Crh (corticotropin releasing hormone) - Rat Genome Database

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Gene: Crh (corticotropin releasing hormone) Rattus norvegicus
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Symbol: Crh
Name: corticotropin releasing hormone
RGD ID: 620505
Description: Enables corticotropin-releasing hormone receptor 1 binding activity and corticotropin-releasing hormone receptor 2 binding activity. Involved in several processes, including regulation of secretion by cell; regulation of signal transduction; and response to corticosteroid. Located in extracellular space; perikaryon; and varicosity. Is active in neuronal dense core vesicle lumen. Used to study hypoglycemia and obesity. Biomarker of several diseases, including alcohol use disorder; cerebrovascular disease (multiple); extrahepatic cholestasis; sciatic neuropathy; and withdrawal disorder. Human ortholog(s) of this gene implicated in obesity and panic disorder. Orthologous to human CRH (corticotropin releasing hormone); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; long term depression; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: corticoliberin; corticotropin-releasing factor; corticotropin-releasing hormone; CRF
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Crhem1Ionsz
Genetic Models: SD-Crhem1Ionsz
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82104,059,184 - 104,061,048 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2104,058,770 - 104,061,386 (-)EnsemblGRCr8
mRatBN7.22102,143,055 - 102,144,919 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2102,143,055 - 102,144,919 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2108,674,139 - 108,676,025 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02106,795,271 - 106,797,157 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02101,764,428 - 101,766,314 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02104,459,999 - 104,461,863 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2104,459,999 - 104,461,863 (-)Ensemblrn6Rnor6.0
Rnor_5.02124,182,919 - 124,184,783 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42104,764,023 - 104,765,887 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera297,536,796 - 97,538,660 (-)NCBICelera
RGSC_v3.12104,708,984 - 104,710,849 (-)NCBI
Cytogenetic Map2q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP)
(R)-noradrenaline  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dichlorophenol  (ISO)
2-arachidonoylglycerol  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-phenoxybenzoic acid  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
8-Br-cAMP  (EXP)
8-OH-DPAT  (EXP)
acephate  (EXP)
acetylcholine  (EXP)
adinazolam  (EXP)
aflatoxin B1  (ISO)
alpha-Zearalanol  (ISO)
AM-251  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
astressin  (EXP)
atropine  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-endorphin  (EXP)
beta-naphthoflavone  (ISO)
betaxolol  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cannabidiol  (ISO)
carbon dioxide  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
cis-caffeic acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
corticotropin  (EXP)
cortisol  (ISO)
Cuprizon  (EXP)
cyanamide  (EXP)
cyclohexane  (EXP)
cyclophosphamide  (EXP,ISO)
DDE  (EXP,ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diprotium oxide  (EXP)
dorsomorphin  (ISO)
doxapram  (EXP)
dynorphin A  (EXP)
E-4031  (EXP)
enzacamene  (EXP)
ethanol  (EXP,ISO)
fentanyl  (EXP)
finasteride  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP,ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gamma-aminobutyric acid  (EXP)
genistein  (ISO)
glycidol  (EXP)
Goe 6976  (ISO)
GTP  (EXP)
guanosine 5'-[beta,gamma-imido]triphosphate  (EXP)
haloperidol  (ISO)
hemin  (ISO)
hydrogen peroxide  (ISO)
idazoxan  (EXP)
imipramine  (EXP)
indometacin  (EXP)
ketamine  (EXP)
lidocaine  (EXP)
linsidomine  (EXP)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
malathion  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
mesoporphyrin IX  (ISO)
metamizole sodium  (EXP)
methamidophos  (EXP)
methamphetamine  (EXP)
methoxamine  (EXP)
methylmercury chloride  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
morphine  (ISO)
naloxone  (EXP)
naltrexone  (EXP)
nickel atom  (EXP)
nicotine  (EXP,ISO)
nitric oxide  (EXP)
nitroprusside  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
pentobarbital  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
Phenelzine  (EXP)
phenytoin  (EXP)
pioglitazone  (ISO)
prednisolone  (EXP)
progesterone  (EXP,ISO)
