Ikbkg (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma) - Rat Genome Database

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Gene: Ikbkg (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma) Rattus norvegicus
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Symbol: Ikbkg
Name: inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
RGD ID: 735223
Description: Enables peroxisome proliferator activated receptor binding activity. Predicted to be involved in several processes, including anoikis; regulation of gene expression; and regulation of signal transduction. Predicted to act upstream of or within several processes, including B cell homeostasis; canonical NF-kappaB signal transduction; and negative regulation of canonical NF-kappaB signal transduction. Part of IkappaB kinase complex. Used to study irritable bowel syndrome and perinatal necrotizing enterocolitis. Biomarker of acute myocardial infarction. Human ortholog(s) of this gene implicated in Behcet's disease; Bloch-Sulzberger syndrome; X-linked recessive disease (multiple); learning disability; and liver cancer. Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma); PARTICIPATES IN FasL mediated signaling pathway; interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH (+)-taxifolin; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: I-kappa-B kinase gamma; I-kappa-B kinase subunit gamma; ikB kinase subunit gamma; ikB kinase-associated protein 1; IKK-gamma; IKKAP1; IKKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of kappaB kinase gamma; inhibitor of nuclear factor kappa B kinase subunit gamma; inhibitor of nuclear factor kappa-B kinase subunit gamma; Nemo; NF-kappa B essential modulator; NF-kappa-B essential modifier; NF-kappa-B essential modulator
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X157,358,279 - 157,397,563 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX157,367,639 - 157,392,757 (+)EnsemblGRCr8
mRatBN7.2X152,216,485 - 152,241,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX152,216,596 - 152,239,499 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX154,366,048 - 154,379,411 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,928,859 - 157,942,222 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,601,075 - 155,614,438 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,254,187 - 156,280,046 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,257,173 - 156,270,748 (-)Ensemblrn6Rnor6.0
Rnor_5.01151,994,689 - 152,019,874 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X160,386,558 - 160,420,190 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1135,659,513 - 135,672,876 (-)NCBICelera
RGSC_v3.1X160,483,372 - 160,496,394 (+)NCBI
Cytogenetic MapXq37NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-benzofuran  (ISO)
17beta-estradiol  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
cannabidiol  (ISO)
capsiate  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carnosic acid  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cycloastragenol  (EXP)
Decursin  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
FR900359  (ISO)
furan  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
naphthalene-1,5-diamine  (ISO)
niclosamide  (ISO)
o-anisidine  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. NEMO expression in human hepatocellular carcinoma and its association with clinical outcome. Aigelsreiter A, etal., Hum Pathol. 2012 Jul;43(7):1012-9. doi: 10.1016/j.humpath.2011.08.009. Epub 2011 Dec 15.
2. Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis. An J, etal., Oncotarget. 2016 Aug 2;7(31):50131-50149. doi: 10.18632/oncotarget.10321.
3. NBD peptides protect against ischemia reperfusion after orthotopic liver transplantation in rats. Cheng MX, etal., J Surg Res. 2012 Aug;176(2):666-71. doi: 10.1016/j.jss.2011.12.005. Epub 2011 Dec 22.
4. Ciglitazone ameliorates lung inflammation by modulating the inhibitor kappaB protein kinase/nuclear factor-kappaB pathway after hemorrhagic shock. Chima RS, etal., Crit Care Med. 2008 Oct;36(10):2849-57.
5. Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury. Cubero FJ, etal., J Hepatol. 2015 Jan;62(1):140-9. doi: 10.1016/j.jhep.2014.08.029. Epub 2014 Aug 27.
6. Inhibition of nuclear factor-kappaB ameliorates bowel injury and prolongs survival in a neonatal rat model of necrotizing enterocolitis. De Plaen IG, etal., Pediatr Res. 2007 Jun;61(6):716-21.
7. Loss of Cyclin E1 attenuates hepatitis and hepatocarcinogenesis in a mouse model of chronic liver injury. Ehedego H, etal., Oncogene. 2018 Jun;37(25):3329-3339. doi: 10.1038/s41388-018-0181-8. Epub 2018 Mar 19.
8. Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout. Ehlken H, etal., Cell Death Differ. 2014 Nov;21(11):1721-32. doi: 10.1038/cdd.2014.83. Epub 2014 Jun 27.
9. NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex. Fontan E, etal., FEBS J. 2007 May;274(10):2540-51. Epub 2007 Apr 10.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
13. Colon-targeted cell-permeable NF¿B inhibitory peptide is orally active against experimental colitis. Hong S, etal., Mol Pharm. 2012 May 7;9(5):1310-9. doi: 10.1021/mp200591q. Epub 2012 Mar 27.
