CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: cefaclor
Accession: CHEBI:3478
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Definition: A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.
Synonyms: exact_synonym: (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7beta-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-3,4-didehydrocepham-4-carboxylic acid
related_synonym: 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid; CCL; Cefaclor anhydrous; Cephaclor; Formula=C15H14ClN3O4S; InChI=1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1; InChIKey=QYIYFLOTGYLRGG-GPCCPHFNSA-N; SMILES=[H][C@]12SCC(Cl)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccccc1)C(O)=O; cefaclorum
alt_id: CHEBI:472656
xref: Beilstein:3632473; CAS:53994-73-3; DrugBank:DB00833; Drug_Central:525; HMDB:HMDB0014971; KEGG:C06877; KEGG:D00256; LINCS:LSM-5368
xref_mesh: MESH:D002433
xref: PMID:10230635; PMID:10930630; PMID:11963587; PMID:12485718; PMID:12569987; PMID:15812119; PMID:18969055; PMID:29017833; Patent:DE2408698; Patent:US3925372; Reaxys:3632473; Wikipedia:Cefaclor
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Abcb11
ATP binding cassette subfamily B member 11
multiple interactions decreases activity
ISO
Cefaclor inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Cefaclor results in decreased activity of ABCB11 protein
CTD
PMID:24014644
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression
ISO
Cefaclor results in increased expression of CYP3A4 mRNA; Cefaclor results in increased expression of CYP3A4 protein
CTD
PMID:18505790
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Slc22a6
solute carrier family 22 member 6
multiple interactions
ISO
Cefaclor inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
CTD
PMID:16098483
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a8
solute carrier family 22 member 8
increases uptake multiple interactions
ISO
SLC22A8 protein results in increased uptake of Cefaclor Cefaclor inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
CTD
PMID:16098483
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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