polar aprotic solvent - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	polar aprotic solvent	go back to main search page
Accession:	CHEBI:48358	browse the term
Definition:	A solvent with a comparatively high relative permittivity (or dielectric constant), greater than ca. 15, and a sizable permanent dipole moment, that cannot donate suitably labile hydrogen atoms to form strong hydrogen bonds.
Synonyms:	exact_synonym:	dipolar aprotic solvent

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Genes (630)

2-nitropropane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1B

increases expression

2-nitropropane results in increased expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

aminocarboxymuconate semialdehyde decarboxylase

decreases expression

2-nitropropane results in decreased expression of ACMSD mRNA

NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209

G

acyl-CoA synthetase long-chain family member 3

increases expression

2-nitropropane results in increased expression of ACSL3 mRNA

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

apoptosis enhancing nuclease

increases expression

2-nitropropane results in increased expression of AEN mRNA

NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523

G

alpha-fetoprotein

multiple interactions
increases expression

diphenyldiselenide inhibits the reaction [2-nitropropane results in increased expression of AFP protein]

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

aldo-keto reductase family 7 member A3

increases expression

2-nitropropane results in increased expression of AKR7A3 mRNA

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

aldehyde dehydrogenase 1 family, member A1

increases expression

2-nitropropane results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

apurinic/apyrimidinic endodeoxyribonuclease 1

affects response to substance
increases expression
multiple interactions

APEX1 protein affects the susceptibility to 2-nitropropane
2-nitropropane results in increased expression of APEX1 mRNA; 2-nitropropane results in increased expression of APEX1 protein
APEX1 protein inhibits the reaction [2-nitropropane results in increased activity of CASP3 protein]; APEX1 protein inhibits the reaction [2-nitropropane results in increased expression of GADD45G mRNA]; APEX1 protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein]

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

apolipoprotein A2

decreases expression

2-nitropropane results in decreased expression of APOA2 mRNA

NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355

G

apolipoprotein A4

decreases expression

2-nitropropane results in decreased expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein C3

decreases expression

2-nitropropane results in decreased expression of APOC3 mRNA

NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583

G

ATPase H+ transporting V1 subunit D

increases expression

2-nitropropane results in increased expression of ATP6V1D mRNA

NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303

G

BCL2 associated X, apoptosis regulator

increases expression

2-nitropropane results in increased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BTG anti-proliferation factor 2

increases expression

2-nitropropane results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

complement C7

increases expression

2-nitropropane results in increased expression of C7 mRNA

NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535

G

caspase 3

increases activity
multiple interactions

2-nitropropane results in increased activity of CASP3 protein
APEX1 protein inhibits the reaction [2-nitropropane results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases activity
multiple interactions

2-nitropropane results in decreased activity of CAT protein
diphenyldiselenide inhibits the reaction [2-nitropropane results in decreased activity of CAT protein]; m-trifluoromethyl-diphenyl diselenide inhibits the reaction [2-nitropropane results in decreased activity of CAT protein]

PMID:16445897 PMID:18818063

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

Cbl proto-oncogene C

increases expression

2-nitropropane results in increased expression of CBLC mRNA

NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755

G

cyclin G1

increases expression

2-nitropropane results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

Cd276 molecule

increases expression

2-nitropropane results in increased expression of CD276 mRNA

NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380

G

cyclin-dependent kinase inhibitor 1A

increases expression

2-nitropropane results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

carboxypeptidase Q

decreases expression

2-nitropropane results in decreased expression of CPQ mRNA

NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546

G

crystallin, alpha B

increases expression

2-nitropropane results in increased expression of CRYAB mRNA

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

cytochrome P450, family 2, subfamily c, polypeptide 13

increases expression

2-nitropropane results in increased expression of CYP2C13 mRNA

NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191

G

cytochrome P450, family 4, subfamily f, polypeptide 5

increases expression

2-nitropropane results in increased expression of CYP4F5 mRNA

NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978

G

dimethylarginine dimethylaminohydrolase 1

increases expression

2-nitropropane results in increased expression of DDAH1 mRNA

NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339

G

epithelial cell adhesion molecule

increases expression

2-nitropropane results in increased expression of EPCAM mRNA

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

G

epoxide hydrolase 1

increases expression

2-nitropropane results in increased expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

Fas cell surface death receptor

increases expression

2-nitropropane results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fragile histidine triad diadenosine triphosphatase

decreases expression

2-nitropropane results in decreased expression of FHIT mRNA

NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340

G

growth arrest and DNA-damage-inducible, gamma

increases expression
multiple interactions

2-nitropropane results in increased expression of GADD45G mRNA
APEX1 protein inhibits the reaction [2-nitropropane results in increased expression of GADD45G mRNA]

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

glutamate ionotropic receptor AMPA type subunit 3

increases expression

2-nitropropane results in increased expression of GRIA3 mRNA

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

glutathione S-transferase mu 1

increases expression

2-nitropropane results in increased expression of GSTM1 mRNA

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

H2A.X variant histone

increases phosphorylation

2-nitropropane results in increased phosphorylation of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hydroxysteroid (17-beta) dehydrogenase 6

decreases expression

2-nitropropane results in decreased expression of HSD17B6 mRNA

NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425

G

interleukin 2 receptor subunit alpha

increases expression

2-nitropropane results in increased expression of IL2RA mRNA

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

O-6-methylguanine-DNA methyltransferase

increases expression

2-nitropropane results in increased expression of MGMT mRNA

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

marker of proliferation Ki-67

increases expression

2-nitropropane results in increased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

nuclear protein 1, transcriptional regulator

decreases expression

2-nitropropane results in decreased expression of NUPR1 mRNA

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

pleckstrin homology-like domain, family A, member 3

increases expression

2-nitropropane results in increased expression of PHLDA3 mRNA

NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335

G

DNA polymerase beta

multiple interactions

2-nitropropane results in increased expression of and results in increased activity of POLB protein; POLB protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein]

NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812

G

Rho-related BTB domain containing 2

increases expression

2-nitropropane results in increased expression of RHOBTB2 mRNA

NCBI chr15:44,868,251...44,888,436
Ensembl chr15:44,870,376...44,888,651

G

serpin family A member 7

increases expression

2-nitropropane results in increased expression of SERPINA7 mRNA

NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040

G

solute carrier family 16 member 10

decreases expression

2-nitropropane results in decreased expression of SLC16A10 mRNA

NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839

G

serine peptidase inhibitor, Kazal type 1

decreases expression

2-nitropropane results in decreased expression of SPINK1 mRNA

NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642

G

succinylCoA:glutarate-CoA transferase

decreases expression

2-nitropropane results in decreased expression of SUGCT mRNA

NCBI chr17:47,376,392...48,234,362
Ensembl chr17:47,376,521...48,234,376

G

sulfatase 2

increases expression

2-nitropropane results in increased expression of SULF2 mRNA

NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415

G

sulfotransferase family 2A member 1

decreases expression

2-nitropropane results in decreased expression of SULT2A1 mRNA

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

tumor protein p53

multiple interactions
increases expression

APEX1 protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein]; POLB protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein]

PMID:12189182 PMID:16720738 PMID:19268524

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

zinc finger, matrin type 3

increases expression

2-nitropropane results in increased expression of ZMAT3 mRNA

NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863

acetone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

multiple interactions

[ADH1 protein results in increased oxidation of allyl alcohol] which results in increased abundance of Acetone

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

catalase

decreases activity

Acetone results in decreased activity of CAT protein

PMID:16169704 PMID:20127315

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin D1

increases expression

Acetone results in increased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Acetone promotes the reaction [Toluene results in increased expression of CYP1A1 protein]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression

Acetone promotes the reaction [Toluene results in increased expression of CYP1A2 protein]
acetone increased expression of Cyp1a2 protein in thoracic aorta of rats

CTD
RGD

PMID:8996725 PMID:12688525

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

decreases expression

Acetone results in decreased expression of CYP2B1 protein

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
increases expression
increases activity
increases metabolic processing

[Acetone results in increased activity of CYP2E1 protein] which results in increased oxidation of Benzene; [Acetone results in increased expression of CYP2E1 protein] which results in increased susceptibility to allyl cyanide; Acetone results in increased expression of and results in increased activity of CYP2E1 protein
Acetone results in increased expression of CYP2E1 mRNA; Acetone results in increased expression of CYP2E1 protein
1,2-dichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]; [Acetone co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Acetone promotes the reaction [2-xylene results in increased expression of CYP2E1 protein]; Acetone promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]; Acetone promotes the reaction [Toluene results in increased expression of CYP2E1 protein]; Trichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]
CYP2E1 protein results in increased metabolism of Acetone

PMID:1968335 PMID:2241968 PMID:3416296 PMID:3782137 PMID:7587954 More...

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

fibroblast growth factor receptor 2

increases expression

Acetone results in increased expression of FGFR2 mRNA

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

fibronectin 1

increases expression

Acetone results in increased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

interleukin 13

multiple interactions

[Acetone co-treated with Olive Oil] results in increased expression of IL13 mRNA

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 4

multiple interactions

[Acetone co-treated with Olive Oil] results in increased expression of IL4 mRNA

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

multiple interactions

[Acetone co-treated with Olive Oil] results in increased expression of IL5 mRNA

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

integrin subunit alpha 5

increases expression

Acetone results in increased expression of ITGA5 mRNA

NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837

G

NAD(P)H quinone dehydrogenase 1

increases expression

Acetone results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

tumor necrosis factor

multiple interactions

[Acetone co-treated with Olive Oil] results in increased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

transient receptor potential cation channel, subfamily M, member 8

increases response to substance

TRPM8 protein results in increased susceptibility to Acetone

NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552

acetonitrile

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily a, polypeptide 2

multiple interactions

acetonitrile inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline]

NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

acetonitrile inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin]

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

acetonitrile inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily d, polypeptide 2

multiple interactions

acetonitrile inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]

NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

acetonitrile inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]
acetonitrile inhibits the reaction [CYP2E1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]

PMID:9143349 PMID:19858067

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions

acetonitrile inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline]

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

neurofilament heavy chain

affects expression

acetonitrile affects the expression of NEFH mRNA

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

NHERF family PDZ scaffold protein 1

increases expression

acetonitrile results in increased expression of NHERF1 protein

NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598

G

sulfotransferase family 1A member 1

multiple interactions
decreases activity

acetonitrile inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; acetonitrile inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]
acetonitrile results in decreased activity of SULT1A1 protein

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 1E member 1

multiple interactions

acetonitrile promotes the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene]

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

acrylonitrile

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alkaline phosphatase, biomineralization associated

multiple interactions

[[Volatile Organic Compounds results in increased abundance of Acrylonitrile] which results in increased abundance of N-acetyl-S-(2-cyanoethyl)cysteine] which results in increased expression of ALPL protein

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

apurinic/apyrimidinic endodeoxyribonuclease 2

increases expression
multiple interactions

Acrylonitrile results in increased expression of APEX2 mRNA
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA]

NCBI chr X:19,425,684...19,508,459
Ensembl chr X:19,487,419...19,508,439

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Acrylonitrile results in increased expression of BAX protein
Acrylonitrile results in increased expression of BAX mRNA; Acrylonitrile results in increased expression of BAX protein
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of BAX protein]

PMID:16173056 PMID:20981856 PMID:33132245 PMID:35429547

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

Acrylonitrile results in decreased expression of BCL2 protein
Acrylonitrile results in decreased expression of BCL2 mRNA; Acrylonitrile results in decreased expression of BCL2 protein

PMID:16173056 PMID:35429547

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

Acrylonitrile results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

beclin 1

increases expression

Acrylonitrile results in increased expression of BECN1 mRNA

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

caspase 12

increases expression

Acrylonitrile results in increased expression of CASP12 protein

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

increases activity
increases expression
increases cleavage
multiple interactions

Acrylonitrile results in increased activity of CASP3 protein
Acrylonitrile results in increased expression of CASP3 mRNA
Acrylonitrile results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased activity of CASP3 protein]

PMID:20981856 PMID:35429547

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases activity
increases expression
multiple interactions

Acrylonitrile results in decreased activity of CAT protein
Acrylonitrile results in increased expression of CAT protein
Curcumin inhibits the reaction [Acrylonitrile results in decreased activity of CAT protein]

PMID:19913070 PMID:20127315 PMID:35429547

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cystathionine beta synthase

decreases expression

Acrylonitrile results in decreased expression of CBS protein

NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764

G

C-C motif chemokine ligand 2

decreases expression
increases expression
multiple interactions

Acrylonitrile results in decreased expression of CCL2 mRNA
Acrylonitrile results in increased expression of CCL2 mRNA
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]

PMID:16173056 PMID:26332274

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

multiple interactions
decreases expression
increases expression

Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCND1 mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND1 mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of CCND1 mRNA]
Acrylonitrile results in decreased expression of CCND1 protein
Acrylonitrile results in increased expression of CCND1 protein

PMID:26332274 PMID:30236600 PMID:33132245

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA]

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin E1

increases expression
decreases expression

Acrylonitrile results in increased expression of CCNE1 protein
Acrylonitrile results in decreased expression of CCNE1 protein

PMID:30236600 PMID:33132245

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cadherin 1

decreases expression

Acrylonitrile results in decreased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

increases expression

Acrylonitrile results in increased expression of CDH2 protein

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression
decreases expression

Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CDKN1A mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CDKN1A mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of CDKN1A mRNA]
Acrylonitrile results in increased expression of CDKN1A protein
Acrylonitrile results in decreased expression of CDKN1A protein