14. [NEMO Delta 4-10 deletion of NEMO gene in Chinese incontinentia pigmenti cases]. Li L, etal., Zhonghua Er Ke Za Zhi. 2005 Feb;43(2):89-92.
15. Cell-permeable Tat-NBD peptide attenuates rat pancreatitis and acinus cell inflammation response. Long YM, etal., World J Gastroenterol. 2009 Feb 7;15(5):561-9.
16. Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Luedde T, etal., Cancer Cell. 2007 Feb;11(2):119-32. doi: 10.1016/j.ccr.2006.12.016.
17. NF-κB essential modifier is required for hepatocyte proliferation and the oval cell reaction after partial hepatectomy in mice. Malato Y, etal., Gastroenterology. 2012 Dec;143(6):1597-1608.e11. doi: 10.1053/j.gastro.2012.08.030. Epub 2012 Aug 23.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. Incontinentia pigmenti: learning disabilities are a fundamental hallmark of the disease. Pizzamiglio MR, etal., PLoS One. 2014 Jan 29;9(1):e87771. doi: 10.1371/journal.pone.0087771. eCollection 2014.
22. Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats. Ren YS, etal., J Proteomics. 2020 Jun 30;222:103691. doi: 10.1016/j.jprot.2020.103691. Epub 2020 Feb 14.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines. Saito N, etal., J Biol Chem 2003 Nov 21;278(47):46565-75. Epub 2003 Sep 10.
28. Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium. Smahi A, etal., Nature. 2000 May 25;405(6785):466-72.
29. NEMO mutation as a cause of familial occurrence of Behçet's disease in female patients. Takada H, etal., Clin Genet. 2010 Dec;78(6):575-9. doi: 10.1111/j.1399-0004.2010.01432.x.
30. Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation. Tas SW, etal., Arthritis Res Ther. 2006;8(4):R86.
31. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
32. Novel splicing mutation in the NEMO (IKK-gamma) gene with severe immunodeficiency and heterogeneity of X-chromosome inactivation. Ørstavik KH, etal., Am J Med Genet A. 2006 Jan 1;140(1):31-9.
Additional References at PubMed
PMID:11113112   PMID:12235208   PMID:14651848   PMID:14654787   PMID:14743216   PMID:15341735   PMID:15620648   PMID:15946255   PMID:17314283   PMID:17702576   PMID:18462684   PMID:21454665  
PMID:21988832   PMID:23016877   PMID:23091055   PMID:23453807   PMID:23776175   PMID:23778976   PMID:24561039   PMID:25861989   PMID:30561431   PMID:37683611  


Genomics

Comparative Map Data
Ikbkg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X157,358,279 - 157,397,563 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX157,367,639 - 157,392,757 (+)EnsemblGRCr8
mRatBN7.2X152,216,485 - 152,241,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX152,216,596 - 152,239,499 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX154,366,048 - 154,379,411 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,928,859 - 157,942,222 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,601,075 - 155,614,438 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,254,187 - 156,280,046 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,257,173 - 156,270,748 (-)Ensemblrn6Rnor6.0
Rnor_5.01151,994,689 - 152,019,874 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X160,386,558 - 160,420,190 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1135,659,513 - 135,672,876 (-)NCBICelera
RGSC_v3.1X160,483,372 - 160,496,394 (+)NCBI
Cytogenetic MapXq37NCBI
IKBKG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,541,238 - 154,565,046 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX154,541,179 - 154,565,047 (+)Ensemblhg38GRCh38
GRCh37X153,769,453 - 153,793,261 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,423,653 - 153,446,455 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X153,339,765 - 153,356,964NCBI
CeleraX153,931,508 - 153,953,200 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,346,885 - 142,356,952 (+)NCBIHuRef
CHM1_1X153,682,228 - 153,705,030 (+)NCBICHM1_1
T2T-CHM13v2.0X152,777,621 - 152,801,428 (+)NCBIT2T-CHM13v2.0
Ikbkg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,436,883 - 73,498,013 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX73,436,896 - 73,497,460 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X74,393,233 - 74,456,792 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,393,290 - 74,453,854 (+)Ensemblmm10GRCm38
MGSCv37X71,638,630 - 71,699,117 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X70,682,424 - 70,704,240 (+)NCBIMGSCv36mm8
CeleraX65,647,484 - 65,706,592 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.0NCBI
Ikbkg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555801,053,823 - 1,069,802 (+)Ensembl
ChiLan1.0NW_0049555801,053,823 - 1,069,802 (+)NCBIChiLan1.0ChiLan1.0
IKBKG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X154,521,470 - 154,539,144 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X154,524,964 - 154,546,311 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X143,988,720 - 144,010,078 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X153,869,352 - 153,876,677 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,854,493 - 153,876,092 (+)EnsemblpanPan2panpan1.1
