indole alkaloid fundamental parent - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	indole alkaloid fundamental parent	go back to main search page
Accession:	CHEBI:38482	browse the term
Synonyms:	related_synonym:	indole alkaloid fundamental parents

show annotations for term's descendants Sort by:
Rat (1449) Mouse (1458) Human (1507) Chinchilla (0) Bonobo (0) Dog (4) Squirrel (0) Pig (2) Green Monkey (0) Naked Mole-rat (0) All
Genes (1449)

ajmaline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

Ajmaline inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Ajmaline results in decreased activity of KCNH2 protein

PMID:15599706 PMID:24052561

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

sodium voltage-gated channel alpha subunit 5

decreases activity
affects response to substance

Ajmaline results in decreased activity of SCN5A protein
SCN5A protein affects the susceptibility to Ajmaline

PMID:10662748 PMID:15520322 PMID:20174578

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

alpha-ergocryptine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity

ergocryptine results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

bromocriptine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression
multiple interactions

Bromocriptine results in increased expression of ABCB1 protein
Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Spiperone inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

increases activity
increases expression
multiple interactions

Bromocriptine results in increased activity of ABCB1B promoter
Bromocriptine results in increased expression of ABCB1B mRNA
Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; eticlopride inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Pertussis Toxin inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Spiperone inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

aldo-keto reductase family 1, member C3

increases expression
multiple interactions

Bromocriptine results in increased expression of AKR1C3 mRNA
methyl cellosolve inhibits the reaction [Bromocriptine results in increased expression of AKR1C3 mRNA]

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

activating transcription factor 3

increases expression

Bromocriptine results in increased expression of ATF3 mRNA; Bromocriptine results in increased expression of ATF3 protein

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Bromocriptine results in increased expression of BAX protein
[Bromocriptine co-treated with Octreotide] results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

brain-derived neurotrophic factor

decreases secretion

Bromocriptine results in decreased secretion of BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

catenin beta 1

multiple interactions

[Bromocriptine co-treated with Estradiol] results in decreased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions
decreases expression

Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of CYP11A1 mRNA]
Bromocriptine results in decreased expression of CYP11A1 protein

PMID:12742521 PMID:21427058

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

Bromocriptine results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Bromocriptine results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects binding
affects metabolic processing
multiple interactions

Bromocriptine binds to CYP3A4 protein
CYP3A4 protein affects the metabolism of Bromocriptine
Bromocriptine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]

PMID:15286053 PMID:17198380 PMID:19299527

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dopamine beta-hydroxylase

decreases activity

Bromocriptine results in decreased activity of DBH protein

NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248

G

dopamine receptor D2

affects expression
affects response to substance
multiple interactions
decreases expression
increases expression
increases response to substance

Bromocriptine affects the expression of DRD2 mRNA
DRD2 protein affects the susceptibility to Bromocriptine
Bromocriptine binds to and results in increased activity of DRD2 mRNA; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]
Bromocriptine results in decreased expression of DRD2 mRNA
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Bromocriptine results in increased expression of DRD2 mRNA
DRD2 polymorphism results in increased susceptibility to Bromocriptine

PMID:1534540 PMID:8103596 PMID:15781964 PMID:16901644 PMID:20063113

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

multiple interactions
decreases expression

[1-Methyl-4-phenylpyridinium co-treated with Bromocriptine] results in decreased expression of DRD3 mRNA
Bromocriptine results in decreased expression of DRD3 mRNA

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

estrogen receptor 1

multiple interactions

[Bromocriptine co-treated with Estradiol] results in increased expression of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

follicle stimulating hormone subunit beta

increases expression

Bromocriptine results in increased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

glial cell derived neurotrophic factor

decreases expression
decreases secretion

Bromocriptine results in decreased expression of GDNF mRNA
Bromocriptine results in decreased secretion of GDNF protein

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

growth hormone 1

increases expression
decreases expression

Bromocriptine results in increased expression of GH1 protein
Bromocriptine results in decreased expression of GH1 protein

PMID:772175 PMID:3226523 PMID:3745407 PMID:7293648 PMID:19420816

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

heme oxygenase 1

increases expression

Bromocriptine results in increased expression of HMOX1 mRNA; Bromocriptine results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

5-hydroxytryptamine receptor 7

multiple interactions

[Bromocriptine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Bromocriptine binds to and results in decreased activity of HTR7 protein

PMID:18996971 PMID:19509219

NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626

G

insulin 2

decreases expression

Bromocriptine results in decreased expression of INS protein

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

luteinizing hormone subunit beta

increases expression

Bromocriptine results in increased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

mitogen activated protein kinase 1

multiple interactions

Bromocriptine promotes the reaction [Estrogens results in increased phosphorylation of and affects the localization of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Bromocriptine promotes the reaction [Estrogens results in increased phosphorylation of and affects the localization of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

NFE2 like bZIP transcription factor 2

increases localization

Bromocriptine results in increased localization of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nerve growth factor

increases secretion

Bromocriptine results in increased secretion of NGF protein

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nitric oxide synthase 2

multiple interactions

Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 5, group A, member 2

multiple interactions

Bromocriptine affects the reaction [methyl cellosolve results in increased expression of NR5A2 mRNA]

NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326

G

proliferating cell nuclear antigen

multiple interactions

[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of PCNA protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

proopiomelanocortin

decreases expression
increases expression
multiple interactions

Bromocriptine results in decreased expression of POMC protein alternative form
Bromocriptine results in increased expression of POMC mRNA; Bromocriptine results in increased expression of POMC protein modified form
Bromocriptine inhibits the reaction [POMC protein results in decreased secretion of Corticosterone]

PMID:1325994 PMID:6274577 PMID:12742521

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

protein kinase C, delta

multiple interactions
affects localization

Bromocriptine promotes the reaction [Estrogens results in increased expression of and results in increased cleavage of PRKCD protein]
Bromocriptine affects the localization of PRKCD protein

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

prolactin

multiple interactions
decreases secretion
decreases expression

Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Nalorphine results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [VIP protein results in increased expression of PRL protein]
Bromocriptine results in decreased secretion of PRL protein
Bromocriptine results in decreased expression of PRL protein
Bromocriptine inhibits the reaction [Amisulpride results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL mRNA]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Bromocriptine inhibits the reaction [Estradiol results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of PRL protein]; Bromocriptine inhibits the reaction [Olanzapine results in increased expression of PRL protein]; Estradiol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Ethanol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]

PMID:86031 PMID:86795 PMID:90217 PMID:1407345 PMID:1874184 More...

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

scavenger receptor class B, member 1

multiple interactions

Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of SCARB1 mRNA]

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

superoxide dismutase 1

multiple interactions

Bromocriptine inhibits the reaction [[SOD1 protein mutant form co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of NOS2 protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of TNF protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

steroidogenic acute regulatory protein

decreases expression

Bromocriptine results in decreased expression of STAR protein

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

signal transducer and activator of transcription 5A

affects localization

Bromocriptine affects the localization of STAT5A protein

NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866

G

transforming growth factor alpha

multiple interactions

Bromocriptine inhibits the reaction [Estradiol results in increased expression of TGFA mRNA]

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

multiple interactions

[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of TGFB1 protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in decreased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

Bromocriptine inhibits the reaction [[SOD1 protein mutant form co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Bromocriptine inhibits the reaction [SOD1 mutant form results in increased expression of TNF protein]
Bromocriptine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:11752888 PMID:21867702

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular endothelial growth factor A

multiple interactions

[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VEGFA protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in decreased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vasoactive intestinal peptide

multiple interactions

Bromocriptine inhibits the reaction [VIP protein results in increased expression of PRL protein]
[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP mRNA]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]

PMID:6441721 PMID:15677882

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216

ergocristine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

ergocristine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
ergocristine results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

caspase 3

increases activity

ergocristine results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

ergosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity

ergosine results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

fumigaclavine C

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interferon gamma

decreases expression

fumigaclavine C results in decreased expression of IFNG mRNA; fumigaclavine C results in decreased expression of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 12A

decreases expression

fumigaclavine C results in decreased expression of IL12A mRNA

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 1 beta

decreases expression

fumigaclavine C results in decreased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

decreases expression

fumigaclavine C results in decreased expression of IL2 mRNA; fumigaclavine C results in decreased expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

matrix metallopeptidase 9

decreases activity
decreases expression

fumigaclavine C results in decreased activity of MMP9 protein
fumigaclavine C results in decreased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

tumor necrosis factor

decreases expression

fumigaclavine C results in decreased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

harmaline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

multiple interactions

Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cadherin 1

increases expression

Harmaline results in increased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
decreases stability

[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein]; Harmaline inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Harmaline results in decreased activity of CYP1A1 protein
Harmaline results in decreased stability of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

endoglin

decreases expression
multiple interactions

Harmaline results in decreased expression of ENG mRNA
Doxorubicin promotes the reaction [Harmaline results in decreased expression of ENG mRNA]

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

interferon gamma

increases secretion

Harmaline results in increased secretion of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 1 beta

multiple interactions

Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

affects secretion
multiple interactions

Harmaline affects the secretion of IL4 protein
Doxorubicin affects the reaction [Harmaline results in decreased secretion of IL4 protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

kinase insert domain receptor

multiple interactions
decreases expression

Doxorubicin promotes the reaction [Harmaline results in decreased expression of KDR mRNA]

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

monoamine oxidase A

decreases activity

Harmaline results in decreased activity of MAOA protein

PMID:15178694 PMID:24373881 PMID:28302559

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

marker of proliferation Ki-67

decreases expression

Harmaline results in decreased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 2

decreases expression

Harmaline results in decreased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

nuclear factor kappa B subunit 1

multiple interactions

Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein]

PMID:12065299 PMID:12107048

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

Doxorubicin promotes the reaction [Harmaline results in decreased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein]

PMID:12065299 PMID:12107048

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

vascular endothelial growth factor A

multiple interactions
decreases expression

Doxorubicin promotes the reaction [Harmaline results in decreased expression of VEGFA mRNA]
Harmaline results in decreased expression of VEGFA mRNA; Harmaline results in decreased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

harmalol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity
increases expression

harmalol results in increased activity of CASP3 protein
harmalol results in increased expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases stability
decreases activity

[Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein]; harmalol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
harmalol results in decreased stability of CYP1A1 protein
harmalol results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

tumor protein p53

increases expression

harmalol results in increased expression of TP53 mRNA; harmalol results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

harman

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

caspase 3

increases cleavage
increases expression

harman results in increased cleavage of CASP3 protein
harman results in increased expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases expression

harman results in increased expression of CASP7 mRNA

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

increases expression

harman results in increased expression of CASP9 mRNA

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases activity

harman results in decreased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression
increases activity

AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [harman results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [harman results in increased activity of CYP1A1 protein]
harman results in increased expression of CYP1A1 mRNA; harman results in increased expression of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

heme oxygenase 1

increases expression

harman results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

monoamine oxidase A

decreases activity

harman results in decreased activity of MAOA protein

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

NFE2 like bZIP transcription factor 2

increases expression

harman results in increased expression of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

increases expression

harman results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

poly (ADP-ribose) polymerase 1

increases cleavage

harman results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

solute carrier family 22 member 1

multiple interactions
decreases activity

harman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
harman results in decreased activity of SLC22A1 protein

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

decreases activity
multiple interactions

harman results in decreased activity of SLC22A2 protein
harman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

trace-amine-associated receptor 1

increases activity
multiple interactions

harman results in increased activity of TAAR1 protein
[harman results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP

NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084

harmine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

Harmine results in decreased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

aryl hydrocarbon receptor

multiple interactions

Harmine inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

axin 2

multiple interactions

Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA]

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

Bcl2-like 11

multiple interactions

Harmine promotes the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L11 protein]

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

calcium/calmodulin-dependent protein kinase II delta

decreases expression

harmine decreases expression of camk2d protein after myocardial infarction in rat heart left ventricle

RGD

NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178

G

cyclin A1

increases expression

Harmine results in increased expression of CCNA1 mRNA; Harmine results in increased expression of CCNA1 protein

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin E2

increases expression

Harmine results in increased expression of CCNE2 mRNA; Harmine results in increased expression of CCNE2 protein

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cell division cycle 25A

increases expression

Harmine results in increased expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle 25C

increases expression

Harmine results in increased expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cyclin-dependent kinase 1

increases expression

Harmine results in increased expression of CDK1 mRNA; Harmine results in increased expression of CDK1 protein

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase inhibitor 1B

decreases phosphorylation

Harmine results in decreased phosphorylation of CDKN1B protein

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 1C

decreases expression

Harmine results in decreased expression of CDKN1C mRNA; Harmine results in decreased expression of CDKN1C protein

NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048

G

cyclin-dependent kinase inhibitor 2A

decreases expression

Harmine results in decreased expression of CDKN2A mRNA; Harmine results in decreased expression of CDKN2A protein

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cyclin-dependent kinase inhibitor 2B

decreases expression

Harmine results in decreased expression of CDKN2B mRNA

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

chromodomain helicase DNA binding protein 4

multiple interactions
increases phosphorylation

AZD 6244 inhibits the reaction [Harmine results in increased phosphorylation of CHD4 protein]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

cell death-inducing DFFA-like effector a

multiple interactions
increases expression

Harmine affects the reaction [Dietary Fats affects the expression of CIDEA mRNA]
Harmine results in increased expression of CIDEA protein