promazine  (ISO)
propranolol  (EXP)
quercetin  (EXP)
reserpine  (EXP)
rimonabant  (EXP)
risperidone  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
serotonin  (EXP)
sertraline  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
Soman  (EXP)
sphingosine  (EXP)
staurosporine  (EXP)
Sulpyrine  (EXP)
telmisartan  (EXP)
terbutaline  (ISO)
testosterone  (EXP)
tetraethylammonium  (EXP)
tetrodotoxin  (ISO)
thioridazine  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trans-caffeic acid  (EXP)
trichloroethene  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP,ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
water  (EXP)
yohimbine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
associative learning  (IDA)
cellular response to cocaine  (IDA)
cellular response to dexamethasone stimulus  (IEP)
diterpenoid metabolic process  (IEP)
female pregnancy  (IEA,ISO)
gamma-aminobutyric acid secretion, neurotransmission  (IMP)
glucocorticoid biosynthetic process  (ISO)
hormone-mediated apoptotic signaling pathway  (IDA)
hypothalamus development  (IEP)
inflammatory response  (IEA,ISO)
learning or memory  (IMP)
locomotory exploration behavior  (ISO)
long-term synaptic potentiation  (IDA)
lung development  (ISO)
memory  (IDA)
modulation of inhibitory postsynaptic potential  (IMP)
monoatomic ion homeostasis  (IEP)
negative regulation of eating behavior  (IDA)
negative regulation of epinephrine secretion  (IBA,IDA)
negative regulation of gene expression  (IMP)
negative regulation of glucagon secretion  (IBA,IDA)
negative regulation of luteinizing hormone secretion  (IMP)
negative regulation of norepinephrine secretion  (IDA)
negative regulation of systemic arterial blood pressure  (IDA)
neuron apoptotic process  (IDA)
positive regulation of behavioral fear response  (IDA)
positive regulation of calcium ion import  (IDA)
positive regulation of cAMP/PKA signal transduction  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of cellular process  (IDA)
positive regulation of corticosterone secretion  (IDA,IMP)
positive regulation of corticotropin secretion  (IDA,IEA,IMP,ISO)
positive regulation of cortisol secretion  (IBA,IEA,ISO)
positive regulation of digestive system process  (IDA)
positive regulation of gene expression  (IMP)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IDA)
positive regulation of protein phosphorylation  (IDA)
regulation of NMDA receptor activity  (IDA,ISO)
regulation of serotonin secretion  (IDA)
regulation of synaptic transmission, GABAergic  (IMP)
response to alcohol  (IEP)
response to aldosterone  (IEP)
response to cocaine  (IEP)
response to corticosterone  (IEP)
response to estrogen  (IEP)
response to ethanol  (IEP)
response to ether  (IEP)
response to immobilization stress  (IEP)
response to pain  (IEP)
response to xenobiotic stimulus  (IEP)
steroid metabolic process  (IEP)
synaptic transmission, dopaminergic  (IDA,IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Down-regulation of hypothalamic corticotropin-releasing hormone messenger ribonucleic acid (mRNA) precedes early-life experience-induced changes in hippocampal glucocorticoid receptor mRNA. Avishai-Eliner S, etal., Endocrinology 2001 Jan;142(1):89-97.
2. Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin-releasing factor and nerve growth factor interplay. Barreau F, etal., J Physiol. 2007 Apr 1;580(Pt 1):347-56. Epub 2007 Jan 18.
3. Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease. Behan DP, etal., Nature. 1995 Nov 16;378(6554):284-7.
4. oCRF and CRF (6-33) depress food but not water intake in the obese Zucker rat. Bjenning CA and Rimvall K, Int J Obes Relat Metab Disord. 2000 Jun;24 Suppl 2:S140-1. doi: 10.1038/sj.ijo.0801304.
5. Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders. Bravo JA, etal., Int J Neuropsychopharmacol. 2011 Jun;14(5):666-83. Epub 2010 Sep 22.
6. CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior. Bruchas MR, etal., PLoS One. 2009 Dec 31;4(12):e8528.
7. Inhibition of food intake induced by acute stress in rats is due to satiation effects. Calvez J, etal., Physiol Behav. 2011 Jul 21;104(5):675-683.
8. Dysregulation of Nociceptin/Orphanin FQ and Dynorphin Systems in the Extended Amygdala of Alcohol Preferring Marchigian Sardinian (msP) Rats. Caputi FF, etal., Int J Mol Sci. 2021 Feb 28;22(5):2448. doi: 10.3390/ijms22052448.
9. Reversal of stress- and CRF-induced anorexia in rats by the synthetic nociceptin/orphanin FQ receptor agonist, Ro 64-6198. Ciccocioppo R, etal., Psychopharmacology (Berl). 2002 May;161(2):113-9. Epub 2002 Mar 22.
