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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dynorphin A
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Accession:CHEBI:4727 term browser browse the term
Definition:A peptide that has formula C69H116N23O13.
Synonyms:related_synonym: (2S)-6-amino-2-{[(2S)-1-[(2R)-2-[(2S)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-(2-{2-[(2R)-2-amino-3-(4-hydroxyphenyl)propanamido]acetamido}acetamido)-3-phenylpropanamido]-4-methylpentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-3-methylpentanamido]-5-[(azaniumylmethanimidoyl)amino]pentanoyl]pyrrolidin-2-yl]formamido}-N-[(1S)-1-carbamoyl-3-methylbutyl]hexanamide;   Dynorphin;   Dynorphin A 1-17;   Formula=C69H116N23O13;   InChI=1S/C69H115N23O13/c1-7-41(6)56(65(104)88-49(22-15-31-81-69(77)78)66(105)92-32-16-23-53(92)64(103)87-46(19-11-12-28-70)60(99)89-50(57(72)96)33-39(2)3)91-61(100)48(21-14-30-80-68(75)76)85-59(98)47(20-13-29-79-67(73)74)86-62(101)51(34-40(4)5)90-63(102)52(36-42-17-9-8-10-18-42)84-55(95)38-82-54(94)37-83-58(97)45(71)35-43-24-26-44(93)27-25-43/h8-10,17-18,24-27,39-41,45-53,56,93H,7,11-16,19-23,28-38,70-71H2,1-6H3,(H2,72,96)(H,82,94)(H,83,97)(H,84,95)(H,85,98)(H,86,101)(H,87,103)(H,88,104)(H,89,99)(H,90,102)(H,91,100)(H4,73,74,79)(H4,75,76,80)(H4,77,78,81)/p+1/t41?,45-,46+,47-,48-,49-,50+,51-,52-,53+,56+/m1/s1;   InChIKey=ZIHYAUCIMOSJIH-QGLXRRFISA-O;   SMILES=CCC(C)[C@H](NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC=1C=CC=CC1)NC(=O)CNC(=O)CNC(=O)[C@H](N)CC=2C=CC(O)=CC2)C(=O)N[C@H](CCCNC([NH3+])=N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N;   Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln
 xref: CAS:74913-18-1;   CAS:80448-90-4;   FooDB:FDB029215;   HMDB:HMDB0012935;   KEGG:C01574
 xref_mesh: MESH:D004399
 xref: PMID:1716470;   Wikipedia:dynorphin_A


show annotations for term's descendants           Sort by:
dynorphin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone multiple interactions
decreases secretion		 EXP Dynorphins inhibits the reaction [Nitroprusside results in increased secretion of CRH protein]; Naltrexone affects the reaction [Dynorphins results in decreased secretion of CRH protein] CTD PMID:3031743 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Oprd1 opioid receptor, delta 1 increases activity ISO Dynorphins results in increased activity of OPRD1 protein CTD PMID:26476280 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
affects binding
increases activity		 EXP
ISO		 Dynorphins binds to and results in increased activity of OPRK1 protein; norbinaltorphimine inhibits the reaction [Dynorphins binds to and results in increased activity of OPRK1 protein]
Dynorphins analog binds to OPRK1 protein
Dynorphins results in increased activity of OPRK1 protein		 CTD PMID:11270320 PMID:11676193 PMID:26476280 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding
increases activity		 EXP
ISO		 Dynorphins analog binds to OPRM1 protein
Dynorphins results in increased activity of OPRM1 protein		 CTD PMID:11270320 PMID:26476280 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      group 19765
        organic group 18936
          amino-acid residue 11122
            peptide 11122
              dynorphin A 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              peptide 11122
                                                dynorphin A 4
paths to the root