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branched-chain keto acid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:branched-chain keto acid
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Accession:CHEBI:191197 term browser browse the term
Definition:An oxo carboxylic acid in which the parent hydrocarbon chain has one or more alkyl substituents. Derivatives formed from the first step in the metabolism of branched-chain amino acids and can provide important information on animal health and disease.
Synonyms:related_synonym: BCKA;   BCKAs;   branched-chain keto acids;   branched-chain ketoacid;   branched-chain ketoacids
 xref: PMCID:PMC8181598;   PMID:23684523;   PMID:29324714;   PMID:31092703;   PMID:31416902;   PMID:31504096;   PMID:32784821;   PMID:32878988;   PMID:33522397;   PMID:34798641;   PMID:35075301
 cyclic_relationship: is_conjugate_acid_of CHEBI:191201

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3-methyl-2-oxobutanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of alpha-ketoisovalerate CTD PMID:20567778 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of alpha-ketoisovalerate CTD PMID:21561886 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
3-methyl-2-oxovaleric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of alpha-keto-beta-methylvaleric acid CTD PMID:20567778 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
4-methyl-2-oxopentanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in decreased secretion of alpha-ketoisocaproic acid CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808 		JBrowse link
G Ins1 insulin 1 increases secretion ISO alpha-ketoisocaproic acid results in increased secretion of INS1 protein CTD PMID:29161229 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO [alpha-ketoisocaproic acid co-treated with monomethyl succinate] inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of alpha-ketoisocaproic acid CTD PMID:21561886 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    chemical entity 20854
      group 20798
        inorganic group 20297
          oxo group 19435
            organic oxo compound 19435
              carbonyl compound 19435
                carboxylic acid 19147
                  oxo carboxylic acid 6335
                    branched-chain keto acid 5
                      3-methyl-2-oxobutanoic acid 2
                      3-methyl-2-oxovaleric acid + 1
                      4-methyl-2-oxopentanoic acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbon oxoacid 19150
                                    carboxylic acid 19147
                                      oxo carboxylic acid 6335
                                        branched-chain keto acid 5
                                          3-methyl-2-oxobutanoic acid 2
                                          3-methyl-2-oxovaleric acid + 1
                                          4-methyl-2-oxopentanoic acid 4
paths to the root