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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:SDZ PSC 833
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Accession:CHEBI:8985 term browser browse the term
Definition:A homodetic cyclic peptide that has formula C63H111N11O12.
Synonyms:related_synonym: 3'-Keto-bmt(1)-val(2)-cyclosporin A;   Formula=C63H111N11O12;   InChI=1S/C63H111N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(14)15)63(86)74(52)25/h26-27,34-47,49-52H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,80)/b27-26+/t41-,42+,43-,44+,45+,46+,47+,49+,50+,51+,52+/m1/s1;   InChIKey=YJDYDFNKCBANTM-QCWCSKBGSA-N;   SMILES=C\\C=C\\C[C@@H](C)C(=O)[C@@H]1N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@@H](NC1=O)C(C)C)C(C)C;   Valspodar
 xref: CAS:121584-18-7;   KEGG:C11213;   KEGG:D06277
 xref_mesh: MESH:C070272



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SDZ PSC 833 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects activity
decreases activity
ISO
EXP
[valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Digoxin; [valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Xanthenes; [valspodar results in decreased activity of ABCB1 protein] which results in increased susceptibility to Paclitaxel; deoxynivalenol inhibits the reaction [valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]]; valspodar inhibits the reaction [[[Tretinoin co-treated with romidepsin] results in increased expression of ABCB1 mRNA] which results in decreased susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to N-caproylsphingosine]; valspodar inhibits the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; valspodar inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; valspodar inhibits the reaction [ABCB1 protein results in increased export of Diazinon]; valspodar inhibits the reaction [ABCB1 protein results in increased export of Paraquat]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Aldosterone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Beclomethasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Dexamethasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Fluticasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Hydrocortisone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Methylprednisolone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Prednisone]; valspodar inhibits the reaction [ABCB1 protein results in increased susceptibility to NSC73306]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Bisoprolol]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Carvedilol]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Sotalol]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of trospium chloride]
valspodar affects the activity of ABCB1 protein
[valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Xanthenes; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Cadmium]; valspodar inhibits the reaction [ABCB1 results in decreased susceptibility to Cadmium Chloride]
valspodar results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
valspodar results in decreased activity of ABCB1A protein
CTD PMID:9815696 PMID:10562306 PMID:10636889 PMID:10997946 PMID:11934808 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B decreases activity
affects activity
EXP valspodar results in decreased activity of ABCB1B protein
valspodar affects the activity of ABCB1B protein
CTD PMID:11934808 PMID:12626638 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO valspodar inhibits the reaction [Doxorubicin affects the localization of RELA protein] CTD PMID:17097285 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    chemical entity 19842
      group 19800
        organic group 18937
          amino-acid residue 11128
            peptide 11128
              cyclic peptide 8876
                homodetic cyclic peptide 8398
                  SDZ PSC 833 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            heteroorganic entity 19486
                              organochalcogen compound 19249
                                organooxygen compound 19167
                                  carbon oxoacid 18634
                                    carboxylic acid 18631
                                      carboacyl group 17703
                                        univalent carboacyl group 17703
                                          carbamoyl group 17554
                                            carboxamide 17554
                                              peptide 11128
                                                cyclic peptide 8876
                                                  homodetic cyclic peptide 8398
                                                    SDZ PSC 833 3
paths to the root