RGD Reference Report - Analysis of the CC chemokine receptor 5 (CCR5) Delta32 polymorphism in Behcet's disease. - Rat Genome Database

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Analysis of the CC chemokine receptor 5 (CCR5) Delta32 polymorphism in Behcet's disease.

Authors: Yang, X  Ahmad, T  Gogus, F  Verity, D  Wallace, GR  Madanat, W  Kanawati, CA  Stanford, MR  Fortune, F  Jewell, DP  Marshall, SE 
Citation: Yang X, etal., Eur J Immunogenet. 2004 Feb;31(1):11-4.
RGD ID: 8551827
Pubmed: PMID:15009175   (View Abstract at PubMed)

Chemokines are important determinants of the early inflammatory response. The CC chemokine receptor 5 (CCR5) Delta32 variant results in a non-functional form of the chemokine receptor, and has been implicated in a variety of immune-mediated diseases. To investigate its role in the pathogenesis of Behcet's disease, we studied 350 patients and 519 healthy controls from three ethnic groups. While significant inter-ethnic variation in allele frequency was observed, no association was identified with disease, even when data were stratified by the known susceptibility gene HLA-B*51.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Behcet's disease no_associationIAGP 8551827DNA:frameshift mutation: :p.S185_T195del (rs333) (human)RGD 
Behcet's disease no_associationISOCCR5 (Homo sapiens)8551827; 8551827DNA:frameshift mutation: :p.S185_T195del (rs333) (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Mus musculus)
Ccr5  (C-C motif chemokine receptor 5)

Genes (Homo sapiens)
CCR5  (C-C motif chemokine receptor 5)


Additional Information