Ccr5 (C-C motif chemokine receptor 5) - Rat Genome Database

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Gene: Ccr5 (C-C motif chemokine receptor 5) Rattus norvegicus
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Symbol: Ccr5
Name: C-C motif chemokine receptor 5
RGD ID: 620596
Description: Enables protein kinase binding activity. Involved in several processes, including negative regulation of axon extension; positive regulation of cytokine production; and response to bacterium. Located in cell surface and endosome. Used to study Alzheimer's disease and plague. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); end stage renal disease; orchitis; and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; West Nile fever; autoimmune disease (multiple); berylliosis; and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif chemokine receptor 5); PARTICIPATES IN interleukin-12 signaling pathway; chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; chemokine (C-C motif) receptor 5; chemokine (C-C) receptor 5; Ckr5; Cmkbr5; MIP-1 alpha receptor
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,629,097 - 132,660,980 (+)NCBIGRCr8
mRatBN7.28123,752,423 - 123,757,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,752,325 - 123,759,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8129,343,076 - 129,348,190 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,542,196 - 127,547,310 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,360,117 - 125,365,231 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08133,192,398 - 133,215,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8133,197,032 - 133,215,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08132,362,664 - 132,367,779 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,907,157 - 128,912,272 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,929,594 - 128,932,000 (+)NCBI
Celera8122,847,673 - 122,852,786 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Ccr5RatAcute Hepatitis disease_progressionISOCcr5 (Mus musculus)14401740 RGD 
Ccr5Ratallergic contact dermatitis  IEP 2325935mRNA:increased expression:skin and lymph node (rat)RGD 
Ccr5RatAlzheimer's disease  ISOCCR5 (Homo sapiens)4890447protein:increased expression:brain and microglia (human)RGD 
Ccr5RatAlzheimer's disease  IMP 4890446 RGD 
Ccr5Ratanterior uveitis  IEP 4890448mRNA:increased expression:iris and ciliary body (rat)RGD 
Ccr5RatArterial Injury  IEP 8552233 RGD 
Ccr5Ratarteriosclerosis  ISOCcr5 (Mus musculus)4890431 RGD 
Ccr5Ratasthma  ISOCCR5 (Homo sapiens)4145638DNA:frameshift mutation:cds:p.S185_T195del rs333 (human)RGD 
Ccr5Ratasthma no_associationISOCCR5 (Homo sapiens)8551842DNA:polymorphism more ...RGD 
Ccr5Ratasthma  ISOCcr5 (Mus musculus)4892093 RGD 
Ccr5Ratasthma  ISOCCR5 (Homo sapiens)4892108protein:decreased expression:blood and lymphocyte (human)RGD 
Ccr5Ratasthma  ISOCcr5 (Mus musculus)4892088mRNA:increased expression:lung (mouse)RGD 
Ccr5Ratatherosclerosis treatmentISOCcr5 (Mus musculus)8549763 RGD 
Ccr5Ratatopic dermatitis  ISOCCR5 (Homo sapiens)6893391 RGD 
Ccr5RatBehcet's disease  ISOCCR5 (Homo sapiens)4892106protein:increased expression:blood and T cell (human)RGD 
Ccr5RatBehcet's disease no_associationISOCCR5 (Homo sapiens)8551827DNA:frameshift mutation: :p.S185_T195del (rs333) (human)RGD 
Ccr5RatBehcet's disease  ISOCCR5 (Homo sapiens)8551814DNA:frameshift mutation: :p.S185_T195del (rs333) (human)RGD 
Ccr5Ratberylliosis disease_progressionISOCCR5 (Homo sapiens)4892065DNA:polymorphisms:5' utr:multiple (human)RGD 
Ccr5RatBirth Injuries  IEP 4890426mRNA:increased expression:multiple organs (rat)RGD 
Ccr5RatBrain Hypoxia-Ischemia  IEP 4890442mRNA:increased expression:cerebral hemisphere (rat)RGD 
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Ccr5Ratacquired immunodeficiency syndrome  ISOCCR5 (Homo sapiens)8554872ClinVar Annotator: match by term: Acquired immunodeficiency syndrome and delayed progression toClinVarPMID:12610055 more ...