IKBKG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X122,232,052 - 122,253,499 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX122,235,878 - 122,250,562 (+)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0X125,373,537 - 125,395,176 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX125,373,743 - 125,395,172 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X121,142,500 - 121,164,137 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,657,571 - 123,679,200 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X123,419,351 - 123,440,993 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ikbkg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,519,768 - 119,569,193 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368091,257,654 - 1,301,813 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049368091,280,254 - 1,306,964 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IKBKG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,036,508 - 125,056,453 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X125,035,575 - 125,056,445 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,478,840 - 143,498,934 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103232832
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,781,975 - 128,816,039 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,787,785 - 128,806,083 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606566,774,279 - 66,797,151 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ikbkg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946996,814 - 1,013,379 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624946997,571 - 1,015,748 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ikbkg
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X128,431,077 - 128,451,167 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:75
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000056275
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118973754157758123Rat

Markers in Region
AF069542  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,238,286 - 152,238,475 (-)MAPPERmRatBN7.2
Rnor_6.0X156,257,188 - 156,257,376NCBIRnor6.0
Rnor_5.01151,997,690 - 151,997,878UniSTSRnor5.0
RGSC_v3.4X160,420,186 - 160,420,374UniSTSRGSC3.4
Celera1135,659,329 - 135,659,517UniSTS
Cytogenetic MapXq37UniSTS
RH134438  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,007,793 - 152,007,978 (-)MAPPERmRatBN7.2
Rnor_6.0X156,487,025 - 156,487,209NCBIRnor6.0
Rnor_5.01152,227,171 - 152,227,355UniSTSRnor5.0
RGSC_v3.4X160,385,406 - 160,385,590UniSTSRGSC3.4
Celera1135,888,751 - 135,888,935UniSTS
Cytogenetic MapXq37UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_199103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC095267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY392762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000078438   ⟹   ENSRNOP00000075158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX157,372,561 - 157,392,757 (+)Ensembl
mRatBN7.2 EnsemblX152,221,280 - 152,239,499 (+)Ensembl
Rnor_6.0 EnsemblX156,257,173 - 156,270,748 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107762   ⟹   ENSRNOP00000092097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX157,367,877 - 157,392,755 (+)Ensembl
mRatBN7.2 EnsemblX152,216,596 - 152,239,499 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122628   ⟹   ENSRNOP00000110774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX157,367,639 - 157,392,757 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129825   ⟹   ENSRNOP00000100028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX157,368,663 - 157,392,757 (+)Ensembl
RefSeq Acc Id: NM_199103   ⟹   NP_954534
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,372,885 - 157,392,757 (+)NCBI
mRatBN7.2X152,221,604 - 152,241,476 (+)NCBI
Rnor_6.0X156,257,372 - 156,270,735 (-)NCBI
Rnor_5.01151,994,689 - 152,019,874 (-)NCBI
RGSC_v3.4X160,386,558 - 160,420,190 (+)RGD
Celera1135,659,513 - 135,672,876 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229580   ⟹   XP_006229642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,358,283 - 157,397,563 (+)NCBI
mRatBN7.2X152,216,497 - 152,241,476 (+)NCBI
Rnor_6.0X156,254,187 - 156,280,045 (-)NCBI
Rnor_5.01151,994,689 - 152,019,874 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773601   ⟹   XP_008771823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,358,279 - 157,397,563 (+)NCBI
mRatBN7.2X152,216,485 - 152,241,476 (+)NCBI
Rnor_6.0X156,254,187 - 156,280,046 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773602   ⟹   XP_008771824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,358,279 - 157,397,563 (+)NCBI
mRatBN7.2X152,216,485 - 152,241,476 (+)NCBI
Rnor_6.0X156,254,187 - 156,280,046 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773603   ⟹   XP_008771825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,358,279 - 157,397,563 (+)NCBI
