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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (R)-mevalonic acid | multiple interactions | ISO | RGD:1351344 | 6480464 | Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]] | CTD | PMID:16321392 | (S)-nicotine | increases expression | ISO | RGD:1351344 | 6480464 | Nicotine results in increased expression of CCR5 mRNA | CTD | PMID:18247414 | 1,3-benzothiazole-2-thiol | increases expression | ISO | RGD:1351344 | 6480464 | captax results in increased expression of CCR5 mRNA | CTD | PMID:20713136 | 1-chloro-2,4-dinitrobenzene | increases expression | ISO | RGD:1351344 | 6480464 | Dinitrochlorobenzene results in increased expression of CCR5 mRNA | CTD | PMID:20713136 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1351344 | 6480464 | [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR5 protein | CTD | PMID:10770211 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of CCR5 mRNA | CTD | PMID:15885639 PMID:12538720 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:620596 | 6480464 | Ethinyl Estradiol results in increased expression of CCR5 mRNA | CTD | PMID:15834898 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCR5 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of CCR5 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of CCR5 mRNA | CTD | PMID:12538720 PMID:15885639 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | EXP | | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCR5 mRNA]; more ... | CTD | PMID:21851831 | 2,2',4,4',5,5'-hexachlorobiphenyl | decreases expression | EXP | | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of CCR5 mRNA | CTD | PMID:21851831 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCR5 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CCR5 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CCR5 mRNA | CTD | PMID:18684927 PMID:21851831 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCR5 mRNA]; more ... | CTD | PMID:21851831 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CCR5 mRNA | CTD | PMID:18684927 | 2,4,6-trinitrobenzenesulfonic acid | increases expression | EXP | | 6480464 | Trinitrobenzenesulfonic Acid results in increased expression of CCR5 mRNA | CTD | PMID:15973123 PMID:17982090 | 2,4,6-trinitrobenzenesulfonic acid | increases expression | EXP | | 6480464 | Trinitrobenzenesulfonic Acid results in increased expression of CCR5 mRNA | CTD | PMID:17982090 PMID:15973123 | 2-naphthylamine | increases expression | ISO | RGD:1351344 | 6480464 | 2-Naphthylamine results in increased expression of CCR5 mRNA | CTD | PMID:18247414 | 3-chlorophenol | decreases expression | ISO | RGD:1351344 | 6480464 | 3-chlorophenol results in decreased expression of CCR5 mRNA | CTD | PMID:18486366 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of CCR5 mRNA | CTD | PMID:19770486 | ammonium chloride | affects expression | ISO | RGD:620596 | 6480464 | Ammonium Chloride affects the expression of CCR5 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases expression | ISO | RGD:1351344 | 6480464 | Benzo(a)pyrene results in increased expression of CCR5 mRNA | CTD | PMID:18247414 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of CCR5 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of CCR5 mRNA | CTD | PMID:21569818 | bis(2-chloroethyl) sulfide | increases expression | EXP | | 6480464 | Mustard Gas results in increased expression of CCR5 mRNA | CTD | PMID:18955075 | celecoxib | decreases expression | EXP | | 6480464 | celecoxib results in decreased expression of CCR5 mRNA | CTD | PMID:12902868 | chloroprene | decreases expression | EXP | | 6480464 | Chloroprene results in decreased expression of CCR5 mRNA | CTD | PMID:23125180 | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of CCR5 mRNA | CTD | PMID:15814532 | cisplatin | multiple interactions | EXP | | 6480464 | pirinixic acid inhibits the reaction [Cisplatin results in increased expression of CCR5 mRNA] | CTD | PMID:15814532 | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of CCR5 mRNA | CTD | PMID:17585979 | cocaine | increases expression | ISO | RGD:1351344 | 6480464 | Cocaine results in increased expression of CCR5 protein | CTD | PMID:16204638 | cyclophosphamide | increases expression | EXP | | 6480464 | Cyclophosphamide results in increased expression of CCR5 mRNA | CTD | PMID:15331540 | cyclosporin A | increases expression | EXP | | 6480464 | Cyclosporine results in increased expression of CCR5 protein | CTD | PMID:21292993 | cyproterone acetate | multiple interactions | ISO | RGD:1351344 | 6480464 | [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR5 protein | CTD | PMID:10770211 | D-penicillamine | increases expression | ISO | RGD:620596 | 6480464 | Penicillamine results in increased expression of CCR5 mRNA | CTD | PMID:19575532 | D-penicillamine | decreases expression | ISO | RGD:620596 | 6480464 | Penicillamine results in decreased expression of CCR5 mRNA | CTD | PMID:19575532 | dioxygen | increases expression | EXP | | 6480464 | Oxygen deficiency results in increased expression of CCR5 mRNA; more ... | CTD | PMID:20880076 | dioxygen | multiple interactions | EXP | | 6480464 | HIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of CCR5 mRNA] | CTD | PMID:20880076 | disulfiram | multiple interactions | EXP | | 6480464 | Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; more ... | CTD | PMID:19016906 | eugenol | increases expression | ISO | RGD:1351344 | 6480464 | Eugenol results in increased expression of CCR5 mRNA | CTD | PMID:17936526 | eugenol | increases expression | ISO | RGD:1351344 | 6480464 | Eugenol results in increased expression of CCR5 mRNA | CTD | PMID:17936526 PMID:20713136 | isopentenyl diphosphate | decreases expression | ISO | RGD:1351344 | 6480464 | isopentenyl pyrophosphate results in decreased expression of CCR5 protein | CTD | PMID:11994442 | ketamine | increases expression | ISO | RGD:620596 | 6480464 | Ketamine results in increased expression of CCR5 mRNA | CTD | PMID:20080153 | mevalonic acid | multiple interactions | ISO | RGD:1351344 | 6480464 | Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]] | CTD | PMID:16321392 | nickel atom | affects expression | ISO | RGD:1351344 | 6480464 | Nickel affects the expression of CCR5 mRNA | CTD | PMID:14575637 | nickel atom | multiple interactions | ISO | RGD:1351344 | 6480464 | trichostatin A inhibits the reaction [Nickel affects the expression of CCR5 mRNA] | CTD | PMID:14575637 | nitric oxide | multiple interactions | EXP | | 6480464 | [CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide; more ... | CTD | PMID:19016906 | pentachlorophenol | decreases expression | ISO | RGD:1351344 | 6480464 | Pentachlorophenol results in decreased expression of CCR5 mRNA | CTD | PMID:18486366 | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of CCR5 mRNA | CTD | PMID:23091169 | pirinixic acid | multiple interactions | EXP | | 6480464 | pirinixic acid inhibits the reaction [Cisplatin results in increased expression of CCR5 mRNA] | CTD | PMID:15814532 | prostaglandin E2 | decreases expression | ISO | RGD:1351344 | 6480464 | Dinoprostone results in decreased expression of CCR5 mRNA; more ... | CTD | PMID:16303787 | simvastatin | multiple interactions | ISO | RGD:1351344 | 6480464 | Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]] | CTD | PMID:16321392 | simvastatin | decreases expression | ISO | RGD:620596 | 6480464 | Simvastatin results in decreased expression of CCR5 protein | CTD | PMID:17449418 | simvastatin | decreases expression | ISO | RGD:1351344 | 6480464 | Simvastatin results in decreased expression of CCR5 mRNA | CTD | PMID:17112859 | sodium dodecyl sulfate | decreases expression | ISO | RGD:1351344 | 6480464 | Sodium Dodecyl Sulfate results in decreased expression of CCR5 mRNA | CTD | PMID:17936526 | staurosporine | multiple interactions | ISO | RGD:620596 | 6480464 | Staurosporine inhibits the reaction [[IL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of and affects the localization of CCR5 protein] | CTD | PMID:12594210 | tetrachloromethane | multiple interactions | EXP | | 6480464 | PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CCR5 mRNA] | CTD | PMID:18038451 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of CCR5 mRNA | CTD | PMID:23288052 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of CCR5 mRNA | CTD | PMID:21259345 | trichostatin A | multiple interactions | ISO | RGD:1351344 | 6480464 | trichostatin A inhibits the reaction [Nickel affects the expression of CCR5 mRNA] | CTD | PMID:14575637 | trimellitic anhydride | increases expression | EXP | | 6480464 | trimellitic anhydride results in increased expression of CCR5 mRNA | CTD | PMID:16141432 | wortmannin | multiple interactions | EXP | | 6480464 | wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide] | CTD | PMID:19016906 | zidovudine | multiple interactions | ISO | RGD:1351344 | 6480464 | [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCR5 mRNA | CTD | PMID:20370541 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Cytokine-cytokine receptor interaction | |
| Endocytosis | |
| Toxoplasmosis | |
| Viral carcinogenesis | |
| Pathway Interaction Database | IL12-mediated signaling events (PID:200045) |
Phenotype Annotations
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Cytokine-cytokine receptor interaction | |
| Endocytosis | |
| Toxoplasmosis | |
| Viral carcinogenesis | |
| Pathway Interaction Database | IL12-mediated signaling events (PID:200045) |
Phenotype Annotations
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| 21963866 | |
| 22001348 | |
| 22042976 | |
| 22154893 | |
| 22160774 | |
| 22203055 | |
| 22214846 | |
| 22271672 | |
| 22282655 | |
| 22425022 | |
