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neostigmine - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:neostigmine
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Accession:CHEBI:7514 term browser browse the term
Definition:A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
Synonyms:exact_synonym: 3-[(dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium
 related_synonym: (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate;   3-Trimethylammoniumphenyl N,N-dimethylcarbamate;   Eustigmin;   Eustigmine;   Formula=C12H19N2O2;   InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1;   InChIKey=ALWKGYPQUAPLQC-UHFFFAOYSA-N;   Prostigmine;   SMILES=CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C;   Vagostigmine;   m-Trimethylammoniumphenyldimethylcarbamate
 xref: CAS:59-99-4;   DrugBank:DB01400;   Drug_Central:1897;   HMDB:HMDB0015472;   KEGG:C07258;   KEGG:D08261;   LINCS:LSM-5360
 xref_mesh: MESH:D009388
 xref: PMID:7200780;   PMID:8584207;   Reaxys:3615946;   Wikipedia:Neostigmine

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neostigmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Neostigmine results in decreased activity of ACHE protein CTD PMID:623676 PMID:19105816 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Avp arginine vasopressin increases abundance EXP Neostigmine increases abundance of Avp protein in plasma RGD PMID:19515985 RGD:596920310 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bche butyrylcholinesterase affects response to substance ISO BCHE affects the susceptibility to Neostigmine CTD PMID:18399847 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Il10 interleukin 10 increases expression EXP Neostigmine results in increased expression of IL10 protein CTD PMID:17872965 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Pygl glycogen phosphorylase L increases activity
multiple interactions 		EXP Neostigmine results in increased activity of PYGL protein modified form
Phentolamine inhibits the reaction [Neostigmine results in increased activity of PYGL protein modified form] 		CTD PMID:1350317 NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:88,697,593...88,740,310 		JBrowse link
G Tnf tumor necrosis factor decreases expression EXP Neostigmine results in decreased expression of TNF protein CTD PMID:17872965 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    chemical entity 20843
      molecular entity 20842
        ion 17362
          organic ion 11511
            organic cation 9023
              quaternary ammonium ion 5311
                neostigmine 6
                  neostigmine bromide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    main group molecular entity 20766
                      s-block molecular entity 20561
                        hydrogen molecular entity 20545
                          hydrides 19679
                            inorganic hydride 18572
                              pnictogen hydride 18558
                                nitrogen hydride 18469
                                  ammonium 8450
                                    ammonium ion derivative 8445
                                      quaternary ammonium ion 5311
                                        neostigmine 6
                                          neostigmine bromide 0
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