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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aminophenazone
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Accession:CHEBI:160246 term browser browse the term
Definition:A pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.
Synonyms:related_synonym: (Dimethylamino)phenazone;   1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone;   1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one;   3-Keto-1,5-dimethyl-4-dimethylamino-2-phenyl-2,3-dihydropyrazole;   4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one;   4-(Dimethylamino)antipyrine;   4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolone;   4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one;   4-Dimethylaminoantipyrine;   4-Dimethylaminophenazone;   Aminofenazone;   Aminophenazon;   Aminopyrine;   Dimethylaminoantipyrine;   Dimethylaminoazophene;   Dimethylaminophenazon;   Dimethylaminophenazone;   Dimethylaminophenyldimethylpyrazolone;   Dipyrine;   Formula=C13H17N3O;   InChI=1S/C13H17N3O/c1-10-12(14(2)3)13(17)16(15(10)4)11-8-6-5-7-9-11/h5-9H,1-4H3;   InChIKey=RMMXTBMQSGEXHJ-UHFFFAOYSA-N;   SMILES=CN(C)c1c(C)n(C)n(-c2ccccc2)c1=O;   aminofenazona;   aminophenazonum
 xref: Beilstein:222626;   CAS:58-15-1;   DrugBank:DB01424;   Drug_Central:171;   Gmelin:103164;   HMDB:HMDB0015493;   KEGG:C07539;   KEGG:D00556;   LINCS:LSM-20000
 xref_mesh: MESH:D000632
 xref: PMID:23603897;   PMID:23727364;   PMID:24428683;   Reaxys:222626;   Wikipedia:Aminophenazone


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aminophenazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions
decreases methylation		 ISO Amoxicillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine]; Piperacillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine] CTD PMID:26763401
G Il1b interleukin 1 beta increases expression ISO Aminopyrine results in increased expression of IL1B mRNA CTD PMID:24747151 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO Aminopyrine analog results in decreased activity of PTGS1 protein; Aminopyrine results in decreased activity of PTGS1 protein CTD PMID:16141368 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        xenobiotic 18707
          aminophenazone 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  heteroarene 17117
                                    monocyclic heteroarene 14853
                                      azole 14358
                                        diazole 10469
                                          pyrazoles 2317
                                            pyrazolone 86
                                              aminophenazone 3
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