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
decreases stability

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Harmine results in decreased stability of CYP1A1 protein]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Harmine results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

iodothyronine deiodinase 2

increases expression

Harmine results in increased expression of DIO2 protein

NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809

G

dual specificity tyrosine phosphorylation regulated kinase 1A

multiple interactions
decreases expression
affects binding
decreases activity

Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]
harmine decreases expression of dyrk1a protein after myocardial infarction in rat heart left ventricle
Harmine binds to DYRK1A protein
Harmine results in decreased activity of DYRK1A protein

CTD
RGD

PMID:21573099 PMID:25751815 PMID:26067684

NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420

G

E2F transcription factor 1

increases expression

Harmine results in increased expression of E2F1 mRNA; Harmine results in increased expression of E2F1 protein

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 2

increases expression

Harmine results in increased expression of E2F2 mRNA; Harmine results in increased expression of E2F2 protein

NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217

G

E2F transcription factor 7

increases expression

Harmine results in increased expression of E2F7 mRNA

NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734

G

E2F transcription factor 8

increases expression

Harmine results in increased expression of E2F8 mRNA

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

G

fatty acid binding protein 4

multiple interactions

[phenylamil co-treated with Harmine] results in increased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

forkhead box M1

increases expression

Harmine results in increased expression of FOXM1 mRNA; Harmine results in increased expression of FOXM1 protein

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

G

inhibitor of DNA binding 2

multiple interactions

Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

insulin 1

multiple interactions

Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin 2

increases expression

Harmine results in increased expression of INS mRNA

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

leptin receptor

multiple interactions

Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein]

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

MAF bZIP transcription factor A

increases expression

Harmine results in increased expression of MAFA mRNA; Harmine results in increased expression of MAFA protein

NCBI chr 7:107,432,292...107,435,084
Ensembl chr 7:107,433,605...107,434,690

G

monoamine oxidase A

decreases activity

Harmine results in decreased activity of MAOA protein

PMID:24373881 PMID:28302559

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

mitogen activated protein kinase 1

increases phosphorylation

Harmine results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

Harmine results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

multiple interactions

Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

MYC proto-oncogene, bHLH transcription factor

increases expression

Harmine results in increased expression of MYC protein

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nuclear factor of activated T-cells 1

affects localization

Harmine affects the localization of NFATC1 protein

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

nuclear factor of activated T-cells 2

affects localization

Harmine affects the localization of NFATC2 protein

NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325

G

nuclear factor of activated T-cells 3

affects localization

Harmine affects the localization of NFATC3 protein

NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150

G

nuclear factor of activated T-cells 4

affects localization

Harmine affects the localization of NFATC4 protein

NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610

G

poly (ADP-ribose) polymerase 1

multiple interactions

Harmine promotes the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pancreatic and duodenal homeobox 1

increases expression

Harmine results in increased expression of PDX1 mRNA; Harmine results in increased expression of PDX1 protein

NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064

G

phospholamban

increases expression

harmine increases expression of Pln protein after myocardial infarction in rat heart left ventricle

RGD

NCBI chr20:32,629,537...32,639,559

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

[phenylamil co-treated with Harmine] results in increased expression of PPARG mRNA
Harmine results in increased expression of PPARG protein

PMID:20519739 PMID:27805061

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

increases expression
multiple interactions

Harmine results in increased expression of PPARGC1A protein
Harmine affects the reaction [Dietary Fats affects the expression of PPARGC1A mRNA]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

PR/SET domain 16

increases expression
multiple interactions

Harmine results in increased expression of PRDM16 protein
Harmine affects the reaction [Dietary Fats affects the expression of PRDM16 mRNA]

NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601

G

uncoupling protein 1

increases expression
multiple interactions

Harmine results in increased expression of UCP1 mRNA; Harmine results in increased expression of UCP1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; AZD 6244 inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; Harmine affects the reaction [Dietary Fats affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]; N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholin-4-ylpropyl)-pyrimidine-2,4-diamine inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]

NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852

G

Wnt family member 3A

multiple interactions

Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]; Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA]

NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324

ibogaine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Ibogaine results in decreased activity of KCNH2 protein

PMID:23707769 PMID:24307198

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

sodium voltage-gated channel alpha subunit 5

decreases activity

Ibogaine results in decreased activity of SCN5A protein

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

G

SEC24 homolog D, COPII coat complex component

increases response to substance

SEC24D protein results in increased susceptibility to Ibogaine

NCBI chr 2:211,418,557...211,526,588
Ensembl chr 2:211,418,623...211,526,587

G

solute carrier family 6 member 3

multiple interactions
increases expression

Ibogaine inhibits the reaction [SLC6A3 protein mutant form results in decreased import of Dopamine]; Ibogaine promotes the reaction [SLC6A3 protein results in increased import of Dopamine]
Ibogaine results in increased expression of SLC6A3 protein

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

lisuride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

multiple interactions

Lisuride binds to and results in decreased activity of ADRA1A protein; Lisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

5-hydroxytryptamine receptor 7

multiple interactions

[Lisuride binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Lisuride binds to and results in decreased activity of HTR7 protein

PMID:18996971 PMID:19509219

NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626

G

interferon gamma

increases expression

Lisuride results in increased expression of IFNG

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

prolactin

multiple interactions
decreases secretion

Lisuride inhibits the reaction [Metoclopramide results in increased secretion of PRL protein]; Lisuride results in decreased expression of and results in decreased secretion of PRL protein
Lisuride analog results in decreased secretion of PRL protein; Lisuride results in decreased secretion of PRL protein

PMID:386688 PMID:6492995

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

solute carrier family 22 member 2

multiple interactions

Lisuride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

lysergic acid diethylamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

dopamine receptor D2

affects binding

LSD binds to Drd2 protein

RGD

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Lysergic Acid Diethylamide results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

5-hydroxytryptamine receptor 2B

multiple interactions
affects binding

2-aminoindan analog inhibits the reaction [Lysergic Acid Diethylamide binds to HTR2B protein]; Lysergic Acid Diethylamide analog binds to and results in increased activity of HTR2B protein; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Lysergic Acid Diethylamide binds to HTR2B protein]

PMID:14659797 PMID:29458138

NCBI chr 9:86,735,793...86,756,638
Ensembl chr 9:86,742,102...86,755,108

G

5-hydroxytryptamine (serotonin) receptor 5B

multiple interactions

lysergic acid diethylamide binds to protein 5-Htr5b; inhibits the reaction[5-carboxamidotryptamine binds to 5-Htr5b]

RGD

NCBI chr13:32,686,911...32,699,835
Ensembl chr13:32,687,042...32,699,835

G

5-hydroxytryptamine receptor 6

affects binding

Lysergic Acid Diethylamide binds to HTR6 protein

NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912

mesulergine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

5-hydroxytryptamine receptor 2B

affects binding
multiple interactions

mesulergine binds to HTR2B protein
Fluoxetine promotes the reaction [mesulergine binds to HTR2B protein]

NCBI chr 9:86,735,793...86,756,638
Ensembl chr 9:86,742,102...86,755,108

G

5-hydroxytryptamine receptor 2C

affects binding
multiple interactions

mesulergine binds to HTR2C protein
N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [mesulergine binds to HTR2C protein]
Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]; Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]

PMID:18083778 PMID:19439326 PMID:19700373 PMID:29458138

NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287

G

5-hydroxytryptamine receptor 7

affects binding
multiple interactions

mesulergine binds to HTR7 protein
[mesulergine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; mesulergine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]

PMID:14578406 PMID:20827463

NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626

G

prolactin

multiple interactions

mesulergine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

methysergide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

Methysergide results in decreased activity of ABCB4 protein

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

adrenoceptor alpha 1A

multiple interactions

Methysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

calcitonin-related polypeptide alpha

affects activity

Methysergide affects the activity of CALCA protein

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

5-hydroxytryptamine receptor 1B

affects binding

Methysergide binds to HTR1B protein

NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549

G

5-hydroxytryptamine (serotonin) receptor 5B

multiple interactions

methysergide binds to protein 5-Htr5b; inhibits the reaction[5-carboxamidotryptamine binds to 5-Htr5b]

RGD

NCBI chr13:32,686,911...32,699,835
Ensembl chr13:32,687,042...32,699,835

rescinnamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression

rescinnamine results in increased expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

potassium voltage-gated channel subfamily H member 2

decreases activity

rescinnamine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

serpentine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity
multiple interactions

serpentine (alkaloid) results in decreased activity of CYP2D6 protein
serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

strychnine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases expression

Strychnine results in increased expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cholinergic receptor, muscarinic 2

affects binding
multiple interactions

Strychnine binds to CHRM2 protein
Strychnine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]

PMID:9495826 PMID:15647330

NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

affects binding

Strychnine binds to CHRM3 protein

PMID:12435818 PMID:15647330

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

G

cholinergic receptor, muscarinic 4

multiple interactions

Strychnine promotes the reaction [N-Methylscopolamine binds to CHRM4 protein]

NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

Strychnine results in increased expression of and results in increased degradation of CYP2B1 protein

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

Strychnine results in increased expression of CYP2B2 protein

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions

[Strychnine co-treated with Ketoconazole] results in decreased expression of CYP3A23-3A1 protein; [Strychnine co-treated with Phenobarbital] results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

glial fibrillary acidic protein

increases expression

Strychnine results in increased expression of GFAP mRNA

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

glycine receptor, alpha 1

multiple interactions
decreases activity

Strychnine analog binds to and results in decreased activity of GLRA1 protein; Strychnine binds to and results in decreased activity of GLRA1 protein; Strychnine promotes the reaction [Genistein results in decreased activity of GLRA1 protein]; Strychnine promotes the reaction [Quercetin results in decreased activity of GLRA1 protein]
Strychnine results in decreased activity of GLRA1 protein
Genistein promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]; Quercetin promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]

PMID:7752562 PMID:15081878 PMID:16687139 PMID:20719748

NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162

G

glycine receptor, alpha 2

decreases activity

Strychnine results in decreased activity of GLRA2 protein

NCBI chr X:29,020,377...29,241,666
Ensembl chr X:29,020,557...29,241,666

G

interleukin 1 beta

multiple interactions

Strychnine inhibits the reaction [NAD inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Strychnine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

sodium voltage-gated channel alpha subunit 5

multiple interactions

Strychnine binds to and results in decreased activity of SCN5A protein

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

G

solute carrier family 22 member 2

multiple interactions

Strychnine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

vincaleukoblastine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 2

decreases response to substance
increases expression

ABCA2 mRNA results in decreased susceptibility to Vinblastine
Vinblastine results in increased expression of ABCA2 mRNA

NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537

G

ATP binding cassette subfamily A member 3

decreases response to substance
increases expression

ABCA3 mRNA results in decreased susceptibility to Vinblastine
Vinblastine results in increased expression of ABCA3 mRNA

NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745

G

ATP binding cassette subfamily B member 11

decreases uptake
decreases activity
multiple interactions
increases export

ABCB11 protein results in decreased uptake of Vinblastine
Vinblastine results in decreased activity of ABCB11 protein
Vinblastine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
ABCB11 protein results in increased export of Vinblastine

PMID:10617675 PMID:24014644

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

decreases response to substance
increases secretion
increases activity
increases expression
affects binding
multiple interactions
affects uptake
increases transport

ABCB1 protein results in decreased susceptibility to Vinblastine
ABCB1A protein results in increased secretion of Vinblastine
Vinblastine results in increased activity of ABCB1 protein mutant form
Vinblastine results in increased expression of ABCB1 protein
Vinblastine binds to ABCB1 protein
[Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]] which results in decreased susceptibility to Vinblastine; [Elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Vinblastine; [Glycyrrhetinic Acid affects the activity of ABCB1 protein] which affects the susceptibility to Vinblastine; [sodium arsenite results in increased expression of ABCB1 protein] which results in decreased susceptibility to Vinblastine; [Vinblastine results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; Amiodarone inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; cnidiadin inhibits the reaction [ABCB1 protein results in increased export of Vinblastine]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Diazinon affects the reaction [ABCB1 protein results in increased transport of Vinblastine]; Erythromycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; NR1I2 protein promotes the reaction [Vinblastine results in increased expression of ABCB1 protein]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Sesquiterpenes analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Verapamil inhibits the reaction [ABCB1 protein affects the uptake of Vinblastine]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]; Vinblastine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]

PMID:1967174 PMID:8917702 PMID:9148857 PMID:11355955 PMID:11455017 More...

