Tff1 (trefoil factor 1) - Rat Genome Database

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Gene: Tff1 (trefoil factor 1) Rattus norvegicus
Analyze
Symbol: Tff1
Name: trefoil factor 1
RGD ID: 620707
Description: Predicted to enable growth factor activity. Involved in several processes, including maintenance of gastrointestinal epithelium; response to immobilization stress; and response to iron ion. Located in extracellular space. Biomarker of colitis and gastric ulcer. Orthologous to human TFF1 (trefoil factor 1); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ps2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,237,095 - 9,240,956 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl209,237,095 - 9,240,956 (-)EnsemblGRCr8
mRatBN7.2209,235,736 - 9,239,597 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,235,736 - 9,239,597 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx209,930,565 - 9,934,421 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,291,735 - 9,295,591 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,766,849 - 9,770,721 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,892,124 - 9,895,984 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,892,124 - 9,895,984 (-)Ensemblrn6Rnor6.0
Rnor_5.02012,071,835 - 12,075,695 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4209,526,674 - 9,530,534 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2010,760,042 - 10,763,903 (-)NCBICelera
RGSC_v3.1209,526,900 - 9,530,761 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rh1  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(3-phenoxyphenyl)methanol  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-benzylpiperazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2-acetamidofluorene  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-methylcholanthrene  (ISO)
3-phenoxybenzoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-nonylphenol  (ISO)
4-tert-butylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
adenine  (ISO)
afimoxifene  (ISO)
alpha-mangostin  (ISO)
alpha-Zearalanol  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzyl benzoate  (ISO)
Benzyl salicylate  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bifenthrin  (ISO)
biphenyl-4-ol  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
camptothecin  (ISO)
capecitabine  (ISO)
captafol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyprodinil  (ISO)
daidzein  (ISO)
DDE  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
equilin  (ISO)
equol  (ISO)
estriol  (ISO)
estrone  (ISO)
ethylparaben  (ISO)
exemestane  (ISO)
fenvalerate  (ISO)
flumethrin  (ISO)
Flumetralin  (ISO)
flutolanil  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
Goe 6976  (ISO)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (ISO)
hexestrol  (ISO)
hydrogen peroxide  (ISO)
icariin  (ISO)
ICI-164384  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
Isobavachin  (ISO)
isoprothiolane  (ISO)
isorhamnetin  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
melatonin  (ISO)
menadione  (ISO)
methimazole  (EXP)
methoxychlor  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
molibresib  (ISO)
Moxestrol  (ISO)
N-nitrosodiethylamine  (EXP)
nandrolone  (ISO)
naphthalene  (ISO)
nilotinib  (ISO)
Nonylphenol  (EXP,ISO)
Norethynodrel  (ISO)
ospemifene  (ISO)
oxazepam  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoropentanoic acid  (ISO)
permethrin  (ISO)
phenothrin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propylparaben  (ISO)
pyrimethanil  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
rosuvastatin calcium  (ISO)
rottlerin  (ISO)
royal jelly  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 203580  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sophoraflavanone B  (ISO)