10. Repeated restraint stress-induced increase in baroreceptor reflex sensitivity: role of corticotropin-releasing factor. Conti LH, etal., Neuropeptides 2001 Apr;35(2):71-81.
11. Effects of corticotropin-releasing factor on prepulse inhibition of the acoustic startle response in two rat strains. Conti LH, etal., Psychopharmacology (Berl) 2002 May;161(3):296-303. Epub 2002 Mar 28.
12. Nociceptin/orphanin FQ blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposure. Cruz MT, etal., Biol Psychiatry. 2012 Apr 15;71(8):666-76. doi: 10.1016/j.biopsych.2011.10.032. Epub 2011 Dec 6.
13. Abnormalities in corticotropin-releasing hormone (CRH) in Alzheimer's disease and other human disorders. De Souza EB, etal., Ann N Y Acad Sci. 1987;512:237-47.
14. Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase. Dermitzaki E, etal., J Biol Chem 2002 Apr 5;277(14):12280-7. Epub 2002 Jan 14.
15. A single amino acid serves as an affinity switch between the receptor and the binding protein of corticotropin-releasing factor: implications for the design of agonists and antagonists. Eckart K, etal., Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11142-7.
16. Potential signalling pathways underlying corticotrophin-releasing hormone-mediated neuroprotection from excitotoxicity in rat hippocampus. Elliott-Hunt CR, etal., J Neurochem 2002 Feb;80(3):416-25.
17. Effects of chronic cocaine exposure on corticotropin-releasing hormone binding protein in the central nucleus of the amygdala and bed nucleus of the stria terminalis. Erb S, etal., Neuroscience. 2004;123(4):1003-9.
18. Corticotropin-releasing factor (CRF) can directly affect brain microvessel endothelial cells. Esposito P, etal., Brain Res 2003 Apr 11;968(2):192-8.
19. Corticotropin-releasing factor (CRF) and related peptides confer neuroprotection via type 1 CRF receptors. Facci L, etal., Neuropharmacology. 2003 Oct;45(5):623-36.
20. Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic-pituitary-adrenal axis and induces anxiety-like behavior in adult male rat offspring. Fan JM, etal., Neuroscience. 2009 Apr 10;159(4):1363-73. Epub 2009 Feb 12.
21. Human neuronal changes in brain edema and increased intracranial pressure. Faragó N, etal., Acta Neuropathol Commun. 2016 Aug 4;4(1):78. doi: 10.1186/s40478-016-0356-x.
22. Role of corticotrophin-releasing hormone in the impairment of counterregulatory responses to hypoglycemia. Flanagan DE, etal., Diabetes 2003 Mar;52(3):605-13.
23. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
24. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
25. Corticotropin releasing hormone promoter polymorphisms in giant cell arteritis and polymyalgia rheumatica. Gonzalez-Gay MA, etal., Clin Exp Rheumatol. 2002 Mar-Apr;20(2):133-8.
26. Roles of two subtypes of corticotrophin-releasing factor receptor in the corticostriatal long-term potentiation under cocaine withdrawal condition. Guan X, etal., J Neurochem. 2010 Nov;115(3):795-803. doi: 10.1111/j.1471-4159.2010.06981.x. Epub 2010 Sep 28.
27. Modulation of social learning in rats by brain corticotropin-releasing factor. Heinrichs SC Brain Res. 2003 Dec 19;994(1):107-14.
28. Selective stimulatory actions of corticotropin-releasing factor ligands on correlates of energy balance. Heinrichs SC, etal., Physiol Behav. 2001 Sep 1-15;74(1-2):5-13.
29. Distribution of corticotropin-releasing factor binding protein-immunoreactivity in the rat hypothalamus: association with corticotropin-releasing factor-, urocortin 1- and vimentin-immunoreactive fibres. Henry BA, etal., J Neuroendocrinol. 2005 Mar;17(3):135-44.
30. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
31. Hypophysiotropic thyrotropin-releasing hormone and corticotropin-releasing hormone neurons of the rat contain vesicular glutamate transporter-2. Hrabovszky E, etal., Endocrinology 2005 Jan;146(1):341-7. Epub 2004 Oct 14.
32. Rapid stress-induced elevations in corticotropin-releasing hormone mRNA in rat central amygdala nucleus and hypothalamic paraventricular nucleus: an in situ hybridization analysis. Hsu DT, etal., Brain Res. 1998 Mar 30;788(1-2):305-10.
