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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:molsidomine
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Accession:CHEBI:31861 term browser browse the term
Definition:A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Synonyms:exact_synonym: N-(ethoxycarbonyl)-3-(morpholin-4-yl)-1,2,3-oxadiazol-3-ium-5-aminide
 related_synonym: 5-[(ethoxycarbonyl)amino]-3-(4-morpholinyl)-1,2,3-oxadiazolium inner salt;   CAS 276;   Corraton;   Coruno;   Corvaton;   Covarsal;   Formula=C9H14N4O4;   InChI=1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3;   InChIKey=XLFWDASMENKTKL-UHFFFAOYSA-N;   MolsiCare;   Molsicor;   Morial;   N-(ethoxycarbonyl)-3-morpholinosydnone imine;   N-carboxy-3-morpholinosydnone imine ethyl ester;   N-ethoxycarbonyl-3-morpholinosydnonimine;   SIN-10;   SMILES=CCOC(=O)[N-]C1=C[N+](=NO1)N1CCOCC1;   Sydnopharm;   molsidolat;   molsidomin;   molsidomina;   molsidominum;   morsydomine;   motazomin
 xref: CAS:25717-80-0;   Chemspider:4090;   DrugBank:DB09282;   Drug_Central:1831;   HMDB:HMDB0245703;   KEGG:D01320
 xref_mesh: MESH:D008981
 xref: PMID:14718172;   PMID:24120390;   PMID:24157421;   PMID:25032121;   PMID:25269886;   PMID:26469102;   PMID:26833172;   PMID:27238492;   PMID:27482866;   PMID:27721541;   PMID:27760216;   PMID:27816693;   PMID:27897441;   PMID:27918857;   PMID:28166419;   PMID:29323543;   PMID:29477039;   PMID:30587924;   PMID:30898683;   PMID:31085310;   PMID:32706246;   PMID:34330056;   PMID:34557650;   Reaxys:3999414;   Wikipedia:Molsidomine


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molsidomine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fxn frataxin increases expression ISO Molsidomine results in increased expression of FXN mRNA CTD PMID:23418481 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G Ptgis prostaglandin I2 synthase multiple interactions EXP Molsidomine inhibits the reaction [Hypoxia increases expression of Ptgis mRNA in the lung] RGD PMID:12062720 RGD:401959327 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Molsidomine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Molsidomine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
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  CHEBI ontology 19808
    role 19784
      chemical role 19420
        antioxidant 16122
          molsidomine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      chalcogen 19513
                        oxygen atom 19488
                          oxygen molecular entity 19488
                            hydroxides 19299
                              organic hydroxy compound 18923
                                alcohol 15686
                                  primary alcohol 14647
                                    ethanols 8804
                                      ethanol 8804
                                        ethyl ester 4135
                                          molsidomine 4
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