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

increases secretion

ABCB1B protein results in increased secretion of Vinblastine

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 1

affects response to substance
decreases response to substance

ABCC1 protein affects the susceptibility to Vinblastine
ABCC1 protein results in decreased susceptibility to Vinblastine

PMID:9334814 PMID:11455017 PMID:16156793

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

affects transport
decreases response to substance
multiple interactions

ABCC2 protein affects the transport of Vinblastine
ABCC2 protein results in decreased susceptibility to Vinblastine
[isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCC2 protein] which results in increased uptake of Vinblastine; [verlukast results in decreased activity of ABCC2 protein] which results in increased uptake of Vinblastine; Probenecid promotes the reaction [ABCC2 protein affects the transport of Vinblastine]

PMID:9525973 PMID:11455017 PMID:15849751 PMID:25844889

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

actin-binding LIM protein 1

affects response to substance

ABLIM1 protein affects the susceptibility to Vinblastine

NCBI chr 1:256,083,747...256,372,075
Ensembl chr 1:256,084,297...256,371,969

G

acetyl-CoA acetyltransferase 2

affects response to substance

ACAT2 protein affects the susceptibility to Vinblastine

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

acyl-CoA thioesterase 13

affects response to substance

ACOT13 protein affects the susceptibility to Vinblastine

NCBI chr17:40,240,378...40,252,851
Ensembl chr17:40,240,378...40,252,851

G

acid phosphatase 1

affects response to substance

ACP1 protein affects the susceptibility to Vinblastine

NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021

G

adducin 3

affects response to substance

ADD3 protein affects the susceptibility to Vinblastine

NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124

G

allograft inflammatory factor 1

decreases expression

Vinblastine results in decreased expression of AIF1 mRNA

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

adenylate kinase 1

decreases expression

Vinblastine results in decreased expression of AK1 mRNA

NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041

G

aldehyde oxidase 1

affects response to substance

AOX1 protein affects the susceptibility to Vinblastine

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

apelin

decreases expression

Vinblastine results in decreased expression of APLN mRNA

NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391

G

ATP synthase membrane subunit e

affects response to substance

ATP5ME protein affects the susceptibility to Vinblastine

NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013

G

ATP synthase membrane subunit f

affects response to substance

ATP5MF protein affects the susceptibility to Vinblastine

NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236

G

aurora kinase B

affects response to substance

AURKB protein affects the susceptibility to Vinblastine

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

Axl receptor tyrosine kinase

affects response to substance

AXL protein affects the susceptibility to Vinblastine

NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265

G

baculoviral IAP repeat-containing 2

affects response to substance

BIRC2 protein affects the susceptibility to Vinblastine

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

affects response to substance

BIRC3 protein affects the susceptibility to Vinblastine

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 7

decreases response to substance

BIRC7 protein results in decreased susceptibility to Vinblastine

NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606

G

BUB1 mitotic checkpoint serine/threonine kinase

affects response to substance

BUB1 protein affects the susceptibility to Vinblastine

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

similar to human chromosome 5 open reading frame 15

affects response to substance

C5ORF15 protein affects the susceptibility to Vinblastine

NCBI chr10:36,563,989...36,576,593
Ensembl chr10:36,563,958...36,576,590

G

caspase 3

increases cleavage
multiple interactions

Vinblastine results in increased cleavage of CASP3 protein
CD40LG protein inhibits the reaction [Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]

PMID:16545138 PMID:20624997

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

affects response to substance

CAT protein affects the susceptibility to Vinblastine

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

increases expression

Vinblastine results in increased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cellular communication network factor 2

affects response to substance

CCN2 protein affects the susceptibility to Vinblastine

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin B1

affects response to substance
increases response to substance

CCNB1 protein affects the susceptibility to Vinblastine
CCNB1 protein results in increased susceptibility to Vinblastine

PMID:16217747 PMID:16849574

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

affects response to substance

CCNB2 protein affects the susceptibility to Vinblastine

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

CD14 molecule

increases expression

Vinblastine results in increased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD40 ligand

decreases response to substance
multiple interactions

CD40LG protein results in decreased susceptibility to Vinblastine
CD40LG protein inhibits the reaction [Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

CD44 molecule

increases expression

Vinblastine results in increased expression of CD44 mRNA

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cell division cycle associated 8

affects response to substance

CDCA8 protein affects the susceptibility to Vinblastine

NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629

G

cyclin-dependent kinase 1

affects response to substance

CDK1 protein affects the susceptibility to Vinblastine

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

affects response to substance

CDK2 protein affects the susceptibility to Vinblastine

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

increases expression

Vinblastine results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2C

affects response to substance

CDKN2C protein affects the susceptibility to Vinblastine

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

cyclin-dependent kinase inhibitor 3

decreases expression

Vinblastine results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

centromere protein A

affects response to substance

CENPA protein affects the susceptibility to Vinblastine

NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675

G

cytoskeleton associated protein 2

affects response to substance

CKAP2 protein affects the susceptibility to Vinblastine

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

cytochrome c oxidase copper chaperone COX17

affects response to substance

COX17 protein affects the susceptibility to Vinblastine

NCBI chr11:62,400,733...62,406,507

G

cytochrome c oxidase subunit 5A

affects response to substance

COX5A protein affects the susceptibility to Vinblastine

NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781

G

cytochrome c oxidase subunit 6B1

affects response to substance

COX6B1 protein affects the susceptibility to Vinblastine

NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001
Ensembl chr 2:85,875,109...85,884,001

G

ceruloplasmin

increases expression

Vinblastine results in increased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

cellular repressor of E1A-stimulated genes 1

affects response to substance

CREG1 protein affects the susceptibility to Vinblastine

NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308

G

CXXC repeat containing interactor of PDZ3 domain

affects response to substance

CRIPT protein affects the susceptibility to Vinblastine

NCBI chr 6:7,581,428...7,589,384
Ensembl chr 6:7,580,703...7,589,399

G

cathepsin S

increases expression

Vinblastine results in increased expression of CTSS mRNA

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Vinblastine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

decapping enzyme, scavenger

affects response to substance

DCPS protein affects the susceptibility to Vinblastine

NCBI chr 8:33,468,669...33,524,407
Ensembl chr 8:33,415,671...33,524,389

G

DEAD-box helicase 23

affects response to substance

DDX23 protein affects the susceptibility to Vinblastine

NCBI chr 7:129,797,620...129,814,909
Ensembl chr 7:129,797,614...129,814,949

G

deoxyribose-phosphate aldolase

affects response to substance

DERA protein affects the susceptibility to Vinblastine

NCBI chr 4:170,663,689...170,742,469
Ensembl chr 4:170,663,665...170,758,865

G

DNA fragmentation factor subunit beta

affects response to substance

DFFB protein affects the susceptibility to Vinblastine

NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628

G

divergent protein kinase domain 1A

affects response to substance

DIPK1A protein affects the susceptibility to Vinblastine

NCBI chr14:1,772,412...1,843,508
Ensembl chr14:1,772,422...1,843,743

G

dickkopf WNT signaling pathway inhibitor 1

affects response to substance

DKK1 protein affects the susceptibility to Vinblastine

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

dickkopf WNT signaling pathway inhibitor 3

affects response to substance

DKK3 protein affects the susceptibility to Vinblastine

NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590

G

DNA replication fork stabilization factor DONSON

affects response to substance

DONSON protein affects the susceptibility to Vinblastine

NCBI chr11:30,919,834...30,933,150
Ensembl chr11:30,923,239...30,932,889

G

DNA replication and sister chromatid cohesion 1

affects response to substance

DSCC1 protein affects the susceptibility to Vinblastine

NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212

G

E2F transcription factor 1

increases response to substance

E2F1 protein results in increased susceptibility to Vinblastine

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

endothelin receptor type B

increases expression

Vinblastine results in increased expression of EDNRB mRNA

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

EF-hand calcium binding domain 7

affects response to substance

EFCAB7 protein affects the susceptibility to Vinblastine

NCBI chr 5:114,525,403...114,576,130
Ensembl chr 5:114,525,167...114,576,129

G

epithelial membrane protein 2

affects response to substance

EMP2 protein affects the susceptibility to Vinblastine

NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733

G

epithelial cell adhesion molecule

affects response to substance

EPCAM protein affects the susceptibility to Vinblastine

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

G

glutamyl-prolyl-tRNA synthetase 1

increases expression

Vinblastine results in increased expression of EPRS1 mRNA

NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966

G

erb-b2 receptor tyrosine kinase 2

affects response to substance

ERBB2 protein affects the susceptibility to Vinblastine

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

epiregulin

affects response to substance

EREG protein affects the susceptibility to Vinblastine

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

endothelial cell-specific molecule 1

decreases expression

Vinblastine results in decreased expression of ESM1 mRNA

NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804

G

electron transfer flavoprotein subunit beta

affects response to substance

ETFB protein affects the susceptibility to Vinblastine

NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068

G

exosome component 9

affects response to substance

EXOSC9 protein affects the susceptibility to Vinblastine

NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051

G

coagulation factor III, tissue factor

increases expression

Vinblastine results in increased expression of F3 mRNA

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

FAM3 metabolism regulating signaling molecule C

affects response to substance

FAM3C protein affects the susceptibility to Vinblastine

NCBI chr 4:50,839,929...50,887,276
Ensembl chr 4:50,838,818...50,888,078

G

FA complementation group L

affects response to substance

FANCL protein affects the susceptibility to Vinblastine

NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255

G

Fas ligand

increases expression

Vinblastine results in increased expression of FASLG protein

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

Fc gamma receptor 2B

increases expression

Vinblastine results in increased expression of FCGR2B mRNA

NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778

G

flap structure-specific endonuclease 1

affects response to substance

FEN1 protein affects the susceptibility to Vinblastine

NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003

G

FKBP prolyl isomerase 1A

affects response to substance

FKBP1A protein affects the susceptibility to Vinblastine

NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743

G

Fli-1 proto-oncogene, ETS transcription factor

affects response to substance

FLI1 protein affects the susceptibility to Vinblastine

NCBI chr 8:30,831,422...30,950,468
Ensembl chr 8:30,832,753...30,950,433

G

fibronectin 1

affects response to substance

FN1 protein affects the susceptibility to Vinblastine

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

FOS like 1, AP-1 transcription factor subunit

affects response to substance

FOSL1 protein affects the susceptibility to Vinblastine

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

G0/G1switch 2

affects response to substance

G0S2 protein affects the susceptibility to Vinblastine

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

growth arrest and DNA-damage-inducible, alpha

increases expression

Vinblastine results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

growth arrest and DNA-damage-inducible, beta

increases expression

Vinblastine results in increased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

growth arrest and DNA-damage-inducible, gamma

increases expression

Vinblastine results in increased expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

growth arrest specific 7

decreases expression

Vinblastine results in decreased expression of GAS7 mRNA

NCBI chr10:52,152,718...52,383,283
Ensembl chr10:52,152,493...52,383,276

G

gamma-glutamyl cyclotransferase

affects response to substance

GGCT protein affects the susceptibility to Vinblastine

NCBI chr 4:84,122,921...84,129,327
Ensembl chr 4:84,123,118...84,129,277

G

gamma-glutamyl carboxylase

affects response to substance

GGCX protein affects the susceptibility to Vinblastine

NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063

G

geminin, DNA replication inhibitor

affects response to substance

GMNN protein affects the susceptibility to Vinblastine

NCBI chr17:40,301,771...40,310,054
Ensembl chr17:40,301,808...40,310,054

G

N-acetylglucosamine-1-phosphate transferase subunits alpha and beta

affects response to substance

GNPTAB protein affects the susceptibility to Vinblastine

NCBI chr 7:22,800,502...22,866,336
Ensembl chr 7:22,800,485...22,866,933

G

G protein-coupled receptor 176

affects response to substance

GPR176 protein affects the susceptibility to Vinblastine

NCBI chr 3:105,236,794...105,337,664
Ensembl chr 3:105,236,795...105,337,226

G

G-protein signaling modulator 2

affects response to substance

GPSM2 protein affects the susceptibility to Vinblastine

NCBI chr 2:196,327,149...196,375,322
Ensembl chr 2:196,327,149...196,375,154

G

glutathione S-transferase pi 1

decreases response to substance

GSTP1 protein results in decreased susceptibility to Vinblastine

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

general transcription factor II I

affects response to substance

GTF2I protein affects the susceptibility to Vinblastine

NCBI chr12:22,400,933...22,476,243
Ensembl chr12:22,401,431...22,476,243

G

general transcription factor III A

affects response to substance

GTF3A protein affects the susceptibility to Vinblastine

NCBI chr12:8,136,746...8,144,690
Ensembl chr12:8,136,747...8,144,690

G

G-2 and S-phase expressed 1

affects response to substance

GTSE1 protein affects the susceptibility to Vinblastine

NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806

G

glucuronidase, beta

affects response to substance

GUSB protein affects the susceptibility to Vinblastine

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

H1.2 linker histone, cluster member

affects response to substance

H1-2 protein affects the susceptibility to Vinblastine

NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635

G

hydroxyacyl-CoA dehydrogenase

affects response to substance

HADH protein affects the susceptibility to Vinblastine

NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353

G

hematopoietic cell specific Lyn substrate 1

affects response to substance

HCLS1 protein affects the susceptibility to Vinblastine

NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014

G

high mobility group box 1

affects response to substance

HMGB1 protein affects the susceptibility to Vinblastine

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

high mobility group box 2

affects response to substance

HMGB2 protein affects the susceptibility to Vinblastine

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140

G

high mobility group nucleosomal binding domain 3

affects response to substance

HMGN3 protein affects the susceptibility to Vinblastine

NCBI chr 8:84,022,493...84,059,329
Ensembl chr 8:84,022,495...84,062,976

G

hyaluronan-mediated motility receptor

affects response to substance

HMMR protein affects the susceptibility to Vinblastine

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060

G

heme oxygenase 1

increases expression

Vinblastine results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

homer scaffold protein 1

affects response to substance

HOMER1 protein affects the susceptibility to Vinblastine

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

G

intercellular adhesion molecule 1

increases expression
decreases expression

Vinblastine results in increased expression of ICAM1 mRNA
Vinblastine results in decreased expression of ICAM1 mRNA; Vinblastine results in decreased expression of ICAM1 protein

