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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenylacetaldehydes
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Accession:CHEBI:25973 term browser browse the term


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2-phenylpropanal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
decreases activity
ISO GSTA1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]
GSTA1 protein results in decreased activity of hydratropic aldehyde
CTD PMID:11368548 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity
multiple interactions
ISO GSTM1 protein results in decreased activity of hydratropic aldehyde; hydratropic aldehyde results in decreased activity of GSTM1 protein
GSTM1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]
CTD PMID:11368548 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity
ISO GSTP1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]
GSTP1 protein results in decreased activity of hydratropic aldehyde; hydratropic aldehyde results in decreased activity of GSTP1 protein
CTD PMID:11368548 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
3,4-dihydroxyphenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member affects binding EXP 3,4-dihydroxyphenylacetaldehyde binds to ALDH2 protein CTD PMID:21238438 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects binding EXP 3,4-dihydroxyphenylacetaldehyde binds to GSTM1 protein CTD PMID:21238438 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Th tyrosine hydroxylase affects binding
decreases activity
multiple interactions
EXP 3,4-dihydroxyphenylacetaldehyde binds to TH protein
3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein
[3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein] which results in decreased chemical synthesis of Levodopa
CTD PMID:21238438, PMID:21514317 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
phenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO phenylacetaldehyde results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Tnf tumor necrosis factor increases secretion ISO phenylacetaldehyde results in increased secretion of TNF protein CTD PMID:17118622 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
Phenylglyoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction ISO AKR1A1 protein results in increased reduction of Phenylglyoxal CTD PMID:10510318 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of Phenylglyoxal CTD PMID:10510318 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of Phenylglyoxal CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of Phenylglyoxal CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G Fut8 fucosyltransferase 8 multiple interactions
decreases activity
ISO Fucose analog inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein]; Guanosine Diphosphate inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein] CTD PMID:12770769 NCBI chr 6:100,305,957...100,537,208
Ensembl chr 6:100,337,226...100,537,224
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        solvent 16486
          formic acid 7884
            formyl group 7850
              aldehyde 7850
                phenylacetaldehydes 12
                  (4-hydroxy-3-methoxyphenyl)acetaldehyde 0
                  (4-hydroxyphenyl)acetaldehyde 0
                  (Z)-4-hydroxyphenylacetaldehyde 0
                  2-hydroxyphenylacetaldehyde 0
                  2-phenylpropanal 3
                  3,4-dihydroxyphenylacetaldehyde 3
                  3-Carbamoyl-2-phenylpropionaldehyde 0
                  4-hydroxy-3-nitrophenylacetaldehyde 0
                  Atropaldehyde 0
                  Phenylglyoxal 5
                  phenylacetaldehyde + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            formyl group 7850
                                              aldehyde 7850
                                                phenylacetaldehydes 12
                                                  (4-hydroxy-3-methoxyphenyl)acetaldehyde 0
                                                  (4-hydroxyphenyl)acetaldehyde 0
                                                  (Z)-4-hydroxyphenylacetaldehyde 0
                                                  2-hydroxyphenylacetaldehyde 0
                                                  2-phenylpropanal 3
                                                  3,4-dihydroxyphenylacetaldehyde 3
                                                  3-Carbamoyl-2-phenylpropionaldehyde 0
                                                  4-hydroxy-3-nitrophenylacetaldehyde 0
                                                  Atropaldehyde 0
                                                  Phenylglyoxal 5
                                                  phenylacetaldehyde + 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.