RGD Reference Report - Cytosolic levels of TFF1/pS2 in breast cancer: Their relationship with clinical-pathological parameters and their prognostic significance. - Rat Genome Database

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Cytosolic levels of TFF1/pS2 in breast cancer: Their relationship with clinical-pathological parameters and their prognostic significance.

Authors: Corte, MD  Tamargo, F  Alvarez, A  Rodriguez, JC  Vazquez, J  Sanchez, R  Lamelas, ML  Gonzalez, LO  Allende, MT  Garcia-Muniz, JL  Fueyo, A  Vizoso, F 
Citation: Corte MD, etal., Breast Cancer Res Treat. 2006 Mar;96(1):63-72. Epub 2005 Nov 3.
RGD ID: 2292002
Pubmed: PMID:16267614   (View Abstract at PubMed)
DOI: DOI:10.1007/s10549-005-9041-7   (Journal Full-text)

BACKGROUND: The Trefoil Factor 1 (TFF1/pS2), a peptide consisting of 60 amino acids, is the most abundant estrogen-induced messenger RNA present in MCF-7 breast cancer cells. The objective of this work was to evaluate the cytosolic TFF1 content in breast carcinomas, its possible relationship with different clinical-pathological parameters, and its potential prognostic significance and predictive value. METHODS: Cytosolic TFF1 levels were examined by immunoradiometric assay in 1031 patients with invasive breast cancer. The median follow-up period was of 50 months. RESULTS: There was a wide variability of cytosolic TFF1 levels in tumors (0.9-743.2 ng/mg protein). Statistical analysis showed that TFF1 levels were significantly higher in premenopausal patients (p = 0.001), as well as in tumors showing any of the following characteristics: good differentiation (p = 0.0001), ER and PgR positivity (p = 0.0001 and p = 0.001, respectively), diploidy (p = 0.045) and a high S-phase fraction (p = 0.001). In addition, the presence of high intratumoral TFF1 levels (cut-off: 2 ng/mg protein) was independently associated with a shorter overall survival in the group of patients as a whole (p = 0.001) as well as in the subgroup with node-negative breast cancer (p = 0.0004). Likewise, high intratumoral TFF1 levels were associated with a more prolonged overall survival in patients who received adjuvant tamoxifen (p = 0.004). CONCLUSIONS: In breast cancer patients, intratumoral TFF1 levels are associated with a better clinical outcome, especially in those with node-negative tumors. In addition, TFF1 levels have a low but significant predictive value in regards to response to adjuvant therapy with tamoxifen.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Breast Neoplasms disease_progressionIEP 2292002protein:increased expression:breastRGD 
Breast Neoplasms disease_progressionISOTFF1 (Homo sapiens)2292002; 2292002protein:increased expression:breastRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tff1  (trefoil factor 1)

Genes (Mus musculus)
Tff1  (trefoil factor 1)

Genes (Homo sapiens)
TFF1  (trefoil factor 1)


Additional Information