Ccr5Rathepatitis C  ISOCCR5 (Homo sapiens)8554872ClinVar Annotator: match by term: HCV and RESISTANCE TOClinVarPMID:10520641 more ...
Ccr5Rathuman immunodeficiency virus infectious disease  ISOCCR5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10520641 more ...
Ccr5Ratmultiple sclerosis  ISOCCR5 (Homo sapiens)8554872ClinVar Annotator: match by term: Multiple sclerosis modifier of disease progressionClinVarPMID:10520641 more ...
Ccr5RatProgressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy  ISOCCR5 (Homo sapiens)8554872ClinVar Annotator: match by term: Microcephaly more ...ClinVarPMID:28492532
Ccr5Rattype 1 diabetes mellitus 22  ISOCCR5 (Homo sapiens)8554872ClinVar Annotator: match by term: Type 1 diabetes mellitus 22ClinVarPMID:25741868
Ccr5RatWest Nile fever  ISOCCR5 (Homo sapiens)8554872ClinVar Annotator: match by term: West Nile virus and susceptibility toClinVarPMID:10520641 more ...
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Ccr5Ratacute kidney failure  ISOCCR5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26055553
Ccr5Ratatopic dermatitis  ISOCCR5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18249437
Ccr5RatColonic Neoplasms  ISOCCR5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36346222
Ccr5RatColorectal Neoplasms  ISOCCR5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35072892
Ccr5RatDisease Progression  ISOCCR5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35072892
Ccr5RatExperimental Neoplasms  ISOCCR5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35072892
Ccr5Rathepatitis C  ISOCCR5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Ccr5Rathuman immunodeficiency virus infectious disease  ISOCCR5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Ccr5RatNeoplasm Metastasis  ISOCCR5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35072892
Ccr5Ratnephritis  ISOCCR5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26055553
Ccr5Rattype 1 diabetes mellitus 22  ISOCCR5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Ccr5RatWest Nile fever  ISOCCR5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
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Ccr5RatCoronavirus infectious disease  ISSCcr5 (Mus musculus)13592920 MouseDO 

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Ccr5Rat(S)-nicotine increases expressionISOCCR5 (Homo sapiens)6480464Nicotine results in increased expression of CCR5 mRNACTDPMID:18247414
Ccr5Rat1,3-benzothiazole-2-thiol increases expressionISOCCR5 (Homo sapiens)6480464captax results in increased expression of CCR5 mRNACTDPMID:20713136
Ccr5Rat1-chloro-2,4-dinitrobenzene increases expressionISOCCR5 (Homo sapiens)6480464Dinitrochlorobenzene results in increased expression of CCR5 mRNACTDPMID:20713136
Ccr5Rat17alpha-ethynylestradiol multiple interactionsISOCCR5 (Homo sapiens)6480464[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR5 proteinCTDPMID:10770211
Ccr5Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of CCR5 mRNACTDPMID:15834898
Ccr5Rat17alpha-ethynylestradiol multiple interactionsISOCcr5 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCR5 mRNACTDPMID:17942748
Ccr5Rat17alpha-ethynylestradiol increases expressionISOCcr5 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of CCR5 mRNACTDPMID:17942748
Ccr5Rat17alpha-ethynylestradiol decreases expressionISOCcr5 (Mus musculus)6480464Ethinyl Estradiol results in decreased expression of CCR5 mRNACTDPMID:12538720 and PMID:15885639
Ccr5Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CCR5 mRNACTDPMID:32741896
Ccr5Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CCR5 mRNACTDPMID:32741896
Ccr5Rat2,2',4,4',5,5'-hexachlorobiphenyl decreases expressionISOCcr5 (Mus musculus)64804642 more ...CTDPMID:21851831
Ccr5Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOCcr5 (Mus musculus)64804642 more ...CTDPMID:21851831
Ccr5Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCcr5 (Mus musculus)64804642 more ...CTDPMID:17942748 and PMID:21851831
Ccr5Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of CCR5 mRNACTDPMID:34747641
Ccr5Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CCR5 mRNACTDPMID:32109520
Ccr5Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCcr5 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of CCR5 mRNACTDPMID:18684927 more ...
