CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: ajmalan
Accession: CHEBI:37673
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Definition: An indole alkaloid fundamental parent that has formula C20H26N2.
Synonyms: related_synonym: Formula=C20H26N2; InChI=1S/C20H26N2/c1-3-12-11-22-17-8-13(12)14-9-20(10-18(14)22)15-6-4-5-7-16(15)21(2)19(17)20/h4-7,12-14,17-19H,3,8-11H2,1-2H3/t12-,13+,14?,17+,18+,19+,20+/m1/s1; InChIKey=AJONLKUQHMDAFG-PAPVJSBLSA-N; SMILES=[H][C@]12C[C@]3([H])N(C[C@H]1CC)[C@H]1C[C@@]4(CC21)c1ccccc1N(C)[C@@]34[H]
alt_id: CHEBI:22274; CHEBI:35913
xref: Beilstein:893162
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
Ajmaline inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]
CTD
PMID:29782822
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Ajmaline results in decreased activity of KCNH2 protein
CTD
PMID:15599706 PMID:24052561
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Scn5a
sodium voltage-gated channel alpha subunit 5
decreases activity affects response to substance
ISO
Ajmaline results in decreased activity of SCN5A protein SCN5A protein affects the susceptibility to Ajmaline
CTD
PMID:10662748 PMID:15520322 PMID:20174578
NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
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