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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
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Accession:CHEBI:18313 term browser browse the term
Definition:A glycotriaosylceramide having alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucose as the trisaccharide component.
Synonyms:exact_synonym: N-[(2S,3R,4E)-1-{[alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]alkanamide
 related_synonym: Burkitt's lymphoma antigen, bla-CD77;   CTH;   D-Galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide;   Formula=C37H66NO18R;   Gal-alpha1->4Gal-beta1->4Glc-beta1->1'Cer;   Gal-alpha1->4LacCer;   Galalpha1-4Galbeta1-4Glcbeta1-1'ceramide;   Gb3;   Gb3Cer;   GbOSe3Cer;   Globotriosylceramide;   SMILES=[C@@H]1([C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)O)O)O)O)O)OC[C@@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)NC(=O)*;   Trihexosylceramide;   a globoside Gb3Cer (d18:1(4E));   alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer;   alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer;   alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide;   ceramide trihexoside;   globotriaosylceramide;   globotrihexosylceramide
 alt_id: CHEBI:12310;   CHEBI:12948;   CHEBI:14310;   CHEBI:16839;   CHEBI:20962;   CHEBI:20969;   CHEBI:27113;   CHEBI:4148;   CHEBI:9719
 xref: CAS:71965-57-6;   KEGG:C04737;   KEGG:G00093
 xref_mesh: MESH:C018549
 xref: MetaCyc:D-GALACTOSYL-14-D-GALACTOSYL-14-D-;   PMID:11437603;   PMID:11525645;   PMID:11946769;   PMID:12227795;   PMID:15113548;   PMID:1528196;   PMID:16120140;   PMID:1724444;   PMID:17258170;   PMID:17674039;   PMID:18176841;   PMID:18810447;   PMID:19655181;   PMID:20424866;   PMID:20623712;   PMID:2120125;   PMID:21252262;   PMID:21376640;   PMID:2448252;   PMID:2456994;   PMID:2500499;   PMID:2960671;   PMID:7691279;   PMID:7841803


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alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases chemical synthesis		 ISO Cyclosporine inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide] CTD PMID:14662772 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Curcumin inhibits the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]; TNF protein promotes the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]] CTD PMID:16819191 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Curcumin inhibits the reaction [TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; TNF protein promotes the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide] CTD PMID:16819191 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        antigen 130
          alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3
            alpha-D-Gal-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-N- acylsphingosine + 0
            alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1/26:1(17Z)) 0
            alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-N-hexacosanoylceramide 0
            alpha-D-galactosyl-D-galactosyl-D-glucosylsphingosine 0
            beta-D-GlcNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-ceramide(d18:1(4E)) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              ceramide 127
                                                oligoglycosylceramide 3
                                                  glycotriaosylceramide 3
                                                    alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3
                                                      alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3
                                                        alpha-D-Gal-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-N- acylsphingosine + 0
                                                        alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1/26:1(17Z)) 0
                                                        alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-N-hexacosanoylceramide 0
                                                        alpha-D-galactosyl-D-galactosyl-D-glucosylsphingosine 0
                                                        beta-D-GlcNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-ceramide(d18:1(4E)) 0
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