Ccr5Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCcr5 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CCR5 mRNACTDPMID:21570461
Ccr5Rat2,4,6-trinitrobenzenesulfonic acid increases expressionISOCcr5 (Mus musculus)6480464Trinitrobenzenesulfonic Acid results in increased expression of CCR5 mRNACTDPMID:15973123 and PMID:17982090
Ccr5Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOCcr5 (Mus musculus)64804642 more ...CTDPMID:38648751
Ccr5Rat2-naphthylamine increases expressionISOCCR5 (Homo sapiens)64804642-Naphthylamine results in increased expression of CCR5 mRNACTDPMID:18247414

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Biological Process
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Ccr5Ratapoptotic process acts_upstream_of_or_withinISOCcr5 (Mus musculus)1624291 PMID:36301669RGDPMID:36301669
Ccr5Ratapoptotic process acts_upstream_of_or_withinIEAUniProtKB:P51682 and ensembl:ENSMUSP000001070691600115GO_REF:0000107EnsemblGO_REF:0000107
Ccr5Ratcalcium ion transport involved_inISOCCR5 (Homo sapiens)1624291 PMID:8699119RGDPMID:8699119
Ccr5Ratcalcium-mediated signaling involved_inISOCCR5 (Homo sapiens)1624291 PMID:10679098 and PMID:19523456RGDPMID:10679098 and PMID:19523456
Ccr5Ratcalcium-mediated signaling involved_inIBAPANTHER:PTN001628461 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr5Ratcell chemotaxis involved_inIBAMGI:103567 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr5Ratcell-cell signaling involved_inISOCCR5 (Homo sapiens)1624291 PMID:10679098RGDPMID:10679098
Ccr5Ratcellular response to lipopolysaccharide involved_inISOCCR5 (Homo sapiens)1624291 PMID:10679098RGDPMID:10679098
Ccr5Ratcellular response to transforming growth factor beta stimulus  IEP 151665477 RGD 
Ccr5Ratcellular response to tumor necrosis factor  IEP 151665477 RGD 
Ccr5Ratchemokine-mediated signaling pathway involved_inIEAGO:00164931600115GO_REF:0000108GOCGO_REF:0000108
Ccr5Ratchemokine-mediated signaling pathway involved_inIEAGO:00049501600115GO_REF:0000108GOCGO_REF:0000108
Ccr5Ratchemotaxis involved_inIEAInterPro:IPR000355 and InterPro:IPR0022401600115GO_REF:0000002InterProGO_REF:0000002
Ccr5Ratdefense response acts_upstream_of_or_withinIEAUniProtKB:P51682 and ensembl:ENSMUSP000001070691600115GO_REF:0000107EnsemblGO_REF:0000107
Ccr5Ratdefense response acts_upstream_of_or_withinISOCcr5 (Mus musculus)1624291MGI:1861911 PMID:10528159RGDPMID:10528159
Ccr5Ratdefense response to bacterium  IEP 632396 RGD 
Ccr5Ratfat cell differentiation  IEP 2307036 RGD 
Ccr5Ratforebrain development  IEP 4890442 RGD 
Ccr5RatG protein-coupled receptor signaling pathway involved_inISOCCR5 (Homo sapiens)1624291 PMID:19523456RGDPMID:19523456
Ccr5RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
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Cellular Component
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Ccr5Ratcell surface  IDA 4144893 RGD 
Ccr5Ratcell surface located_inIEAUniProtKB:P51682 and ensembl:ENSMUSP000001070691600115GO_REF:0000107EnsemblGO_REF:0000107
Ccr5Ratcell surface located_inISOCcr5 (Mus musculus)1624291 PMID:23620790RGDPMID:23620790
Ccr5Ratcell surface is_active_inISOCCR5 (Homo sapiens)1624291 PMID:29739880RGDPMID:29739880
Ccr5Ratcell surface located_inISOCCR5 (Homo sapiens)1624291 PMID:10521508RGDPMID:10521508
Ccr5Ratcytoplasm is_active_inIBAPANTHER:PTN001628676 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr5Ratendosome located_inISOCCR5 (Homo sapiens)1624291 PMID:10679098RGDPMID:10679098
Ccr5Ratendosome  IDA 632389 RGD 
Ccr5Ratexternal side of plasma membrane located_inISOCCR5 (Homo sapiens)1624291 PMID:10383387 more ...RGDPMID:10383387 more ...
