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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3,4-dihydroxyphenylacetaldehyde
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Accession:CHEBI:27978 term browser browse the term
Definition:A phenylacetaldehyde in which the 3 and 4 positions of the phenyl group are substituted by hydroxy groups.
Synonyms:exact_synonym: (3,4-dihydroxyphenyl)acetaldehyde
 related_synonym: 2-(3,4-dihydroxyphenyl)ethanal;   DOPAL;   Formula=C8H8O3;   InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2;   InChIKey=IADQVXRMSNIUEL-UHFFFAOYSA-N;   Protocatechuatealdehyde;   SMILES=[H]C(=O)Cc1ccc(O)c(O)c1
 alt_id: CHEBI:1385;   CHEBI:19888
 xref: CAS:5707-55-1;   FooDB:FDB023227;   HMDB:HMDB0003791;   KEGG:C04043;   KNApSAcK:C00052036
 xref_mesh: MESH:C007430
 xref: MetaCyc:34-DIHYDROXYPHENYLACETALDEHYDE;   PMID:12729575;   PMID:14556942;   PMID:17379813;   PMID:19537779;   Reaxys:1941234;   Wikipedia:3\,4-Dihydroxyphenylacetaldehyde


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3,4-dihydroxyphenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member affects binding EXP 3,4-dihydroxyphenylacetaldehyde binds to ALDH2 protein CTD PMID:21238438 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects binding EXP 3,4-dihydroxyphenylacetaldehyde binds to GSTM1 protein CTD PMID:21238438 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Th tyrosine hydroxylase affects binding
multiple interactions
decreases activity		 EXP 3,4-dihydroxyphenylacetaldehyde binds to TH protein
[3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein] which results in decreased chemical synthesis of Levodopa		 CTD PMID:21238438 PMID:21514317 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        solvent 17012
          formic acid 9037
            formyl group 8999
              aldehyde 8999
                phenylacetaldehydes 11
                  3,4-dihydroxyphenylacetaldehyde 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          formyl group 8999
                                            aldehyde 8999
                                              phenylacetaldehydes 11
                                                3,4-dihydroxyphenylacetaldehyde 3
paths to the root