multiple interactions increases expression |
ISO |
MIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA] sporidesmin results in increased expression of MIR31 mRNA |
CTD |
PMID:28193462 |
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NCBI chr 5:103,599,038...103,599,143
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Mir375 |
microRNA 375 |
increases expression |
ISO |
sporidesmin results in increased expression of MIR375 mRNA |
CTD |
PMID:28193462 |
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NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985
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Mir382 |
microRNA 382 |
increases expression |
ISO |
sporidesmin results in increased expression of MIR382 mRNA |
CTD |
PMID:28193462 |
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NCBI chr 6:128,748,539...128,748,618
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Mir409 |
microRNA 409 |
increases expression |
ISO |
sporidesmin results in increased expression of MIR409 mRNA |
CTD |
PMID:28193462 |
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NCBI chr 6:128,757,780...128,757,856
Ensembl chr 6:128,757,779...128,757,858
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Mir487b |
microRNA 487b |
increases expression |
ISO |
sporidesmin results in increased expression of MIR487B mRNA |
CTD |
PMID:28193462 |
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NCBI chr 6:128,741,485...128,741,566
Ensembl chr 6:128,741,485...128,741,566
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Sfrp1 |
secreted frizzled-related protein 1 |
decreases expression multiple interactions |
ISO |
sporidesmin results in decreased expression of SFRP1 mRNA MIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA] |
CTD |
PMID:28193462 |
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NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286
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G |
Wif1 |
Wnt inhibitory factor 1 |
multiple interactions affects expression |
ISO |
MIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA] |
CTD |
PMID:28193462 |
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NCBI chr 7:56,548,060...56,618,364
Ensembl chr 7:56,548,053...56,618,360
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Casp3 |
caspase 3 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of and results in increased cleavage of CASP3 protein] |
CTD |
PMID:34732784 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein] geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] |
CTD |
PMID:37307957 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein] |
CTD |
PMID:37307957 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A2 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A2 protein] |
CTD |
PMID:37307957 |
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NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Dlg1 |
discs large MAGUK scaffold protein 1 |
increases expression multiple interactions |
ISO |
geranylgeranylacetone results in increased expression of DLG1 mRNA; geranylgeranylacetone results in increased expression of DLG1 protein geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]; Niacinamide inhibits the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA]; resveratrol promotes the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA] |
CTD |
PMID:21232033 |
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NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
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Edn1 |
endothelin 1 |
decreases expression |
EXP |
geranylgeranylacetone results in decreased expression of EDN1 protein |
CTD |
PMID:16324314 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of FN1 protein] |
CTD |
PMID:37307957 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Hsf1 |
heat shock transcription factor 1 |
multiple interactions affects response to substance increases expression |
ISO |
geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA] HSF1 protein affects the susceptibility to geranylgeranylacetone geranylgeranylacetone results in increased expression of HSF1 protein |
CTD |
PMID:17189318 PMID:21232033 |
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NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
multiple interactions |
ISO |
geranylgeranylacetone promotes the reaction [Bleomycin results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [Ethanol results in increased expression of HSPA1A protein] geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A protein] |
CTD |
PMID:17189318 PMID:37307957 |
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NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
multiple interactions |
ISO |
[Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B mRNA; [Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B protein; geranylgeranylacetone promotes the reaction [Bleomycin results in increased expression of HSPA1B mRNA] geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B protein] |
CTD |
PMID:15340226 PMID:37307957 |
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NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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G |
Kcna5 |
potassium voltage-gated channel subfamily A member 5 |
increases expression |
ISO |
geranylgeranylacetone results in increased expression of KCNA5 protein |
CTD |
PMID:21232033 |
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NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
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G |
Map3k5 |
mitogen-activated protein kinase kinase kinase 5 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MAP3K5 protein] |
CTD |
PMID:34732784 |
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NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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G |
Nox4 |
NADPH oxidase 4 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein] geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA] |
CTD |
PMID:37307957 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of PARP1 protein] |
CTD |
PMID:34732784 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of RELA protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA protein] geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of RELA mRNA] |
CTD |
PMID:34732784 PMID:37307957 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A protein]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B protein] |
CTD |
PMID:37307957 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Txn1 |
thioredoxin 1 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN mRNA]; geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN protein] |
CTD |
PMID:34732784 |
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NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Vim |
vimentin |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of VIM protein] geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] |
CTD |
PMID:37307957 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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