mRatBN7.2X152,216,485 - 152,241,476 (+)NCBI
Rnor_6.0X156,254,187 - 156,280,046 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773607   ⟹   XP_008771829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,358,281 - 157,397,563 (+)NCBI
mRatBN7.2X152,216,489 - 152,241,476 (+)NCBI
Rnor_6.0X156,254,187 - 156,278,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773608   ⟹   XP_008771830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,372,697 - 157,397,563 (+)NCBI
mRatBN7.2X152,221,299 - 152,241,476 (+)NCBI
Rnor_6.0X156,254,187 - 156,274,120 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773610   ⟹   XP_008771832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,372,697 - 157,397,563 (+)NCBI
mRatBN7.2X152,221,299 - 152,241,476 (+)NCBI
Rnor_6.0X156,254,187 - 156,274,120 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063279970   ⟹   XP_063136040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,358,279 - 157,397,563 (+)NCBI
RefSeq Acc Id: XM_063279971   ⟹   XP_063136041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,358,280 - 157,397,563 (+)NCBI
RefSeq Acc Id: XM_063279972   ⟹   XP_063136042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,372,697 - 157,397,563 (+)NCBI
RefSeq Acc Id: NP_954534   ⟸   NM_199103
- UniProtKB: Q6TMG5 (UniProtKB/Swiss-Prot),   A0A8L2RB98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229642   ⟸   XM_006229580
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AH74 (UniProtKB/TrEMBL),   A0A8L2RB98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771823   ⟸   XM_008773601
- Peptide Label: isoform X1
- UniProtKB: A6KRP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771824   ⟸   XM_008773602
- Peptide Label: isoform X1
- UniProtKB: A6KRP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771825   ⟸   XM_008773603
- Peptide Label: isoform X1
- UniProtKB: A6KRP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771829   ⟸   XM_008773607
- Peptide Label: isoform X5
- UniProtKB: A6KRP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771832   ⟸   XM_008773610
- Peptide Label: isoform X5
- UniProtKB: A6KRP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771830   ⟸   XM_008773608
- Peptide Label: isoform X5
- UniProtKB: A6KRP8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075158   ⟸   ENSRNOT00000078438
Ensembl Acc Id: ENSRNOP00000092097   ⟸   ENSRNOT00000107762
RefSeq Acc Id: XP_063136040   ⟸   XM_063279970
- Peptide Label: isoform X3
- UniProtKB: A0A8L2RB98 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136041   ⟸   XM_063279971
- Peptide Label: isoform X4
- UniProtKB: A6KRP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136042   ⟸   XM_063279972
- Peptide Label: isoform X5
- UniProtKB: A6KRP8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100028   ⟸   ENSRNOT00000129825
Ensembl Acc Id: ENSRNOP00000110774   ⟸   ENSRNOT00000122628
Protein Domains
CCHC NOA-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6TMG5-F1-model_v2 AlphaFold Q6TMG5 1-412 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735223 AgrOrtholog
BioCyc Gene G2FUF-618 BioCyc
Ensembl Genes ENSRNOG00000060936 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000078438 ENTREZGENE
  ENSRNOT00000107762 ENTREZGENE
  ENSRNOT00000122628 ENTREZGENE
  ENSRNOT00000129825 ENTREZGENE
Gene3D-CATH L1 transposable element, trimerization domain UniProtKB/Swiss-Prot
  Nemo cc2-lz domain - 1d5 darpin complex UniProtKB/Swiss-Prot
InterPro CC2-LZ_dom UniProtKB/Swiss-Prot
  NEMO_N UniProtKB/Swiss-Prot
  NEMO_ZF UniProtKB/Swiss-Prot
  Optineurin/NFkB_EssMod UniProtKB/Swiss-Prot
KEGG Report rno:309295 UniProtKB/Swiss-Prot
NCBI Gene 309295 ENTREZGENE
PANTHER NF-KAPPA-B ESSENTIAL MODULATOR UniProtKB/Swiss-Prot
  NF-KAPPA-B ESSENTIAL MODULATOR UniProtKB/Swiss-Prot
Pfam CC2-LZ UniProtKB/Swiss-Prot
  NEMO UniProtKB/Swiss-Prot
  zf_C2H2_10 UniProtKB/Swiss-Prot
PhenoGen Ikbkg PhenoGen
PROSITE ZF_CCHC_NOA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000060936 RatGTEx
UniProt A0A8I6AH74 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2RB98 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LEZ1_RAT UniProtKB/TrEMBL
  A0ABK0LWR3_RAT UniProtKB/TrEMBL
  A6KRP8 ENTREZGENE, UniProtKB/TrEMBL
  NEMO_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Ikbkg  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma  Ikbkg  inhibitor of nuclear factor kappa B kinase subunit gamma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-02-01 Ikbkg  inhibitor of nuclear factor kappa B kinase subunit gamma  Ikbkg  inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-05-27 Ikbkg  inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma  Ikbkg  inhibitor of kappaB kinase gamma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Ikbkg  inhibitor of kappaB kinase gamma    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma  Name updated 1299863 APPROVED