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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620707 Species: Rattus norvegicus RGD Object: Gene Symbol: Tff1 Name: trefoil factor 1

Acc ID: CHEBI:28088 Term: genistein Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties. CasRN: 446-72-0 Chemical ID: MESH:D019833

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1344671	6480464	CTD	Genistein results in increased expression of TFF1 mRNA	PMID:16474171 PMID:15090535 PMID:11368622 PMID:11331657
increases expression	ISO	RGD:1344671	6480464	CTD	Genistein results in increased expression of TFF1 mRNA	PMID:16474171 PMID:15090535 PMID:11331657 PMID:11368622
increases expression	ISO	RGD:1344671	6480464	CTD	Genistein results in increased expression of TFF1 mRNA	PMID:16474171 PMID:11331657 PMID:11368622 PMID:15090535
increases expression	ISO	RGD:1344671	6480464	CTD	Genistein results in increased expression of TFF1 mRNA	PMID:11368622 PMID:15090535 PMID:16474171 PMID:11331657
increases expression	ISO	RGD:1344671	6480464	CTD	Genistein results in increased expression of TFF1 mRNA	PMID:16474171 PMID:11368622 PMID:15090535 PMID:11331657
increases expression	ISO	RGD:1344671	6480464	CTD	Genistein results in increased expression of TFF1 mRNA	PMID:11331657 PMID:11368622 PMID:15090535 PMID:16474171
multiple interactions	ISO	RGD:1344671	6480464	CTD	fulvestrant inhibits the reaction [Genistein results in increased expression of TFF1 mRNA]	PMID:22562034
increases expression	ISO	RGD:1344671	6480464	CTD	Genistein results in increased expression of TFF1 mRNA	PMID:11331657 PMID:11368622 PMID:15090535 PMID:16474171 PMID:22562034
increases expression	ISO	RGD:1344671	6480464	CTD	Genistein results in increased expression of TFF1 mRNA	PMID:11331657 PMID:11368622 PMID:15090535 PMID:16474171 PMID:22562034 PMID:23384675
multiple interactions	ISO	RGD:1344671	6480464	CTD	ESR1 protein inhibits the reaction [Genistein results in increased expression of TFF1 mRNA]	PMID:23384675