PMID:12649748 PMID:20624997

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 2

affects response to substance

ID2 protein affects the susceptibility to Vinblastine

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

isocitrate dehydrogenase (NADP(+)) 2

affects response to substance

IDH2 protein affects the susceptibility to Vinblastine

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

insulin-like growth factor 2 mRNA binding protein 3

affects response to substance

IGF2BP3 protein affects the susceptibility to Vinblastine

NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865

G

inhibitor of nuclear factor kappa B kinase subunit beta

increases phosphorylation
multiple interactions

Vinblastine results in increased phosphorylation of IKBKB protein
Vinblastine results in decreased localization of [IKBKB protein binds to NFKBIA protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 13 receptor subunit alpha 2

affects response to substance

IL13RA2 protein affects the susceptibility to Vinblastine

NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381

G

interleukin 1 beta

affects response to substance
increases expression

IL1B protein affects the susceptibility to Vinblastine
Vinblastine results in increased expression of IL1B mRNA

PMID:16217747 PMID:20624997

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

decreases chemical synthesis
increases stability

Vinblastine results in decreased chemical synthesis of IL6 protein
Vinblastine results in increased stability of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibin subunit alpha

decreases expression

Vinblastine results in decreased expression of INHA mRNA

NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248

G

inhibin subunit beta A

affects response to substance

INHBA protein affects the susceptibility to Vinblastine

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

integrin subunit alpha L

decreases expression

Vinblastine results in decreased expression of ITGAL mRNA; Vinblastine results in decreased expression of ITGAL protein

NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732

G

integrin subunit beta 1 binding protein 1

affects response to substance

ITGB1BP1 protein affects the susceptibility to Vinblastine

NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases phosphorylation

TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

KN motif and ankyrin repeat domains 1

affects response to substance

KANK1 protein affects the susceptibility to Vinblastine

NCBI chr 1:222,877,962...223,074,514
Ensembl chr 1:222,877,622...223,074,514

G

kazrin, periplakin interacting protein

affects response to substance

KAZN protein affects the susceptibility to Vinblastine

NCBI chr 5:154,392,793...155,381,567
Ensembl chr 5:154,392,793...154,779,074

G

kinesin family member 11

affects response to substance

KIF11 protein affects the susceptibility to Vinblastine

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 15

affects response to substance

KIF15 protein affects the susceptibility to Vinblastine

NCBI chr 8:122,601,888...122,672,750
Ensembl chr 8:122,601,897...122,672,750

G

kinesin family member 1B

affects response to substance

KIF1B protein affects the susceptibility to Vinblastine

NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778

G

kinesin family member 20A

affects response to substance

KIF20A protein affects the susceptibility to Vinblastine

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member 23

affects response to substance

KIF23 protein affects the susceptibility to Vinblastine

NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072

G

kinesin family member 4A

affects response to substance

KIF4A protein affects the susceptibility to Vinblastine

NCBI chr X:65,721,746...65,824,277
Ensembl chr X:65,721,779...65,824,139

G

karyopherin subunit alpha 2

affects response to substance

KPNA2 protein affects the susceptibility to Vinblastine

NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150

G

lamin B1

affects response to substance

LMNB1 protein affects the susceptibility to Vinblastine

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

lysophosphatidic acid receptor 1

affects response to substance

LPAR1 protein affects the susceptibility to Vinblastine

NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895

G

leucine rich repeat containing 1

affects response to substance

LRRC1 protein affects the susceptibility to Vinblastine

NCBI chr 8:78,239,897...78,407,347
Ensembl chr 8:78,239,900...78,406,490

G

LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated

affects response to substance

LSM7 protein affects the susceptibility to Vinblastine

NCBI chr 7:8,856,698...8,859,113
Ensembl chr 7:8,856,489...8,859,119

G

latent transforming growth factor beta binding protein 2

affects response to substance

LTBP2 protein affects the susceptibility to Vinblastine

NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:104,429,947...104,526,208

G

mitotic arrest deficient 2 like 1

affects response to substance

MAD2L1 protein affects the susceptibility to Vinblastine

NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470

G

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

Vinblastine results in increased phosphorylation of MAPK8 protein
TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

MAPK activated protein kinase 5

affects response to substance

MAPKAPK5 protein affects the susceptibility to Vinblastine

NCBI chr12:34,993,520...35,013,059
Ensembl chr12:34,994,092...35,013,052

G

maternal embryonic leucine zipper kinase

affects response to substance

MELK protein affects the susceptibility to Vinblastine

NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937

G

membrane metallo-endopeptidase

affects response to substance

MME protein affects the susceptibility to Vinblastine

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

matrix metallopeptidase 1

affects response to substance

MMP1 protein affects the susceptibility to Vinblastine

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

MOK protein kinase

affects response to substance

MOK protein affects the susceptibility to Vinblastine

NCBI chr 6:129,823,794...129,854,669
Ensembl chr 6:129,823,795...129,854,700

G

mitochondrial ribosomal protein L57

affects response to substance

MRPL57 protein affects the susceptibility to Vinblastine

NCBI chr15:31,970,904...31,971,766
Ensembl chr15:31,970,860...31,973,993

G

MYC proto-oncogene, bHLH transcription factor

affects response to substance
increases expression

MYC protein affects the susceptibility to Vinblastine
Vinblastine results in increased expression of MYC mRNA

PMID:18802399 PMID:20624997

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

Myc binding protein

affects response to substance

MYCBP protein affects the susceptibility to Vinblastine

NCBI chr 5:136,135,955...136,143,163
Ensembl chr 5:136,135,931...136,145,616

G

nibrin

increases expression

Vinblastine results in increased expression of NBN mRNA

NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150

G

non-SMC condensin I complex, subunit G

affects response to substance

NCAPG protein affects the susceptibility to Vinblastine

NCBI chr14:65,403,930...65,432,902
Ensembl chr14:65,404,163...65,432,902

G

non-SMC condensin I complex, subunit H

affects response to substance

NCAPH protein affects the susceptibility to Vinblastine

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

G

NDC80 kinetochore complex component

affects response to substance

NDC80 protein affects the susceptibility to Vinblastine

NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924

G

NADH:ubiquinone oxidoreductase subunit A1

affects response to substance

NDUFA1 protein affects the susceptibility to Vinblastine

NCBI chr X:116,424,223...116,427,875
Ensembl chr X:116,424,223...116,428,633

G

NADH:ubiquinone oxidoreductase subunit A13

affects response to substance

NDUFA13 protein affects the susceptibility to Vinblastine

NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726

G

NADH:ubiquinone oxidoreductase subunit A3

affects response to substance

NDUFA3 protein affects the susceptibility to Vinblastine

NCBI chr 1:65,597,567...65,600,197
Ensembl chr 1:65,597,578...65,600,235

G

NADH:ubiquinone oxidoreductase subunit A7

affects response to substance

NDUFA7 protein affects the susceptibility to Vinblastine

NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976

G

NADH:ubiquinone oxidoreductase subunit B2

affects response to substance

NDUFB2 protein affects the susceptibility to Vinblastine

NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851
Ensembl chr 4:46,536,062...46,536,851

G

NADH:ubiquinone oxidoreductase subunit C1

affects response to substance

NDUFC1 protein affects the susceptibility to Vinblastine

NCBI chr 2:135,447,067...135,450,950
Ensembl chr 2:135,447,119...135,450,874

G

NADH:ubiquinone oxidoreductase subunit C2

affects response to substance

NDUFC2 protein affects the susceptibility to Vinblastine

NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189

G

NADH:ubiquinone oxidoreductase subunit S6

affects response to substance

NDUFS6 protein affects the susceptibility to Vinblastine

NCBI chr 1:29,968,833...29,977,423
Ensembl chr 1:29,968,842...29,977,467

G

NADH:ubiquinone oxidoreductase core subunit V2

affects response to substance

NDUFV2 protein affects the susceptibility to Vinblastine

NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713

G

nuclear factor of activated T-cells 4

decreases localization

Vinblastine results in decreased localization of NFATC4 protein

NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610

G

NFKB inhibitor alpha

increases phosphorylation
multiple interactions

Vinblastine results in increased phosphorylation of NFKBIA protein
Vinblastine results in decreased localization of [IKBKB protein binds to NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor

decreases response to substance

Vinblastine results in decreased susceptibility to NGF protein

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

neuropeptide Y

decreases expression

Vinblastine results in decreased expression of NPY mRNA

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

Vinblastine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

[Vinblastine results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; NR1I2 protein promotes the reaction [Vinblastine results in increased expression of ABCB1 protein]

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

neutral sphingomyelinase activation associated factor

affects response to substance

NSMAF protein affects the susceptibility to Vinblastine

NCBI chr 5:19,517,795...19,578,773
Ensembl chr 5:19,518,348...19,577,627

G

nudix hydrolase 15

affects response to substance

NUDT15 protein affects the susceptibility to Vinblastine

NCBI chr15:48,707,776...48,713,847
Ensembl chr15:48,709,700...48,747,363

G

nudix hydrolase 4

affects response to substance

NUDT4 protein affects the susceptibility to Vinblastine

NCBI chr 7:30,188,100...30,204,615
Ensembl chr 7:30,188,100...30,204,615

G

nucleolar and spindle associated protein 1

affects response to substance

NUSAP1 protein affects the susceptibility to Vinblastine

NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624

G

ornithine decarboxylase antizyme 1

affects response to substance

OAZ1 protein affects the susceptibility to Vinblastine

NCBI chr 7:8,883,855...8,886,315
Ensembl chr 7:8,883,851...8,886,310

G

ornithine decarboxylase 1

multiple interactions

Vinblastine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

Opa interacting protein 5

affects response to substance

OIP5 protein affects the susceptibility to Vinblastine

NCBI chr 3:106,593,746...106,603,281
Ensembl chr 3:106,593,760...106,603,250

G

olfactory receptor family 1 subfamily I member 2

affects response to substance

OR1I1 protein affects the susceptibility to Vinblastine

NCBI chr 7:10,985,938...10,986,879
Ensembl chr 7:10,980,344...10,987,036

G

origin recognition complex, subunit 6

affects response to substance

ORC6 protein affects the susceptibility to Vinblastine

NCBI chr19:21,757,867...21,765,638
Ensembl chr19:21,757,866...21,765,662

G

oxysterol binding protein-like 10

affects response to substance

OSBPL10 protein affects the susceptibility to Vinblastine

NCBI chr 8:114,661,050...114,918,664
Ensembl chr 8:114,660,743...114,918,625

G

poly (ADP-ribose) polymerase 1

multiple interactions

CD40LG protein inhibits the reaction [Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; Vinblastine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pyruvate dehydrogenase E1 subunit beta

affects response to substance

PDHB protein affects the susceptibility to Vinblastine

NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500

G

pelota mRNA surveillance and ribosome rescue factor

affects response to substance

PELO protein affects the susceptibility to Vinblastine

NCBI chr 2:46,797,853...46,799,621
Ensembl chr 2:46,797,853...46,799,746

G

progesterone receptor membrane component 1

affects response to substance

PGRMC1 protein affects the susceptibility to Vinblastine

NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682

G

pirin

affects response to substance

PIR protein affects the susceptibility to Vinblastine

NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218

G

PLAG1 like zinc finger 1

increases expression

Vinblastine results in increased expression of PLAGL1 mRNA

NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228

G

plasminogen activator, tissue type

increases expression

Vinblastine results in increased expression of PLAT mRNA

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

plasminogen activator, urokinase

affects response to substance

PLAU protein affects the susceptibility to Vinblastine

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

plasminogen activator, urokinase receptor

increases expression

Vinblastine results in increased expression of PLAUR mRNA

NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Vinblastine results in increased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein regulator of cytokinesis 1

affects response to substance

PRC1 protein affects the susceptibility to Vinblastine

NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765

G

protein kinase C, delta

affects localization

Vinblastine affects the localization of PRKCD protein

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

proteasome 20S subunit beta 1

affects response to substance

PSMB1 protein affects the susceptibility to Vinblastine

NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560

G

proteasome activator subunit 4

affects response to substance

PSME4 protein affects the susceptibility to Vinblastine

NCBI chr14:104,505,716...104,609,410
Ensembl chr14:104,505,716...104,609,408

G

prostaglandin E synthase 3

affects response to substance

PTGES3 protein affects the susceptibility to Vinblastine

NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084

G

PTTG1 regulator of sister chromatid separation, securin

affects response to substance

PTTG1 protein affects the susceptibility to Vinblastine

NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837

G

pentraxin 3

affects response to substance

PTX3 protein affects the susceptibility to Vinblastine

NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323

G

glutamine-rich 1

increases phosphorylation

Vinblastine results in increased phosphorylation of QRICH1 protein

NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359

G

RAB11 family interacting protein 1

affects response to substance

RAB11FIP1 protein affects the susceptibility to Vinblastine

NCBI chr16:64,886,902...64,917,491
Ensembl chr16:64,884,676...64,917,491

G

Rac GTPase-activating protein 1

affects response to substance

RACGAP1 protein affects the susceptibility to Vinblastine

NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831

G

RAN binding protein 1

affects response to substance

RANBP1 protein affects the susceptibility to Vinblastine

NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838

G

Ras association domain family member 1

increases expression

Vinblastine results in increased expression of RASSF1 mRNA

NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164

G

REV3 like, DNA directed polymerase zeta catalytic subunit

affects response to substance

REV3L protein affects the susceptibility to Vinblastine

NCBI chr20:43,131,841...43,290,102
Ensembl chr20:43,132,363...43,290,099

G

replication factor C subunit 5

affects response to substance

RFC5 protein affects the susceptibility to Vinblastine

NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312

G

replication protein A3

affects response to substance

RPA3 protein affects the susceptibility to Vinblastine

NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709

G

ribonucleotide reductase regulatory subunit M2

affects response to substance

RRM2 protein affects the susceptibility to Vinblastine

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

S100 calcium binding protein A8

increases expression

Vinblastine results in increased expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

increases expression

Vinblastine results in increased expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

selectin E

increases expression

Vinblastine results in increased expression of SELE mRNA

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

serpin family B member 2

affects response to substance

SERPINB2 protein affects the susceptibility to Vinblastine

NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408

G

serpin family E member 1

increases expression
affects response to substance

Vinblastine results in increased expression of SERPINE1 mRNA
SERPINE1 protein affects the susceptibility to Vinblastine

