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ONTOLOGY REPORT - ANNOTATIONS


Term:ceramide
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Accession:CHEBI:17761 term browser browse the term
Definition:Ceramides (N-acyl-sphingoid bases) are a major subclass of sphingoid base derivatives with an amide-linked fatty acid. The fatty acids are typically saturated or monounsaturated with chain lengths from 14 to 26 carbon atoms; the presence of a hydroxyl group on carbon 2 is fairly common. Ceramides are generally precursors of more complex sphingolipids. In the illustrated generalised structure, R(1) = OH, OX (where X = acyl, glycosyl, phosphate, phosphonate, etc.), or H.
Synonyms:related_synonym: Cer;   Formula=C4H6NO2R3;   N-acylated sphingoid;   SMILES=O[C@H]([*])[C@H](C[*])NC([*])=O;   a ceramide;   ceramides
 alt_id: CHEBI:12487;   CHEBI:13954;   CHEBI:23074;   CHEBI:7242
 xref: KEGG:C00195;   LIPID_MAPS_class:LMSP02;   PMID:7542630;   Wikipedia:Ceramide


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1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
alpha-galactosylceramide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Il17a interleukin 17A JBrowse link 9 26,841,299 26,844,786 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Rorc RAR-related orphan receptor C JBrowse link 2 195,612,471 195,636,797 RGD:6480464
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:6480464
beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
ceramide 1-phosphate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cerk ceramide kinase JBrowse link 7 127,015,162 127,058,056 RGD:6480464
ganglioside GM1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Npc1 NPC intracellular cholesterol transporter 1 JBrowse link 18 3,616,878 3,662,656 RGD:6480464
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:6480464
G Pld1 phospholipase D1 JBrowse link 2 113,651,967 113,849,403 RGD:6480464
G Pld2 phospholipase D2 JBrowse link 10 57,161,921 57,181,148 RGD:6480464
G Slc18a2 solute carrier family 18 member A2 JBrowse link 1 280,397,831 280,457,968 RGD:6480464
G Slc6a3 solute carrier family 6 member 3 JBrowse link 1 32,323,011 32,363,983 RGD:6480464
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:6480464
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:6480464
N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
N-acetylsphingosine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G Clk1 CDC-like kinase 1 JBrowse link 9 65,296,777 65,308,017 RGD:6480464
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:6480464
G Dapk1 death associated protein kinase 1 JBrowse link 17 4,297,038 4,454,941 RGD:6480464
G Dffb DNA fragmentation factor subunit beta JBrowse link 5 171,250,559 171,261,875 RGD:6480464
G Dnm1l dynamin 1-like JBrowse link 11 88,830,968 88,882,271 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Fis1 fission, mitochondrial 1 JBrowse link 12 22,750,485 22,765,324 RGD:6480464
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Gsta2 glutathione S-transferase alpha 2 JBrowse link 8 85,640,081 85,645,621 RGD:6480464
G Gsta3 glutathione S-transferase alpha 3 JBrowse link 9 27,357,490 27,417,023 RGD:6480464
G Gsta5 glutathione S-transferase alpha 5 JBrowse link 8 85,553,659 85,564,914 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hnf1a HNF1 homeobox A JBrowse link 12 47,407,811 47,433,342 RGD:6480464
G Hrk harakiri, BCL2 interacting protein JBrowse link 12 44,008,879 44,029,211 RGD:6480464
G Id2 inhibitor of DNA binding 2 JBrowse link 6 44,360,077 44,361,908 RGD:6480464
G Il16 interleukin 16 JBrowse link 1 145,781,923 145,881,538 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6480464
G Klf6 Kruppel-like factor 6 JBrowse link 17 67,887,939 67,945,052 RGD:6480464
G Lgals3 galectin 3 JBrowse link 15 24,153,602 24,165,537 RGD:6480464
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6480464
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:6480464
G Mir15b microRNA 15b JBrowse link 2 165,605,923 165,606,020 RGD:6480464
G Mir20a microRNA 20a JBrowse link 15 100,180,334 100,180,418 RGD:6480464
G Mir25 microRNA 25 JBrowse link 12 19,307,340 19,307,423 RGD:6480464
G Mir93 microRNA 93 JBrowse link 12 19,307,543 19,307,629 RGD:6480464
G Mirlet7b microRNA let-7b JBrowse link 7 126,590,627 126,590,711 RGD:6480464
G Mirlet7d microRNA let-7d JBrowse link 17 16,419,980 16,420,077 RGD:6480464
G Mirlet7i microRNA let-7i JBrowse link 7 66,802,731 66,802,815 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Nrp1 neuropilin 1 JBrowse link 19 61,332,351 61,486,166 RGD:6480464
G Nrp2 neuropilin 2 JBrowse link 9 69,496,875 69,609,802 RGD:6480464
G Odc1 ornithine decarboxylase 1 JBrowse link 6 42,852,529 42,859,142 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:6480464
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:6480464
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:6480464