PMID:10451498 PMID:26332274 PMID:30236600 PMID:33132245

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

decreases expression
increases expression

Acrylonitrile results in decreased expression of CDKN1B protein
Acrylonitrile results in increased expression of CDKN1B protein

PMID:30236600 PMID:33132245

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cystathionine gamma-lyase

decreases expression

Acrylonitrile results in decreased expression of CTH protein

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

C-X-C motif chemokine receptor 4

decreases expression

Acrylonitrile results in decreased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 2, subfamily e, polypeptide 1

affects response to substance
increases metabolic processing
multiple interactions
increases expression
increases oxidation

CYP2E1 protein affects the susceptibility to Acrylonitrile
CYP2E1 protein results in increased metabolism of Acrylonitrile
[CYP2E1 protein results in increased metabolism of Acrylonitrile] which results in increased chemical synthesis of 2-cyanoethylene oxide; CYP2E1 gene mutant form inhibits the reaction [Acrylonitrile results in increased mutagenesis of HPRT1 gene]
Acrylonitrile results in increased expression of CYP2E1 mRNA
Acetylcysteine promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]; Acrylonitrile inhibits the reaction [[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Benzene]; alpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]; Plant Extracts promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]
CYP2E1 protein results in increased oxidation of Acrylonitrile

PMID:1664256 PMID:9010585 PMID:20127315 PMID:26332274 PMID:32529832

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

DNA-damage inducible transcript 3

increases expression

Acrylonitrile results in increased expression of DDIT3 protein
Acrylonitrile results in increased expression of DDIT3 mRNA

PMID:33132245 PMID:35429547

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2 subunit alpha

increases expression

Acrylonitrile results in increased expression of EIF2S1 protein modified form

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

Acrylonitrile results in decreased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutathione peroxidase 3

increases expression

Acrylonitrile results in increased expression of GPX3 protein

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

H2A.X variant histone

increases expression

Acrylonitrile results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

heme oxygenase 1

increases expression

Acrylonitrile results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hypoxanthine phosphoribosyltransferase 1

increases mutagenesis
multiple interactions

Acrylonitrile results in increased mutagenesis of HPRT1 gene
CYP2E1 gene mutant form inhibits the reaction [Acrylonitrile results in increased mutagenesis of HPRT1 gene]

PMID:32529823 PMID:32529832

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

heat shock protein family A (Hsp70) member 5

increases expression

Acrylonitrile results in increased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

interleukin 1 beta

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of IL1B mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of IL1B mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression

Acrylonitrile results in increased expression of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

Acrylonitrile results in decreased expression of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

microtubule-associated protein 1 light chain 3 alpha

increases expression

Acrylonitrile results in increased expression of MAP1LC3A mRNA

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

Acrylonitrile results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]; rottlerin inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]

PMID:17080406 PMID:30236600

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein]; rottlerin inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein]

PMID:17080406 PMID:30236600

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases expression

Acrylonitrile results in increased expression of MAPK8 mRNA

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mercaptopyruvate sulfurtransferase

decreases expression

Acrylonitrile results in decreased expression of MPST protein

NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141

G

mechanistic target of rapamycin kinase

increases expression

Acrylonitrile results in increased expression of MTOR mRNA

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

NAD(P)H quinone dehydrogenase 1

increases activity
increases expression

Acrylonitrile results in increased activity of NQO1 protein
Acrylonitrile results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

occludin

decreases expression

Acrylonitrile results in decreased expression of OCLN protein

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

Acrylonitrile results in increased cleavage of PARP1 protein
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phospholipase C beta 1

affects localization

Acrylonitrile affects the localization of PLCB1 protein

NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869

G

phospholipase C, delta 1

multiple interactions

Acrylonitrile results in increased expression of and affects the localization of PLCD1 protein

NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186

G

phospholipase C, gamma 1

increases expression

Acrylonitrile results in increased expression of PLCG1 protein

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

RELA proto-oncogene, NF-kB subunit

increases expression

Acrylonitrile results in increased expression of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

S100 calcium binding protein A8

decreases expression

Acrylonitrile results in decreased expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

snail family transcriptional repressor 2

increases expression

Acrylonitrile results in increased expression of SNAI2 protein

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

superoxide dismutase 1

increases expression

Acrylonitrile results in increased expression of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression

Acrylonitrile results in increased expression of SOD2 protein

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

tyrosine hydroxylase

multiple interactions

Acrylonitrile inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of TH protein]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

tumor necrosis factor

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of TNF mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of TNF mRNA]
Acrylonitrile results in increased expression of TNF protein

PMID:26332274 PMID:35429547

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression

Acrylonitrile results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

X-ray repair cross complementing 6

multiple interactions
increases expression

Acetylcysteine promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA]; alpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA]; Plant Extracts promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA]

NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762

aminoacetone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

multiple interactions

CAT protein results in decreased susceptibility to [aminoacetone co-treated with Copper]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

glutathione-disulfide reductase

multiple interactions

[aminoacetone co-treated with Copper] results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

superoxide dismutase 1

multiple interactions

[aminoacetone co-treated with Copper] results in increased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions

[aminoacetone co-treated with Copper] results in increased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

butan-2-one

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcium voltage-gated channel auxiliary subunit gamma 6

decreases expression

methylethyl ketone results in decreased expression of CACNG6 mRNA

NCBI chr 1:65,732,910...65,747,377
Ensembl chr 1:65,732,632...65,747,341

G

cytochrome P450, family 2, subfamily e, polypeptide 1

affects response to substance

CYP2E1 gene mutant form affects the susceptibility to methylethyl ketone

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

glutamate dehydrogenase 1

multiple interactions

methylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]

NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957

G

PPARG coactivator 1 alpha

increases expression

methylethyl ketone results in increased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

serine and arginine rich splicing factor 2

decreases expression

methylethyl ketone results in decreased expression of SRSF2 mRNA

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

buten-2-one

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amyloid beta precursor protein

multiple interactions

[3-buten-2-one results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

3-buten-2-one binds to and results in decreased activity of GAPDH protein

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

prostaglandin reductase 1

multiple interactions

[PTGR1 protein co-treated with NADP] affects the reduction of 3-buten-2-one

NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666

dichloromethane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 1

multiple interactions

[Particulate Matter co-treated with Methylene Chloride] results in decreased expression of ADRB1 mRNA

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

AKT serine/threonine kinase 1

multiple interactions

[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of AKT1 mRNA

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

androgen receptor

decreases expression

Methylene Chloride results in decreased expression of AR mRNA

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

activating transcription factor 5

decreases expression

Methylene Chloride results in decreased expression of ATF5 mRNA

NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707

G

BTB domain and CNC homolog 2

decreases expression

Methylene Chloride results in decreased expression of BACH2 mRNA

NCBI chr 5:46,632,338...46,982,676
Ensembl chr 5:46,638,317...46,977,877

G

BCL2, apoptosis regulator

multiple interactions

[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

increases expression

Methylene Chloride results in increased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

BCL6, transcription repressor

increases expression

Methylene Chloride results in increased expression of BCL6 mRNA

PMID:20359517 PMID:28392392

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

basic helix-loop-helix family, member e40

increases expression

Methylene Chloride results in increased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

baculoviral IAP repeat-containing 3

increases expression

Methylene Chloride results in increased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

basic helix-loop-helix ARNT like 1

decreases expression

Methylene Chloride results in decreased expression of BMAL1 mRNA

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

basonuclin zinc finger protein 1

decreases expression

Methylene Chloride results in decreased expression of BNC1 mRNA

NCBI chr 1:135,917,676...135,943,333
Ensembl chr 1:135,917,687...135,943,333

G

BTG anti-proliferation factor 1

increases expression

Methylene Chloride results in increased expression of BTG1 mRNA

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

caspase 1

multiple interactions

[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of CASP1 mRNA

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions

[Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP3 protein]; Methylene Chloride inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in decreased expression of CAT mRNA; [Lipopolysaccharides co-treated with Methylene Chloride] results in increased activity of CAT protein

PMID:15563889 PMID:29335169

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

Cbl proto-oncogene B

increases expression

Methylene Chloride results in increased expression of CBLB mRNA

NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839

G

C-C motif chemokine ligand 5

decreases expression

Methylene Chloride results in decreased expression of CCL5 mRNA

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

CD37 molecule

decreases expression

Methylene Chloride results in decreased expression of CD37 mRNA

NCBI chr 1:95,719,171...95,724,662
Ensembl chr 1:95,719,190...95,724,648

G

CD38 molecule

increases expression

Methylene Chloride results in increased expression of CD38 mRNA

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

Cd4 molecule

increases expression

Methylene Chloride results in increased expression of CD4 mRNA

NCBI chr 4:157,668,878...157,695,366

G

CD8 subunit alpha

increases expression

Methylene Chloride results in increased expression of CD8A mRNA

NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040

G

cadherin 1

affects expression

Methylene Chloride affects the expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

CCAAT/enhancer binding protein beta

increases expression

Methylene Chloride results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

class II, major histocompatibility complex, transactivator

increases expression

Methylene Chloride results in increased expression of CIITA mRNA

NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440

G

clock circadian regulator

decreases expression

Methylene Chloride results in decreased expression of CLOCK mRNA

NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400

G

cAMP responsive element binding protein 3-like 1

decreases expression

Methylene Chloride results in decreased expression of CREB3L1 mRNA

NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456

G

cAMP responsive element binding protein 3-like 2

decreases expression

Methylene Chloride results in decreased expression of CREB3L2 mRNA

NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763

G

cAMP responsive element modulator

decreases expression

Methylene Chloride results in decreased expression of CREM mRNA

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

cryptochrome circadian regulator 1

decreases expression

Methylene Chloride results in decreased expression of CRY1 mRNA

NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091

G

cryptochrome circadian regulator 2

increases expression

Methylene Chloride results in increased expression of CRY2 mRNA

NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965

G

cold shock domain containing E1

increases expression

Methylene Chloride results in increased expression of CSDE1 mRNA

NCBI chr 2:190,546,015...190,582,787
Ensembl chr 2:190,554,980...190,582,784

G

cystathionine gamma-lyase

increases expression

Methylene Chloride results in increased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

catenin beta 1

increases mutagenesis

Methylene Chloride results in increased mutagenesis of CTNNB1 gene

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cut-like homeobox 1

decreases expression

Methylene Chloride results in decreased expression of CUX1 mRNA

NCBI chr12:20,107,062...20,425,868
Ensembl chr12:20,107,311...20,425,866

G

cut-like homeobox 2

decreases expression

Methylene Chloride results in decreased expression of CUX2 mRNA

NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806

G

C-X-C motif chemokine receptor 2

increases expression

Methylene Chloride results in increased expression of CXCR2 mRNA

NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425

G

C-X-C motif chemokine receptor 4

increases expression

Methylene Chloride results in increased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects expression

Methylene Chloride affects the expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases expression

Methylene Chloride results in decreased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily C, polypeptide 6

affects expression

Methylene Chloride affects the expression of CYP2C29 mRNA

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
increases oxidation
increases metabolic processing

3-xylene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]; Benzene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]; Toluene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]
[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of CYP2E1 mRNA
CYP2E1 protein results in increased oxidation of Methylene Chloride

PMID:1664256 PMID:8889796 PMID:29335169

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 51

affects expression

Methylene Chloride affects the expression of CYP51 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

death associated protein kinase 1

increases methylation

Methylene Chloride results in increased methylation of DAPK1 promoter

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

D-box binding PAR bZIP transcription factor

increases expression

Methylene Chloride results in increased expression of DBP mRNA

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745

G

DENN domain containing 5A

increases expression

Methylene Chloride results in increased expression of DENND5A mRNA

NCBI chr 1:163,928,183...163,994,207
Ensembl chr 1:163,928,183...163,994,316

G

24-dehydrocholesterol reductase

affects expression

Methylene Chloride affects the expression of DHCR24 mRNA

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

Methylene Chloride results in increased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

EBP, cholestenol delta-isomerase

affects expression

Methylene Chloride affects the expression of EBP mRNA

NCBI chr X:14,299,427...14,305,826
Ensembl chr X:14,299,448...14,305,826

G

early growth response 1

affects expression

Methylene Chloride affects the expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 3

increases expression

Methylene Chloride results in increased expression of EGR3 mRNA

NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627

G

E74 like ETS transcription factor 1

decreases expression

Methylene Chloride results in decreased expression of ELF1 mRNA

NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699

G

ELOVL fatty acid elongase 6

increases expression

Methylene Chloride results in increased expression of ELOVL6 mRNA

NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186

G

estrogen receptor 1

decreases expression

Methylene Chloride results in decreased expression of ESR1 mRNA

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

ecotropic viral integration site 2A

increases expression

Methylene Chloride results in increased expression of EVI2A mRNA

NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843

G

Fc gamma receptor 1A

increases expression

Methylene Chloride results in increased expression of FCGR1 mRNA

NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994

G

farnesyl diphosphate farnesyl transferase 1

affects expression

Methylene Chloride affects the expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

farnesyl diphosphate synthase

affects expression

Methylene Chloride affects the expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

filamin A interacting protein 1-like

increases expression

Methylene Chloride results in increased expression of FILIP1L mRNA

NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

Methylene Chloride results in decreased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box A1

decreases expression

Methylene Chloride results in decreased expression of FOXA1 mRNA

NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188

G

forkhead box O3

increases expression

Methylene Chloride results in increased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

growth arrest and DNA-damage-inducible, alpha

increases expression

Methylene Chloride results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in decreased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glycoprotein Ib platelet subunit beta

decreases expression

Methylene Chloride results in decreased expression of GP1BB mRNA

NCBI chr11:82,378,216...82,379,393
Ensembl chr11:82,378,199...82,379,392

G

glutathione peroxidase 1

multiple interactions

[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

multiple interactions

[Lipopolysaccharides co-treated with Methylene Chloride] results in increased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase theta 1

affects metabolic processing
multiple interactions
increases metabolic processing
affects response to substance

GSTT1 gene polymorphism affects the metabolism of Methylene Chloride; GSTT1 protein affects the metabolism of Methylene Chloride
GSTT1 protein results in increased metabolism of and results in increased activity of Methylene Chloride
GSTT1 protein results in increased metabolism of Methylene Chloride
[GSTT1 protein affects the metabolism of Methylene Chloride] which results in increased abundance of Formaldehyde; GSTT1 protein affects the metabolism of and results in increased activity of Methylene Chloride
GSTT1 protein alternative form affects the susceptibility to Methylene Chloride

PMID:7979958 PMID:8670055 PMID:8761485 PMID:9854036 PMID:10413528 More...