Ccr5Ratexternal side of plasma membrane is_active_inIBAMGI:103011 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr5Ratexternal side of plasma membrane located_inISOCcr5 (Mus musculus)1624291 PMID:16301745 more ...RGDPMID:16301745 more ...
Ccr5Ratexternal side of plasma membrane located_inIEAUniProtKB:P51682 and ensembl:ENSMUSP000001070691600115GO_REF:0000107EnsemblGO_REF:0000107
Ccr5Ratexternal side of plasma membrane located_inISSUniProtKB:P516811600115GO_REF:0000024UniProtGO_REF:0000024
Ccr5Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Ccr5Ratmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Ccr5Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Ccr5Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Ccr5Ratactin binding enablesISOCCR5 (Homo sapiens)1624291 PMID:12421915RGDPMID:12421915
Ccr5RatC-C chemokine binding enablesIEAUniProtKB:P51682 and ensembl:ENSMUSP000001070691600115GO_REF:0000107EnsemblGO_REF:0000107
Ccr5RatC-C chemokine binding enablesISOCCR5 (Homo sapiens)1624291UniProtKB:P10147 more ...RGDPMID:10383387 more ...
Ccr5RatC-C chemokine binding enablesISOCcr5 (Mus musculus)1624291UniProtKB:P13501 and PMID:9139699RGDPMID:9139699
Ccr5RatC-C chemokine receptor activity  TAS 632395 RGD 
Ccr5RatC-C chemokine receptor activity enablesISOCcr5 (Mus musculus)1624291 PMID:8631787RGDPMID:8631787
Ccr5RatC-C chemokine receptor activity enablesIBAMGI:103011 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr5RatC-C chemokine receptor activity enablesIEAInterPro:IPR0022401600115GO_REF:0000002InterProGO_REF:0000002
Ccr5RatC-C chemokine receptor activity enablesISOCCR5 (Homo sapiens)1624291 PMID:10383387 more ...RGDPMID:10383387 more ...
Ccr5RatC-C chemokine receptor activity enablesISSUniProtKB:P516811600115GO_REF:0000024UniProtGO_REF:0000024
Ccr5RatC-C chemokine receptor activity enablesIEAUniProtKB:P51682 and ensembl:ENSMUSP000001070691600115GO_REF:0000107EnsemblGO_REF:0000107
Ccr5Ratchemokine (C-C motif) ligand 5 binding enablesISOCCR5 (Homo sapiens)1624291UniProtKB:P13501 and PMID:8699119RGDPMID:8699119
Ccr5Ratchemokine (C-C motif) ligand 5 binding enablesIBAPANTHER:PTN000659270 and UniProtKB:P516811600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccr5Ratchemokine receptor activity enablesIEAInterPro:IPR0003551600115GO_REF:0000002InterProGO_REF:0000002
Ccr5RatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Ccr5RatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Ccr5Ratidentical protein binding enablesISOCCR5 (Homo sapiens)1624291UniProtKB:P51681 more ...RGDPMID:18230715 more ...
Ccr5Ratprotein binding  IPINes (Rattus norvegicus)4889986 RGD 
Ccr5Ratprotein binding  IPIInterPro:IPR0007774890441 RGD 
Ccr5Ratprotein binding enablesISOCCR5 (Homo sapiens)1624291UniProtKB:O43889-2 more ...RGDPMID:10816381 more ...
