Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrazolone
go back to main search page
Accession:CHEBI:83328 term browser browse the term
Definition:A member of the class of pyrazoles in which one of the carbons of the pyrazole ring is substituted by an oxo group.
Synonyms:related_synonym: pyrazolones


show annotations for term's descendants           Sort by:
 
aminophenazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions
decreases methylation
ISO Amoxicillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine]; Piperacillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine] CTD PMID:26763401 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Il1b interleukin 1 beta increases expression ISO Aminopyrine results in increased expression of IL1B mRNA CTD PMID:24747151 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO Aminopyrine analog results in decreased activity of PTGS1 protein; Aminopyrine results in decreased activity of PTGS1 protein CTD PMID:16141368 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
antipyrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgds prostaglandin D2 synthase decreases activity ISO Antipyrine results in decreased activity of PTGDS protein CTD PMID:15718289 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO Antipyrine analog results in decreased activity of PTGS1 protein; Antipyrine results in decreased activity of PTGS1 protein CTD PMID:16141368 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein affects the reaction [Endotoxins results in increased abundance of Antipyrine] CTD PMID:15659313 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
C646 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir224 microRNA 224 decreases expression ISO C646 decreased expression of miR244 in a human hepatocellular carcinoma cell line RGD PMID:22459148 RGD:18182922 NCBI chr  X:152,223,754...152,223,835
Ensembl chr  X:152,223,754...152,223,835
JBrowse link
edaravone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of ADORA1 mRNA] CTD PMID:31344373 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP Edaravone inhibits the reaction [Lipopolysaccharides results in decreased expression of AGTR1A mRNA] CTD PMID:19118600 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR2 mRNA] CTD PMID:19118600 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 mRNA]; Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 protein] CTD PMID:18078833 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions EXP Edaravone inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]; Edaravone inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein] CTD PMID:18951527 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Edaravone inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA]; Edaravone inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA]; Edaravone inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA] CTD PMID:26111763 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Edaravone inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA] CTD PMID:26111763 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Edaravone inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA] CTD PMID:26111763 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp12 caspase 12 multiple interactions EXP Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein] CTD PMID:21429313 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP
ISO
Edaravone inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; Edaravone inhibits the reaction [PRNP protein alternative form results in increased activity of CASP3 protein]
Edaravone analog results in increased activity of CASP3 protein
CTD PMID:20806394, PMID:25684395, PMID:25947082 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity ISO Edaravone analog results in increased activity of CASP7 protein CTD PMID:25684395 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 decreases expression EXP Edaravone results in decreased expression of CASP8 protein CTD PMID:17967739 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO Edaravone analog results in increased activity of CASP9 protein CTD PMID:25684395 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 multiple interactions EXP Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL12 mRNA] CTD PMID:12954792 NCBI chr10:69,476,866...69,478,416
Ensembl chr10:69,476,775...69,478,462
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
EXP Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 mRNA]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of CCL2 protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of CCL2 protein]
Edaravone results in decreased expression of CCL2 mRNA; Edaravone results in decreased expression of CCL2 protein
CTD PMID:12954792, PMID:15948865, PMID:18803305, PMID:19381132 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression EXP Edaravone results in decreased expression of CCL3 mRNA CTD PMID:15948865 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of COMT mRNA] CTD PMID:31344373 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions
EXP Edaravone results in decreased expression of CXCL1 mRNA; Edaravone results in decreased expression of CXCL1 protein
Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]
CTD PMID:14654979, PMID:15629513 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions EXP Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of CXCL12 protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of CXCL12 protein] CTD PMID:18803305 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression
multiple interactions
EXP Edaravone results in decreased expression of CXCL2 mRNA
Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 mRNA]
CTD PMID:12954792, PMID:15948865 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression EXP Edaravone results in decreased expression of CXCL3 mRNA CTD PMID:15948865 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Edaravone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA] CTD PMID:18643790 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Edaravone inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA] CTD PMID:26111763 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Daxx death-domain associated protein decreases expression EXP Edaravone results in decreased expression of DAXX mRNA; Edaravone results in decreased expression of DAXX protein CTD PMID:17967739 NCBI chr20:5,480,103...5,485,962
Ensembl chr20:5,480,103...5,485,926
JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO Edaravone inhibits the reaction [Cisplatin results in decreased expression of EPHX2 protein] CTD PMID:26165641 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression EXP Edaravone results in increased expression of ERN1 mRNA CTD PMID:19558813 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fadd Fas associated via death domain decreases expression EXP Edaravone results in decreased expression of FADD mRNA; Edaravone results in decreased expression of FADD protein CTD PMID:17967739 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of FKBP5 mRNA] CTD PMID:31344373 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO Edaravone inhibits the reaction [cobaltous chloride results in increased expression of FLT1 mRNA]; Edaravone inhibits the reaction [cobaltous chloride results in increased expression of FLT1 protein] CTD PMID:24840734 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Edaravone inhibits the reaction [HIF1A protein binds to VEGFA promoter]] which affects the expression of VEGFA mRNA; Edaravone inhibits the reaction [HIF1A protein binds to VEGFA promoter]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] CTD PMID:17889387 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Edaravone results in increased expression of HMOX1 mRNA; Edaravone results in increased expression of HMOX1 protein