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

decreases expression

Methylene Chloride results in decreased expression of HERC1 mRNA

NCBI chr 8:66,857,169...67,070,318
Ensembl chr 8:66,856,935...67,070,312

G

hes family bHLH transcription factor 6

increases expression

Methylene Chloride results in increased expression of HES6 mRNA

NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559

G

HIVEP zinc finger 2

increases expression

Methylene Chloride results in increased expression of HIVEP2 mRNA

NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993

G

HLF transcription factor, PAR bZIP family member

increases expression

Methylene Chloride results in increased expression of HLF mRNA

NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935

G

heme oxygenase 1

increases expression
multiple interactions

Methylene Chloride results in increased expression of HMOX1 mRNA
[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of HMOX1 mRNA
[Particulate Matter co-treated with Methylene Chloride] results in increased expression of HMOX1 mRNA

PMID:20359517 PMID:29335169 PMID:30503853

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein L-like

increases expression

Methylene Chloride results in increased expression of HNRNPLL mRNA

NCBI chr 6:14,969,953...15,000,574
Ensembl chr 6:14,970,057...14,999,745

G

hydroxysteroid (17-beta) dehydrogenase 7

affects expression

Methylene Chloride affects the expression of HSD17B7 mRNA

NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017

G

inhibitor of DNA binding 3

decreases expression

Methylene Chloride results in decreased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

isopentenyl-diphosphate delta isomerase 1

affects expression

Methylene Chloride affects the expression of IDI1 mRNA

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

interferon-induced protein with tetratricopeptide repeats 2

increases expression

Methylene Chloride results in increased expression of IFIT2 mRNA

NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635

G

interferon-induced protein with tetratricopeptide repeats 3

increases expression

Methylene Chloride results in increased expression of IFIT3 mRNA

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon gamma

multiple interactions

[Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IFNG protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon gamma receptor 2

increases expression

Methylene Chloride results in increased expression of IFNGR2 mRNA

NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005

G

interleukin 10

multiple interactions

[Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 alpha

multiple interactions

[Particulate Matter co-treated with Methylene Chloride] results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 receptor antagonist

multiple interactions

[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of IL1RN mRNA

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2 receptor subunit gamma

increases expression

Methylene Chloride results in increased expression of IL2RG mRNA

NCBI chr X:66,395,330...66,399,026
Ensembl chr X:66,392,542...66,399,823

G

interleukin 6

multiple interactions

[Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 7 receptor

decreases expression

Methylene Chloride results in decreased expression of IL7R mRNA

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

G

interleukin 9

increases expression

Methylene Chloride results in increased expression of IL9 mRNA

NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895

G

interferon regulatory factor 5

decreases expression

Methylene Chloride results in decreased expression of IRF5 mRNA

NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267

G

interferon regulatory factor 6

decreases expression

Methylene Chloride results in decreased expression of IRF6 mRNA

NCBI chr13:104,672,179...104,691,386
Ensembl chr13:104,672,179...104,691,386

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

Methylene Chloride results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

Methylene Chloride results in increased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

KLF transcription factor 13

decreases expression

Methylene Chloride results in decreased expression of KLF13 mRNA

NCBI chr 1:117,505,857...117,536,626
Ensembl chr 1:117,503,602...117,551,227

G

lanosterol synthase

affects expression

Methylene Chloride affects the expression of LSS mRNA

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

MAF bZIP transcription factor B

increases expression

Methylene Chloride results in increased expression of MAFB mRNA

NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031

G

mitogen-activated protein kinase kinase kinase 8

increases expression

Methylene Chloride results in increased expression of MAP3K8 mRNA

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

microsomal glutathione S-transferase 1

multiple interactions

[propylene dichloride co-treated with Methylene Chloride] affects the activity of and affects the expression of MGST1 protein; Methylene Chloride affects the activity of and affects the expression of MGST1 protein

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

matrix metallopeptidase 1

multiple interactions

[Particulate Matter co-treated with Methylene Chloride] results in increased expression of MMP1 mRNA; carazolol inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of MMP1 mRNA]

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 9

increases expression

Methylene Chloride results in increased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mitochondrially encoded cytochrome c oxidase I

multiple interactions
decreases expression

[propylene dichloride co-treated with Methylene Chloride] affects the expression of COX1 protein
Methylene Chloride results in decreased expression of COX1 protein

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

metallothionein 2A

multiple interactions

[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of MT2 mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

mevalonate diphosphate decarboxylase

affects expression

Methylene Chloride affects the expression of MVD mRNA

NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971

G

mevalonate kinase

affects expression

Methylene Chloride affects the expression of MVK mRNA

NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882

G

max dimerization protein 1

increases expression

Methylene Chloride results in increased expression of MXD1 mRNA

NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751

G

myb-like, SWIRM and MPN domains 1

decreases expression

Methylene Chloride results in decreased expression of MYSM1 mRNA

NCBI chr 5:109,761,345...109,826,652
Ensembl chr 5:109,776,286...109,819,967

G

nicotinamide phosphoribosyltransferase

decreases expression

Methylene Chloride results in decreased expression of NAMPT mRNA

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

neural cell adhesion molecule 1

decreases expression

Methylene Chloride results in decreased expression of NCAM1 mRNA

NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014

G

neutrophil cytosolic factor 2

increases expression

Methylene Chloride results in increased expression of NCF2 mRNA

NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277

G

nuclear receptor co-repressor 1

decreases expression

Methylene Chloride results in decreased expression of NCOR1 mRNA

NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032

G

NADH:ubiquinone oxidoreductase subunit B8

increases expression

Methylene Chloride results in increased expression of NDUFB8 protein

NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817

G

NADH:ubiquinone oxidoreductase core subunit S3

multiple interactions
affects expression

[propylene dichloride co-treated with Methylene Chloride] results in decreased expression of NDUFS3 protein
Methylene Chloride affects the expression of NDUFS3 protein

NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824

G

nectin cell adhesion molecule 3

decreases expression

Methylene Chloride results in decreased expression of NECTIN3 mRNA

NCBI chr11:54,362,712...54,469,351
Ensembl chr11:54,364,487...54,462,519

G

neural precursor cell expressed, developmentally down-regulated 9

increases expression

Methylene Chloride results in increased expression of NEDD9 mRNA

NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019

G

nuclear factor of activated T-cells 5

increases expression

Methylene Chloride results in increased expression of NFAT5 mRNA

NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675

G

nuclear factor of activated T-cells 3

decreases expression

Methylene Chloride results in decreased expression of NFATC3 mRNA

NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150

G

NFE2 like bZIP transcription factor 2

increases activity
increases expression
multiple interactions

Methylene Chloride results in increased activity of NFE2L2 protein
Methylene Chloride results in increased expression of NFE2L2 mRNA
[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of NFE2L2 mRNA

PMID:29335169 PMID:30114225 PMID:30203046 PMID:34280354

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor I/B

increases expression

Methylene Chloride results in increased expression of NFIB mRNA

NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479

G

nuclear factor, interleukin 3 regulated

decreases expression

Methylene Chloride results in decreased expression of NFIL3 mRNA

NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858

G

NFKB inhibitor alpha

increases expression

Methylene Chloride results in increased expression of NFKBIA mRNA

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of NOS2 mRNA; Methylene Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Methylene Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:15563889 PMID:29335169

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

neuronal PAS domain protein 2

decreases expression

Methylene Chloride results in decreased expression of NPAS2 mRNA

NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group D, member 1

increases expression

Methylene Chloride results in increased expression of NR1D1 mRNA

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

G

nuclear receptor subfamily 1, group D, member 2

increases expression

Methylene Chloride results in increased expression of NR1D2 mRNA

NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553

G

nuclear receptor subfamily 2, group F, member 6

increases expression

Methylene Chloride results in increased expression of NR2F6 mRNA

NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

Methylene Chloride results in decreased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nardilysin convertase

decreases expression

Methylene Chloride results in decreased expression of NRDC mRNA

NCBI chr 5:123,755,807...123,818,910
Ensembl chr 5:123,755,806...123,818,595

G

one cut homeobox 2

decreases expression

Methylene Chloride results in decreased expression of ONECUT2 mRNA

NCBI chr18:57,831,647...57,890,884
Ensembl chr18:57,832,111...57,879,629

G

pellino E3 ubiquitin protein ligase 1

increases expression

Methylene Chloride results in increased expression of PELI1 mRNA

NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285

G

period circadian regulator 3

increases expression

Methylene Chloride results in increased expression of PER3 mRNA

NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607

G

platelet factor 4

decreases expression

Methylene Chloride results in decreased expression of PF4 mRNA

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

protein inhibitor of activated STAT, 1

decreases expression

Methylene Chloride results in decreased expression of PIAS1 mRNA

NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

Methylene Chloride results in increased expression of PMAIP1 mRNA

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

phosphomevalonate kinase

affects expression

Methylene Chloride affects the expression of PMVK mRNA

NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364

G

peroxisome proliferator-activated receptor delta

decreases expression

Methylene Chloride results in decreased expression of PPARD mRNA

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

PPARG coactivator 1 alpha

decreases expression

Methylene Chloride results in decreased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

prion protein

increases expression

Methylene Chloride results in increased expression of PRNP mRNA

NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937

G

prostaglandin E receptor 2

increases expression

Methylene Chloride results in increased expression of PTGER2 mRNA

NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714

G

prostaglandin-endoperoxide synthase 2

multiple interactions

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of PTGS2 mRNA]; [Particulate Matter co-treated with Methylene Chloride] results in increased expression of PTGS2 mRNA; carazolol inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RAB8B, member RAS oncogene family

increases expression

Methylene Chloride results in increased expression of RAB8B mRNA

NCBI chr 8:67,458,921...67,536,466
Ensembl chr 8:67,458,923...67,536,384

G

RELB proto-oncogene, NF-kB subunit

increases expression

Methylene Chloride results in increased expression of RELB mRNA

NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507

G

regulatory factor X4

decreases expression

Methylene Chloride results in decreased expression of RFX4 mRNA

NCBI chr 7:18,853,065...19,015,378
Ensembl chr 7:18,853,322...19,014,967

G

ring finger protein 149

increases expression

Methylene Chloride results in increased expression of RNF149 mRNA

NCBI chr 9:41,826,825...41,854,381
Ensembl chr 9:41,830,233...41,854,279

G

RAR-related orphan receptor A

decreases expression

Methylene Chloride results in decreased expression of RORA mRNA

NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931

G

ras responsive element binding protein 1

decreases expression

Methylene Chloride results in decreased expression of RREB1 mRNA

NCBI chr17:26,876,687...27,002,554
Ensembl chr17:26,876,697...27,002,615

G

RT1 class II, locus Ba

increases expression

Methylene Chloride results in increased expression of RT1-BA mRNA

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class II, locus Db1

increases expression

Methylene Chloride results in increased expression of RT1-DB1 mRNA

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

RT1 class II, locus DMb

increases expression

Methylene Chloride results in increased expression of HLA-DMB mRNA

NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340

G

spalt-like transcription factor 1

decreases expression

Methylene Chloride results in decreased expression of SALL1 mRNA

NCBI chr19:18,005,782...18,022,705
Ensembl chr19:18,007,503...18,022,705

G

succinate dehydrogenase complex iron sulfur subunit B

multiple interactions
affects expression

[propylene dichloride co-treated with Methylene Chloride] affects the expression of SDHB protein
Methylene Chloride affects the expression of SDHB protein

NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293

G

succinate dehydrogenase complex subunit C

increases expression
multiple interactions

Methylene Chloride results in increased expression of SDHC protein
[propylene dichloride co-treated with Methylene Chloride] affects the expression of SDHC protein

NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253

G

succinate dehydrogenase complex subunit D

affects expression
multiple interactions

Methylene Chloride affects the expression of SDHD protein
[propylene dichloride co-treated with Methylene Chloride] affects the expression of SDHD protein

NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238

G

selectin L

increases expression

Methylene Chloride results in increased expression of SELL mRNA

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

G

serpin family B member 2

multiple interactions

[Particulate Matter co-treated with Methylene Chloride] results in increased expression of SERPINB2 mRNA

NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408

G

sestrin 2

increases expression

Methylene Chloride results in increased expression of SESN2 mRNA

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

solute carrier family 38, member 2

increases expression

Methylene Chloride results in increased expression of SLC38A2 mRNA

NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436

G

solute carrier family 7 member 11

increases expression

Methylene Chloride results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

superoxide dismutase 1

multiple interactions

[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in decreased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions