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Rhob ras homolog family member B JBrowse link 6 33,689,127 33,691,301 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6480464
G Tfe3 transcription factor binding to IGHM enhancer 3 JBrowse link X 15,574,579 15,587,826 RGD:6480464
G Tgif1 TGFB-induced factor homeobox 1 JBrowse link 9 119,181,079 119,190,698 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:6480464
G Txnip thioredoxin interacting protein JBrowse link 2 198,683,168 198,686,971 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
N-acylsphinganine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp6 caspase 6 JBrowse link 2 235,341,326 235,353,715 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
N-hexadecanoylsphingosine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Asah2 N-acylsphingosine amidohydrolase 2 JBrowse link 1 250,557,042 250,665,083 RGD:6480464
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6480464
G Atf6 activating transcription factor 6 JBrowse link 13 89,053,457 89,242,531 RGD:6480464
G Cs citrate synthase JBrowse link 7 2,752,680 2,778,963 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 JBrowse link 4 140,247,297 140,580,749 RGD:6480464
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 JBrowse link 4 180,423,452 180,800,088 RGD:6480464
G Lipc lipase C, hepatic type JBrowse link 8 77,272,582 77,398,485 RGD:6480464
G Lipg lipase G, endothelial type JBrowse link 18 70,903,528 70,924,434 RGD:6480464
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:6480464
G Pacs2 phosphofurin acidic cluster sorting protein 2 JBrowse link 6 137,824,136 137,889,144 RGD:6480464
G Pc pyruvate carboxylase JBrowse link 1 219,759,157 219,859,854 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Vdac1 voltage-dependent anion channel 1 JBrowse link 10 37,724,915 37,752,827 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19769
      atom 19768
        nonmetal atom 19642
          carbon atom 19537
            organic molecular entity 19537
              lipid 16971
                sphingolipid 183
                  ceramide 108
                    1-O-acyl-N-acylsphingosine + 0
                    1-O-acylceramide + 0
                    Cer(d18:0/18:1(11Z)) 0
                    Cer(d18:1(8Z)/19:0) 0
                    Cer(d18:1/18:1(11Z)) 0
                    N-(1,3-dihydroxyoctadec-4-en-2-yl)acetamide 0
                    N-(2-hydroxy-tetracosanoyl)-hexadecasphing-4-enine 0
                    N-(2-hydroxyacyl)sphingoid 0
                    N-(2-hydroxyhenicosanoyl)-4,8-sphingadienine 0
                    N-(2-hydroxytridecanoyl)-phytosphingosine 0
                    N-[(2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]acetamide 0
                    N-[12-[(7-Nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-ceramide 0
                    N-[omega-(acylyloxy)]acylsphin-4-enine + 0
                    N-acyl-(4E,14Z)-sphingadienine + 0
                    N-acyl-(4E,8E)-9-methylsphinga-4,8-dienine 0
                    N-acyl-(4E,8E)-sphinga-4,8-dienine 0
                    N-acyl-(4E,8E,10E)-sphinga-4,8,10-trienine 0
                    N-acyl-(4E,8Z)-sphinga-4,8-dienine 0
                    N-acyl-1-deoxy-4-hydroxysphinganine + 0
                    N-acyl-1-deoxysphinganine 0
                    N-acyl-15-methylhexadecasphing-4-enine + 0
                    N-acylheptadecasphingosine + 0
                    N-acylhexadecasphingosine 0
                    N-acylsphingoid + 85
                    N-acyltetradecasphing-4-enine 0
                    N-docosanoyl-(4E,14Z)-sphinga-4,14-dienine 0
                    N-docosanoyl-14-methylhexadecasphingosine 0
                    N-henicosanoyl-14-methylhexadecasphingosine 0
                    N-heptadecanoyl-14-methylhexadecasphingosine 0
                    N-hexacosanoyl-14-methylhexadecasphinganine 0
                    N-hexacosanoyl-14-methylhexadecasphingosine 0
                    N-hexadecanoyl-14-methylhexadecasphingosine 0
                    N-pentacosanoyl-14-methylhexadecasphingosine 0
                    N-tetracosanoyl-14-methylhexadecasphingosine 0
                    N-tetracosenoyl-C17-sphingosine 0
                    N-tricosanoyl-(4E,14Z)-sphinga-4,14-dienine 0
                    N-tricosanoyl-14-methylhexadecasphingosine 0
                    N-tricosenoyl-14-methylhexadecasphingosine 0
                    ceramide 1-phosphate + 1
                    ceramide 1-phosphonate + 0
                    cerebroside + 10
                    ganglioside + 12
                    glycosylceramide + 10
                    oligoglycosylceramide + 3
                    omega-hydroxy-ultra-long chain fatty acylceramide + 0
                    omega-linoleoyloxy-O-ultra-long chain acylceramide + 0
                    phosphocerebroside + 0
                    phytoceramides + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19548
                        carbon atom 19537
