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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trichlormethiazide
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Accession:CHEBI:9683 term browser browse the term
Definition:A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension.
Synonyms:exact_synonym: 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
 related_synonym: Formula=C8H8Cl3N3O4S2;   InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16);   InChIKey=LMJSLTNSBFUCMU-UHFFFAOYSA-N;   SMILES=C12=C(NC(C(Cl)Cl)NS1(=O)=O)C=C(Cl)C(=C2)S(N)(=O)=O;   hydrotrichlorothiazide;   trichlormethiazidum;   triclormetiazida
 xref: CAS:133-67-5;   DrugBank:DB01021;   Drug_Central:2733;   KEGG:C07767;   KEGG:D00658;   LINCS:LSM-4383
 xref_mesh: MESH:D014237
 xref: PMID:21605415;   PMID:24678944;   PMID:25692026;   PMID:25938807;   PMID:28089902;   PMID:28166217;   PMID:29438107;   Wikipedia:Trichlormethiazide


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trichlormethiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a7 solute carrier family 12 member 7 decreases activity ISO Trichlormethiazide results in decreased activity of SLC12A7 protein CTD PMID:10913127 NCBI chr 1:29,472,692...29,554,246
Ensembl chr 1:29,472,692...29,554,302 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Trichlormethiazide inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Trichlormethiazide affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Tpmt thiopurine S-methyltransferase decreases activity ISO Trichlormethiazide results in decreased activity of TPMT protein CTD PMID:8866635 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      biological role 19858
        antimicrobial agent 18239
          sulfonamide antibiotic 2939
            trichlormethiazide 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      chalcogen 19577
                        oxygen atom 19549
                          oxygen molecular entity 19529
                            hydroxides 19334
                              oxoacid 18791
                                chalcogen oxoacid 13796
                                  sulfur oxoacid 13585
                                    sulfonic acid 11613
                                      sulfonic acid derivative 11634
                                        sulfonamide 5322
                                          sulfonamide antibiotic 2939
                                            trichlormethiazide 4
paths to the root