[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

Sp3 transcription factor

increases expression

Methylene Chloride results in increased expression of SP3 mRNA

NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342

G

signal transducer and activator of transcription 5A

decreases expression

Methylene Chloride results in decreased expression of STAT5A mRNA

NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866

G

signal transducer and activator of transcription 5B

decreases expression
increases activity

Methylene Chloride results in decreased expression of STAT5B mRNA
Methylene Chloride results in increased activity of STAT5B protein

PMID:28392392 PMID:30114225

NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668

G

syntaxin 11

increases expression

Methylene Chloride results in increased expression of STX11 mRNA

NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164

G

TEF transcription factor, PAR bZIP family member

increases expression

Methylene Chloride results in increased expression of TEF mRNA

NCBI chr 7:113,317,191...113,341,783
Ensembl chr 7:113,317,283...113,341,783

G

tumor necrosis factor

multiple interactions

[Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

increases expression

Methylene Chloride results in increased expression of TNFAIP3 mRNA

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

thyroid hormone receptor interactor 12

decreases expression

Methylene Chloride results in decreased expression of TRIP12 mRNA

NCBI chr 9:85,916,691...86,043,312
Ensembl chr 9:85,916,691...86,051,403

G

transcriptional repressor GATA binding 1

increases expression

Methylene Chloride results in increased expression of TRPS1 mRNA

NCBI chr 7:81,916,668...82,142,733
Ensembl chr 7:81,921,601...82,141,905

G

ubiquinol cytochrome c reductase core protein 2

multiple interactions

[propylene dichloride co-treated with Methylene Chloride] affects the expression of UQCRC2 protein

NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453

G

ubiquitin specific peptidase 18

increases expression

Methylene Chloride results in increased expression of USP18 mRNA

NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144

G

WEE1 G2 checkpoint kinase

increases expression

Methylene Chloride results in increased expression of WEE1 mRNA

NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688

G

WW domain containing E3 ubiquitin protein ligase 1

decreases expression

Methylene Chloride results in decreased expression of WWP1 mRNA

NCBI chr 5:33,092,379...33,185,887
Ensembl chr 5:33,098,494...33,186,046

G

X-box binding protein 1

increases expression

Methylene Chloride results in increased expression of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

zinc finger and BTB domain containing 22

decreases expression

Methylene Chloride results in decreased expression of ZBTB22 mRNA

NCBI chr20:4,966,331...4,969,853
Ensembl chr20:4,966,271...4,969,498

G

zinc finger and BTB domain containing 41

decreases expression

Methylene Chloride results in decreased expression of ZBTB41 mRNA

NCBI chr13:51,042,948...51,065,768
Ensembl chr13:51,042,948...51,065,768

G

zinc finger CCCH-type containing, antiviral 1

increases expression

Methylene Chloride results in increased expression of ZC3HAV1 mRNA

NCBI chr 4:67,012,129...67,062,428
Ensembl chr 4:67,012,185...67,062,428

G

zinc finger CCHC-type containing 2

increases expression

Methylene Chloride results in increased expression of ZCCHC2 mRNA

NCBI chr13:22,118,677...22,193,626
Ensembl chr13:22,119,568...22,166,373

G

zinc finger homeobox 4

decreases expression

Methylene Chloride results in decreased expression of ZFHX4 mRNA

NCBI chr 2:96,224,763...96,408,245
Ensembl chr 2:96,224,767...96,408,228

G

zinc finger protein 260

affects expression
increases expression

Methylene Chloride affects the expression of ZFP260 mRNA
Methylene Chloride results in increased expression of ZFP260 mRNA

NCBI chr 1:85,336,567...85,349,896
Ensembl chr 1:85,336,618...85,350,067

G

zinc finger protein 266

decreases expression

Methylene Chloride results in decreased expression of ZFP266 mRNA

NCBI chr 8:19,030,766...19,061,381
Ensembl chr 8:19,030,768...19,060,937

G

zinc finger protein 37

increases expression

Methylene Chloride results in increased expression of ZFP37 mRNA

NCBI chr 5:75,598,732...75,638,896
Ensembl chr 5:75,598,732...75,638,942

G

zinc finger protein 386 (Kruppel-like)

increases expression

Methylene Chloride results in increased expression of ZFP386 mRNA

NCBI chr 6:136,966,547...136,984,013
Ensembl chr 6:136,966,586...136,983,441

G

zinc finger protein 445

increases expression

Methylene Chloride results in increased expression of ZFP445 mRNA

NCBI chr 8:122,453,175...122,473,355
Ensembl chr 8:122,454,328...122,473,286

G

zinc finger protein 451

decreases expression

Methylene Chloride results in decreased expression of ZFP451 mRNA

NCBI chr 9:35,985,441...36,040,991
Ensembl chr 9:35,985,443...36,040,652

G

zinc finger protein 472

increases expression

Methylene Chloride results in increased expression of ZFP119A mRNA

NCBI chr 7:12,074,623...12,082,890
Ensembl chr 7:12,074,603...12,082,892

G

zinc finger protein 51

increases expression

Methylene Chloride results in increased expression of ZFP51 mRNA

NCBI chr 1:61,203,159...61,235,545
Ensembl chr 1:61,191,368...61,235,540

G

zinc finger protein 58

increases expression

Methylene Chloride results in increased expression of ZFP58 mRNA

NCBI chr 1:35,020,477...35,053,203
Ensembl chr 1:35,002,321...35,033,216

G

zinc finger protein 62

increases expression

Methylene Chloride results in increased expression of ZFP62 mRNA

NCBI chr10:33,522,618...33,539,446
Ensembl chr10:33,500,323...33,542,013

G

zinc finger protein 647

decreases expression

Methylene Chloride results in decreased expression of ZFP647 mRNA

NCBI chr 7:108,632,248...108,649,264
Ensembl chr 7:108,632,250...108,637,433

G

zinc finger protein 708

increases expression

Methylene Chloride results in increased expression of ZFP708 mRNA

NCBI chr 2:84,473,436...84,525,070
Ensembl chr 2:84,473,454...84,523,500

G

zinc finger protein 74

increases expression

Methylene Chloride results in increased expression of ZFP74 mRNA

NCBI chr 1:85,158,159...85,183,407
Ensembl chr 1:85,158,980...85,183,522

G

zinc finger protein 758

affects expression
increases expression

Methylene Chloride affects the expression of ZFP758 mRNA
Methylene Chloride results in increased expression of ZFP758 mRNA

NCBI chr 1:61,941,284...61,989,354
Ensembl chr 1:61,942,116...61,989,490

G

zinc finger protein 948

increases expression

Methylene Chloride results in increased expression of ZFP948 mRNA

NCBI chr 1:61,366,068...61,396,300
Ensembl chr 1:61,368,076...61,395,282

G

zinc fingers and homeoboxes 1

affects expression
increases expression

Methylene Chloride affects the expression of ZHX1 mRNA
Methylene Chloride results in increased expression of ZHX1 mRNA

NCBI chr 7:89,582,363...89,611,337
Ensembl chr 7:89,582,243...89,611,264

G

zinc finger, matrin-type 1

increases expression

Methylene Chloride results in increased expression of ZMAT1 mRNA

NCBI chr X:98,168,388...98,199,415
Ensembl chr X:98,168,456...98,199,733

G

zinc finger protein 354B

increases expression

Methylene Chloride results in increased expression of ZFP354B mRNA

NCBI chr10:35,233,783...35,251,110
Ensembl chr10:35,185,028...35,245,505

G

zinc finger and SCAN domain containing 12

decreases expression

Methylene Chloride results in decreased expression of ZSCAN12 mRNA

NCBI chr17:43,247,250...43,253,206
Ensembl chr17:43,247,095...43,253,264

dimethyl sulfoxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

increases expression

Dimethyl Sulfoxide results in increased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily B member 1A

affects expression

Dimethyl Sulfoxide affects the expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

actin alpha 2, smooth muscle

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 protein; LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 mRNA]

PMID:11682029 PMID:35366062

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin, alpha, cardiac muscle 1

increases expression
decreases expression

Dimethyl Sulfoxide results in increased expression of ACTC1 mRNA
Dimethyl Sulfoxide results in decreased expression of ACTC1 mRNA

NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523

G

agouti related neuropeptide

affects expression

Dimethyl Sulfoxide affects the expression of AGRP mRNA

NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584

G

aryl hydrocarbon receptor

multiple interactions
increases expression
decreases expression

Dimethyl Sulfoxide promotes the reaction [AHR protein binds to CAD promoter]
Dimethyl Sulfoxide results in increased expression of AHR mRNA; Dimethyl Sulfoxide results in increased expression of AHR protein
AHR protein affects the reaction [Dimethyl Sulfoxide results in increased phosphorylation of MYL2 protein]; Dimethyl Sulfoxide promotes the reaction [AHR protein binds to AHR promoter]; Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to AHR promoter]; Dimethyl Sulfoxide promotes the reaction [JDP2 protein binds to AHR promoter]; Dimethyl Sulfoxide promotes the reaction [NFE2L2 protein binds to AHR promoter]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [AHR protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [JDP2 protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [NFE2L2 protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide results in increased expression of AHR mRNA]; JDP2 protein affects the reaction [Dimethyl Sulfoxide results in increased expression of AHR protein]
Dimethyl Sulfoxide results in decreased expression of AHR mRNA

PMID:16675542 PMID:22486318 PMID:33723743

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

activation-induced cytidine deaminase

affects expression

Dimethyl Sulfoxide affects the expression of AICDA mRNA

NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions
affects localization

Dimethyl Sulfoxide inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein]
Dimethyl Sulfoxide affects the localization of AIFM1 protein

PMID:20423716 PMID:22535522

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

5'-aminolevulinate synthase 2

increases expression

Dimethyl Sulfoxide results in increased expression of ALAS2 mRNA

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519

G

albumin

decreases expression
multiple interactions

Dimethyl Sulfoxide results in decreased expression of ALB mRNA
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of ALB mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased secretion of ALB protein
Dimethyl Sulfoxide results in decreased expression of ALB mRNA; Dimethyl Sulfoxide results in decreased expression of ALB protein

PMID:14757319 PMID:22105179 PMID:35366062

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

increases expression

Dimethyl Sulfoxide results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

apolipoprotein A1

increases expression
increases activity

Dimethyl Sulfoxide results in increased expression of APOA1 mRNA; Dimethyl Sulfoxide results in increased expression of APOA1 protein
Dimethyl Sulfoxide results in increased activity of APOA1 promoter

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein M

affects expression

Dimethyl Sulfoxide affects the expression of APOM mRNA

NCBI chr20:3,690,950...3,693,550
Ensembl chr20:3,688,413...3,693,550

G

aquaporin 1

increases expression

Dimethyl Sulfoxide results in increased expression of AQP1 mRNA

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

androgen receptor

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Androgens results in increased activity of AR protein]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to CAD promoter]
Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to AHR promoter]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to AHR promoter]]

PMID:16675542 PMID:33723743

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

actin related protein 2/3 complex, subunit 4

affects expression

Dimethyl Sulfoxide affects the expression of ARPC4 mRNA

NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785

G

activating transcription factor 3

increases expression

Dimethyl Sulfoxide results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATPase Na+/K+ transporting subunit alpha 2

increases expression

Dimethyl Sulfoxide results in increased expression of ATP1A2 mRNA

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATPase Na+/K+ transporting subunit beta 1

increases expression

Dimethyl Sulfoxide results in increased expression of ATP1B1 mRNA

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

ATPase Na+/K+ transporting subunit beta 3

increases expression

Dimethyl Sulfoxide results in increased expression of ATP1B3 mRNA

NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598

G

ATP synthase membrane subunit f

affects expression

Dimethyl Sulfoxide affects the expression of ATP5MF mRNA

NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236

G

BarH-like homeobox 2

affects expression

Dimethyl Sulfoxide affects the expression of BARHL2 mRNA

NCBI chr14:3,340,465...3,345,362
Ensembl chr14:3,340,465...3,345,353

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Dimethyl Sulfoxide results in increased expression of BAX mRNA
Dimethyl Sulfoxide results in increased expression of BAX protein
Quercetin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of BAX mRNA]

PMID:17652743 PMID:36305173

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Dimethyl Sulfoxide results in decreased expression of BCL2 protein
[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in decreased expression of BCL2 protein

PMID:36305173 PMID:37365769

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BEN domain containing 6

affects expression

Dimethyl Sulfoxide affects the expression of BEND6 mRNA

NCBI chr 9:36,081,033...36,135,309
Ensembl chr 9:36,081,484...36,135,228

G

BTG anti-proliferation factor 2

increases expression

Dimethyl Sulfoxide results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

similar to human chromosome 16 open reading frame 74

affects expression

Dimethyl Sulfoxide affects the expression of C16ORF74 mRNA

NCBI chr19:48,660,288...48,686,287
Ensembl chr19:48,660,288...48,686,349

G

simlar to human chromosome 19 open reading frame 81

affects expression

Dimethyl Sulfoxide affects the expression of C19ORF81 mRNA

NCBI chr 1:94,857,301...94,871,323
Ensembl chr 1:94,857,115...94,871,813

G

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

multiple interactions

Dimethyl Sulfoxide promotes the reaction [AHR protein binds to CAD promoter]; Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to CAD promoter]; Dimethyl Sulfoxide promotes the reaction [ESR1 protein binds to CAD promoter]; Dimethyl Sulfoxide promotes the reaction [SP1 protein binds to CAD promoter]

NCBI chr 6:25,292,133...25,315,078
Ensembl chr 6:25,292,133...25,319,861

G

cell adhesion molecule 1

increases expression

Dimethyl Sulfoxide results in increased expression of CADM1 mRNA

NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833

G

caspase 3

multiple interactions
decreases expression
increases cleavage

[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide co-treated with 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine] results in increased expression of CASP3 protein; [lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of CASP3 protein; Dimethyl Sulfoxide results in decreased cleavage of and results in decreased activity of CASP3 protein
Dimethyl Sulfoxide results in decreased expression of CASP3 protein
Dimethyl Sulfoxide results in increased cleavage of CASP3 protein

PMID:12370186 PMID:22535522 PMID:36305173 PMID:37365769

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Paraquat results in increased expression of CAT mRNA]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions
increases secretion
decreases expression

Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Dimethyl Sulfoxide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Dimethyl Sulfoxide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Dimethyl Sulfoxide inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Dimethyl Sulfoxide results in increased secretion of CCL2 protein]
Dimethyl Sulfoxide results in decreased expression of CCL2 mRNA
Dimethyl Sulfoxide inhibits the reaction [sodium arsenite results in increased expression of CCL2 mRNA]

PMID:10925121 PMID:14576080 PMID:15689417 PMID:17529908 PMID:21878375 More...