33. Diurnal changes in corticotropin-releasing hormone messenger RNA in the rat thalamus. Hsu DT, etal., Neurosci Lett 2003 Feb 20;338(1):33-6.
34. CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner. Huising MO, etal., Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):912-7. Epub 2009 Dec 22.
35. Characterization of peptide-protein interactions using photoaffinity labeling and LC/MS. Jahn O, etal., Anal Bioanal Chem. 2004 Feb;378(4):1031-6. doi: 10.1007/s00216-003-2353-8. Epub 2003 Dec 11.
36. Three-amino acid motifs of urocortin II and III determine their CRF receptor subtype selectivity. Jahn O, etal., Neuropharmacology. 2004 Aug;47(2):233-42.
37. Modulation of Ca2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cells. Kageyama K, etal., Peptides. 2006 Jul;27(7):1814-9. Epub 2006 Feb 28.
38. Corticotrophin-releasing factor alters the timing of puberty in the female rat. Kinsey-Jones JS, etal., J Neuroendocrinol. 2010 Feb;22(2):102-9. Epub 2009 Dec 4.
39. Changes in hypothalamic corticotropin-releasing hormone, neuropeptide Y, and proopiomelanocortin gene expression during chronic rapid eye movement sleep deprivation of rats. Koban M, etal., Endocrinology. 2006 Jan;147(1):421-31. doi: 10.1210/en.2005-0695. Epub 2005 Oct 6.
40. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
41. Effects of acute ethanol on corticotropin-releasing hormone and beta-endorphin systems at the level of the rat central amygdala. Lam MP and Gianoulakis C, Psychopharmacology (Berl). 2011 May 20.
42. Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults. Liu L, etal., PLoS One. 2011 May 12;6(5):e19498.
43. Chronic ethanol ingestion modulates proanxiety factors expressed in rat central amygdala. Läck AK, etal., Alcohol. 2005 Jun;36(2):83-90. doi: 10.1016/j.alcohol.2005.07.004.
44. Reward devaluation and heroin escalation is associated with differential expression of CRF signaling genes. McFalls AJ, etal., Brain Res Bull. 2016 May;123:81-93. doi: 10.1016/j.brainresbull.2015.11.009. Epub 2015 Dec 2.
45. Stress and glucocorticoids regulated corticotropin releasing factor in rat prefrontal cortex. Meng QY, etal., Mol Cell Endocrinol. 2011 Aug 6;342(1-2):54-63. Epub 2011 Jun 1.
46. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
47. Role of corticotropin-releasing hormone in ovarian steroidogenesis. Murase M, etal., Endocrine 2002 Aug;18(3):255-60.
48. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
49. Role of urocortin 2 secreted by the pituitary in the stress-induced suppression of luteinizing hormone secretion in rats. Nemoto T, etal., Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E567-75. Epub 2010 Jul 27.
50. Gene expression changes in the retina after systemic administration of aldosterone. Ono A, etal., Jpn J Ophthalmol. 2018 Jul;62(4):499-507. doi: 10.1007/s10384-018-0595-4. Epub 2018 Apr 30.
51. Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I. Pedersen WA, etal., J Neurosci 2002 Jan 15;22(2):404-12.
52. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
53. Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. Radulovic J, etal., J Neurosci. 1999 Jun 15;19(12):5016-25.
54. Corticotropin-releasing hormone and proopiomelanocortin gene expression is altered selectively in the male rat fetal thymus by maternal alcohol consumption. Revskoy S, etal., Endocrinology. 1997 Jan;138(1):389-96. doi: 10.1210/endo.138.1.4838.
55. GOA pipeline RGD automated data pipeline
56. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
57. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
58. Intraventricular insulin potentiates the anorexic effect of corticotropin releasing hormone in rats. Richardson RD, etal., Am J Physiol Regul Integr Comp Physiol 2002 Dec;283(6):R1321-6.
59. Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence. Roberto M, etal., Biol Psychiatry. 2010 May 1;67(9):831-9. Epub 2010 Jan 8.
60. Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation. Roozendaal B, etal., Proc Natl Acad Sci U S A 2002 Oct 15;99(21):13908-13.
61. Experimental neuropathy increases limbic forebrain CRF. Rouwette T, etal., Eur J Pain. 2011 Jun 17.
62. Differential responses of corticotropin-releasing factor and urocortin 1 to acute pain stress in the rat brain. Rouwette T, etal., Neuroscience. 2011 Jun 2;183:15-24. Epub 2011 Apr 2.
