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ipriflavone - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ipriflavone
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Accession:CHEBI:31719 term browser browse the term
Definition:A member of the class of isoflavones that is isoflavone in which the hydrogen at position 7 is replaced by an isopropoxy group. A synthetic isoflavone, it was formerly used for the treatment of osteoporosis, although a randomised controlled study failed to show any benefit. It is still used to prevent osteoporosis in post-menopausal women.
Synonyms:exact_synonym: 7-isopropoxy-3-phenyl-4H-chromen-4-one
 related_synonym: 7-(1-methylethoxy)-3-phenyl-4H-1-benzopyran-4-one;   7-isopropoxyisoflavone;   FL-113;   Formula=C18H16O3;   InChI=1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3;   InChIKey=SFBODOKJTYAUCM-UHFFFAOYSA-N;   Iprosten;   Osten;   SMILES=CC(C)Oc1ccc2c(c1)occ(-c1ccccc1)c2=O;   Yambolap;   ipriflavona;   ipriflavonum
 xref: CAS:35212-22-7;   Drug_Central:1477;   HMDB:HMDB0032987;   KEGG:D01338;   LINCS:LSM-5981
 xref_mesh: MESH:C018986
 xref: PMID:11255425;   PMID:17297162;   PMID:21594876;   PMID:23265084;   PMID:24084576;   PMID:24389340;   PMID:24404906;   PMID:7196240;   PMID:8148667;   PMID:8461568;   PMID:9263607;   PMID:9263610;   PMID:9263615;   PMID:9517377;   PMID:9988779;   Patent:DE2125245;   Patent:US3833730;   Patent:US3949085;   Reaxys:4754346;   Wikipedia:Ipriflavone

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ipriflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO ipriflavone binds to and results in increased activity of ESR1 protein CTD PMID:9751507 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO ipriflavone binds to and results in increased activity of ESR2 protein CTD PMID:9751507 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions ISO ipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO ipriflavone results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO ipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
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  CHEBI ontology 20856
    role 20816
      application 20617
        pharmaceutical 20413
          drug 20413
            bone density conservation agent 6100
              ipriflavone 5
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  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            organic molecule 20649
                              organic cyclic compound 20400
                                organic heterocyclic compound 19383
                                  oxacycle 18292
                                    benzopyran 12079
                                      1-benzopyran 11825
                                        isoflavonoid 3900
                                          isoflavones 3882
                                            ipriflavone 5
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