Edaravone promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]
CTD PMID:25348283, PMID:25422538 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression EXP Edaravone results in decreased expression of HSPA1A mRNA; Edaravone results in decreased expression of HSPA1A protein CTD PMID:19338546, PMID:19694712 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Edaravone promotes the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein] CTD PMID:21429313 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression EXP Edaravone results in decreased expression of ICAM1 mRNA; Edaravone results in decreased expression of ICAM1 protein alternative form CTD PMID:15948865, PMID:16301206 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions EXP Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IFNG mRNA]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein] CTD PMID:12954792, PMID:15629513 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Edaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL10 mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 mRNA] CTD PMID:12954792, PMID:14567445 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
decreases activity
ISO
EXP
Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA]; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein]
Edaravone results in decreased expression of IL1B mRNA
Edaravone inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 mRNA]; Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 protein]; Edaravone inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Edaravone inhibits the reaction [IL1B protein results in increased localization of and results in increased activity of RELA protein]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of IL1B protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of IL1B protein]
Edaravone results in decreased activity of IL1B protein
CTD PMID:15629513, PMID:15948865, PMID:16390820, PMID:18078833, PMID:18803305, PMID:19951488 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions EXP Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 mRNA]; Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 protein] CTD PMID:18078833 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il4 interleukin 4 multiple interactions EXP Edaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL4 mRNA] CTD PMID:14567445 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 affects activity
decreases expression
multiple interactions
EXP Edaravone affects the activity of IL6 protein
Edaravone results in decreased expression of IL6 mRNA
Edaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; Edaravone inhibits the reaction [Paraquat results in increased expression of IL6 protein]; Edaravone promotes the reaction [Taurocholic Acid results in increased expression of IL6 mRNA]
CTD PMID:12954792, PMID:14567445, PMID:15629865, PMID:18031376, PMID:20035747, PMID:21040696 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases activity ISO Edaravone results in decreased activity of MAP3K5 protein CTD PMID:15824197 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
decreases phosphorylation
ISO Edaravone results in increased phosphorylation of MAPK8 protein
Edaravone results in decreased phosphorylation of MAPK8 protein
CTD PMID:15824197, PMID:19954754 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
EXP Edaravone results in decreased expression of MMP2 protein
Edaravone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA]
CTD PMID:19381132, PMID:21040696 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Edaravone inhibits the reaction [PLAT protein results in increased expression of and results in increased activity of MMP9 protein]; Edaravone inhibits the reaction [PLAT protein results in increased expression of MMP9 mRNA] CTD PMID:19095969 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase affects expression
decreases activity
multiple interactions
decreases expression
EXP Edaravone affects the expression of MPO mRNA
Edaravone results in decreased activity of MPO protein
Edaravone inhibits the reaction [Taurocholic Acid results in increased activity of MPO protein]
Edaravone results in decreased expression of MPO protein
CTD PMID:14654979, PMID:18031376, PMID:19694712, PMID:20035747 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP Edaravone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NCF1 mRNA] CTD PMID:18643790 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 multiple interactions EXP Edaravone inhibits the reaction [Rotenone results in decreased expression of NDUFS1 mRNA] CTD PMID:27108097 NCBI chr 9:69,919,863...69,953,182
Ensembl chr 9:69,919,867...69,953,182
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions EXP Edaravone inhibits the reaction [Rotenone results in decreased expression of NDUFS4 mRNA] CTD PMID:27108097 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
ISO
EXP
Edaravone affects the localization of NFE2L2 protein
[Edaravone co-treated with Chlorpyrifos] results in increased expression of NFE2L2 protein; Edaravone promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 protein]
CTD PMID:25348283, PMID:25422538, PMID:30758894 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression EXP Edaravone results in increased expression of NFKBIA mRNA CTD PMID:18078833 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor increases expression
multiple interactions
ISO Edaravone results in increased expression of NGF mRNA; Edaravone results in increased expression of NGF protein
pyrazolanthrone inhibits the reaction [Edaravone results in increased expression of NGF mRNA]; pyrazolanthrone inhibits the reaction [Edaravone results in increased expression of NGF protein]; U 0126 inhibits the reaction [Edaravone results in increased expression of NGF mRNA]; U 0126 inhibits the reaction [Edaravone results in increased expression of NGF protein]
CTD PMID:19954754 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS1 protein] CTD PMID:18672383 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases degradation
decreases expression
ISO
EXP
Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]
Edaravone results in increased degradation of NOS2 mRNA
Edaravone results in decreased expression of NOS2 protein
Edaravone inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Edaravone inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]
CTD PMID:15629513, PMID:18078833, PMID:18496239, PMID:18672383 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
decreases degradation
EXP
ISO
Edaravone results in increased expression of NOS3 mRNA; Edaravone results in increased expression of NOS3 protein