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Imported Annotations - KEGG (archival)

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Ccr5Ratchemokine mediated signaling pathway  IEA 6907045 KEGGrno:04062
Ccr5Ratcytokine mediated signaling pathway  IEA 6907045 KEGGrno:04060
Ccr5Ratendocytosis pathway  IEA 6907045 KEGGrno:04144
Ccr5Rattoxoplasmosis pathway  IEA 6907045 KEGGrno:05145

Imported Annotations - PID (archival)

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Ccr5Ratinterleukin-12 signaling pathway  ISOCCR5 (Homo sapiens)6484113 PIDPID:200045

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Reference Title
Reference Citation
1. CCR5 Polymorphism as a Protective Factor for Hepatocellular Carcinoma in Hepatitis B Virus-Infected Iranian Patients Abdolmohammadi R, etal., Asian Pac J Cancer Prev. 2016 Oct 1;17(10):4643-4646.
2. Polymorphisms of chemokine and chemokine receptor genes in idiopathic immune-mediated posterior segment uveitis. Ahad MA, etal., Mol Vis. 2007 Mar 23;13:388-96.
3. Effects of the CCR5-Delta32 mutation on antiviral treatment in chronic hepatitis C. Ahlenstiel G, etal., J Hepatol. 2003 Aug;39(2):245-52.
4. Association of genetic variations in CCR5 and its ligand, RANTES with clearance of hepatitis B virus in Korea. Ahn SH, etal., J Med Virol. 2006 Dec;78(12):1564-71. doi: 10.1002/jmv.20739.
5. Linkage and haplotype analysis for chemokine receptors clustered on chromosome 3p21.3 and transmitted in family pedigrees with asthma and atopy. Al-Abdulhadi SA and Al-Rabia MW, Ann Saudi Med. 2010 Mar-Apr;30(2):115-22.
6. Temporal course of changes in gene expression suggests a cytokine-related mechanism for long-term hippocampal alteration after controlled cortical impact. Almeida-Suhett CP, etal., J Neurotrauma. 2014 Apr 1;31(7):683-90. doi: 10.1089/neu.2013.3029. Epub 2014 Mar 3.
7. Sustained inhibition of corneal neovascularization by genetic ablation of CCR5. Ambati BK, etal., Invest Ophthalmol Vis Sci 2003 Feb;44(2):590-3.
8. M- and T-tropic HIVs promote apoptosis in rat neurons. Bachis A, etal., J Neuroimmune Pharmacol. 2009 Mar;4(1):150-60. Epub 2008 Nov 26.
9. Host inflammatory response and development of complications of Chlamydia trachomatis genital infection in CCR5-deficient mice and subfertile women with the CCR5delta32 gene deletion. Barr EL, etal., J Microbiol Immunol Infect. 2005 Aug;38(4):244-54.
10. CCR 4 and CCR 5 expression in conjunctival specimens as differential markers of T(H)1/ T(H)2 in ocular surface disorders. Baudouin C, etal., J Allergy Clin Immunol. 2005 Sep;116(3):614-9.
11. Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. Bhangoo S, etal., Mol Pain. 2007 Dec 12;3:38.
12. Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome. Bixler GV, etal., BMC Med Genomics. 2011 May 15;4:40. doi: 10.1186/1755-8794-4-40.
13. Influence of insulin therapy on expression of chemokine receptor CCR5 and selected inflammatory markers in patients with type 2 diabetes mellitus. Bogdanski P, etal., Int J Clin Pharmacol Ther. 2007 Oct;45(10):563-7.
14. T cell polarization identifies distinct clinical phenotypes in scleroderma lung disease. Boin F, etal., Arthritis Rheum. 2008 Apr;58(4):1165-74.
15. Chemokine and chemokine receptor expression analysis in target organs of acute graft-versus-host disease. Bouazzaoui A, etal., Genes Immun. 2009 Dec;10(8):687-701. Epub 2009 Jul 2.
16. Cigarette smoke-induced pulmonary inflammation, but not airway remodelling, is attenuated in chemokine receptor 5-deficient mice. Bracke KR, etal., Clin Exp Allergy. 2007 Oct;37(10):1467-79.
17. Analysis of the CC chemokine receptor 5 delta32 polymorphism in a Brazilian population with cutaneous leishmaniasis. Brajao de Oliveira K, etal., J Cutan Pathol. 2007 Jan;34(1):27-32.
18. Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice. Braunersreuther V, etal., Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):373-9. Epub 2006 Nov 30.
19. Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease. Breunis WB, etal., Clin Exp Immunol. 2007 Oct;150(1):83-90. Epub 2007 Aug 2.
20. Chemotactic mediators of Th1 T-cell trafficking in smokers and COPD patients. Brozyna S, etal., COPD. 2009 Feb;6(1):4-16.
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PMID:8631787   PMID:8699119   PMID:9139699   PMID:9655467   PMID:10383387   PMID:10521508   PMID:10528159   PMID:10679098   PMID:11278962   PMID:12032188   PMID:12421915   PMID:16208318  
PMID:16301745   PMID:16841089   PMID:18230715   PMID:18632580   PMID:19008373   PMID:19523456   PMID:21515370   PMID:22353418   PMID:23610400   PMID:23620790   PMID:24086760   PMID:25300256  
PMID:26550961   PMID:26740279   PMID:26983670   PMID:27848062   PMID:31574524   PMID:32446198   PMID:34774582   PMID:34843718  



Ccr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,629,097 - 132,660,980 (+)NCBIGRCr8
mRatBN7.28123,752,423 - 123,757,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,752,325 - 123,759,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8129,343,076 - 129,348,190 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,542,196 - 127,547,310 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,360,117 - 125,365,231 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08133,192,398 - 133,215,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8133,197,032 - 133,215,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08132,362,664 - 132,367,779 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,907,157 - 128,912,272 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,929,594 - 128,932,000 (+)NCBI
Celera8122,847,673 - 122,852,786 (+)NCBICelera
Cytogenetic Map8q32NCBI
CCR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,370,142 - 46,376,206 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,370,946 - 46,376,206 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,411,633 - 46,417,697 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,386,637 - 46,392,701 (+)NCBINCBI36Build 36hg18NCBI36
Celera346,348,960 - 46,355,024 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,455,276 - 46,461,340 (+)NCBIHuRef
CHM1_1346,361,630 - 46,367,689 (+)NCBICHM1_1
T2T-CHM13v2.0346,385,976 - 46,392,040 (+)NCBIT2T-CHM13v2.0
Ccr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,921,557 - 123,934,153 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,921,580 - 123,947,736 (+)EnsemblGRCm39 Ensembl
GRCm389124,121,543 - 124,127,183 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,121,543 - 124,147,699 (+)EnsemblGRCm38mm10GRCm38
MGSCv379124,036,282 - 124,041,922 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera9124,872,533 - 124,878,180 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
CCR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,330,233 - 46,335,608 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,335,001 - 46,340,376 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,273,096 - 46,278,471 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,377,564 - 47,383,625 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,380,321 - 47,381,379 (+)Ensemblpanpan1.1panPan2
CCR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,293,288 - 42,297,952 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,294,996 - 42,297,952 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,210,909 - 42,213,866 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,775,514 - 42,780,183 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,775,514 - 42,780,191 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,018,434 - 42,021,393 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,419,865 - 42,422,824 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,700,801 - 42,703,760 (-)NCBIUU_Cfam_GSD_1.0
CCR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,383,303 - 29,387,895 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,382,383 - 29,387,902 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,546,545 - 32,551,732 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,803,794 - 7,818,112 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041159,335,032 - 159,341,705 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

.