| 22430509 | |
| 22442210 | |
| 22474027 | |
| 22526024 | |
| 22528550 | |
| 22567084 | |
| 22664873 | |
| 22674804 | |
| 22677420 | |
| 22811524 | |
| 22906987 | |
| 22907530 | |
| 23028638 | |
| 23152559 | |
| 23235831 | |
| 23248310 | |
| 23352234 | |
| 8631787 | |
| 8662890 | |
| 9139699 | |
| 9184207 | |
| 9261347 | |
| 9343222 | |
| 9558111 |
RGD Disease Portals| Ccr5 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Ccr5 (Mus musculus) |
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| CCR5 (Homo sapiens) |
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| Ccr5 (Rattus norvegicus) |
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Position Markers| D83648 |
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| PMC122923P1 |
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| PMC151896P1 |
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| UniSTS:224352 |
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| PMC24402P2 |
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| PMC228408P2 |
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| Cmkbr5 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_009917 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01082722 | (Get FASTA) | Search GEO for Microarray Profiles |
| AC168021 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF019772 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF022990 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK141906 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK154595 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK155628 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK155632 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK155867 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK170303 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK171391 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC103574 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC103586 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC103587 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC105643 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BG091923 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BY198155 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466671 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D83648 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U47036 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U68565 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U83327 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X94151 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_009917 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_034047 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_034047 | (Get FASTA) |
| GenBank Protein | AAB37273 | (Get FASTA) |
| AAB71183 | (Get FASTA) | |
| AAC52454 | (Get FASTA) | |
| AAC53386 | (Get FASTA) | |
| AAC53389 | (Get FASTA) | |
| AAI03575 | (Get FASTA) | |
| AAI03587 | (Get FASTA) | |
| AAI03588 | (Get FASTA) | |
| AAI05644 | (Get FASTA) | |
| BAA12024 | (Get FASTA) | |
| BAE24879 | (Get FASTA) | |
| BAE32698 | (Get FASTA) | |
| BAE33354 | (Get FASTA) | |
| BAE33471 | (Get FASTA) | |
| BAE41700 | (Get FASTA) | |
| CAA63867 | (Get FASTA) | |
| EDL37177 | (Get FASTA) | |
| P51682 | (Get FASTA) |
Promoters| RGD ID: | 6844300 | ||||||||||
| Promoter ID: | MM_KWN:59292 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | BoneMarrow_4Hour | ||||||||||
| Transcripts: | NM_009917 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000079227 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000107069 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000111442 | ENTREZGENE |
| Entrez Gene | 12774 | ENTREZGENE |
| Germonline | ENSMUSG00000073993 | |
| ENSMUSG00000075434 | ||
| HomoloGene Group ID | 37325 | ENTREZGENE |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot |
| Chemokine_CCR5 | UniProtKB/Swiss-Prot | |
| Chemokine_rcpt | UniProtKB/Swiss-Prot | |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| IPI | IPI00312494 | UniProtKB/Swiss-Prot |
| IPI00986430 | UniProtKB/TrEMBL | |
| IPI00986969 | UniProtKB/TrEMBL | |
| KEGG Report | mmu:12774 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:107182 | ENTREZGENE |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| PharmGKB | CCR5 | RGD |
| PRINTS | CCCHEMOKINER | UniProtKB/Swiss-Prot |
| CHEMOKINER5 | UniProtKB/Swiss-Prot | |
| GPCRRHODOPSN | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| UniGene | Mm.14302 | ENTREZGENE |
| UniProt | CCR5_MOUSE | UniProtKB/Swiss-Prot |
| E9Q351_MOUSE | UniProtKB/TrEMBL | |
| E9Q3E5_MOUSE | UniProtKB/TrEMBL | |
| Q3TDA4_MOUSE | UniProtKB/TrEMBL |
| More on Ccr5 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 733487 |
| Created: | 2004-01-12 |
| Species: | Mus musculus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