spironolactone  (ISO)
stilbene-4,4'-diol  (ISO)
SU6656  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
titanium dioxide  (ISO)
toxaphene  (ISO)
trans-stilbene-4,4'-diol  (ISO)
trichostatin A  (ISO)
triclocarban  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)
xanthohumol  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Gene chip analyses reveal differential genetic responses to iron deficiency in rat duodenum and jejunum. Collins JF Biol Res. 2006;39(1):25-37.
2. Differential RNA expression of the pS2 gene in the human benign and malignant prostatic tissue. Colombel M, etal., J Urol. 1999 Sep;162(3 Pt 1):927-30.
3. Cytosolic levels of TFF1/pS2 in breast cancer: Their relationship with clinical-pathological parameters and their prognostic significance. Corte MD, etal., Breast Cancer Res Treat. 2006 Mar;96(1):63-72. Epub 2005 Nov 3.
4. Gastric TFF1 Expression from Acute to Chronic Helicobacter Infection. Esposito R, etal., Front Cell Infect Microbiol. 2017 Oct 9;7:434. doi: 10.3389/fcimb.2017.00434. eCollection 2017.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis. Itoh H, etal., Biochem J 1996 Sep 15;318 ( Pt 3):939-44.
7. Trefoil factors are expressed in human and rat endocrine pancreas: differential regulation by growth hormone. Jackerott M, etal., Endocrinology. 2006 Dec;147(12):5752-9. Epub 2006 Sep 14.
8. Effect of omeprazole-induced achlorhydria on trefoil peptide expression in the rat stomach. Kang B, etal., J Gastroenterol Hepatol. 2001 Nov;16(11):1222-7.
9. Expression of pS2 protein in endometrial carcinomas: correlation with clinicopathologic features and sex steroid receptor status. Koshiyama M, etal., Int J Cancer. 1997 Jun 20;74(3):237-44.
10. Tumor-associated neoexpression of the pS2 peptide and MUC5AC mucin in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder. Kunze E, etal., Histol Histopathol. 2008 May;23(5):539-48.
11. Expression of pS2 protein in transitional cell bladder tumours. Lipponen PK and Eskelinen MJ, J Pathol. 1994 Aug;173(4):327-32.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue Nie SN, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005 May;17(5):302-6.
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Estrogen receptor alpha and beta, progesterone receptor, pS2 and HER-2/neu expression delineate different subgroups in ductal carcinoma in situ of the breast. Rody A, etal., Oncol Rep. 2004 Oct;12(4):695-9.
19. Changes in expression of estrogen receptors alpha and beta in relation to progesterone receptor and pS2 status in normal and malignant endometrium. Saegusa M and Okayasu I, Jpn J Cancer Res. 2000 May;91(5):510-8.
20. Up-regulation of pS2 expression during the development of adenocarcinomas but not squamous cell carcinomas of the uterine cervix, independently of expression of c-jun or oestrogen and progesterone receptors. Saegusa M, etal., J Pathol. 2000 Apr;190(5):554-63.
21. pS2 and PAI-1 in ovarian cancer: correlation to pathohistological parameters. Speiser P, etal., Anticancer Res. 1997 Jan-Feb;17(1B):679-83.
22. Spatio-temporal expression of trefoil peptide following severe gastric ulceration in the rat implicates it in late-stage repair processes. Ulaganathan M, etal., J Gastroenterol Hepatol. 2001 May;16(5):506-12.
23. Plasma levels of trefoil factors are increased in patients with advanced prostate cancer. Vestergaard EM, etal., Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):807-12.
24. Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer. Walker G, etal., Gynecol Oncol. 2007 Sep;106(3):461-8. Epub 2007 Jul 10.
Additional References at PubMed
PMID:8824193   PMID:15526382   PMID:18813976   PMID:24107452   PMID:24116124   PMID:24588600   PMID:26459015   PMID:39142164  