63. Hypothalamic cocaine- and amphetamine-regulated transcript and corticotrophin releasing factor neurons are stimulated by extracellular volume and osmotic changes. Ruginsk SG, etal., Neuroscience. 2011 Jul 14;186:57-64. Epub 2011 Apr 28.
64. Corticotropin-releasing factor as well as opioid and dopamine are involved in tail-pinch-induced food intake of rats. Samarghandian S, etal., Neuroscience 2003;116(2):519-24.
65. Corticotropin releasing factor-distribution in rat intestine and role in neuroprotection. Sand E, etal., Regul Pept. 2011 Jan 17;166(1-3):68-75. Epub 2010 Aug 27.
66. Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotrophin-releasing hormone gene expression in diabetes. Schwartz MW, etal., Regul Pept. 1997 Oct 31;72(2-3):105-12.
67. Acute effects of acephate and methamidophos and interleukin-1 on corticotropin-releasing factor (CRF) synthesis in and release from the hypothalamus in vitro. Singh AK Comp Biochem Physiol C Toxicol Pharmacol 2002 May;132(1):9-24.
68. Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilus. Smith MA, etal., Brain Res. 1997 Jan 16;745(1-2):248-56.
69. Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition. Smoller JW, etal., Biol Psychiatry 2003 Dec 15;54(12):1376-81.
70. Acute ether stress differentially affects corticotropin-releasing factor and urocortin 1 in the Brattleboro rat. Sterrenburg L, etal., Brain Res. 2011 Jun 29;1398:21-9. Epub 2011 May 6.
71. Suppression of hypothalamic-pituitary-adrenal axis responsiveness to stress in a rat model of acute cholestasis. Swain MG, etal., J Clin Invest. 1993 May;91(5):1903-8.
72. Central alpha-adrenergic receptors and corticotropin releasing factor mediate hemodynamic responses to acute cold stress. Tan Y, etal., Brain Res 2003 Apr 4;968(1):122-9.
73. Effect of lamotrigine and carbamazepine on corticotropin-releasing factor-associated serotonergic transmission in rat dorsal raphe nucleus. Tanahashi S, etal., Psychopharmacology (Berl). 2011 Sep 27.
74. Nicotine withdrawal increases stress-associated genes in the nucleus accumbens of female rats in a hormone-dependent manner. Torres OV, etal., Nicotine Tob Res. 2015 Apr;17(4):422-30. doi: 10.1093/ntr/ntu278. Epub 2015 Mar 11.
75. Electron microscopic localization of corticotropin-releasing factor (CRF) and CRF receptor in rat and mouse central nucleus of the amygdala. Treweek JB, etal., J Comp Neurol. 2009 Jan 20;512(3):323-35. doi: 10.1002/cne.21884.
76. Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Ungless MA, etal., Neuron. 2003 Jul 31;39(3):401-7.
77. Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats. Van Waes V, etal., Eur J Neurosci. 2006 Aug;24(4):1193-200. doi: 10.1111/j.1460-9568.2006.04973.x. Epub 2006 Aug 21.
78. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Vaughan J, etal., Nature 1995 Nov 16;378(6554):287-92.
79. Comparison of CRF-immunoreactive neurons distribution in mouse and rat brains and selective induction of Fos in rat hypothalamic CRF neurons by abdominal surgery. Wang L, etal., Brain Res. 2011 Jul 23.
80. [Influence of electroacupuncture on efficacy of estrogen in regulating hypothalamic reproductive endocrine activity in rats]. Wang SJ, etal., Zhen Ci Yan Jiu. 2011 Feb;36(1):1-6, 39.
81. The function of the adrenocortical axis in permanent middle cerebral artery occlusion: effect of glucocorticoids on the neurological outcome. Weidenfeld J, etal., Brain Res. 2011 Aug 17;1407:90-6. Epub 2011 Jun 23.
82. Sex differences in corticotropin releasing factor regulation of medial septum-mediated memory formation. Wiersielis KR, etal., Neurobiol Stress. 2019 Feb 20;10:100150. doi: 10.1016/j.ynstr.2019.100150. eCollection 2019 Feb.
83. Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin. Wigger A, etal., Neuropsychopharmacology 2004 Jan;29(1):1-14.