Edaravone results in decreased degradation of NOS3 mRNA
CTD PMID:12969758, PMID:15721014 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Edaravone results in decreased expression of NPPA mRNA CTD PMID:15824197 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Edaravone analog results in increased cleavage of PARP1 protein CTD PMID:25684395 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions EXP Edaravone inhibits the reaction [PLAT protein results in increased activity of RELA protein]; Edaravone inhibits the reaction [PLAT protein results in increased expression of and results in increased activity of MMP9 protein]; Edaravone inhibits the reaction [PLAT protein results in increased expression of MMP9 mRNA] CTD PMID:19095969 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Edaravone inhibits the reaction [Rotenone results in decreased expression of PPARGC1A mRNA] CTD PMID:30240821 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prnp prion protein multiple interactions EXP Edaravone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD1 protein]; Edaravone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD2 protein]; Edaravone inhibits the reaction [PRNP protein alternative form results in increased activity of CASP3 protein] CTD PMID:20806394 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
EXP Edaravone inhibits the reaction [IL1B protein results in increased localization of and results in increased activity of RELA protein]; Edaravone inhibits the reaction [PLAT protein results in increased activity of RELA protein]
Edaravone results in decreased expression of RELA protein
CTD PMID:18078833, PMID:19095969, PMID:19381132 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sdc2 syndecan 2 multiple interactions EXP Edaravone inhibits the reaction [SDC2 protein promotes the reaction [Oxygen deficiency results in increased abundance of Reactive Oxygen Species]]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of CCL2 protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of CXCL12 protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of IL1B protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of TNF protein] CTD PMID:18803305 NCBI chr 7:71,572,731...71,686,139
Ensembl chr 7:71,572,941...71,686,044
JBrowse link
G Sele selectin E decreases expression EXP Edaravone results in decreased expression of SELE mRNA; Edaravone results in decreased expression of SELE protein CTD PMID:17064733 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of SLC6A15 mRNA] CTD PMID:31344373 NCBI chr 7:45,328,207...45,381,920
Ensembl chr 7:45,328,105...45,382,229
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Edaravone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD1 protein] CTD PMID:20806394 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Edaravone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD2 protein] CTD PMID:20806394 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Edaravone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:21040696 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Edaravone inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:27108097 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Edaravone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA] CTD PMID:21040696 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP Edaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of TNF protein]; Edaravone inhibits the reaction [Paraquat results in increased expression of TNF protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of TNF protein]; Edaravone promotes the reaction [Taurocholic Acid results in increased expression of TNF mRNA]
Edaravone results in decreased expression of TNF mRNA; Edaravone results in decreased expression of TNF protein
CTD PMID:12954792, PMID:14567445, PMID:15629513, PMID:15948865, PMID:17064733, PMID:18803305, PMID:20035747, PMID:21040696 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP Edaravone inhibits the reaction [Isoproterenol results in increased expression of UCP2 mRNA]; Edaravone inhibits the reaction [Isoproterenol results in increased expression of UCP2 protein] CTD PMID:16580698 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP Edaravone results in decreased expression of VCAM1 protein CTD PMID:19381132 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [Edaravone inhibits the reaction [HIF1A protein binds to VEGFA promoter]] which affects the expression of VEGFA mRNA; Edaravone inhibits the reaction [HIF1A protein binds to VEGFA promoter]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein] CTD PMID:17889387 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wdr35 WD repeat domain 35 multiple interactions EXP Edaravone inhibits the reaction [domoic acid results in increased expression of WDR35 protein] CTD PMID:23289926 NCBI chr 6:34,094,291...34,152,048
Ensembl chr 6:34,094,306...34,151,622
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      group 19728
        inorganic group 19185
          oxo group 18436
            organic oxo compound 18436
              carbonyl compound 18436
                pyrazolone 77
                  (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)\{4-[(6-methoxypyridazin-3-yl)sulfamoyl]anilino\}methanesulfonic acid + 0
                  3-hydroxymethylantipyrine 0
                  4-(5-carboxypentanamido)antipyrine 0
                  4-[1-(benzylamino)ethylidene]-2-(2,4-dibromophenyl)-5-methyl-2,4-dihydropyrazol-3-one 0
                  4-aminoantipyrine 0
                  4-formylaminoantipyrine 0
                  C646 1
                  aminophenazone 3
                  antipyrine + 3
                  edaravone 73
                  fenpyrazamine 0
                  propyphenazone 0
                  topramezone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  heteroarene 16467
                                    monocyclic heteroarene 13313
                                      azole 12480
                                        diazole 8135
                                          pyrazoles 1300
                                            pyrazolone 77
                                              (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)\{4-[(6-methoxypyridazin-3-yl)sulfamoyl]anilino\}methanesulfonic acid + 0
                                              3-hydroxymethylantipyrine 0
                                              4-(5-carboxypentanamido)antipyrine 0
                                              4-[1-(benzylamino)ethylidene]-2-(2,4-dibromophenyl)-5-methyl-2,4-dihydropyrazol-3-one 0
                                              4-aminoantipyrine 0
                                              4-formylaminoantipyrine 0
                                              C646 1
                                              aminophenazone 3
                                              antipyrine + 3
                                              edaravone 73
                                              fenpyrazamine 0
                                              propyphenazone 0
                                              topramezone 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.