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 28

affects expression

Dimethyl Sulfoxide affects the expression of CCL28 mRNA

NCBI chr 2:51,601,354...51,625,999
Ensembl chr 2:51,601,331...51,625,997

G

C-C motif chemokine ligand 5

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

CD14 molecule

increases expression

Dimethyl Sulfoxide results in increased expression of CD14 protein

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD38 molecule

multiple interactions

Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CD38 mRNA]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CD38 mRNA]]

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

CD3 gamma subunit of T-cell receptor complex

affects expression

Dimethyl Sulfoxide affects the expression of CD3G mRNA

NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147

G

CD59b molecule

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Asbestos, Crocidolite results in increased mutagenesis of CD59 gene]; Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased mutagenesis of CD59 gene]

PMID:12361925 PMID:15033018

NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847

G

cell division cycle 25B

decreases expression

Dimethyl Sulfoxide results in decreased expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cadherin 1

increases expression
multiple interactions

Dimethyl Sulfoxide results in increased expression of CDH1 mRNA
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CDH1 mRNA

PMID:22193206 PMID:35366062

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of CDH2 mRNA

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

CEA cell adhesion molecule 19

affects expression

Dimethyl Sulfoxide affects the expression of CEACAM19 mRNA

NCBI chr 1:79,542,107...79,550,927
Ensembl chr 1:79,542,107...79,550,927

G

CCAAT/enhancer binding protein beta

increases expression

Dimethyl Sulfoxide results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

cilia and flagella associated protein 300

affects expression

Dimethyl Sulfoxide affects the expression of CFAP300 mRNA

NCBI chr 8:5,180,180...5,198,840
Ensembl chr 8:5,180,675...5,198,807

G

CASP8 and FADD-like apoptosis regulator

affects expression

Dimethyl Sulfoxide affects the expression of CFLAR mRNA

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

cell growth regulator with EF hand domain 1

affects expression

Dimethyl Sulfoxide affects the expression of CGREF1 mRNA

NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852

G

checkpoint kinase 2

affects expression

Dimethyl Sulfoxide affects the expression of CHEK2 mRNA

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

chemokine-like factor

affects expression

Dimethyl Sulfoxide affects the expression of CKLF mRNA

NCBI chr19:698,097...706,570
Ensembl chr19:698,033...706,570

G

claudin 6

multiple interactions
decreases methylation
increases expression

Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN6 mRNA]
Dimethyl Sulfoxide results in decreased methylation of CLDN6 promoter
Dimethyl Sulfoxide results in increased expression of CLDN6 mRNA

NCBI chr10:12,710,302...12,713,987
Ensembl chr10:12,709,960...12,715,973

G

claudin 8

increases expression

Dimethyl Sulfoxide results in increased expression of CLDN8 mRNA

NCBI chr11:27,875,857...27,878,106
Ensembl chr11:27,875,692...27,878,513

G

claudin 9

multiple interactions
increases expression
decreases methylation

Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN9 mRNA]
Dimethyl Sulfoxide results in increased expression of CLDN9 mRNA
Dimethyl Sulfoxide results in decreased methylation of CLDN9 promoter

NCBI chr10:12,714,137...12,715,568

G

ciliary neurotrophic factor

affects expression

Dimethyl Sulfoxide affects the expression of CNTF mRNA

NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877

G

collagen type XI alpha 1 chain

increases expression

Dimethyl Sulfoxide results in increased expression of COL11A1 mRNA

NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853

G

collagen type I alpha 1 chain

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased expression of COL1A1 protein]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of COL1A2 mRNA; LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of COL1A2 mRNA]

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type IV alpha 1 chain

increases expression

Dimethyl Sulfoxide results in increased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

collagen type IV alpha 5 chain

increases expression

Dimethyl Sulfoxide results in increased expression of COL4A5 mRNA

NCBI chr X:105,118,762...105,322,699
Ensembl chr X:105,118,820...105,322,692

G

collagen type V alpha 1 chain

increases expression

Dimethyl Sulfoxide results in increased expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

cytochrome c oxidase subunit 4i1

increases expression

Dimethyl Sulfoxide results in increased expression of COX4I1 protein

NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921

G

ceruloplasmin

increases expression

Dimethyl Sulfoxide results in increased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carboxypeptidase M

increases expression

Dimethyl Sulfoxide results in increased expression of CPM mRNA

NCBI chr 7:53,225,647...53,286,220
Ensembl chr 7:53,225,696...53,286,220

G

citrate synthase

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

colony stimulating factor 1 receptor

increases expression

Dimethyl Sulfoxide results in increased expression of CSF1R mRNA

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

centriolar satellite-associated tubulin polyglutamylase complex regulator 1

affects expression

Dimethyl Sulfoxide affects the expression of CSTPP1 mRNA

NCBI chr 3:77,247,393...77,416,307
Ensembl chr 3:77,248,375...77,416,274

G

cystathionine gamma-lyase

affects expression

Dimethyl Sulfoxide affects the expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

catenin beta 1

increases expression

Dimethyl Sulfoxide results in increased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cutA divalent cation tolerance homolog

affects expression

Dimethyl Sulfoxide affects the expression of CUTA mRNA

NCBI chr20:5,022,956...5,024,580
Ensembl chr20:5,022,956...5,024,552

G

C-X-C motif chemokine ligand 14

affects expression

Dimethyl Sulfoxide affects the expression of CXCL14 mRNA

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

CXXC finger protein 4

affects expression

Dimethyl Sulfoxide affects the expression of CXXC4 mRNA

NCBI chr 2:222,664,148...222,689,365
Ensembl chr 2:222,664,771...222,689,365

G

cytochrome P450, family 11, subfamily b, polypeptide 3

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [adrenocorticotropin zinc results in decreased expression of CYP11B2 mRNA]; Dimethyl Sulfoxide promotes the reaction [adrenocorticotropin zinc results in decreased activity of CYP11B2 protein]

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 1, subfamily a, polypeptide 1

affects expression
multiple interactions
increases expression

Dimethyl Sulfoxide affects the expression of CYP1A1 mRNA
JDP2 protein affects the reaction [Dimethyl Sulfoxide results in increased expression of CYP1A1 protein]
Dimethyl Sulfoxide results in increased expression of CYP1A1; Dimethyl Sulfoxide results in increased expression of CYP1A1 protein
Dimethyl Sulfoxide results in increased expression of CYP1A1 mRNA; Dimethyl Sulfoxide results in increased expression of CYP1A1 protein
Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]]

PMID:12147272 PMID:12843640 PMID:22486318 PMID:31096615 PMID:33723743

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects expression
increases expression
multiple interactions

Dimethyl Sulfoxide affects the expression of CYP1A2 mRNA
Dimethyl Sulfoxide results in increased expression of CYP1A2 mRNA
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP1A2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP1A2 protein; [hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP1A2

PMID:12843640 PMID:18347083 PMID:30262279 PMID:35366062

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

affects expression
increases expression

Dimethyl Sulfoxide affects the expression of CYP1B1 mRNA
Dimethyl Sulfoxide results in increased expression of CYP1B1 protein

PMID:12843640 PMID:33723743

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 27, subfamily a, polypeptide 1

multiple interactions

Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CYP27A1 mRNA]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CYP27A1 mRNA]]

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily a, polypeptide 2

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline]

NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin]

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
multiple interactions

Dimethyl Sulfoxide results in increased expression of CYP2B6 mRNA; Dimethyl Sulfoxide results in increased expression of CYP2B6 protein
[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2B10 protein; NR1I3 gene mutant form inhibits the reaction [[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2B10 protein]
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2B6 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2B6 protein

PMID:20371638 PMID:30262279 PMID:31096615 PMID:35366062

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily c, polypeptide 24

multiple interactions

[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2C55 mRNA; [Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2C55 protein; NR1I3 gene mutant form inhibits the reaction [[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2C55 mRNA]; NR1I3 gene mutant form inhibits the reaction [[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2C55 protein]

NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [CYP2C6 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2C19 protein

PMID:19858067 PMID:35366062

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 2

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]

NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

affects expression
increases expression
increases activity
multiple interactions

Dimethyl Sulfoxide affects the expression of CYP2E1 mRNA
Dimethyl Sulfoxide results in increased expression of CYP2E1 protein
Dimethyl Sulfoxide results in increased activity of CYP2E1 protein
Dimethyl Sulfoxide binds to and results in increased expression of CYP2E1 protein; Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]; Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein results in increased metabolism of methylformamide]
Dimethyl Sulfoxide results in increased expression of CYP2E1 mRNA; Dimethyl Sulfoxide results in increased expression of CYP2E1 protein
Dimethyl Sulfoxide inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]; Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]]

PMID:1538706 PMID:3113478 PMID:3337723 PMID:8074729 PMID:9143349 More...

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
affects expression
increases expression

Dimethyl Sulfoxide inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline]
Dimethyl Sulfoxide affects the expression of CYP3A4 mRNA
Dimethyl Sulfoxide results in increased expression of CYP3A4 mRNA; Dimethyl Sulfoxide results in increased expression of CYP3A4 protein
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP3A4 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP3A4 protein; [Dimethyl Sulfoxide results in increased susceptibility to Rifampin] which results in increased expression of CYP3A4 mRNA; [hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP3A4; Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; PRMT1 protein affects the reaction [[Dimethyl Sulfoxide results in increased susceptibility to Rifampin] which results in increased expression of CYP3A4 mRNA]; PRMT1 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; trichostatin A affects the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]

PMID:12843640 PMID:18347083 PMID:19858067 PMID:30262279 PMID:31096615 More...

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline]

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects expression

Dimethyl Sulfoxide affects the expression of CYP3A5 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450 family 7 subfamily A member 1

increases expression

DMSO increases expression of Cyp7a1 mRNA in rat liver; reaction inhibited by INT-767

RGD

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cysteine rich tail 1

affects expression

Dimethyl Sulfoxide affects the expression of CYSRT1 mRNA

NCBI chr 3:8,054,195...8,057,846
Ensembl chr 3:8,053,482...8,059,721

G

DNA-damage inducible transcript 3

increases expression

Dimethyl Sulfoxide results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEPP autophagy regulator 1

affects expression

Dimethyl Sulfoxide affects the expression of DEPP1 mRNA

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

DNA fragmentation factor subunit alpha

increases cleavage

Dimethyl Sulfoxide results in increased cleavage of DFFA protein

NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633

G

DNA methyltransferase 1-associated protein 1

affects expression

Dimethyl Sulfoxide affects the expression of DMAP1 mRNA

NCBI chr 5:131,143,726...131,151,760
Ensembl chr 5:131,143,729...131,151,742

G

DnaJ heat shock protein family (Hsp40) member B5

increases expression

Dimethyl Sulfoxide results in increased expression of DNAJB5 mRNA

NCBI chr 5:57,176,840...57,186,067
Ensembl chr 5:57,176,845...57,185,490

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

Dimethyl Sulfoxide results in increased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

DNA methyltransferase 1

decreases expression

Dimethyl Sulfoxide results in decreased expression of DNMT1 protein

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

dual specificity phosphatase 1

increases expression

Dimethyl Sulfoxide results in increased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

ELL associated factor 2

affects expression

Dimethyl Sulfoxide affects the expression of EAF2 mRNA

NCBI chr11:63,960,200...64,004,610
Ensembl chr11:63,960,200...64,004,610

G

endothelin 2

decreases expression

Dimethyl Sulfoxide results in decreased expression of EDN2 mRNA

NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814

G

endothelin receptor type A

multiple interactions

[Dimethyl Sulfoxide co-treated with Cycloheximide] results in decreased expression of EDNRA mRNA; [Dimethyl Sulfoxide co-treated with Cycloheximide] results in decreased expression of EDNRA protein; [Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA mRNA; [Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA protein

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

endothelin receptor type B

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter promotes the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter promotes the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]]; Cycloheximide inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; Cycloheximide inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; Dactinomycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; Dactinomycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; pyrazolanthrone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; pyrazolanthrone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; wedelolactone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; wedelolactone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]
Dimethyl Sulfoxide results in increased expression of EDNRB mRNA; Dimethyl Sulfoxide results in increased expression of EDNRB protein