84. Focal cerebral ischemia induces CRH mRNA in rat cerebral cortex and amygdala. Wong ML, etal., Neuroreport. 1995 Sep 11;6(13):1785-8.
85. Aging associated changes in amygdalar corticotropin-releasing hormone (CRH) and CRH-binding protein in Fischer 344 rats. Xiao C, etal., Brain Res. 2006 Feb 16;1073-1074:325-31. Epub 2006 Feb 2.
86. Central actions of corticotropin releasing factor on sensori-autonomic processing in normotensive and hypertensive rats. Youngblood K, etal., Brain Res 1996 Sep 23;734(1-2):175-85.
87. Corticotrophin-releasing hormone (CRH) facilitates axon outgrowth. Yuan H, etal., Spinal Cord. 2010 Dec;48(12):850-6. Epub 2010 May 11.
88. Ferulic acid-induced anti-depression and prokinetics similar to Chaihu-Shugan-San via polypharmacology. Zhang YJ, etal., Brain Res Bull. 2011 Jul 20.
89. [The relationship of ultrastructure and function of hypothalamus-pituitary-adrenal axis in early stage of sepsis in rats]. Zhang YX, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011 May;23(5):286-9.
90. Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine. Zhou Y, etal., Brain Res Mol Brain Res. 2003 May 26;114(1):73-9.
91. Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats. Zorrilla EP, etal., Addict Biol. 2011 Jul 18. doi: 10.1111/j.1369-1600.2011.00329.x.
Additional References at PubMed
PMID:3274895   PMID:3876950   PMID:6603620   PMID:10861000   PMID:11329063   PMID:11826130   PMID:11860185   PMID:12223536   PMID:12372003   PMID:12394282   PMID:12463966   PMID:12639912  
PMID:12694372   PMID:12763250   PMID:12782246   PMID:12933679   PMID:12953161   PMID:14555722   PMID:14561874   PMID:14563696   PMID:14596843   PMID:14636174   PMID:15044366   PMID:15159534  
PMID:15375029   PMID:15512854   PMID:15564578   PMID:15585943   PMID:15591144   PMID:15752579   PMID:15800377   PMID:15989796   PMID:16123229   PMID:16195412   PMID:16198122   PMID:16337313  
PMID:16357101   PMID:16360122   PMID:16423352   PMID:17055465   PMID:17099900   PMID:17244200   PMID:17347308   PMID:17363455   PMID:17388940   PMID:17477982   PMID:17505125   PMID:17514764  
PMID:17631870   PMID:17636405   PMID:17640185   PMID:17690163   PMID:17722034   PMID:17766644   PMID:17825268   PMID:17904655   PMID:17908177   PMID:17921249   PMID:17927669   PMID:17947354  
PMID:17947358   PMID:18001698   PMID:18047555   PMID:18055027   PMID:18067140   PMID:18067977   PMID:18079206   PMID:18082275   PMID:18205263   PMID:18243550   PMID:18276081   PMID:18304530  
PMID:18329818   PMID:18343362   PMID:18367364   PMID:18374921   PMID:18505443   PMID:18559919   PMID:18579737   PMID:18595780   PMID:18596687   PMID:18619422   PMID:18624927   PMID:18656313  
PMID:18662341   PMID:18784337   PMID:19036986   PMID:19065825   PMID:19074588   PMID:19140304   PMID:19279290   PMID:19285486   PMID:19293294   PMID:19418633   PMID:19460861   PMID:19500229  
PMID:19543827   PMID:19699720   PMID:19729048   PMID:19901333   PMID:19944726   PMID:20004705   PMID:20548297   PMID:20561155   PMID:20624690   PMID:20688066   PMID:20699230   PMID:20709096  
PMID:20814066   PMID:20832430   PMID:20833218   PMID:20881118   PMID:20966530   PMID:20974156   PMID:21121974   PMID:21306450   PMID:21376756   PMID:21382355   PMID:21481539   PMID:21527271  
PMID:21600959   PMID:21719534   PMID:21848921   PMID:22033279   PMID:22109884   PMID:22132228   PMID:22245501   PMID:22249942   PMID:22290119   PMID:22322324   PMID:22375940   PMID:22510725  
PMID:22698524   PMID:22768175   PMID:22801106   PMID:22831701   PMID:23084728   PMID:23205497   PMID:23371389   PMID:23416448   PMID:23425370   PMID:23432085   PMID:23538212   PMID:23568325  
PMID:23628776   PMID:23895427   PMID:23916912   PMID:24021806   PMID:24065704   PMID:24139460   PMID:24246425   PMID:24317347   PMID:24464021   PMID:24682755   PMID:24718660   PMID:25051447  
PMID:25089000   PMID:25139171   PMID:25236411   PMID:25275258   PMID:25406021   PMID:25433848   PMID:25567426   PMID:25640835   PMID:25716783   PMID:26109804   PMID:26138585   PMID:26333123  
PMID:26363852   PMID:26387568   PMID:26578428   PMID:26755731   PMID:26821289   PMID:27150225   PMID:27376372   PMID:27452579   PMID:27538655   PMID:27637621   PMID:27805752   PMID:28655627  
PMID:28689880   PMID:28807676   PMID:28935440   PMID:29033027   PMID:29126185   PMID:29514102   PMID:30139928   PMID:30192883   PMID:30530860   PMID:31558322   PMID:31614362   PMID:33441166  
PMID:33745155   PMID:34111125   PMID:35732494   PMID:37041718   PMID:38419452   PMID:39048594  


Genomics

Comparative Map Data
Crh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82104,059,184 - 104,061,048 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2104,058,770 - 104,061,386 (-)EnsemblGRCr8
