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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxolane
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Accession:CHEBI:26911 term browser browse the term
Definition:A cyclic ether that is butane in which one hydrogen from each methyl group is substituted by an oxygen.
Synonyms:related_synonym: 1,4-epoxybutane;   Formula=C4H8O;   InChI=1S/C4H8O/c1-2-4-5-3-1/h1-4H2;   InChIKey=WYURNTSHIVDZCO-UHFFFAOYSA-N;   SMILES=C1CCOC1;   THF;   butane alpha,delta-oxide;   butylene oxide;   furanidine;   tetrahydrofuran;   tetramethylene oxide
 xref: CAS:109-99-9;   Gmelin:1767;   HMDB:HMDB0000246
 xref_mesh: MESH:C018674
 xref: PMID:12571688;   PMID:1811956;   PMID:1911404;   PMID:19716170;   PMID:21316415;   PMID:21842397;   PMID:2675957;   Reaxys:102391;   UM-BBD_compID:c0019;   Wikipedia:THF


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oxolane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO NR1I2 protein affects the reaction [tetrahydrofuran results in increased expression of CYP1A2 mRNA]; NR1I3 protein affects the reaction [tetrahydrofuran results in increased expression of CYP1A2 mRNA] CTD PMID:28495613 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
increases activity
multiple interactions		 ISO tetrahydrofuran results in increased expression of CYP2B10 mRNA
tetrahydrofuran results in increased activity of CYP2B10 protein
NR1I2 protein affects the reaction [tetrahydrofuran results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [tetrahydrofuran results in increased expression of CYP2B10 mRNA]		 CTD PMID:28495613 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO NR1I2 protein affects the reaction [tetrahydrofuran results in increased expression of CYP1A2 mRNA]; NR1I2 protein affects the reaction [tetrahydrofuran results in increased expression of CYP2B10 mRNA] CTD PMID:28495613 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the reaction [tetrahydrofuran results in increased expression of CYP1A2 mRNA]; NR1I3 protein affects the reaction [tetrahydrofuran results in increased expression of CYP2B10 mRNA] CTD PMID:28495613 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      application 19714
        solvent 17246
          polar solvent 15721
            polar aprotic solvent 630
              oxolane 4
                10-hydroxy-pre-flavunoidine 0
                2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane + 0
                2-(dichloromethyl)tetrahydrofuran 0
                flavunoidine(2+) 0
                oxolan-3-one 0
                pre-flavunoidine(2+) + 0
                tanegool 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            organic molecule 19724
                              organic cyclic compound 19515
                                organic heterocyclic compound 18890
                                  organic heteromonocyclic compound 17820
                                    oxolanes 5852
                                      oxolane 4
                                        10-hydroxy-pre-flavunoidine 0
                                        2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane + 0
                                        2-(dichloromethyl)tetrahydrofuran 0
                                        flavunoidine(2+) 0
                                        oxolan-3-one 0
                                        pre-flavunoidine(2+) + 0
                                        tanegool 0
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