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

EEF1A lysine methyltransferase 1

affects expression

Dimethyl Sulfoxide affects the expression of EEF1AKMT1 mRNA

NCBI chr15:31,694,284...31,711,367
Ensembl chr15:31,694,292...31,711,336

G

EGF containing fibulin extracellular matrix protein 1

increases expression

Dimethyl Sulfoxide results in increased expression of EFEMP1 mRNA

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

early growth response 1

increases expression

Dimethyl Sulfoxide results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 4E binding protein 1

increases phosphorylation
multiple interactions

Dimethyl Sulfoxide results in increased phosphorylation of EIF4EBP1 protein
[Mechlorethamine co-treated with Dimethyl Sulfoxide] results in increased phosphorylation of EIF4EBP1 protein; Mechlorethamine inhibits the reaction [Dimethyl Sulfoxide results in increased phosphorylation of EIF4EBP1 protein]

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 4, gamma 2

increases expression

Dimethyl Sulfoxide results in increased expression of EIF4G2 protein

NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588

G

epithelial membrane protein 1

increases expression

Dimethyl Sulfoxide results in increased expression of EMP1 mRNA

NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904

G

endonuclease G

affects localization

Dimethyl Sulfoxide affects the localization of ENDOG protein

NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

decreases expression

Dimethyl Sulfoxide results in decreased expression of ENPP2 protein

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

epididymal peptidase inhibitor

affects expression

Dimethyl Sulfoxide affects the expression of EPPIN mRNA

NCBI chr 3:153,312,396...153,319,310
Ensembl chr 3:153,312,396...153,319,310

G

estrogen receptor 1

multiple interactions

Dimethyl Sulfoxide promotes the reaction [ESR1 protein binds to CAD promoter]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

eva-1 homolog B

affects expression

Dimethyl Sulfoxide affects the expression of EVA1B mRNA

NCBI chr 5:138,427,088...138,429,602
Ensembl chr 5:138,427,151...138,432,433

G

Fas cell surface death receptor

increases expression

Dimethyl Sulfoxide results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

decreases expression

Dimethyl Sulfoxide results in decreased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

F-box and leucine-rich repeat protein 21

affects expression

Dimethyl Sulfoxide affects the expression of FBXL21P mRNA

NCBI chr17:8,060,412...8,077,415
Ensembl chr17:8,060,414...8,073,359

G

fibrinogen gamma chain

increases expression

Dimethyl Sulfoxide results in increased expression of FGG mRNA; Dimethyl Sulfoxide results in increased expression of FGG protein

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

filamin C

increases expression

Dimethyl Sulfoxide results in increased expression of FLNC mRNA

NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844

G

fragile X messenger ribonucleoprotein 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]

NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Dimethyl Sulfoxide results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box A2

decreases expression

Dimethyl Sulfoxide results in decreased expression of FOXA2 mRNA

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326

G

fibroblast growth factor receptor substrate 3

affects expression

Dimethyl Sulfoxide affects the expression of FRS3 mRNA

NCBI chr 9:13,288,559...13,297,285
Ensembl chr 9:13,288,667...13,295,382

G

glutamate decarboxylase 1

increases expression

Dimethyl Sulfoxide results in increased expression of GAD1 mRNA

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

growth arrest and DNA-damage-inducible, alpha

affects expression

Dimethyl Sulfoxide affects the expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

growth arrest and DNA-damage-inducible, gamma

increases expression

Dimethyl Sulfoxide results in increased expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

glyceraldehyde-3-phosphate dehydrogenase

affects expression

Dimethyl Sulfoxide affects the expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

GATA binding protein 4

decreases expression
increases expression

Dimethyl Sulfoxide results in decreased expression of GATA4 mRNA
Dimethyl Sulfoxide results in increased expression of GATA4 mRNA

NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636

G

GATA binding protein 6

decreases expression

Dimethyl Sulfoxide results in decreased expression of GATA6 mRNA

NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532

G

gap junction protein, alpha 1

increases expression

Dimethyl Sulfoxide results in increased expression of GJA1 mRNA

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, beta 1

increases expression

Dimethyl Sulfoxide results in increased expression of GJB1 mRNA

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

gap junction protein, beta 2

increases expression

Dimethyl Sulfoxide results in increased expression of GJB2 mRNA

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

glycosyltransferase 8 domain containing 1

affects expression

Dimethyl Sulfoxide affects the expression of GLT8D1 mRNA

NCBI chr16:6,192,269...6,207,227
Ensembl chr16:6,192,300...6,207,229

G

G protein subunit gamma 3

affects expression

Dimethyl Sulfoxide affects the expression of GNG3 mRNA

NCBI chr 1:205,731,837...205,733,603
Ensembl chr 1:205,731,837...205,733,603

G

G protein-coupled bile acid receptor 1

decreases expression

DMSO decreases expression of Gpbar1 protein in rat liver; reaction inhibited by INT-767

RGD

NCBI chr 9:75,860,758...75,863,260
Ensembl chr 9:75,860,677...75,863,168

G

G protein-coupled receptor 75

affects expression

Dimethyl Sulfoxide affects the expression of GPR75 mRNA

NCBI chr14:104,609,542...104,618,885
Ensembl chr14:104,611,089...104,620,370

G

glutamic--pyruvic transaminase

multiple interactions

[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

granulin precursor

increases expression

Dimethyl Sulfoxide results in increased expression of GRN mRNA

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

glutathione S-transferase alpha 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in decreased expression of GSTA1 protein]

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase kappa 1

affects expression

Dimethyl Sulfoxide affects the expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

glutathione S-transferase mu 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in decreased expression of GSTM1 protein]

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

increases expression

Dimethyl Sulfoxide results in increased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

increases expression

Dimethyl Sulfoxide results in increased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

H2B clustered histone 6

affects expression

Dimethyl Sulfoxide affects the expression of H2BC6 mRNA

NCBI chr17:41,520,775...41,521,238

G

H3.4 histone, cluster member

multiple interactions
decreases methylation

[Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H3-4 protein modified form binds to TGM2 gene]; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased acetylation of H3-4 protein]
Dimethyl Sulfoxide results in decreased methylation of H3-4 protein

NCBI chr10:43,740,702...43,741,262

G

H1.3 linker histone, cluster member

affects expression

Dimethyl Sulfoxide affects the expression of H1-3 mRNA

NCBI chr17:41,551,524...41,552,303
Ensembl chr17:41,529,667...41,552,334

G

heart and neural crest derivatives expressed 1

decreases expression
increases expression

Dimethyl Sulfoxide results in decreased expression of HAND1 mRNA
Dimethyl Sulfoxide results in increased expression of HAND1 mRNA

NCBI chr10:42,006,646...42,009,213
Ensembl chr10:42,006,651...42,009,213

G

hemoglobin subunit beta

increases expression

Dimethyl Sulfoxide results in increased expression of HBB mRNA

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

hydroxycarboxylic acid receptor 1

affects expression

Dimethyl Sulfoxide affects the expression of HCAR1 mRNA

NCBI chr12:32,710,680...32,713,934
Ensembl chr12:32,711,027...32,712,082

G

HEXIM P-TEFb complex subunit 1

increases expression

Dimethyl Sulfoxide results in increased expression of HEXIM1 mRNA; Dimethyl Sulfoxide results in increased expression of HEXIM1 protein

NCBI chr10:88,062,808...88,064,920
Ensembl chr10:88,062,803...88,066,189

G

hypoxia inducible factor 1 subunit alpha

increases expression

Dimethyl Sulfoxide results in increased expression of HIF1A mRNA

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

histone cluster 1 H2a family member I like 1

affects expression

Dimethyl Sulfoxide affects the expression of H3C6 mRNA

NCBI chr17:41,568,181...41,569,093
Ensembl chr17:41,568,471...41,569,109

G

histone cluster 1 H2A family like 1

affects expression

Dimethyl Sulfoxide affects the expression of H2AC6 mRNA

NCBI chr17:42,707,954...42,708,420

G

heme oxygenase 1

decreases expression
multiple interactions
increases expression

Dimethyl Sulfoxide results in decreased expression of HMOX1 protein
[Dimethyl Sulfoxide co-treated with resveratrol] inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Dimethyl Sulfoxide inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]
Dimethyl Sulfoxide results in increased expression of HMOX1 mRNA

PMID:15689417 PMID:22118543 PMID:22193206 PMID:26497626 PMID:36305173

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

haptoglobin

increases expression

Dimethyl Sulfoxide results in increased expression of HP mRNA; Dimethyl Sulfoxide results in increased expression of HP protein

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

hypoxanthine phosphoribosyltransferase 1

decreases expression

Dimethyl Sulfoxide results in decreased expression of HPRT1 mRNA

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

HRas proto-oncogene, GTPase

affects expression

Dimethyl Sulfoxide affects the expression of HRAS mRNA

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

heat shock protein family A (Hsp70) member 1A

increases expression

Dimethyl Sulfoxide results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

intercellular adhesion molecule 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [beryllium sulfate results in increased secretion of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

immediate early response 2

increases expression

Dimethyl Sulfoxide results in increased expression of IER2 mRNA

NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211

G

interferon gamma

multiple interactions

[Dimethyl Sulfoxide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA; Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of CCL5 protein]; Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of IL6 protein]

PMID:21878375 PMID:29594315

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon gamma receptor 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IFNGR1 mRNA]

NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785

G

intraflagellar transport 81

affects expression

Dimethyl Sulfoxide affects the expression of IFT81 mRNA

NCBI chr12:33,957,744...34,037,164
Ensembl chr12:33,957,806...34,037,057

G

interleukin 1 alpha

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
decreases expression

Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of CCL5 protein]; Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of IL6 protein]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IFNGR1 mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IL1B mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of NFKB2 mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of NFKBIA mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]
[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of IL1B protein
Dimethyl Sulfoxide results in decreased expression of IL1B mRNA

PMID:21878375 PMID:29594315 PMID:37365769

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 1

decreases expression

Dimethyl Sulfoxide results in decreased expression of IL1R1 mRNA

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 2

multiple interactions

[Dimethyl Sulfoxide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 23 subunit alpha

affects expression

Dimethyl Sulfoxide affects the expression of IL23A mRNA

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 6

multiple interactions
decreases secretion

Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of IL6 protein]; Dimethyl Sulfoxide inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]
Dimethyl Sulfoxide results in decreased secretion of IL6 protein
[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of IL6 protein; Dimethyl Sulfoxide inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA]

PMID:9378980 PMID:10022265 PMID:15689417 PMID:21878375 PMID:24296301 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

immunity-related GTPase M

affects expression

Dimethyl Sulfoxide affects the expression of IRGM mRNA

NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578

G

ISG15 ubiquitin-like modifier

affects expression

Dimethyl Sulfoxide affects the expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

integrin subunit alpha M

multiple interactions
increases expression

[Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of ITGAM protein; Dexamethasone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of ITGAM protein]; Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of ITGAM protein]

PMID:7909661 PMID:15964820 PMID:16617325 PMID:22118543 PMID:26330309

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit alpha X

multiple interactions

Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of ITGAX protein]

NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698

G

integrin subunit beta 2

multiple interactions

Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of ITGB2 protein]

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

Jun dimerization protein 2

multiple interactions

Dimethyl Sulfoxide promotes the reaction [JDP2 protein binds to AHR promoter]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [AHR protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [JDP2 protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [NFE2L2 protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide results in increased expression of AHR mRNA]; JDP2 protein affects the reaction [Dimethyl Sulfoxide results in increased expression of AHR protein]; JDP2 protein affects the reaction [Dimethyl Sulfoxide results in increased expression of CYP1A1 protein]

NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Dimethyl Sulfoxide results in increased expression of JUN mRNA
Dimethyl Sulfoxide inhibits the reaction [Paraquat results in increased expression of JUN mRNA]

PMID:7662713 PMID:22193206

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

KLF transcription factor 2

increases expression

Dimethyl Sulfoxide results in increased expression of KLF2 mRNA

NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944

G

KLF transcription factor 4

increases expression

Dimethyl Sulfoxide results in increased expression of KLF4 mRNA

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

kelch-like family member 41

affects expression

Dimethyl Sulfoxide affects the expression of KLHL41 mRNA

NCBI chr 3:54,434,291...54,447,415
Ensembl chr 3:54,434,234...54,449,222

G

keratin 15

decreases expression

Dimethyl Sulfoxide results in decreased expression of KRT15 mRNA

NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799

G

keratin 18

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of KRT18 mRNA

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166

G

laminin subunit alpha 1

increases expression

Dimethyl Sulfoxide results in increased expression of LAMA1 mRNA

NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478

G

laminin subunit beta 2

increases expression

Dimethyl Sulfoxide results in increased expression of LAMB2 mRNA

NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549

G

lactate dehydrogenase C

affects expression

Dimethyl Sulfoxide affects the expression of LDHC mRNA

NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378

G

galectin 1

affects expression

Dimethyl Sulfoxide affects the expression of LGALS1 mRNA

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

LLGL scribble cell polarity complex component 2

affects expression

Dimethyl Sulfoxide affects the expression of LLGL2 mRNA

NCBI chr10:101,050,978...101,086,527
Ensembl chr10:101,051,408...101,086,525

G

leucine rich repeat containing 4

affects expression

Dimethyl Sulfoxide affects the expression of LRRC4 mRNA

NCBI chr 4:57,433,518...57,437,114
Ensembl chr 4:57,433,428...57,437,911

G

LYR motif containing 9

affects expression

Dimethyl Sulfoxide affects the expression of LYRM9 mRNA

NCBI chr10:63,725,718...63,739,772
Ensembl chr10:63,725,743...63,739,772

G

mitogen activated protein kinase kinase 1

increases expression
multiple interactions

Dimethyl Sulfoxide results in increased expression of MAP2K1 mRNA
cucurbitacin IIa inhibits the reaction [Dimethyl Sulfoxide results in increased expression of MAP2K1 mRNA]