PMID:16217747 PMID:20624997

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

sideroflexin 1

affects response to substance

SFXN1 protein affects the susceptibility to Vinblastine

NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529

G

shootin 1

affects response to substance

SHTN1 protein affects the susceptibility to Vinblastine

NCBI chr 1:258,121,966...258,225,861
Ensembl chr 1:258,121,968...258,228,265

G

SKI8 subunit of superkiller complex

affects response to substance

SKIC8 protein affects the susceptibility to Vinblastine

NCBI chr 8:55,103,542...55,120,837
Ensembl chr 8:55,103,545...55,120,813

G

S-phase kinase associated protein 2

affects response to substance

SKP2 protein affects the susceptibility to Vinblastine

NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338

G

solute carrier family 22 member 3

affects response to substance

SLC22A3 protein affects the susceptibility to Vinblastine

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

small nuclear ribonucleoprotein U11/U12 subunit 25

affects response to substance

SNRNP25 protein affects the susceptibility to Vinblastine

NCBI chr10:15,420,482...15,423,806
Ensembl chr10:15,420,486...15,423,804

G

sorting nexin 10

affects response to substance

SNX10 protein affects the susceptibility to Vinblastine

NCBI chr 4:80,612,648...80,677,005
Ensembl chr 4:80,612,669...80,676,996

G

superoxide dismutase 1

affects response to substance

SOD1 protein affects the susceptibility to Vinblastine

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
increases expression

bisindolylmaleimide I inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]; calphostin C inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]; Cycloheximide promotes the reaction [Vinblastine results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sortilin 1

affects response to substance

SORT1 protein affects the susceptibility to Vinblastine

NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354

G

spondin 1

increases expression

Vinblastine results in increased expression of SPON1 mRNA

NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226

G

steroid 5 alpha-reductase 1

affects response to substance

SRD5A1 protein affects the susceptibility to Vinblastine

NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461

G

serglycin

affects response to substance

SRGN protein affects the susceptibility to Vinblastine

NCBI chr20:30,442,810...30,479,549
Ensembl chr20:30,442,813...30,457,406

G

signal transducer and activator of transcription 1

multiple interactions

Vinblastine deficiency results in decreased activity of and affects the localization of STAT1 protein

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

multiple interactions

Vinblastine deficiency results in decreased activity of and affects the localization of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

stanniocalcin 2

affects response to substance

STC2 protein affects the susceptibility to Vinblastine

NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973

G

serine/threonine kinase 26

affects response to substance

STK26 protein affects the susceptibility to Vinblastine

NCBI chr X:130,325,064...130,375,674
Ensembl chr X:130,310,885...130,374,291

G

striatin

affects response to substance

STRN protein affects the susceptibility to Vinblastine

NCBI chr 6:16,335,265...16,422,159
Ensembl chr 6:16,335,358...16,417,083

G

succinate-CoA ligase ADP-forming subunit beta

affects response to substance

SUCLA2 protein affects the susceptibility to Vinblastine

NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

affects response to substance

SUCLG1 protein affects the susceptibility to Vinblastine

NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600

G

sulfotransferase family 1A member 1

affects response to substance

SULT1A1 protein affects the susceptibility to Vinblastine

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

synapse defective Rho GTPase homolog 1

affects response to substance

SYDE1 protein affects the susceptibility to Vinblastine

NCBI chr 7:11,032,931...11,038,917
Ensembl chr 7:11,032,898...11,039,869

G

TBC1 domain family, member 4

affects response to substance

TBC1D4 protein affects the susceptibility to Vinblastine

NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265

G

thymine-DNA glycosylase

affects response to substance

TDG protein affects the susceptibility to Vinblastine

NCBI chr 7:21,077,853...21,097,617
Ensembl chr 7:21,077,853...21,097,567

G

tissue factor pathway inhibitor 2

affects response to substance
increases expression

TFPI2 protein affects the susceptibility to Vinblastine
Vinblastine results in increased expression of TFPI2 mRNA

PMID:16217747 PMID:20624997

NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600

G

thrombomodulin

increases expression

Vinblastine results in increased expression of THBD mRNA

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

G

thrombospondin 1

increases expression

Vinblastine results in increased expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

TIMP metallopeptidase inhibitor 1

increases expression

Vinblastine results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

transmembrane protein 134

affects response to substance

TMEM134 protein affects the susceptibility to Vinblastine

NCBI chr 1:201,419,225...201,424,778
Ensembl chr 1:201,419,264...201,431,411

G

transmembrane protein 14A

affects response to substance

TMEM14A protein affects the susceptibility to Vinblastine

NCBI chr 9:23,640,594...23,652,379
Ensembl chr 9:23,733,039...23,734,463
Ensembl chr 9:23,733,039...23,734,463

G

transmembrane protein 156

affects response to substance

TMEM156 protein affects the susceptibility to Vinblastine

NCBI chr14:43,221,464...43,252,453
Ensembl chr14:43,223,381...43,252,449

G

transmembrane protein 97

affects response to substance

TMEM97 protein affects the susceptibility to Vinblastine

NCBI chr10:63,438,228...63,447,311
Ensembl chr10:63,438,222...63,589,730

G

thymopoietin

affects response to substance

TMPO protein affects the susceptibility to Vinblastine

NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727

G

DNA topoisomerase II alpha

affects response to substance

TOP2A protein affects the susceptibility to Vinblastine

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

multiple interactions

TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of JUN protein]; TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK8 protein]; TP53 protein affects the reaction [Vinblastine results in increased phosphorylation of MAPK9 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TPD52 like 1

increases expression
affects response to substance

Vinblastine results in increased expression of TPD52L1 mRNA
TPD52L1 protein affects the susceptibility to Vinblastine

PMID:16217747 PMID:20624997

NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109

G

tripartite motif-containing 2

affects response to substance

TRIM2 protein affects the susceptibility to Vinblastine

NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927

G

tRNA methyltransferase 5

affects response to substance

TRMT5 protein affects the susceptibility to Vinblastine

NCBI chr 6:91,963,558...91,987,660
Ensembl chr 6:91,943,724...91,987,555

G

tetraspanin 13

affects response to substance

TSPAN13 protein affects the susceptibility to Vinblastine

NCBI chr 6:52,738,748...52,765,503
Ensembl chr 6:52,738,758...52,765,547

G

transcription termination factor 2

affects response to substance

TTF2 protein affects the susceptibility to Vinblastine

NCBI chr 2:188,366,321...188,397,750
Ensembl chr 2:188,366,331...188,397,689

G

Ttk protein kinase

affects response to substance

TTK protein affects the susceptibility to Vinblastine

NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651

G

tubulin, alpha 1B

decreases expression

Vinblastine results in decreased expression of TUBA1B mRNA

NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186

G

tubulin, alpha 4A

decreases expression

Vinblastine results in decreased expression of TUBA4A mRNA

NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918

G

tubulin, beta 4B class IVb

decreases expression

Vinblastine results in decreased expression of TUBB4B mRNA

NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296

G

tubulin, beta 5 class I

decreases expression

Vinblastine results in decreased expression of TUBB5 mRNA

NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940

G

tubulin, gamma 1

decreases expression

Vinblastine results in decreased expression of TUBG1 mRNA

NCBI chr10:86,052,845...86,059,436
Ensembl chr10:86,052,743...86,059,433

G

ubiquinol-cytochrome c reductase, complex III subunit X

affects response to substance

UQCR10 protein affects the susceptibility to Vinblastine

NCBI chr14:79,566,151...79,569,017
Ensembl chr14:79,566,157...79,569,003

G

vascular cell adhesion molecule 1

increases expression

Vinblastine results in increased expression of VCAM1 mRNA

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

decreases expression

Vinblastine results in decreased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor C

affects response to substance

VEGFC protein affects the susceptibility to Vinblastine

NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848

G

von Willebrand factor

increases expression

Vinblastine results in increased expression of VWF mRNA

NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539

G

WD repeat and SOCS box-containing 2

affects response to substance

WSB2 protein affects the susceptibility to Vinblastine

NCBI chr12:39,217,645...39,238,634
Ensembl chr12:39,217,648...39,238,640

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta

affects response to substance

YWHAQ protein affects the susceptibility to Vinblastine

NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273

G

zinc finger, DHHC-type containing 11

affects response to substance

ZDHHC11 protein affects the susceptibility to Vinblastine

NCBI chr 1:29,296,334...29,327,227
Ensembl chr 1:29,296,334...29,326,898

G

zinc finger protein 36, C3H type-like 2

affects response to substance

ZFP36L2 protein affects the susceptibility to Vinblastine

NCBI chr 6:10,490,032...10,494,073
Ensembl chr 6:10,490,032...10,494,064

G

ZW10 interacting kinetochore protein

affects response to substance

ZWINT protein affects the susceptibility to Vinblastine

NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957

vincamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

allograft inflammatory factor 1

multiple interactions

Vincamine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IBA1 protein]

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

glial fibrillary acidic protein

multiple interactions

Vincamine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein]

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

heme oxygenase 1

multiple interactions

Vincamine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 1 beta

multiple interactions

Vincamine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B mRNA]; Vincamine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

Vincamine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL6 mRNA]; Vincamine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Vincamine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

NFE2 like bZIP transcription factor 2

multiple interactions

Vincamine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

Vincamine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Vincamine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

tumor necrosis factor

multiple interactions

Vincamine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF mRNA]; Vincamine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

vincristine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adipogenesis associated, Mth938 domain containing

increases expression

Vincristine results in increased expression of AAMDC mRNA

NCBI chr 1:151,861,990...151,893,621
Ensembl chr 1:151,845,255...151,892,398

G

ATP binding cassette subfamily A member 1

multiple interactions

[Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily A member 12

increases expression
multiple interactions

Vincristine results in increased expression of ABCA12 mRNA
[Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCA12 mRNA

PMID:19944135 PMID:23649840

NCBI chr 9:72,822,661...72,995,748
Ensembl chr 9:72,823,350...72,996,049

G

ATP binding cassette subfamily A member 4

multiple interactions

[Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCA4 mRNA

NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069

G

ATP binding cassette subfamily A member 5

multiple interactions

[Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCA5 mRNA

NCBI chr10:95,240,159...95,309,195
Ensembl chr10:95,240,154...95,308,976

G

ATP binding cassette subfamily A member 8

multiple interactions

[Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCA8 mRNA

NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988

G

ATP binding cassette subfamily B member 1A

affects response to substance
increases expression
multiple interactions
increases transport
decreases uptake
decreases response to substance
affects uptake

ABCB1 protein affects the susceptibility to Vincristine
Vincristine results in increased expression of ABCB1A mRNA
Vincristine results in increased expression of ABCB1 protein
[Estradiol results in decreased expression of ABCB1 protein] which results in increased uptake of and results in increased susceptibility to Vincristine; [MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Vincristine; [Paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to Vincristine; [Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCB1 mRNA; [Vincristine results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; CEP 33779 inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; Cyclosporine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; Fenofibrate inhibits the reaction [ABCB1 protein results in increased transport of Vincristine]; Flupenthixol analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; NR1I2 protein promotes the reaction [Vincristine results in increased expression of ABCB1 protein]; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; zosuquidar trihydrochloride inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]
ABCB1 protein results in decreased uptake of Vincristine
ABCB1 protein affects the uptake of Vincristine

PMID:7905786 PMID:10617675 PMID:11792417 PMID:11934808 PMID:15239124 More...

