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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-methyl-2-oxopentanoic acid
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Accession:CHEBI:48430 term browser browse the term
Definition:A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Synonyms:related_synonym: 2-OXO-4-METHYLPENTANOIC ACID;   2-Oxoisocaproate;   4-Methyl-2-oxopentanoate;   4-methyl-2-oxovaleric acid;   Formula=C6H10O3;   InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9);   InChIKey=BKAJNAXTPSGJCU-UHFFFAOYSA-N;   Ketoleucine;   SMILES=CC(C)CC(=O)C(O)=O;   alpha-ketoisocaproic acid
 alt_id: CHEBI:1891;   CHEBI:41619
 xref: CAS:816-66-0;   DrugBank:DB03229;   HMDB:HMDB0000695;   KEGG:C00233;   KNApSAcK:C00019677
 xref_mesh: MESH:C013082
 xref: MetaCyc:2K-4CH3-PENTANOATE;   PDBeChem:COI;   PMID:14636955;   PMID:22770225;   Reaxys:1701823
 cyclic_relationship: is_conjugate_acid_of CHEBI:17865

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4-methyl-2-oxopentanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in decreased secretion of alpha-ketoisocaproic acid CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
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G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO [alpha-ketoisocaproic acid co-treated with monomethyl succinate] inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of alpha-ketoisocaproic acid CTD PMID:21561886 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            eukaryotic metabolite 19044
              algal metabolite 13941
                4-methyl-2-oxopentanoic acid 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          fatty acid 16012
                                            saturated fatty acid 15986
                                              straight-chain saturated fatty acid 15442
                                                valeric acid 14349
                                                  4-methyl-2-oxopentanoic acid 3
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