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

multiple interactions
increases expression

cucurbitacin IIa inhibits the reaction [Dimethyl Sulfoxide results in increased expression of MAP2K2 mRNA]

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions
decreases activity

Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased activity of MAP3K5 protein]
Dimethyl Sulfoxide results in decreased activity of MAP3K5 protein

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

G

mitogen activated protein kinase 3

affects expression
multiple interactions
increases expression

Dimethyl Sulfoxide affects the expression of MAPK3 mRNA
cucurbitacin IIa inhibits the reaction [Dimethyl Sulfoxide results in increased expression of MAPK3 mRNA]

PMID:24834073 PMID:31265865

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

methionine adenosyltransferase 1A

increases activity

Dimethyl Sulfoxide results in increased activity of MAT1A protein

NCBI chr16:16,983,084...17,001,284
Ensembl chr16:16,983,022...17,001,274

G

methionine adenosyltransferase 2A

increases activity

Dimethyl Sulfoxide results in increased activity of MAT2A protein

NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493

G

melanocortin 1 receptor

affects expression

Dimethyl Sulfoxide affects the expression of MC1R mRNA

NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192

G

myocyte enhancer factor 2C

increases expression
decreases expression

Dimethyl Sulfoxide results in increased expression of MEF2C mRNA
Dimethyl Sulfoxide results in decreased expression of MEF2C mRNA

NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880

G

methyltransferase like 26

affects expression

Dimethyl Sulfoxide affects the expression of METTL26 mRNA

NCBI chr10:14,894,574...14,908,067
Ensembl chr10:14,894,581...14,905,851

G

microfibril associated protein 5

affects expression

Dimethyl Sulfoxide affects the expression of MFAP5 mRNA

NCBI chr 4:155,727,925...155,750,458
Ensembl chr 4:155,727,925...155,750,458

G

microRNA 320a

multiple interactions

dimethyl sulfoxide promotes the reaction [ischemia-reperfusion injury increases expression of Mir320a miRNA in nucleus]

RGD

NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473

G

matrix metallopeptidase 1

increases expression

Dimethyl Sulfoxide results in increased expression of MMP1 mRNA; Dimethyl Sulfoxide results in increased expression of MMP1 protein

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 13

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of MMP13 mRNA

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

multiple interactions
increases expression

[Dimethyl Sulfoxide co-treated with resveratrol] inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]
Dimethyl Sulfoxide results in increased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions
increases expression

[Dimethyl Sulfoxide co-treated with resveratrol] inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Dimethyl Sulfoxide inhibits the reaction [Ethanol results in increased activity of MMP9 protein]
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of MMP9 mRNA
Dimethyl Sulfoxide results in increased expression of MMP9 protein

PMID:17603938 PMID:26497626 PMID:35366062

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

increases secretion
increases expression
multiple interactions

Dimethyl Sulfoxide results in increased secretion of MPO protein
Dimethyl Sulfoxide results in increased expression of MPO mRNA
[Irinotecan co-treated with Dimethyl Sulfoxide] results in increased activity of MPO protein; [Tetradecanoylphorbol Acetate co-treated with Dimethyl Sulfoxide] results in increased activity of MPO protein; GSK484 inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Dimethyl Sulfoxide] results in increased activity of MPO protein]; Irinotecan promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Dimethyl Sulfoxide] results in increased activity of MPO protein]; phenethyl isothiocyanate inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Dimethyl Sulfoxide] results in increased activity of MPO protein]; Tetradecanoylphorbol Acetate promotes the reaction [Dimethyl Sulfoxide results in increased expression of MPO mRNA]

PMID:21633126 PMID:38341106

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

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mitochondrial ribosomal protein L43

affects expression

Dimethyl Sulfoxide affects the expression of MRPL43 mRNA

NCBI chr 1:243,866,848...243,868,285
Ensembl chr 1:243,866,931...243,868,281

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

murinoglobulin 2

increases expression

Dimethyl Sulfoxide results in increased expression of PZP mRNA; Dimethyl Sulfoxide results in increased expression of PZP protein

NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475

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matrix remodeling associated 8

increases expression

Dimethyl Sulfoxide results in increased expression of MXRA8 mRNA

NCBI chr 5:166,448,919...166,453,645
Ensembl chr 5:166,449,154...166,453,636

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MYC proto-oncogene, bHLH transcription factor

decreases expression

Dimethyl Sulfoxide results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

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myosin light chain 2

increases phosphorylation
multiple interactions

Dimethyl Sulfoxide results in increased phosphorylation of MYL2 protein
AHR protein affects the reaction [Dimethyl Sulfoxide results in increased phosphorylation of MYL2 protein]

NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983

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myosin IG

increases expression

Dimethyl Sulfoxide results in increased expression of MYO1G mRNA

NCBI chr14:81,386,701...81,401,843
Ensembl chr14:81,386,701...81,401,843

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Nanog homeobox

decreases expression

Dimethyl Sulfoxide results in decreased expression of NANOG mRNA

NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116

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neurofilament heavy chain

decreases expression

Dimethyl Sulfoxide results in decreased expression of NEFH mRNA

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

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nestin

decreases expression

Dimethyl Sulfoxide results in decreased expression of NES mRNA

NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777

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NFE2 like bZIP transcription factor 2

multiple interactions
increases expression
affects response to substance
decreases expression

[Dimethyl Sulfoxide co-treated with resveratrol] inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]
Dimethyl Sulfoxide results in increased expression of NFE2L2 protein modified form
NFE2L2 protein affects the susceptibility to Dimethyl Sulfoxide
dimethyl sulfoxide promotes the reaction [ischemia-reperfusion injury increases expression of Nfe2l2 protein in nucleus]
Dimethyl Sulfoxide promotes the reaction [NFE2L2 protein binds to AHR promoter]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [NFE2L2 protein binds to AHR promoter]]
Dimethyl Sulfoxide results in decreased expression of NFE2L2 protein

CTD
RGD

PMID:26497626 PMID:32023790 PMID:33723743 PMID:36305173 PMID:31089916

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

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nuclear factor kappa B subunit 2

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of NFKB2 mRNA]

NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213

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NFKB inhibitor alpha

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of NFKBIA mRNA]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

N-myc (and STAT) interactor

affects expression

Dimethyl Sulfoxide affects the expression of NMI mRNA

NCBI chr 3:36,415,607...36,439,716
Ensembl chr 3:36,415,607...36,439,498

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nicotinamide riboside kinase 1

affects expression

Dimethyl Sulfoxide affects the expression of NMRK1 mRNA

NCBI chr 1:216,049,350...216,076,792
Ensembl chr 1:216,049,437...216,076,791

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nitric oxide synthase 2

decreases expression

Dimethyl Sulfoxide results in decreased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

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notch receptor 3

increases expression

Dimethyl Sulfoxide results in increased expression of NOTCH3 mRNA

NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025

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NAD(P)H quinone dehydrogenase 1

increases expression

Dimethyl Sulfoxide results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

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nuclear receptor subfamily 1, group H, member 4

decreases expression

DMSO decreases expression of Nr1h4 mRNA and protein in rat liver; reaction inhibited by INT-767

RGD

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

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nuclear receptor subfamily 1, group I, member 3

multiple interactions

NR1I3 gene mutant form inhibits the reaction [[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2B10 protein]; NR1I3 gene mutant form inhibits the reaction [[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2C55 mRNA]; NR1I3 gene mutant form inhibits the reaction [[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2C55 protein]

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

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nudix hydrolase 1

affects expression

Dimethyl Sulfoxide affects the expression of NUDT1 mRNA

NCBI chr12:14,302,514...14,309,559
Ensembl chr12:14,302,694...14,305,826

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occludin

increases expression

Dimethyl Sulfoxide results in increased expression of OCLN mRNA

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

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ornithine decarboxylase 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Paraquat results in increased activity of ODC1 protein]

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

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orosomucoid 1

increases expression

Dimethyl Sulfoxide results in increased expression of ORM1 mRNA; Dimethyl Sulfoxide results in increased expression of ORM1 protein

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

osteocrin

affects expression

Dimethyl Sulfoxide affects the expression of OSTN mRNA

NCBI chr11:73,442,167...73,478,498
Ensembl chr11:73,442,487...73,468,603

G

purinergic receptor P2X 7

multiple interactions

[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of P2RX7 protein

NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619

G

peptidyl arginine deiminase 4

multiple interactions
increases expression

Calcimycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of PADI4 protein]; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of PADI4 mRNA]

PMID:15964820 PMID:29425503

NCBI chr 5:153,041,351...153,074,412
Ensembl chr 5:153,041,352...153,074,362

G

par-6 family cell polarity regulator alpha

affects expression

Dimethyl Sulfoxide affects the expression of PARD6A mRNA

NCBI chr19:33,589,531...33,591,900
Ensembl chr19:33,589,542...33,591,900

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poly (ADP-ribose) polymerase 1

increases cleavage

Dimethyl Sulfoxide results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

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programmed cell death 4

increases expression

Dimethyl Sulfoxide results in increased expression of PDCD4 protein

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

PHD finger protein 6

affects expression

Dimethyl Sulfoxide affects the expression of PHF6 mRNA

NCBI chr X:132,656,658...132,699,720
Ensembl chr X:132,656,672...132,699,127

G

phosphoinositide kinase, FYVE-type zinc finger containing

affects expression

Dimethyl Sulfoxide affects the expression of PIKFYVE mRNA

NCBI chr 9:66,563,747...66,657,873
Ensembl chr 9:66,563,727...66,657,868

G

pejvakin

affects expression

Dimethyl Sulfoxide affects the expression of PJVK mRNA

NCBI chr 3:61,594,644...61,605,051
Ensembl chr 3:61,596,641...61,605,045

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phospholipase A2 group IIA

decreases expression

Dimethyl Sulfoxide results in decreased expression of PLA2G2A mRNA

NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014

G

pleckstrin homology and FYVE domain containing 1

affects expression

Dimethyl Sulfoxide affects the expression of PLEKHF1 mRNA

NCBI chr 1:90,908,304...90,915,862
Ensembl chr 1:90,904,742...90,915,820

G

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

increases expression

Dimethyl Sulfoxide results in increased expression of PLOD2 mRNA

NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255

G

proopiomelanocortin

decreases expression

Dimethyl Sulfoxide results in decreased expression of POMC protein

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

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cytochrome p450 oxidoreductase

multiple interactions
decreases activity

Dimethyl Sulfoxide inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]
Dimethyl Sulfoxide results in decreased activity of POR protein
Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Dimethyl Sulfoxide promotes the reaction [Hemin results in decreased activity of POR protein]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin promotes the reaction [Dimethyl Sulfoxide results in decreased activity of POR protein]

PMID:11368792 PMID:21215309

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

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protection of telomeres 1

multiple interactions

2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [[Dimethyl Sulfoxide co-treated with Tretinoin] results in increased expression of POT1 mRNA]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [[Dimethyl Sulfoxide co-treated with Tretinoin] results in increased expression of POT1 mRNA]; [Dimethyl Sulfoxide co-treated with Tretinoin] results in increased expression of POT1 mRNA

NCBI chr 4:54,205,330...54,263,137
Ensembl chr 4:54,205,332...54,263,042

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POU class 5 homeobox 1

affects expression

Dimethyl Sulfoxide affects the expression of POU5F1 mRNA

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

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peroxisome proliferator activated receptor alpha

decreases expression

Dimethyl Sulfoxide results in decreased expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

decreases expression

Dimethyl Sulfoxide results in decreased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

polyglutamine binding protein 1

affects expression

Dimethyl Sulfoxide affects the expression of PQBP1 mRNA

NCBI chr X:14,603,516...14,608,091
Ensembl chr X:14,603,539...14,608,087

G

protein arginine methyltransferase 1

multiple interactions

PRMT1 protein affects the reaction [[Dimethyl Sulfoxide results in increased susceptibility to Rifampin] which results in increased expression of CYP3A4 mRNA]; PRMT1 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]

NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345

G

peripherin

affects expression

Dimethyl Sulfoxide affects the expression of PRPH mRNA

NCBI chr 7:130,218,149...130,222,136
Ensembl chr 7:130,218,357...130,222,136

G

prostaglandin-endoperoxide synthase 1

decreases expression

Dimethyl Sulfoxide results in decreased expression of PTGS1 mRNA

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

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prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
[Dimethyl Sulfoxide co-treated with resveratrol] inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Dimethyl Sulfoxide results in increased expression of PTGS2 protein

PMID:21878375 PMID:26497626

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

peroxidasin

increases expression

Dimethyl Sulfoxide results in increased expression of PXDN mRNA

NCBI chr 6:46,580,749...46,658,345
Ensembl chr 6:46,580,761...46,658,345

G

RAB3C, member RAS oncogene family

affects expression

Dimethyl Sulfoxide affects the expression of RAB3C mRNA

NCBI chr 2:41,627,720...41,843,541
Ensembl chr 2:41,627,720...41,843,749

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

[cucurbitacin IIa co-treated with Dimethyl Sulfoxide] results in increased expression of RAF1 mRNA

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

reelin

increases expression

Dimethyl Sulfoxide results in increased expression of RELN mRNA

NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211

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regulatory factor X3

affects expression

Dimethyl Sulfoxide affects the expression of RFX3 mRNA

NCBI chr 1:225,449,872...225,709,622
Ensembl chr 1:225,456,187...225,709,402

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ribonuclease A family member 4

affects expression

Dimethyl Sulfoxide affects the expression of RNASE4 mRNA

NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117

G

ring finger protein 152

affects expression

Dimethyl Sulfoxide affects the expression of RNF152 mRNA

NCBI chr13:21,324,039...21,403,405
Ensembl chr13:21,323,824...21,403,113

G

ribosomal protein S6

multiple interactions
increases phosphorylation
affects phosphorylation

[Dimethyl Sulfoxide co-treated with Mechlorethamine] results in increased phosphorylation of RPS6 protein; Mechlorethamine inhibits the reaction [Dimethyl Sulfoxide results in increased phosphorylation of RPS6 protein]
Mechlorethamine affects the reaction [Dimethyl Sulfoxide affects the phosphorylation of RPS6 protein]