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

affects uptake

ABCB1B protein affects the uptake of Vincristine

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily B member 4

multiple interactions

[Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily B member 6

multiple interactions
decreases response to substance

[Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCB6 mRNA
ABCB6 protein results in decreased susceptibility to Vincristine

PMID:19944135 PMID:25202056

NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924

G

ATP binding cassette subfamily C member 1

increases response to substance
increases expression
multiple interactions
decreases response to substance
affects transport
affects response to substance
affects export

ABCC1 gene SNP results in increased susceptibility to Vincristine
Vincristine results in increased expression of ABCC1 mRNA
[Genistein results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine; [Indomethacin results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine; [Probenecid results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine; [Sulfinpyrazone results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine; [verlukast results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
ABCC1 protein results in decreased susceptibility to Vincristine; ABCC1 results in decreased susceptibility to Vincristine
[MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Vincristine; [Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCC1 mRNA; ABCC1 protein affects the export of and results in decreased susceptibility to Vincristine; Buthionine Sulfoximine inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Cyclosporine inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Doxorubicin inhibits the reaction [ABCC1 protein affects the transport of Vincristine]; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; myricetin inhibits the reaction [ABCC1 protein affects the export of and results in decreased susceptibility to Vincristine]; myricetin inhibits the reaction [ABCC1 protein affects the export of Vincristine]; myricetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Quercetin promotes the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Vincristine inhibits the reaction [ABCC1 protein affects the transport of fluorexon]; Vincristine inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; zafirlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]
ABCC1 protein affects the transport of Vincristine; ABCC1 protein mutant form affects the transport of Vincristine
ABCC1 protein affects the susceptibility to Vincristine

PMID:7954421 PMID:8649356 PMID:8968083 PMID:10348353 PMID:10685512 More...

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 10

multiple interactions
decreases response to substance

Imatinib Mesylate inhibits the reaction [ABCC10 protein results in decreased susceptibility to Vincristine]; nilotinib inhibits the reaction [ABCC10 protein results in decreased susceptibility to Vincristine]

NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178

G

ATP binding cassette subfamily C member 2

affects export
multiple interactions
decreases response to substance

ABCC2 protein affects the export of Vincristine
[Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCC2 mRNA; ABCC2 protein affects the export of and results in decreased susceptibility to Vincristine; myricetin inhibits the reaction [ABCC2 protein affects the export of and results in decreased susceptibility to Vincristine]; myricetin inhibits the reaction [ABCC2 protein affects the export of Vincristine]; myricetin inhibits the reaction [ABCC2 protein results in decreased susceptibility to Vincristine]

PMID:15896345 PMID:19944135 PMID:22095822

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

multiple interactions

[Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

multiple interactions

[Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCC4 mRNA

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily C member 5

multiple interactions

[Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCC5 mRNA

NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253

G

ATP binding cassette subfamily C member 6

multiple interactions

[Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCC6 mRNA

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

ATP binding cassette subfamily D member 3

multiple interactions

[Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCD3 mRNA

NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020

G

ATP binding cassette subfamily G member 1

multiple interactions

[Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

ATP binding cassette subfamily G member 2

multiple interactions

[Paclitaxel results in decreased expression of ABCG2] which results in decreased susceptibility to Vincristine; [Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCG2 mRNA

PMID:19944135 PMID:21833476

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ATP binding cassette subfamily G member 4

multiple interactions

[Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCG4 mRNA

NCBI chr 8:44,611,187...44,629,818
Ensembl chr 8:44,611,187...44,626,881

G

abhydrolase domain containing 11

decreases expression

Vincristine results in decreased expression of ABHD11 mRNA

NCBI chr12:21,682,206...21,685,331
Ensembl chr12:21,682,202...21,685,398

G

ankyrin repeat and BTB domain containing 2

increases expression

Vincristine results in increased expression of ABTB2 mRNA

NCBI chr 3:89,954,726...90,108,549
Ensembl chr 3:89,954,713...90,108,548

G

acyl-CoA dehydrogenase family, member 9

decreases expression

Vincristine results in decreased expression of ACAD9 mRNA

NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547

G

acetylcholinesterase

decreases expression
multiple interactions

Vincristine results in decreased expression of ACHE protein
xaliproden inhibits the reaction [Vincristine results in decreased expression of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

atypical chemokine receptor 3

increases expression

Vincristine results in increased expression of ACKR3 mRNA

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

actin related protein 2

increases expression

Vincristine results in increased expression of ACTR2 mRNA

NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524

G

adenosine deaminase, tRNA-specific 2

decreases expression

Vincristine results in decreased expression of ADAT2 mRNA

NCBI chr 1:7,954,520...7,975,254
Ensembl chr 1:7,954,631...7,975,251

G

adhesion G protein-coupled receptor F4

increases expression

Vincristine results in increased expression of ADGRF4 mRNA

NCBI chr 9:18,272,050...18,303,219
Ensembl chr 9:18,272,050...18,303,217

G

adrenoceptor beta 1

decreases expression

Vincristine results in decreased expression of ADRB1 mRNA

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

increases response to substance

ADRB2 gene SNP results in increased susceptibility to Vincristine

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

AGBL carboxypeptidase 3

decreases expression

Vincristine results in decreased expression of AGBL3 mRNA

NCBI chr 4:63,448,789...63,535,538
Ensembl chr 4:63,453,940...63,531,188

G

activator of HSP90 ATPase homolog 2

decreases expression

Vincristine results in decreased expression of AHSA2P mRNA

NCBI chr14:97,476,304...97,485,725
Ensembl chr14:97,476,817...97,485,657

G

absent in melanoma 2

increases expression

Vincristine results in increased expression of AIM2 mRNA

NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975

G

adenylate kinase 1

decreases expression

Vincristine results in decreased expression of AK1 mRNA

NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041

G

adenylate kinase 3

decreases expression

Vincristine results in decreased expression of AK3 mRNA

NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625

G

A-kinase anchoring protein 10

increases expression

Vincristine results in increased expression of AKAP10 mRNA

NCBI chr10:46,545,371...46,608,730
Ensembl chr10:46,551,532...46,608,769

G

AKT serine/threonine kinase 1

multiple interactions
decreases expression

Vincristine inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]
Vincristine results in decreased expression of AKT1 mRNA
Quercetin inhibits the reaction [Vincristine results in decreased expression of AKT1 mRNA]
Vincristine promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]]

PMID:16740780 PMID:18590705 PMID:33038355

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

decreases expression
multiple interactions

Vincristine results in decreased expression of AKT2 mRNA
Quercetin inhibits the reaction [Vincristine results in decreased expression of AKT2 mRNA]

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

aldolase, fructose-bisphosphate C

decreases expression

Vincristine results in decreased expression of ALDOC mRNA

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

ALMS1, centrosome and basal body associated protein

decreases expression

Vincristine results in decreased expression of ALMS1 mRNA

NCBI chr 4:118,125,581...118,226,005
Ensembl chr 4:118,125,607...118,226,005

G

alpha-kinase 2

increases expression

Vincristine results in increased expression of ALPK2 mRNA

NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258

G

anti-Mullerian hormone

decreases secretion

Vincristine results in decreased secretion of AMH protein

NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282

G

anaphase-promoting complex subunit 5

increases expression

Vincristine results in increased expression of ANAPC5 mRNA

NCBI chr12:33,748,709...33,781,709
Ensembl chr12:33,748,735...33,781,781

G

ankyrin repeat and death domain containing 1A

decreases expression

Vincristine results in decreased expression of ANKDD1A mRNA

NCBI chr 8:66,017,571...66,043,738
Ensembl chr 8:66,017,773...66,042,651

G

ankyrin repeat and KH domain containing 1

increases expression

Vincristine results in increased expression of ANKHD1 mRNA

NCBI chr18:28,161,882...28,260,917
Ensembl chr18:28,162,311...28,268,024

G

ankyrin repeat family A member 2

increases expression

Vincristine results in increased expression of ANKRA2 mRNA

NCBI chr 2:29,612,867...29,623,748
Ensembl chr 2:29,612,925...29,623,730

G

ankyrin repeat domain 13C

decreases expression

Vincristine results in decreased expression of ANKRD13C mRNA

NCBI chr 2:247,023,040...247,070,433
Ensembl chr 2:247,022,286...247,070,433

G

ankyrin repeat domain 33B

increases expression

Vincristine results in increased expression of ANKRD33B mRNA

NCBI chr 2:82,277,604...82,359,420
Ensembl chr 2:82,283,108...82,358,872

G

ankyrin repeat domain 37

decreases expression

Vincristine results in decreased expression of ANKRD37 mRNA

NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963

G

acidic nuclear phosphoprotein 32 family member E

decreases expression

Vincristine results in decreased expression of ANP32E mRNA

NCBI chr 2:183,472,600...183,489,057
Ensembl chr 2:183,472,609...183,489,054

G

annexin A1

increases expression

Vincristine results in increased expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A2

increases expression

Vincristine results in increased expression of ANXA2 mRNA

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

adaptor related protein complex 1 subunit sigma 2

decreases expression

Vincristine results in decreased expression of AP1S2 mRNA

NCBI chr X:30,572,746...30,598,961
Ensembl chr X:30,572,751...30,597,262

G

apurinic/apyrimidinic endodeoxyribonuclease 2

decreases expression

Vincristine results in decreased expression of APEX2 mRNA

NCBI chr X:19,425,684...19,508,459
Ensembl chr X:19,487,419...19,508,439

G

apelin

decreases expression

Vincristine results in decreased expression of APLN mRNA

NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391

G

apolipoprotein D

increases expression

Vincristine results in increased expression of APOD mRNA

NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305

G

apolipoprotein L domain containing 1

increases expression

Vincristine results in increased expression of APOLD1 mRNA

NCBI chr 4:167,768,437...167,825,706
Ensembl chr 4:167,818,271...167,825,706

G

aquaporin 9

increases expression

Vincristine results in increased expression of AQP9 mRNA

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

decreases expression

Vincristine results in decreased expression of ARAP2 mRNA

NCBI chr14:46,717,657...46,917,326
Ensembl chr14:46,718,760...46,917,154

G

ADP-ribosylation factor 1

increases expression

Vincristine results in increased expression of ARF1 mRNA

NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434

G

Rho GTPase activating protein 15

increases expression

Vincristine results in increased expression of ARHGAP15 mRNA

NCBI chr 3:27,989,368...28,592,722
Ensembl chr 3:27,989,633...28,600,265

G

Rho GTPase activating protein 18

decreases expression

Vincristine results in decreased expression of ARHGAP18 mRNA

NCBI chr 1:18,403,531...18,637,306
Ensembl chr 1:18,403,537...18,637,256

G

Rho GTPase activating protein 5

decreases expression

Vincristine results in decreased expression of ARHGAP5 mRNA

NCBI chr 6:69,975,904...70,039,299
Ensembl chr 6:69,976,214...70,037,660

G

Rac/Cdc42 guanine nucleotide exchange factor 6

increases expression

Vincristine results in increased expression of ARHGEF6 mRNA

NCBI chr X:135,145,447...135,264,636
Ensembl chr X:135,146,786...135,275,304

G

Rho guanine nucleotide exchange factor 7

increases expression

Vincristine results in increased expression of ARHGEF7 mRNA

NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697

G

AT-rich interaction domain 2

increases expression

Vincristine results in increased expression of ARID2 mRNA

NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512

G

AT-rich interaction domain 4B

increases expression

Vincristine results in increased expression of ARID4B mRNA

NCBI chr17:51,138,419...51,262,894
Ensembl chr17:51,138,535...51,262,906

G

ADP-ribosylation factor like GTPase 5A

decreases expression

Vincristine results in decreased expression of ARL5A mRNA

NCBI chr 3:36,878,461...36,903,362
Ensembl chr 3:36,880,712...36,903,211

G

ADP-ribosylation factor like GTPase 5B

increases expression

Vincristine results in increased expression of ARL5B mRNA

NCBI chr17:77,955,864...77,979,895
Ensembl chr17:77,955,818...77,979,854

G

ADP-ribosylation factor like GTPase 6 interacting protein 1

decreases expression

Vincristine results in decreased expression of ARL6IP1 mRNA

NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994

G

armadillo repeat containing 8

decreases expression

Vincristine results in decreased expression of ARMC8 mRNA

NCBI chr 8:100,036,946...100,131,544
Ensembl chr 8:100,036,946...100,131,520

G

assembly factor for spindle microtubules

increases expression

Vincristine results in increased expression of ASPM mRNA

NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755

G

ASXL transcriptional regulator 1

increases expression

Vincristine results in increased expression of ASXL1 mRNA

NCBI chr 3:141,814,012...141,881,526
Ensembl chr 3:141,813,433...141,881,538

G

ATPase family, AAA domain containing 2

decreases expression

Vincristine results in decreased expression of ATAD2 mRNA

NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738

G

activating transcription factor 3

increases expression

Vincristine results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 5

increases expression

Vincristine results in increased expression of ATF5 mRNA

NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707

G

activating transcription factor 6

multiple interactions
increases expression

Quercetin inhibits the reaction [Vincristine results in increased expression of ATF6 mRNA]

