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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxolane
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Accession:CHEBI:26911 term browser browse the term
Definition:A cyclic ether that is butane in which one hydrogen from each methyl group is substituted by an oxygen.
Synonyms:related_synonym: 1,4-epoxybutane;   Formula=C4H8O;   InChI=1S/C4H8O/c1-2-4-5-3-1/h1-4H2;   InChIKey=WYURNTSHIVDZCO-UHFFFAOYSA-N;   SMILES=C1CCOC1;   THF;   butane alpha,delta-oxide;   butylene oxide;   furanidine;   tetrahydrofuran;   tetramethylene oxide
 xref: CAS:109-99-9;   Gmelin:1767;   HMDB:HMDB0000246
 xref_mesh: MESH:C018674
 xref: PMID:12571688;   PMID:1811956;   PMID:1911404;   PMID:19716170;   PMID:21316415;   PMID:21842397;   PMID:2675957;   Reaxys:102391;   UM-BBD_compID:c0019;   Wikipedia:THF


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oxolane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO NR1I2 protein affects the reaction [tetrahydrofuran results in increased expression of CYP1A2 mRNA]; NR1I3 protein affects the reaction [tetrahydrofuran results in increased expression of CYP1A2 mRNA] CTD PMID:28495613 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
increases activity
multiple interactions		 ISO tetrahydrofuran results in increased expression of CYP2B10 mRNA
tetrahydrofuran results in increased activity of CYP2B10 protein
NR1I2 protein affects the reaction [tetrahydrofuran results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [tetrahydrofuran results in increased expression of CYP2B10 mRNA]		 CTD PMID:28495613 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO NR1I2 protein affects the reaction [tetrahydrofuran results in increased expression of CYP1A2 mRNA]; NR1I2 protein affects the reaction [tetrahydrofuran results in increased expression of CYP2B10 mRNA] CTD PMID:28495613 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the reaction [tetrahydrofuran results in increased expression of CYP1A2 mRNA]; NR1I3 protein affects the reaction [tetrahydrofuran results in increased expression of CYP2B10 mRNA] CTD PMID:28495613 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      application 19703
        solvent 17229
          polar solvent 15723
            polar aprotic solvent 630
              oxolane 4
                10-hydroxy-pre-flavunoidine 0
                2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane + 0
                2-(dichloromethyl)tetrahydrofuran 0
                flavunoidine(2+) 0
                oxolan-3-one 0
                pre-flavunoidine(2+) + 0
                tanegool 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            organic molecule 19714
                              organic cyclic compound 19485
                                organic heterocyclic compound 18881
                                  organic heteromonocyclic compound 17787
                                    oxolanes 5853
                                      oxolane 4
                                        10-hydroxy-pre-flavunoidine 0
                                        2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane + 0
                                        2-(dichloromethyl)tetrahydrofuran 0
                                        flavunoidine(2+) 0
                                        oxolan-3-one 0
                                        pre-flavunoidine(2+) + 0
                                        tanegool 0
paths to the root