mRatBN7.22102,143,055 - 102,144,919 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2102,143,055 - 102,144,919 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2108,674,139 - 108,676,025 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02106,795,271 - 106,797,157 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02101,764,428 - 101,766,314 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02104,459,999 - 104,461,863 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2104,459,999 - 104,461,863 (-)Ensemblrn6Rnor6.0
Rnor_5.02124,182,919 - 124,184,783 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42104,764,023 - 104,765,887 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera297,536,796 - 97,538,660 (-)NCBICelera
RGSC_v3.12104,708,984 - 104,710,849 (-)NCBI
Cytogenetic Map2q24NCBI
CRH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38866,176,376 - 66,178,464 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl866,176,376 - 66,178,464 (-)Ensemblhg38GRCh38
GRCh37867,088,611 - 67,090,699 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36867,251,173 - 67,253,252 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34867,251,172 - 67,253,252NCBI
Celera863,080,325 - 63,082,559 (-)NCBICelera
Cytogenetic Map8q13.1NCBI
HuRef862,578,767 - 62,581,001 (-)NCBIHuRef
CHM1_1867,143,265 - 67,145,499 (-)NCBICHM1_1
T2T-CHM13v2.0866,602,063 - 66,612,357 (-)NCBIT2T-CHM13v2.0
Crh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39319,747,565 - 19,749,560 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl319,747,565 - 19,749,560 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38319,693,401 - 19,695,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl319,693,401 - 19,695,396 (-)Ensemblmm10GRCm38
MGSCv37319,593,401 - 19,595,396 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36319,885,565 - 19,887,480 (-)NCBIMGSCv36mm8
Celera319,686,501 - 19,688,496 (-)NCBICelera
Cytogenetic Map3A2NCBI
cM Map35.75NCBI
Crh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544412,990,267 - 12,990,814 (+)Ensembl
ChiLan1.0NW_00495544412,989,210 - 12,991,300 (+)NCBIChiLan1.0ChiLan1.0
CRH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2781,908,836 - 81,919,149 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1857,548,461 - 57,558,776 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0862,714,721 - 62,716,979 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1864,382,912 - 64,385,175 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl864,383,419 - 64,384,009 (-)EnsemblpanPan2panpan1.1
CRH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12915,831,944 - 15,840,560 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2915,831,944 - 15,834,384 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2916,146,733 - 16,149,174 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02915,890,845 - 16,097,836 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2915,910,573 - 15,913,018 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12915,940,159 - 15,942,599 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02916,042,480 - 16,044,918 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02916,298,228 - 16,300,672 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Crh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530367,023,855 - 67,026,364 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364967,760,532 - 7,761,122 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364967,759,656 - 7,761,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl468,484,053 - 68,486,121 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1468,481,696 - 68,486,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2474,349,511 - 74,653,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1862,052,155 - 62,056,424 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl862,052,592 - 62,053,182 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603979,456,894 - 79,459,404 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474425,194,495 - 25,196,488 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474425,194,458 - 25,196,658 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Crh
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13134,362,647 - 134,364,784 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Crh
22 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:190
Count of miRNA genes:140
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000016953
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261556902106556902Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)278269809104744824Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat


