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dihydrosanguinarine - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dihydrosanguinarine
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Accession:CHEBI:17209 term browser browse the term
Definition:A benzophenanthridine alkaloid obtained by selective hydrogenation of the 13,14-position of sanguinarine.
Synonyms:exact_synonym: 13-methyl-13,14-dihydro-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine
 related_synonym: 13,14-dihydro-13-methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine;   Formula=C20H15NO4;   InChI=1S/C20H15NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-7H,8-10H2,1H3;   InChIKey=CIUHLXZTZWTVFL-UHFFFAOYSA-N;   SMILES=CN1Cc2c3OCOc3ccc2-c2ccc3cc4OCOc4cc3c12;   dihydroavicine
 alt_id: CHEBI:14161;   CHEBI:23766;   CHEBI:4584
 xref: CAS:3606-45-9;   KEGG:C05191;   KNApSAcK:C00001847;   KNApSAcK:C00024647
 xref_mesh: MESH:C501843
 xref: PMID:11488455;   PMID:11488467;   PMID:12898646;   PMID:17260290;   PMID:18309269;   PMID:18420297;   PMID:18495316;   PMID:19346183;   PMID:19578993;   PMID:19629460;   PMID:19647059;   PMID:19873781;   PMID:20226485;   PMID:20385218;   PMID:20600683;   PMID:20683512;   PMID:20686258;   PMID:21500094;   Reaxys:48770

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show annotations for term's descendants           Sort by:
dihydrosanguinarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO dihydrosanguinarine results in increased activity of CASP3 protein CTD PMID:19346183 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO dihydrosanguinarine results in increased activity of CASP9 protein CTD PMID:19346183 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases chemical synthesis EXP NQO1 protein results in increased chemical synthesis of dihydrosanguinarine CTD PMID:24300172 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        biochemical role 19566
          metabolite 19554
            dihydrosanguinarine 3
              dihydrochelirubine 0
              dihydromacarpine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            organic molecule 19713
                              organic cyclic compound 19505
                                organic heterocyclic compound 18875
                                  organonitrogen heterocyclic compound 18154
                                    benzophenanthridine 146
                                      benzophenanthridine alkaloid 125
                                        sanguinarine 64
                                          dihydrosanguinarine 3
                                            dihydrochelirubine 0
                                            dihydromacarpine 0
paths to the root