Variants in Ccr5
75 total Variants

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000075564
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat

Cmkbr5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28123,756,008 - 123,756,165 (+)MAPPERmRatBN7.2
Rnor_6.08133,214,070 - 133,214,226NCBIRnor6.0
Rnor_5.08132,366,250 - 132,366,406UniSTSRnor5.0
RGSC_v3.48128,910,743 - 128,910,899UniSTSRGSC3.4
Celera8122,851,258 - 122,851,414UniSTS
Cytogenetic Map8q32UniSTS
PMC122923P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28123,755,127 - 123,755,373 (+)MAPPERmRatBN7.2
Rnor_6.08133,213,189 - 133,213,434NCBIRnor6.0
Rnor_5.08132,365,369 - 132,365,614UniSTSRnor5.0
RGSC_v3.48128,909,862 - 128,910,107UniSTSRGSC3.4
Celera8122,850,377 - 122,850,622UniSTS
Cytogenetic Map8q32UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 47 113 91 90 59 25 59 6 216 95 93 45 60 31



Ensembl Acc Id: ENSRNOT00000075564   ⟹   ENSRNOP00000066146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8133,197,032 - 133,214,257 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082774   ⟹   ENSRNOP00000073121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,752,325 - 123,759,260 (+)Ensembl
Rnor_6.0 Ensembl8133,210,473 - 133,215,614 (+)Ensembl
RefSeq Acc Id: NM_053960   ⟹   NP_446412
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,629,843 - 132,634,958 (+)NCBI
mRatBN7.28123,752,423 - 123,757,538 (+)NCBI
Rnor_6.08133,210,484 - 133,215,599 (+)NCBI
Rnor_5.08132,362,664 - 132,367,779 (+)NCBI
RGSC_v3.48128,907,157 - 128,912,272 (+)RGD
Celera8122,847,673 - 122,852,786 (+)RGD
Sequence:
RefSeq Acc Id: XM_063264783   ⟹   XP_063120853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,629,097 - 132,660,980 (+)NCBI
RefSeq Acc Id: XM_063264784   ⟹   XP_063120854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,629,097 - 132,660,980 (+)NCBI
RefSeq Acc Id: XR_010053918
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,629,097 - 132,660,980 (+)NCBI
RefSeq Acc Id: XR_010053919
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,629,097 - 132,660,980 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_446412 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120853 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120854 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC03243 (Get FASTA)   NCBI Sequence Viewer  
  AAH78756 (Get FASTA)   NCBI Sequence Viewer  
  CAA72737 (Get FASTA)   NCBI Sequence Viewer  
  EDL76743 (Get FASTA)   NCBI Sequence Viewer  
  EDL76744 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073121
GenBank Protein O08556 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_446412   ⟸   NM_053960
- UniProtKB: Q68G28 (UniProtKB/TrEMBL),   A6I4D3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073121   ⟸   ENSRNOT00000082774
Ensembl Acc Id: ENSRNOP00000066146   ⟸   ENSRNOT00000075564
RefSeq Acc Id: XP_063120853   ⟸   XM_063264783
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063120854   ⟸   XM_063264784
- Peptide Label: isoform X1
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-O08556-F1-model_v2 AlphaFold O08556 1-354 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696416
Promoter ID:EPDNEW_R6941
Type:initiation region
Name:Ccr5_1
Description:chemokine (C-C motif) receptor 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08133,210,484 - 133,210,544EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-28594 BioCyc
Ensembl Genes ENSRNOG00000049115 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000082774 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109679 IMAGE-MGC_LOAD
InterPro Chemokine_CCR5 UniProtKB/Swiss-Prot
  Chemokine_rcpt UniProtKB/Swiss-Prot
  GPCR1 UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:117029 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93260 IMAGE-MGC_LOAD
NCBI Gene 117029 ENTREZGENE
PANTHER C-C CHEMOKINE RECEPTOR TYPE 5 UniProtKB/Swiss-Prot
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB CCR5 RGD
PhenoGen Ccr5 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot
  CHEMOKINER5 UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000049115 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6I4D3 ENTREZGENE, UniProtKB/TrEMBL
  A6I4D4_RAT UniProtKB/TrEMBL
  CCR5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q68G28 ENTREZGENE, UniProtKB/TrEMBL
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-16 Ccr5  C-C motif chemokine receptor 5  Ccr5  chemokine (C-C motif) receptor 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ccr5  chemokine (C-C motif) receptor 5    chemokine (C-C) receptor 5  Name updated 1299863 APPROVED
2004-09-10 Ccr5  chemokine (C-C) receptor 5  Cmkbr5    Symbol and Name updated 1299863 APPROVED
2002-08-07 Cmkbr5  chemokine (C-C) receptor 5      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_regulation phosphorylated by GPCR kinase (GRK)- and protein kinase C (PKC) following RANTES/CCL5 binding to receptor 632395
gene_regulation expression upregulated following bacterial infection 632396
gene_regulation downregulation of receptor is induced by interleukin-1beta 632389