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

RT1 class II, locus Da

decreases expression

Dimethyl Sulfoxide results in decreased expression of HLA-DRA mRNA

NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455

G

retinoid X receptor alpha

increases expression
affects response to substance

Dimethyl Sulfoxide results in increased expression of RXRA mRNA; Dimethyl Sulfoxide results in increased expression of RXRA protein
RXRA protein affects the susceptibility to Dimethyl Sulfoxide

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

retinoid X receptor gamma

decreases expression

Dimethyl Sulfoxide results in decreased expression of RXRG protein

NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167

G

S100 calcium binding protein A13

affects expression

Dimethyl Sulfoxide affects the expression of S100A13 mRNA

NCBI chr 2:175,999,439...176,005,933

G

S100 calcium binding protein A8

increases expression

Dimethyl Sulfoxide results in increased expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

increases expression

Dimethyl Sulfoxide results in increased expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

succinate dehydrogenase complex assembly factor 4

affects expression

Dimethyl Sulfoxide affects the expression of SDHAF4 mRNA

NCBI chr 9:26,408,332...26,416,478

G

selenium binding protein 1

increases abundance

SELENBP1 gene mutant form results in increased abundance of Dimethyl Sulfoxide

NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594

G

stress-associated endoplasmic reticulum protein family member 2

affects expression

Dimethyl Sulfoxide affects the expression of SERP2 mRNA

NCBI chr15:51,879,882...51,903,958
Ensembl chr15:51,879,877...51,904,785

G

solute carrier family 24 member 2

increases expression

Dimethyl Sulfoxide results in increased expression of SLC24A2 mRNA

NCBI chr 5:101,497,916...101,741,840
Ensembl chr 5:101,502,278...101,739,337

G

solute carrier family 24 member 4

increases expression

Dimethyl Sulfoxide results in increased expression of SLC24A4 mRNA

NCBI chr 6:121,279,590...121,419,811
Ensembl chr 6:121,280,031...121,414,949

G

solute carrier family 2 member 6

affects expression

Dimethyl Sulfoxide affects the expression of SLC2A6 mRNA

NCBI chr 3:10,348,395...10,355,208
Ensembl chr 3:10,348,395...10,355,208

G

solute carrier family 35, member E4

affects expression

Dimethyl Sulfoxide affects the expression of SLC35E4 mRNA

NCBI chr14:78,803,320...78,810,186
Ensembl chr14:78,803,323...78,810,241

G

SMAD family member 2

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD2 protein modified form

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

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SMAD family member 3

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD3 protein modified form

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

SMAD family member 4

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD4 protein

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

snail family transcriptional repressor 1

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SNAI1 mRNA

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SNAI2 mRNA

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

sorting nexin 15

affects expression

Dimethyl Sulfoxide affects the expression of SNX15 mRNA

NCBI chr 1:203,417,029...203,426,173
Ensembl chr 1:203,417,029...203,426,247

G

superoxide dismutase 3

increases expression

Dimethyl Sulfoxide results in increased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

sorbitol dehydrogenase

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of SORD protein]

NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133

G

SRY-box transcription factor 17

decreases expression

Dimethyl Sulfoxide results in decreased expression of SOX17 mRNA

NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228

G

Sp1 transcription factor

multiple interactions

Dimethyl Sulfoxide promotes the reaction [SP1 protein binds to CAD promoter]

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

serine peptidase inhibitor, Kazal type 2

affects expression

Dimethyl Sulfoxide affects the expression of SPINK2 mRNA

NCBI chr14:30,967,682...30,974,326
Ensembl chr14:30,967,714...30,974,326

G

sterol regulatory element binding transcription factor 1

increases expression

DMSO increases expression of Srebf1 mRNA in rat liver; reaction inhibited by INT-767

RGD

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

sulfiredoxin 1

increases expression

Dimethyl Sulfoxide results in increased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

SH3 and cysteine rich domain 3

affects expression

Dimethyl Sulfoxide affects the expression of STAC3 mRNA

NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589

G

signal transducer and activator of transcription 3

multiple interactions

[cucurbitacin IIa co-treated with Dimethyl Sulfoxide] results in increased expression of STAT3 mRNA

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

sulfotransferase family 1A member 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; Dimethyl Sulfoxide inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

small ubiquitin-like modifier 1

affects expression

Dimethyl Sulfoxide affects the expression of SUMO1 mRNA

NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761

G

synaptonemal complex central element protein 2

affects expression

Dimethyl Sulfoxide affects the expression of SYCE2 mRNA

NCBI chr19:23,266,236...23,291,265
Ensembl chr19:23,268,869...23,300,980

G

taste receptor, type 2, member 116

affects expression

Dimethyl Sulfoxide affects the expression of TAS2R14 mRNA

NCBI chr 4:166,266,984...166,267,958
Ensembl chr 4:166,266,984...166,267,958

G

TatD DNase domain containing 1

affects expression

Dimethyl Sulfoxide affects the expression of TATDN1 mRNA

NCBI chr 7:90,449,979...90,481,000
Ensembl chr 7:90,441,079...90,481,133

G

telomerase RNA component

multiple interactions

2,4,5,2',4',5'-hexachlorobiphenyl affects the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERC mRNA]; 3,4,5,3',4'-pentachlorobiphenyl affects the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERC mRNA]; [Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERC mRNA

NCBI chr 2:112,815,654...112,816,041

G

telomeric repeat binding factor 1

multiple interactions

2,4,5,2',4',5'-hexachlorobiphenyl affects the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERF1 mRNA]; 3,4,5,3',4'-pentachlorobiphenyl affects the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERF1 mRNA]; [Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERF1 mRNA

NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340

G

telomeric repeat binding factor 2

multiple interactions

[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Dimethyl Sulfoxide co-treated with Tretinoin] results in decreased expression of TERF2 mRNA; [Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERF2 mRNA

NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819

G

telomerase reverse transcriptase

decreases expression
multiple interactions

Dimethyl Sulfoxide results in decreased expression of TERT mRNA
2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased activity of TERT protein]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased expression of TERT mRNA]; 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased activity of TERT protein]; [Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased activity of TERT protein; [Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased expression of TERT mRNA

PMID:16180984 PMID:26330309

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transferrin

increases expression

Dimethyl Sulfoxide results in increased expression of TF mRNA

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

tissue factor pathway inhibitor

affects expression

Dimethyl Sulfoxide affects the expression of TFPI mRNA

NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880

G

transforming growth factor, beta 1

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased abundance of Adenosine Triphosphate; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of ALB mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CDH1 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP1A2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP1A2 protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2B6 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2B6 protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2C19 protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2C9 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2C9 protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP3A4 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP3A4 protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of KRT18 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of MMP13 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of MMP9 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased secretion of ALB protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of CDH2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of COL1A2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD2 protein modified form; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD3 protein modified form; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD4 protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SNAI1 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SNAI2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of TIMP1 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of TIMP2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of VIM mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ZEB1 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ZEB2 mRNA; LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 mRNA]; LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of COL1A2 mRNA]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transglutaminase 2

multiple interactions

[Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H3-4 protein modified form binds to TGM2 gene]; [Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H4C16 protein modified form binds to TGM2 gene]; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 mRNA]; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 protein]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 mRNA]]

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

G

TIMP metallopeptidase inhibitor 1

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of TIMP2 mRNA

PMID:11682029 PMID:35366062

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

TIR domain containing adaptor protein

affects expression

Dimethyl Sulfoxide affects the expression of TIRAP mRNA

NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432

G

tight junction protein 1

increases expression

Dimethyl Sulfoxide results in increased expression of TJP1 mRNA

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

transmembrane protein 121

affects expression

Dimethyl Sulfoxide affects the expression of TMEM121 mRNA

NCBI chr 6:132,262,182...132,265,797
Ensembl chr 6:132,262,176...132,265,914

G

transmembrane protein 134

affects expression

Dimethyl Sulfoxide affects the expression of TMEM134 mRNA

NCBI chr 1:201,419,225...201,424,778
Ensembl chr 1:201,419,264...201,431,411

G

transmembrane protein 150C

affects expression

Dimethyl Sulfoxide affects the expression of TMEM150C mRNA

NCBI chr14:9,454,999...9,525,300
Ensembl chr14:9,508,515...9,525,298

G

transmembrane protein 266

affects expression

Dimethyl Sulfoxide affects the expression of TMEM266 mRNA

NCBI chr 8:55,707,122...55,820,692
Ensembl chr 8:55,707,122...55,820,692

G

tumor necrosis factor

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of CCL5 protein]; Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of IL6 protein]; Dimethyl Sulfoxide inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of TNF protein; Dimethyl Sulfoxide inhibits the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein]; Dimethyl Sulfoxide inhibits the reaction [ferrous sulfate promotes the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]]
Dimethyl Sulfoxide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Ethanol promotes the reaction [Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]]]; Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]; Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]]

PMID:7539275 PMID:14576080 PMID:21878375 PMID:22319556 PMID:37365769

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 12A

increases expression

Dimethyl Sulfoxide results in increased expression of TNFRSF12A mRNA

NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045

G

TNF receptor superfamily member 1A

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]; Dimethyl Sulfoxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF1A protein]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

translocase of outer mitochondrial membrane 5

affects expression

Dimethyl Sulfoxide affects the expression of TOMM5 mRNA

NCBI chr 5:59,362,360...59,365,191
Ensembl chr 5:59,362,240...59,365,269

G

tropomyosin 3

increases expression

Dimethyl Sulfoxide results in increased expression of TPM3 mRNA

NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013

G

transformer 2 beta

increases expression

Dimethyl Sulfoxide results in increased expression of TRA2B mRNA

NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249

G

tribbles pseudokinase 3

increases expression

Dimethyl Sulfoxide results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

TSC22 domain family, member 3

affects expression

Dimethyl Sulfoxide affects the expression of TSC22D3 mRNA

NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861

G

t-SNARE domain containing 1

affects expression

Dimethyl Sulfoxide affects the expression of TSNARE1 mRNA

NCBI chr 7:106,226,056...106,407,308

G

tubulin, beta 3 class III

decreases expression

Dimethyl Sulfoxide results in decreased expression of TUBB3 mRNA

NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243

G

U2 small nuclear RNA auxiliary factor 1-like 4

affects expression

Dimethyl Sulfoxide affects the expression of U2AF1L4 mRNA

NCBI chr 1:85,816,268...85,818,462
Ensembl chr 1:85,815,101...85,818,462

G

ubiquitin-conjugating enzyme E2C

affects expression

Dimethyl Sulfoxide affects the expression of UBE2C mRNA

NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339

G

UFM1-specific peptidase 1

affects expression

Dimethyl Sulfoxide affects the expression of UFSP1 mRNA

NCBI chr12:19,406,133...19,407,147
Ensembl chr12:19,406,142...19,407,195

G

UDP glucuronosyltransferase family 1 member A6

affects expression

Dimethyl Sulfoxide affects the expression of UGT1A6 mRNA

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

affects expression

Dimethyl Sulfoxide affects the expression of UGT1A9 mRNA

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

uroplakin 3B

affects expression

Dimethyl Sulfoxide affects the expression of UPK3B mRNA

NCBI chr12:20,630,231...20,637,634
Ensembl chr12:20,631,525...20,637,724

G

urotensin 2 receptor

affects expression

Dimethyl Sulfoxide affects the expression of UTS2R mRNA

NCBI chr10:106,438,092...106,439,252
Ensembl chr10:106,438,092...106,439,252

G

vimentin

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of VIM mRNA

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

vomeronasal 1 receptor 10

affects expression

Dimethyl Sulfoxide affects the expression of VN1R2 mRNA

NCBI chr 1:60,064,704...60,065,639
Ensembl chr 1:60,064,501...60,082,218

G

WAPL cohesin release factor

increases expression

Dimethyl Sulfoxide results in increased expression of WAPL mRNA

NCBI chr16:10,005,520...10,075,270
Ensembl chr16:10,004,941...10,073,510

G

Wnt family member 11

affects expression

Dimethyl Sulfoxide affects the expression of WNT11 mRNA

NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294

G

zinc finger E-box binding homeobox 1

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ZEB1 mRNA

NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214

G

zinc finger E-box binding homeobox 2

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ZEB2 mRNA

NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157

G

zinc finger protein 36

affects expression

Dimethyl Sulfoxide affects the expression of ZFP36 mRNA

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564

ethyl acetate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 5

increases expression

ethyl acetate results in increased expression of CCL5 protein

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

colony stimulating factor 2

increases expression

ethyl acetate results in increased expression of CSF2 protein

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

dopamine receptor D1

multiple interactions

[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to ethyl acetate; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to ethyl acetate]

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

nuclear factor kappa B subunit 1

multiple interactions

ethyl acetate results in increased localization of and results in increased activity of NFKB1 protein

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ethyl acetate results in increased localization of and results in increased activity of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

isobutyronitrile

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases response to substance

CYP2E1 protein results in increased susceptibility to isobutyronitrile

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

N,N-dimethylformamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1B

decreases expression

Dimethylformamide results in decreased expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199