                          organic molecular entity 19537
                            organic group 18451
                              organic divalent group 18445
                                organodiyl group 18445
                                  carbonyl group 18346
                                    carbonyl compound 18346
                                      carboxylic acid 18019
                                        carboacyl group 17177
                                          univalent carboacyl group 17177
                                            carbamoyl group 16916
                                              carboxamide 16916
                                                ceramide 108
                                                  1-O-acyl-N-acylsphingosine + 0
                                                  1-O-acylceramide + 0
                                                  Cer(d18:0/18:1(11Z)) 0
                                                  Cer(d18:1(8Z)/19:0) 0
                                                  Cer(d18:1/18:1(11Z)) 0
                                                  N-(1,3-dihydroxyoctadec-4-en-2-yl)acetamide 0
                                                  N-(2-hydroxy-tetracosanoyl)-hexadecasphing-4-enine 0
                                                  N-(2-hydroxyacyl)sphingoid 0
                                                  N-(2-hydroxyhenicosanoyl)-4,8-sphingadienine 0
                                                  N-(2-hydroxytridecanoyl)-phytosphingosine 0
                                                  N-[(2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]acetamide 0
                                                  N-[12-[(7-Nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-ceramide 0
                                                  N-[omega-(acylyloxy)]acylsphin-4-enine + 0
                                                  N-acyl-(4E,14Z)-sphingadienine + 0
                                                  N-acyl-(4E,8E)-9-methylsphinga-4,8-dienine 0
                                                  N-acyl-(4E,8E)-sphinga-4,8-dienine 0
                                                  N-acyl-(4E,8E,10E)-sphinga-4,8,10-trienine 0
                                                  N-acyl-(4E,8Z)-sphinga-4,8-dienine 0
                                                  N-acyl-1-deoxy-4-hydroxysphinganine + 0
                                                  N-acyl-1-deoxysphinganine 0
                                                  N-acyl-15-methylhexadecasphing-4-enine + 0
                                                  N-acylheptadecasphingosine + 0
                                                  N-acylhexadecasphingosine 0
                                                  N-acylsphingoid + 85
                                                  N-acyltetradecasphing-4-enine 0
                                                  N-docosanoyl-(4E,14Z)-sphinga-4,14-dienine 0
                                                  N-docosanoyl-14-methylhexadecasphingosine 0
                                                  N-henicosanoyl-14-methylhexadecasphingosine 0
                                                  N-heptadecanoyl-14-methylhexadecasphingosine 0
                                                  N-hexacosanoyl-14-methylhexadecasphinganine 0
                                                  N-hexacosanoyl-14-methylhexadecasphingosine 0
                                                  N-hexadecanoyl-14-methylhexadecasphingosine 0
                                                  N-pentacosanoyl-14-methylhexadecasphingosine 0
                                                  N-tetracosanoyl-14-methylhexadecasphingosine 0
                                                  N-tetracosenoyl-C17-sphingosine 0
                                                  N-tricosanoyl-(4E,14Z)-sphinga-4,14-dienine 0
                                                  N-tricosanoyl-14-methylhexadecasphingosine 0
                                                  N-tricosenoyl-14-methylhexadecasphingosine 0
                                                  ceramide 1-phosphate + 1
                                                  ceramide 1-phosphonate + 0
                                                  cerebroside + 10
                                                  ganglioside + 12
                                                  glycosylceramide + 10
                                                  oligoglycosylceramide + 3
                                                  omega-hydroxy-ultra-long chain fatty acylceramide + 0
                                                  omega-linoleoyloxy-O-ultra-long chain acylceramide + 0
                                                  phosphocerebroside + 0
                                                  phytoceramides + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.