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

ATPase plasma membrane Ca2+ transporting 4

increases expression

Vincristine results in increased expression of ATP2B4 mRNA

NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246

G

ATP synthase F1 subunit gamma

decreases expression

Vincristine results in decreased expression of ATP5F1C mRNA

NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367

G

ATPase H+ transporting V0 subunit e1

increases expression

Vincristine results in increased expression of ATP6V0E1 mRNA

NCBI chr10:16,479,656...16,502,732
Ensembl chr10:16,479,567...16,524,434

G

ATPase copper transporting alpha

decreases response to substance

ATP7A protein results in decreased susceptibility to Vincristine

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

ATPase phospholipid transporting 8A1

decreases expression

Vincristine results in decreased expression of ATP8A1 mRNA

NCBI chr14:40,315,013...40,557,572
Ensembl chr14:40,315,049...40,554,611

G

aurora kinase A

increases response to substance
increases expression

AURKA gene SNP results in increased susceptibility to Vincristine
Vincristine results in increased expression of AURKA mRNA

PMID:17374387 PMID:20864405

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

aurora kinase B

decreases expression

Vincristine results in decreased expression of AURKB mRNA

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

arginine vasopressin

increases expression

Vincristine results in increased expression of AVP protein

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

Beta-1,3-galactosyltransferase 6

decreases expression

Vincristine results in decreased expression of B3GALT6 mRNA

NCBI chr 5:166,584,202...166,586,338
Ensembl chr 5:166,584,202...166,586,338

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

increases expression

Vincristine results in increased expression of B3GNT5 mRNA

NCBI chr11:81,141,102...81,153,206
Ensembl chr11:81,140,599...81,156,166

G

BCL2-antagonist/killer 1

affects response to substance

BAK1 protein affects the susceptibility to Vincristine

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BMP and activin membrane-bound inhibitor

increases expression

Vincristine results in increased expression of BAMBI mRNA

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

G

BRCA1 associated RING domain 1

decreases expression

Vincristine results in decreased expression of BARD1 mRNA

NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265

G

brain abundant, membrane attached signal protein 1

increases expression

Vincristine results in increased expression of BASP1 mRNA

NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043

G

basic leucine zipper ATF-like transcription factor

increases expression

Vincristine results in increased expression of BATF mRNA

NCBI chr 6:105,353,715...105,376,051
Ensembl chr 6:105,353,715...105,376,051

G

BCL2 associated X, apoptosis regulator

decreases expression
multiple interactions
increases expression
affects response to substance

Vincristine results in decreased expression of BAX mRNA
KN 93 inhibits the reaction [Vincristine results in increased expression of BAX mRNA]; KN 93 inhibits the reaction [Vincristine results in increased expression of BAX protein]
Vincristine results in increased expression of BAX mRNA; Vincristine results in increased expression of BAX protein
Quercetin inhibits the reaction [Vincristine results in increased expression of BAX mRNA]
BAX protein affects the susceptibility to Vincristine
[Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BAX protein; Vincristine results in increased cleavage of and results in increased expression of BAX protein

PMID:9815696 PMID:15131059 PMID:16001973 PMID:22178383 PMID:33038355 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

branched chain amino acid transaminase 1

increases expression

Vincristine results in increased expression of BCAT1 mRNA

NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597

G

BCL2, apoptosis regulator

decreases response to substance
multiple interactions
decreases expression
increases phosphorylation

BCL2 protein results in decreased susceptibility to Vincristine
KN 93 inhibits the reaction [Vincristine results in decreased expression of BCL2 mRNA]; KN 93 inhibits the reaction [Vincristine results in decreased expression of BCL2 protein]
Vincristine results in decreased expression of BCL2 mRNA; Vincristine results in decreased expression of BCL2 protein
Quercetin inhibits the reaction [Vincristine results in decreased expression of BCL2 mRNA]
Vincristine results in increased phosphorylation of BCL2 protein
[Doxorubicin co-treated with Dexamethasone co-treated with Vincristine co-treated with Cytarabine co-treated with Mercaptopurine co-treated with Methotrexate co-treated with Cyclophosphamide co-treated with Enzymes and Coenzymes] results in increased expression of BCL2 protein; [Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BCL2 protein; [MIR497 results in decreased expression of BCL2 protein] which results in increased susceptibility to Vincristine; TYMP inhibits the reaction [Vincristine results in increased phosphorylation of BCL2 protein]

PMID:9815696 PMID:15907805 PMID:20162574 PMID:21182165 PMID:21258880 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

increases expression

Vincristine results in increased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 1

increases expression
affects response to substance

Vincristine results in increased expression of BCL2L1 mRNA
BCL2L1 protein affects the susceptibility to Vincristine

PMID:22178383 PMID:23649840

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

BCL2-associated transcription factor 1

decreases expression

Vincristine results in decreased expression of BCLAF1 mRNA

NCBI chr 1:15,088,436...15,117,666
Ensembl chr 1:15,070,894...15,148,832

G

BCL6 co-repressor

increases expression

Vincristine results in increased expression of BCOR mRNA

NCBI chr X:10,609,756...10,729,613
Ensembl chr X:10,687,732...10,729,613

G

bradykinin receptor B1

multiple interactions

[HOE 140, desArg(10)- binds to and results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Vincristine

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

bradykinin receptor B2

multiple interactions

[icatibant binds to and results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Vincristine

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

baculoviral IAP repeat-containing 2

increases expression

Vincristine results in increased expression of BIRC2 mRNA

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

increases expression

Vincristine results in increased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

BLM RecQ like helicase

decreases expression

Vincristine results in decreased expression of BLM mRNA

NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312

G

bone morphogenetic protein 2

increases expression

Vincristine results in increased expression of BMP2 mRNA

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

BCL2 interacting protein 3

decreases expression
multiple interactions

Vincristine results in decreased expression of BNIP3 mRNA
Vincristine affects the reaction [Valproic Acid affects the localization of BNIP3 protein]

PMID:23649840 PMID:25446377

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BCL2 interacting protein 3 like

decreases expression

Vincristine results in decreased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

BLOC-1 related complex subunit 7

increases expression

Vincristine results in increased expression of BORCS7 mRNA

NCBI chr 1:245,564,347...245,578,182
Ensembl chr 1:245,564,369...245,579,343

G

BRCA1 interacting helicase 1

decreases expression

Vincristine results in decreased expression of BRIP1 mRNA

NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324

G

bromodomain and WD repeat domain containing 1

decreases expression

Vincristine results in decreased expression of BRWD1 mRNA

NCBI chr11:35,286,364...35,378,768
Ensembl chr11:35,288,313...35,378,768

G

BTG anti-proliferation factor 1

increases expression

Vincristine results in increased expression of BTG1 mRNA

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

BTG anti-proliferation factor 2

increases expression

Vincristine results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

BTG anti-proliferation factor 4

increases expression

Vincristine results in increased expression of BTG4 mRNA

NCBI chr 8:51,410,774...51,425,802
Ensembl chr 8:51,422,061...51,425,796

G

BUB3 mitotic checkpoint protein

decreases expression

Vincristine results in decreased expression of BUB3 mRNA

NCBI chr 1:186,330,358...186,340,969
Ensembl chr 1:186,327,931...186,395,036

G

similar to human chromosome 1 open reading frame 74

decreases expression

Vincristine results in decreased expression of C1ORF74 mRNA

NCBI chr13:104,692,769...104,695,368
Ensembl chr13:104,692,824...104,695,470

G

core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1

decreases expression

Vincristine results in decreased expression of C1GALT1 mRNA

NCBI chr 4:35,930,981...35,966,100
Ensembl chr 4:35,928,104...35,961,831

G

similar to human chromosome 12 open reading frame 54

increases expression

Vincristine results in increased expression of C12ORF54 mRNA

NCBI chr 7:129,529,811...129,548,676

G

similar to human chromosome 15 open reading frame 39

decreases expression

Vincristine results in decreased expression of C15ORF39 mRNA

NCBI chr 8:57,646,324...57,655,896
Ensembl chr 8:57,645,756...57,655,941

G

Cdk5 and Abl enzyme substrate 2

decreases expression

Vincristine results in decreased expression of CABLES2 mRNA

NCBI chr 3:167,347,527...167,362,274
Ensembl chr 3:167,347,461...167,362,279

G

calcium voltage-gated channel subunit alpha1 H

increases expression
multiple interactions

Vincristine results in increased expression of CACNA1H mRNA; Vincristine results in increased expression of CACNA1H protein
Ascorbic Acid inhibits the reaction [Vincristine results in increased expression of CACNA1H mRNA]; Ascorbic Acid inhibits the reaction [Vincristine results in increased expression of CACNA1H protein]; KN 62 inhibits the reaction [Vincristine results in increased expression of CACNA1H protein]; KN 93 inhibits the reaction [Vincristine results in increased expression of CACNA1H mRNA]; KN 93 inhibits the reaction [Vincristine results in increased expression of CACNA1H protein]; zinc chloride inhibits the reaction [Vincristine results in increased expression of CACNA1H protein]

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

G

calcium voltage-gated channel auxiliary subunit beta 2

increases expression

Vincristine results in increased expression of CACNB2 mRNA

NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106

G

caldesmon 1

increases expression

Vincristine results in increased expression of CALD1 mRNA

NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932

G

calmodulin 2

decreases expression

Vincristine results in decreased expression of CALM2 mRNA

NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287

G

calumenin

increases expression

Vincristine results in increased expression of CALU mRNA

NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593

G

calcium/calmodulin-dependent protein kinase II delta

decreases expression

Vincristine results in decreased expression of CAMK2D mRNA

NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178

G

calcium/calmodulin-dependent protein kinase kinase 1

increases response to substance

CAMKK1 gene SNP results in increased susceptibility to Vincristine

NCBI chr10:57,637,335...57,660,498
Ensembl chr10:57,637,391...57,660,498

G

capping actin protein, gelsolin like

increases expression

Vincristine results in increased expression of CAPG mRNA

NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856

G

calcium regulated heat stable protein 1

decreases expression

Vincristine results in decreased expression of CARHSP1 mRNA

NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019

G

caspase 1

increases expression

Vincristine results in increased expression of CASP1 mRNA

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

increases cleavage
multiple interactions
increases expression

Vincristine results in increased cleavage of CASP3 protein
KN 93 inhibits the reaction [Vincristine results in increased cleavage of CASP3 protein]
coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of CASP3 protein]; Quercetin inhibits the reaction [Vincristine results in increased expression of CASP3 mRNA]; Quercetin inhibits the reaction [Vincristine results in increased expression of CASP3 protein]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of CASP3 mRNA]; Sumatriptan inhibits the reaction [Vincristine results in increased expression of CASP3 protein]
Vincristine results in increased expression of CASP3 mRNA; Vincristine results in increased expression of CASP3 protein

PMID:20624997 PMID:29958920 PMID:33038355 PMID:34286406 PMID:34939713 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

increases expression

Vincristine results in increased expression of CASP6 mRNA

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 8

increases expression
increases response to substance
multiple interactions

Vincristine results in increased expression of CASP8 mRNA
CASP8 protein results in increased susceptibility to Vincristine
Vincristine results in increased expression of and results in increased cleavage of CASP8 protein

PMID:16001973 PMID:22010212

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

affects response to substance
decreases activity
decreases expression
multiple interactions

CAT protein affects the susceptibility to Vincristine
Vincristine results in decreased activity of CAT protein
Vincristine results in decreased expression of CAT protein
Quercetin inhibits the reaction [Vincristine results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [Vincristine results in decreased expression of CAT protein]; Vincristine inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Vincristine inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]

PMID:11178967 PMID:24201307 PMID:25537132 PMID:26102012 PMID:36808657

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

chromobox 3

decreases expression

Vincristine results in decreased expression of CBX3 mRNA

NCBI chr 4:80,545,450...80,559,284
Ensembl chr 4:80,546,010...80,559,283

G

chromobox 5

decreases expression

Vincristine results in decreased expression of CBX5 mRNA

NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022

G

cell division cycle and apoptosis regulator 1

decreases expression

Vincristine results in decreased expression of CCAR1 mRNA

NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526

G

coiled-coil domain containing 12

decreases expression

Vincristine results in decreased expression of CCDC12 mRNA

NCBI chr 8:110,635,276...110,686,417
Ensembl chr 8:110,635,710...110,686,417

G

coiled-coil domain containing 186

decreases expression

Vincristine results in decreased expression of CCDC186 mRNA

NCBI chr 1:255,831,663...255,871,954
Ensembl chr 1:255,839,595...255,871,935

G

coiled-coil domain containing 198

decreases expression

Vincristine results in decreased expression of CCDC198 mRNA

NCBI chr15:22,500,181...22,527,011
Ensembl chr15:22,502,687...22,526,992

G

coiled-coil domain containing 32

decreases expression

Vincristine results in decreased expression of CCDC32 mRNA

NCBI chr 3:105,998,429...106,010,985
Ensembl chr 3:105,998,430...106,010,975

G

coiled-coil domain containing 82

increases expression

Vincristine results in increased expression of CCDC82 mRNA

NCBI chr 8:10,227,727...10,265,963
Ensembl chr 8:10,228,430...10,265,963

G

coiled-coil alpha-helical rod protein 1

decreases expression

Vincristine results in decreased expression of CCHCR1 mRNA

NCBI chr20:3,205,675...3,218,437
Ensembl chr20:3,205,676...3,218,308

G

C-C motif chemokine ligand 1

increases expression

Vincristine results in increased expression of CCL1 mRNA

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

G

C-C motif chemokine ligand 2

increases expression

Vincristine results in increased expression of CCL2 mRNA

PMID:20624997 PMID:23649840

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

increases expression

Vincristine results in increased expression of CCL20 mRNA

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 22

increases expression

Vincristine results in increased expression of CCL22 mRNA

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

G

C-C motif chemokine ligand 4

increases expression

Vincristine results in increased expression of CCL4 mRNA

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

increases expression

Vincristine results in increased expression of CCL5 mRNA

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 2

decreases response to substance

CCN2 mRNA results in decreased susceptibility to Vincristine

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin B1

affects response to substance
increases expression

CCNB1 protein affects the susceptibility to Vincristine
Vincristine results in increased expression of CCNB1 mRNA

