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ONTOLOGY REPORT - ANNOTATIONS


Term:sanguinarine
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Accession:CHEBI:17183 term browser browse the term
Definition:A botanical anti-fungal agent that has formula C20H14NO4.
Synonyms:exact_synonym: 13-methyl-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridinium
 related_synonym: 13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium;   Formula=C20H14NO4;   InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1;   InChIKey=INVGWHRKADIJHF-UHFFFAOYSA-N;   SMILES=C[n+]1cc2c3OCOc3ccc2c2ccc3cc4OCOc4cc3c12
 alt_id: CHEBI:15064;   CHEBI:26601;   CHEBI:9022
 xref: BPDB:2914;   CAS:2447-54-3 "KEGG COMPOUND";   KEGG:C06162;   KNApSAcK:C00001917;   KNApSAcK:C00024663;   LINCS:LSM-6639
 xref_mesh: MESH:C005705
 xref: PMID:19346183 "Europe PMC"


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sanguinarine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Arnt aryl hydrocarbon receptor nuclear translocator JBrowse link 2 196,594,178 196,651,486 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l14 BCL2 like 14 JBrowse link 4 168,139,964 168,183,726 RGD:6480464
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:6480464
G Bik BCL2-interacting killer JBrowse link 7 124,390,924 124,410,449 RGD:6480464
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6480464
G Bnip3l BCL2 interacting protein 3 like JBrowse link 15 43,643,897 43,667,123 RGD:6480464
G Card6 caspase recruitment domain family, member 6 JBrowse link 2 54,810,676 54,824,050 RGD:6480464
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp4 caspase 4 JBrowse link 8 2,616,391 2,651,682 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cldn2 claudin 2 JBrowse link X 111,122,552 111,133,188 RGD:6480464
G Cldn3 claudin 3 JBrowse link 12 21,831,341 21,832,813 RGD:6480464
G Cldn4 claudin 4 JBrowse link 12 24,761,210 24,763,008 RGD:6480464
G Cldn5 claudin 5 JBrowse link 11 86,356,292 86,357,718 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Dedd2 death effector domain containing 2 JBrowse link 1 82,073,024 82,089,028 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:6480464
G Ggt1 gamma-glutamyltransferase 1 JBrowse link 20 14,019,723 14,045,781 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Hal histidine ammonia lyase JBrowse link 7 34,326,087 34,356,413 RGD:6480464
G Hpgds hematopoietic prostaglandin D synthase JBrowse link 4 95,945,356 95,970,666 RGD:6480464
G Ltb lymphotoxin beta JBrowse link 20 5,184,631 5,186,476 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Nfkbiz NFKB inhibitor zeta JBrowse link 11 47,243,342 47,271,487 RGD:6480464
G Nlrp1a NLR family, pyrin domain containing 1A JBrowse link 10 57,692,474 57,747,608 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:6480464
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:6480464
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:6480464
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:6480464
G Tyr tyrosinase JBrowse link 1 151,012,598 151,106,802 RGD:6480464
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:6480464
dihydrosanguinarine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        antimicrobial agent 17154
          alkaloid antibiotic 262
            sanguinarine 51
              10-hydroxydihydrosanguinarine 0
              chelirubine + 0
              dihydrosanguinarine + 3
              macarpine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic molecule 19337
                              organic cyclic compound 19089
                                organic heterocyclic compound 18164
                                  organonitrogen heterocyclic compound 16979
                                    benzophenanthridine 119
                                      benzophenanthridine alkaloid 96
                                        sanguinarine 51
                                          10-hydroxydihydrosanguinarine 0
                                          chelirubine + 0
                                          dihydrosanguinarine + 3
                                          macarpine 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.