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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-methyl-2-oxopentanoic acid
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Accession:CHEBI:48430 term browser browse the term
Definition:A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Synonyms:related_synonym: 2-OXO-4-METHYLPENTANOIC ACID;   2-Oxoisocaproate;   4-Methyl-2-oxopentanoate;   4-methyl-2-oxovaleric acid;   Formula=C6H10O3;   InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9);   InChIKey=BKAJNAXTPSGJCU-UHFFFAOYSA-N;   Ketoleucine;   SMILES=CC(C)CC(=O)C(O)=O;   alpha-ketoisocaproic acid
 alt_id: CHEBI:1891;   CHEBI:41619
 xref: CAS:816-66-0;   DrugBank:DB03229;   HMDB:HMDB0000695;   KEGG:C00233;   KNApSAcK:C00019677
 xref_mesh: MESH:C013082
 xref: MetaCyc:2K-4CH3-PENTANOATE;   PDBeChem:COI;   PMID:14636955;   PMID:22770225;   Reaxys:1701823
 cyclic_relationship: is_conjugate_acid_of CHEBI:17865


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4-methyl-2-oxopentanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in decreased secretion of alpha-ketoisocaproic acid CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808 		JBrowse link
G Ins1 insulin 1 increases secretion ISO alpha-ketoisocaproic acid results in increased secretion of INS1 protein CTD PMID:29161229 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO [alpha-ketoisocaproic acid co-treated with monomethyl succinate] inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of alpha-ketoisocaproic acid CTD PMID:21561886 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        biochemical role 19496
          metabolite 19484
            eukaryotic metabolite 19303
              algal metabolite 15564
                4-methyl-2-oxopentanoic acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      monocarboxylic acid 17952
                                        fatty acid 16689
                                          saturated fatty acid 16375
                                            straight-chain saturated fatty acid 15875
                                              valeric acid 14533
                                                4-methyl-2-oxopentanoic acid 4
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