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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620707 Species: Rattus norvegicus RGD Object: Gene Symbol: Tff1 Name: trefoil factor 1

Acc ID: CHEBI:4953 Term: exemestane Definition: A 17-oxo steroid that is androsta-1,4-diene-3,17-dione in which the hydrogens at position 6 are replaced by a double bond to a methylene group. A selective inhibitor of the aromatase (oestrogen synthase) system, it is used in the treatment of advanced breast cancer. CasRN: 107868-30-4 Chemical ID: MESH:C056516

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1344671	6480464	CTD	exemestane results in increased expression of TFF1 mRNA	PMID:18677558