Genomics

Comparative Map Data
Tff1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,237,095 - 9,240,956 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl209,237,095 - 9,240,956 (-)EnsemblGRCr8
mRatBN7.2209,235,736 - 9,239,597 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,235,736 - 9,239,597 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx209,930,565 - 9,934,421 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,291,735 - 9,295,591 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,766,849 - 9,770,721 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,892,124 - 9,895,984 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,892,124 - 9,895,984 (-)Ensemblrn6Rnor6.0
Rnor_5.02012,071,835 - 12,075,695 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4209,526,674 - 9,530,534 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2010,760,042 - 10,763,903 (-)NCBICelera
RGSC_v3.1209,526,900 - 9,530,761 (-)NCBI
Cytogenetic Map20p12NCBI
TFF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382142,362,282 - 42,366,535 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2142,362,282 - 42,366,535 (-)Ensemblhg38GRCh38
GRCh372143,782,391 - 43,786,644 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,655,460 - 42,659,713 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342142,655,459 - 42,659,713NCBI
Celera2128,931,367 - 28,935,619 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2129,199,645 - 29,203,896 (-)NCBIHuRef
CHM1_12143,342,564 - 43,346,817 (-)NCBICHM1_1
T2T-CHM13v2.02140,751,729 - 40,755,982 (-)NCBIT2T-CHM13v2.0
Tff1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,380,369 - 31,384,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1731,380,369 - 31,384,251 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381731,161,395 - 31,165,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1731,161,395 - 31,165,277 (-)Ensemblmm10GRCm38
MGSCv371731,298,341 - 31,301,998 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361730,888,408 - 30,892,034 (-)NCBIMGSCv36mm8
Celera1732,078,643 - 32,082,300 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.8NCBI
Tff1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540739,363,693 - 39,365,724 (+)NCBIChiLan1.0ChiLan1.0
TFF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22238,417,954 - 38,422,193 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12133,270,372 - 33,274,614 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02128,669,323 - 28,673,556 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12141,988,039 - 41,992,270 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2141,988,039 - 41,992,270 (-)EnsemblpanPan2panpan1.1
TFF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13136,681,478 - 36,684,571 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3136,681,357 - 36,695,665 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3135,832,379 - 35,835,472 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03136,197,946 - 36,201,048 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3136,197,825 - 36,201,061 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13136,090,916 - 36,094,013 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03136,071,100 - 36,074,201 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03136,566,194 - 36,569,306 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
TFF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13205,687,560 - 205,691,460 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113205,687,558 - 205,691,512 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213216,090,047 - 216,093,946 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TFF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1286,239,101 - 86,244,491 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl286,239,105 - 86,243,795 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605414,199,648 - 14,204,451 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tff1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1182,714,155 - 2,717,891 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tff1
39 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:98
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000001538
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20904109911115921Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
13 1 7 9 9 7 2 25 12 2 20 9

Sequence


Ensembl Acc Id: ENSRNOT00000001538   ⟹   ENSRNOP00000001538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl209,237,095 - 9,240,956 (-)Ensembl
mRatBN7.2 Ensembl209,235,736 - 9,239,597 (-)Ensembl
Rnor_6.0 Ensembl209,892,124 - 9,895,984 (-)Ensembl
RefSeq Acc Id: NM_057129   ⟹   NP_476470
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,237,095 - 9,240,956 (-)NCBI
mRatBN7.2209,235,736 - 9,239,597 (-)NCBI
Rnor_6.0209,892,124 - 9,895,984 (-)NCBI
Rnor_5.02012,071,835 - 12,075,695 (-)NCBI
RGSC_v3.4209,526,674 - 9,530,534 (-)RGD
Celera2010,760,042 - 10,763,903 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_476470 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA11857 (Get FASTA)   NCBI Sequence Viewer  
  EDL97005 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001538
  ENSRNOP00000001538.1
GenBank Protein Q63467 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476470   ⟸   NM_057129
- Peptide Label: precursor
- UniProtKB: Q63467 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001538   ⟸   ENSRNOT00000001538
Protein Domains
P-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63467-F1-model_v2 AlphaFold Q63467 1-81 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701472
Promoter ID:EPDNEW_R11996
Type:multiple initiation site
Name:Tff1_1
Description:trefoil factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0209,895,981 - 9,896,041EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620707 AgrOrtholog
BioCyc Gene G2FUF-4326 BioCyc
Ensembl Genes ENSRNOG00000001164 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001538 ENTREZGENE
  ENSRNOT00000001538.2 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.110.10 UniProtKB/Swiss-Prot
InterPro P_trefoil_chordata UniProtKB/Swiss-Prot
  P_trefoil_CS UniProtKB/Swiss-Prot
  P_trefoil_dom UniProtKB/Swiss-Prot
  P_trefoil_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:117270 UniProtKB/Swiss-Prot
NCBI Gene 117270 ENTREZGENE
PANTHER PTHR13826 UniProtKB/Swiss-Prot
  TREFOIL FACTOR 1 UniProtKB/Swiss-Prot
Pfam Trefoil UniProtKB/Swiss-Prot
PhenoGen Tff1 PhenoGen
PRINTS PTREFOIL UniProtKB/Swiss-Prot
PROSITE P_TREFOIL_1 UniProtKB/Swiss-Prot
  P_TREFOIL_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001164 RatGTEx
SMART SM00018 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57492 UniProtKB/Swiss-Prot
UniProt A6JJY9_RAT UniProtKB/TrEMBL
  Q63467 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Tff1  trefoil factor 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tff1  trefoil factor 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in stomach and only faintly in the duodenum 625375