PMID:22178383 PMID:23649840

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

increases expression

Vincristine results in increased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin E1

decreases expression

Vincristine results in decreased expression of CCNE1 mRNA

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin E2

decreases expression

Vincristine results in decreased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin L1

decreases expression

Vincristine results in decreased expression of CCNL1 mRNA

NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368

G

CD109 molecule

increases expression

Vincristine results in increased expression of CD109 mRNA

NCBI chr 8:79,454,480...79,569,195
Ensembl chr 8:79,454,480...79,569,194

G

CD14 molecule

increases expression

Vincristine results in increased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

Cd200 molecule

increases expression

Vincristine results in increased expression of CD200 mRNA

NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648

G

CD274 molecule

increases expression

Vincristine results in increased expression of CD274 mRNA

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

CD36 molecule

increases expression

Vincristine results in increased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD40 molecule

increases expression

Vincristine results in increased expression of CD40 mRNA

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD44 molecule

increases expression

Vincristine results in increased expression of CD44 mRNA

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

Cd48 molecule

increases expression

Vincristine results in increased expression of CD48 mRNA

NCBI chr13:84,184,884...84,209,144
Ensembl chr13:84,185,532...84,209,142

G

CD55 molecule (Cromer blood group)

increases expression

Vincristine results in increased expression of CD55 mRNA

NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831

G

Cd69 molecule

increases expression

Vincristine results in increased expression of CD69 mRNA

NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542

G

Cd80 molecule

increases expression

Vincristine results in increased expression of CD80 mRNA

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD83 molecule

increases expression

Vincristine results in increased expression of CD83 mRNA

NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083

G

CD86 molecule

increases expression

Vincristine results in increased expression of CD86 mRNA

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

CDC42 effector protein 3

increases expression

Vincristine results in increased expression of CDC42EP3 mRNA

NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721

G

CDC42 effector protein 4

increases expression

Vincristine results in increased expression of CDC42EP4 mRNA

NCBI chr10:98,772,613...98,797,924
Ensembl chr10:98,772,495...98,797,695

G

CDC42 small effector 1

increases expression

Vincristine results in increased expression of CDC42SE1 mRNA

NCBI chr 2:182,805,691...182,813,520
Ensembl chr 2:182,804,925...182,814,028

G

cell division cycle 6

decreases expression

Vincristine results in decreased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cell division cycle associated 3

decreases expression

Vincristine results in decreased expression of CDCA3 mRNA

NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799

G

cell division cycle associated 7

decreases expression

Vincristine results in decreased expression of CDCA7 mRNA

NCBI chr 3:57,322,718...57,333,353
Ensembl chr 3:57,322,708...57,333,353

G

cadherin 1

increases expression

Vincristine results in increased expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase 1

decreases expression

Vincristine results in decreased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 10

decreases expression

Vincristine results in decreased expression of CDK10 mRNA

NCBI chr19:51,260,012...51,273,009
Ensembl chr19:51,261,356...51,269,078

G

cyclin-dependent kinase 19

decreases expression

Vincristine results in decreased expression of CDK19 mRNA

NCBI chr20:43,770,409...43,910,629
Ensembl chr20:43,770,409...43,910,628

G

cyclin dependent kinase 2

decreases expression

Vincristine results in decreased expression of CDK2 mRNA

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

Vincristine results in increased expression of CDKN1A mRNA
[XL019 compound co-treated with Vincristine] results in increased expression of CDKN1A protein; Resveratrol inhibits the reaction [Vincristine results in increased expression of CDKN1A mRNA]

PMID:20624997 PMID:23649840 PMID:26055805 PMID:29187454

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

increases response to substance

CDKN2A protein results in increased susceptibility to Vincristine

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cyclin-dependent kinase inhibitor 2C

decreases expression

Vincristine results in decreased expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

CEA cell adhesion molecule 1

increases expression

Vincristine results in increased expression of CEACAM1 mRNA

NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992

G

CCAAT/enhancer binding protein beta

increases expression

Vincristine results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

CUGBP, Elav-like family member 1

decreases expression

Vincristine results in decreased expression of CELF1 mRNA

NCBI chr 3:76,924,591...76,999,429
Ensembl chr 3:76,924,613...76,999,426

G

centromere protein C

decreases expression

Vincristine results in decreased expression of CENPC1 mRNA

NCBI chr14:21,988,067...22,046,732
Ensembl chr14:21,988,144...22,055,476

G

centromere protein F

decreases expression

Vincristine results in decreased expression of CENPF mRNA

NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669

G

centromere protein I

decreases expression

Vincristine results in decreased expression of CENPI mRNA

NCBI chr X:97,515,919...97,567,671
Ensembl chr X:97,515,972...97,567,657

G

centromere protein U

decreases expression

Vincristine results in decreased expression of CENPU mRNA

NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823

G

centrosomal protein 135

increases expression

Vincristine results in increased expression of CEP135 mRNA

NCBI chr14:31,530,538...31,595,812
Ensembl chr14:31,531,482...31,595,772

G

carboxylesterase 5A

increases expression

Vincristine results in increased expression of CES5A mRNA

NCBI chr19:11,469,431...11,499,007
Ensembl chr19:11,469,469...11,499,006

G

CASP8 and FADD-like apoptosis regulator

increases expression

Vincristine results in increased expression of CFLAR mRNA

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

chromodomain helicase DNA binding protein 1-like

increases expression

Vincristine results in increased expression of CHD1L mRNA

NCBI chr 2:185,138,526...185,217,498
Ensembl chr 2:185,139,308...185,217,595

G

checkpoint kinase 2

decreases expression

Vincristine results in decreased expression of CHEK2 mRNA

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

CHM Rab escort protein

increases expression

Vincristine results in increased expression of CHM mRNA

NCBI chr X:78,203,200...78,361,996
Ensembl chr X:78,203,204...78,361,943

G

CHM like Rab escort protein

decreases expression

Vincristine results in decreased expression of CHML mRNA

NCBI chr13:87,609,647...87,619,868
Ensembl chr13:87,589,298...87,619,862

G

chromosome transmission fidelity factor 18

decreases expression

Vincristine results in decreased expression of CHTF18 mRNA

NCBI chr10:14,743,006...14,751,044
Ensembl chr10:14,742,621...14,751,050

G

cytokine induced apoptosis inhibitor 1

decreases response to substance

CIAPIN1 protein results in decreased susceptibility to Vincristine

NCBI chr19:10,179,963...10,195,511
Ensembl chr19:10,180,100...10,195,503

G

cold inducible RNA binding protein

decreases expression

Vincristine results in decreased expression of CIRBP mRNA

NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818

G

cytoplasmic linker associated protein 2

increases expression

Vincristine results in increased expression of CLASP2 mRNA

NCBI chr 8:113,677,345...113,859,957
Ensembl chr 8:113,677,284...113,858,731

G

C-type lectin domain family 2, member D

decreases expression

Vincristine results in decreased expression of CLEC2D mRNA

NCBI chr 4:162,216,052...162,239,530
Ensembl chr 4:162,216,572...162,239,527

G

chloride intracellular channel 2

increases expression

Vincristine results in increased expression of CLIC2 mRNA

NCBI chr20:149,337...164,375
Ensembl chr20:148,907...164,355

G

claspin

decreases expression

Vincristine results in decreased expression of CLSPN mRNA

NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034

G

connector enhancer of kinase suppressor of Ras 2

decreases expression

Vincristine results in decreased expression of CNKSR2 mRNA

NCBI chr X:36,908,135...37,148,337
Ensembl chr X:36,907,850...37,150,555

G

CCR4-NOT transcription complex, subunit 3

decreases expression

Vincristine results in decreased expression of CNOT3 mRNA

NCBI chr 1:65,555,924...65,572,167
Ensembl chr 1:65,555,924...65,572,167

G

CCR4-NOT transcription complex, subunit 6-like

decreases expression

Vincristine results in decreased expression of CNOT6L mRNA

NCBI chr14:13,410,499...13,502,511
Ensembl chr14:13,411,281...13,498,203

G

centlein

decreases expression

Vincristine results in decreased expression of CNTLN mRNA

NCBI chr 5:99,295,865...99,576,402
Ensembl chr 5:99,296,000...99,576,396

G

collagen type XV alpha 1 chain

decreases response to substance

COL15A1 mRNA results in decreased susceptibility to Vincristine

NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591

G

collagen type I alpha 2 chain

increases response to substance

COL1A2 mRNA results in increased susceptibility to Vincristine

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type III alpha 1 chain

decreases response to substance

COL3A1 mRNA results in decreased susceptibility to Vincristine

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type V alpha 2 chain

decreases response to substance

COL5A2 mRNA results in decreased susceptibility to Vincristine

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

catechol-O-methyltransferase domain containing 1

decreases expression

Vincristine results in decreased expression of COMTD1 mRNA

NCBI chr15:2,459,783...2,462,895
Ensembl chr15:2,459,783...2,462,895

G

ceruloplasmin

increases expression

Vincristine results in increased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

cytoplasmic polyadenylation element binding protein 2

increases expression

Vincristine results in increased expression of CPEB2 mRNA

NCBI chr14:67,787,503...67,839,973
Ensembl chr14:67,787,507...67,840,743

G

copine 3

decreases expression

Vincristine results in decreased expression of CPNE3 mRNA

NCBI chr 5:33,014,658...33,063,934
Ensembl chr 5:33,016,307...33,063,934

G

cleavage and polyadenylation specific factor 6

decreases expression

Vincristine results in decreased expression of CPSF6 mRNA

NCBI chr 7:52,956,589...53,001,783
Ensembl chr 7:52,956,589...52,988,122

G

CREB binding protein

increases expression

Vincristine results in increased expression of CREBBP mRNA

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

CREB3 regulatory factor

increases expression

Vincristine results in increased expression of CREBRF mRNA

NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999

G

CREB/ATF bZIP transcription factor

decreases expression

Vincristine results in decreased expression of CREBZF mRNA

NCBI chr 1:144,416,864...144,423,540
Ensembl chr 1:144,417,446...144,428,553

G

cartilage associated protein

decreases expression

Vincristine results in decreased expression of CRTAP mRNA

NCBI chr 8:114,047,929...114,067,636
Ensembl chr 8:114,047,933...114,067,631

G

CREB regulated transcription coactivator 3

increases expression

Vincristine results in increased expression of CRTC3 mRNA

NCBI chr 1:134,552,830...134,655,929
Ensembl chr 1:134,554,696...134,655,500

G

cysteine sulfinic acid decarboxylase

decreases expression

Vincristine results in decreased expression of CSAD mRNA

NCBI chr 7:133,308,571...133,337,914
Ensembl chr 7:133,308,574...133,337,615

G

colony stimulating factor 2

increases expression

Vincristine results in increased expression of CSF2 mRNA

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

casein kinase 1, alpha 1

increases expression

Vincristine results in increased expression of CSNK1A1 mRNA

NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271

G

casein kinase 1, gamma 1

increases expression

Vincristine results in increased expression of CSNK1G1 mRNA

NCBI chr 8:66,439,760...66,577,247
Ensembl chr 8:66,439,864...66,572,826

G

cystatin A

increases expression

Vincristine results in increased expression of CSTA mRNA

NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488

G

cleavage stimulation factor subunit 1

decreases expression

Vincristine results in decreased expression of CSTF1 mRNA

NCBI chr 3:161,144,522...161,156,294
Ensembl chr 3:161,144,548...161,156,300

G

CST telomere replication complex component 1

decreases expression

Vincristine results in decreased expression of CTC1 mRNA

NCBI chr10:53,714,614...53,735,298
Ensembl chr10:53,714,644...53,735,298

G

cystathionine gamma-lyase

increases expression

Vincristine results in increased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

catenin alpha-like 1

decreases expression

Vincristine results in decreased expression of CTNNAL1 mRNA

NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431

G

catenin beta 1

increases expression
decreases response to substance

Vincristine results in increased expression of CTNNB1 mRNA
CTNNB1 results in decreased susceptibility to Vincristine

PMID:22000491 PMID:23649840

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cullin 4A

increases expression

Vincristine results in increased expression of CUL4A mRNA

NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330