Genetic Models
This gene Crh is modified in the following models/strains:
SD-Crhem1Ionsz    


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 32 101 18 20 13 15 13 4 77 55 1 96 1 27 7 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000016953   ⟹   ENSRNOP00000016953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2104,058,770 - 104,061,386 (-)Ensembl
mRatBN7.2 Ensembl2102,143,055 - 102,144,919 (-)Ensembl
Rnor_6.0 Ensembl2104,459,999 - 104,461,863 (-)Ensembl
RefSeq Acc Id: NM_031019   ⟹   NP_112281
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82104,059,184 - 104,061,048 (-)NCBI
mRatBN7.22102,143,055 - 102,144,919 (-)NCBI
Rnor_6.02104,459,999 - 104,461,863 (-)NCBI
Rnor_5.02124,182,919 - 124,184,783 (-)NCBI
RGSC_v3.42104,764,023 - 104,765,887 (-)RGD
Celera297,536,796 - 97,538,660 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_112281 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40965 (Get FASTA)   NCBI Sequence Viewer  
  CAA26838 (Get FASTA)   NCBI Sequence Viewer  
  EDM01068 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016953
  ENSRNOP00000016953.1
GenBank Protein P01143 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112281   ⟸   NM_031019
- Peptide Label: precursor
- UniProtKB: P01143 (UniProtKB/Swiss-Prot),   A6IHC0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016953   ⟸   ENSRNOT00000016953
Protein Domains
Corticotropin-releasing factor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01143-F1-model_v2 AlphaFold P01143 1-187 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6849970
Promoter ID:EP30038
Type:single initiation site
Name:RN_CRF
Description:Corticotropin-releasing factor, CRH gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 170; Mammalian corticotropin-releasing factor
Tissues & Cell Lines:brainstem > hypothalamus
Experiment Methods:Primer extension; experiments performed with closely related; gene
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.42104,765,887 - 104,765,947EPD

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620505 AgrOrtholog
BioCyc Gene G2FUF-53615 BioCyc
Ensembl Genes ENSRNOG00000012703 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016953 ENTREZGENE
  ENSRNOT00000016953.3 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.1920 UniProtKB/Swiss-Prot
InterPro Corticotropin-releasing_fac_CS UniProtKB/Swiss-Prot
  CRF UniProtKB/Swiss-Prot
  Urocortin_CRF UniProtKB/Swiss-Prot
KEGG Report rno:81648 UniProtKB/Swiss-Prot
NCBI Gene 81648 ENTREZGENE
PANTHER CORTICOLIBERIN UniProtKB/Swiss-Prot
  PTHR15035 UniProtKB/Swiss-Prot
Pfam CRF UniProtKB/Swiss-Prot
PharmGKB CRH RGD
PhenoGen Crh PhenoGen
PRINTS CRFFAMILY UniProtKB/Swiss-Prot
PROSITE CRF UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012703 RatGTEx
SMART CRF UniProtKB/Swiss-Prot
UniProt A6IHC0 ENTREZGENE, UniProtKB/TrEMBL
  CRF_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Crh  corticotropin releasing hormone      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Crh  corticotropin releasing hormone      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease decreases prepulse inhibition and the acoustic startle response; may be involved in exacerbation of schizophrenia symptoms in response to stress 1358959
gene_expression expressed in hippocampus 628441
gene_mapping maps within the Cia7 QTL region and may be a candidate gene for this QTL locus 70860
gene_process may play a role in increased sensitivity of baroreceptor reflex in response to stress 1358969
gene_process involved in exerting an inhibitory role on the pressor and bradycardia responses in WKY rats 1358987
gene_process involved in exerting a permissive role on the bradycardia response which is lost when blood pressure is normalized with chronic hydralazine in SHR rats 1358987
gene_process may play a critical role in early-life experience that influences the hormonal stress-response long-term 628441
gene_process plays a role in learning and memory; is a key neuroendocrine stress mediator that initiates activation of the hypothalamic-pituitary-adrenocortical axis; directly mediates neuronal activity in several limbic regions 625745
gene_process reduced hypothalamic expression mediates handling-induced reduction in stress responses 628441
gene_regulation expression levels are increased in the central nucleus of the amygdala (CEA) by brief footshock 625745
gene_regulation hypothalamic mRNA levels in daily-handled rats reduced around the 9th postnatal day and are sustained through postnatal days 23 and 45, i.e. beyond puberty 628441