RGD Reference Report - Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness. - Rat Genome Database

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Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness.

Authors: Walker, JK  Ahumada, A  Frank, B  Gaspard, R  Berman, K  Quackenbush, J  Schwartz, DA 
Citation: Walker JK, etal., Am J Respir Cell Mol Biol. 2006 Jun;34(6):711-8. Epub 2006 Feb 10.
RGD ID: 4892093
Pubmed: PMID:16474097   (View Abstract at PubMed)
PMCID: PMC2644233   (View Article at PubMed Central)
DOI: DOI:10.1165/rcmb.2005-0314OC   (Journal Full-text)

Asthma is a ubiquitous disease with a broad range of clinical phenotypes. To better understand the complex genetic and environmental interactions underlying asthma, we compared the gene-gene interactions of four genetically distinct mouse strains that demonstrate biologically distinct responses to allergen. Using DNA microarrays and knock-out mouse studies, we showed that CCR5 plays a definitive role in the development of ovalbumin-induced allergic airway inflammatory disease. In addition, gene expression profiling data have revealed other potential novel targets for therapeutics-based research and has enhanced the understanding of the molecular mechanisms underlying the etiology of "asthma."

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma  ISOCcr5 (Mus musculus)4892093; 4892093 RGD 
asthma  IMP 4892093 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Mus musculus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Homo sapiens)
CCR5  (C-C motif chemokine receptor 5)


Additional Information