Crh (corticotropin releasing hormone) - Rat Genome Database

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Gene: Crh (corticotropin releasing hormone) Mus musculus
Analyze
Symbol: Crh
Name: corticotropin releasing hormone
RGD ID: 730947
MGI Page MGI
Description: Predicted to enable corticotropin-releasing hormone activity; corticotropin-releasing hormone receptor 1 binding activity; and corticotropin-releasing hormone receptor 2 binding activity. Acts upstream of or within several processes, including adrenal gland development; glucocorticoid biosynthetic process; and locomotory exploration behavior. Located in neuronal cell body. Is expressed in several structures, including central nervous system; extraembryonic component; lung; placenta; and thymus. Used to study primary hyperaldosteronism. Human ortholog(s) of this gene implicated in obesity and panic disorder. Orthologous to human CRH (corticotropin releasing hormone).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: corticoliberin; corticotropin releasing factor; corticotropin-releasing factor; corticotropin-releasing hormone; CR; CRF; Gm1347; MGC151298
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39319,747,565 - 19,749,560 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl319,747,565 - 19,749,560 (-)EnsemblGRCm39 Ensembl
GRCm38319,693,401 - 19,695,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl319,693,401 - 19,695,396 (-)EnsemblGRCm38mm10GRCm38
MGSCv37319,593,401 - 19,595,396 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36319,885,565 - 19,887,480 (-)NCBIMGSCv36mm8
Celera319,686,501 - 19,688,496 (-)NCBICelera
Cytogenetic Map3A2NCBI
cM Map35.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-arachidonoylglycerol  (EXP)
3',5'-cyclic AMP  (ISO)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-phenoxybenzoic acid  (EXP)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
8-Br-cAMP  (ISO)
8-OH-DPAT  (ISO)
acephate  (ISO)
acetylcholine  (ISO)
adinazolam  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-Zearalanol  (ISO)
AM-251  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anandamide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenous acid  (ISO)
astemizole  (ISO)
astressin  (ISO)
atropine  (ISO)
benzo[a]pyrene  (ISO)
beta-endorphin  (ISO)
beta-naphthoflavone  (ISO)
betaxolol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
Butylparaben  (ISO)
cannabidiol  (EXP)
carbon dioxide  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cis-caffeic acid  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
corticotropin  (ISO)
cortisol  (ISO)
Cuprizon  (ISO)
cyanamide  (ISO)
cyclophosphamide  (EXP,ISO)
DDE  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (ISO)
diethyl phthalate  (EXP)
Diisodecyl phthalate  (EXP)
diprotium oxide  (ISO)
dorsomorphin  (ISO)
doxapram  (ISO)
dynorphin A  (ISO)
E-4031  (ISO)
enzacamene  (ISO)
ethanol  (EXP,ISO)
fentanyl  (ISO)
finasteride  (ISO)
flavonoids  (ISO)
fluoxetine  (EXP,ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
gamma-aminobutyric acid  (ISO)
genistein  (EXP)
glycidol  (ISO)
Goe 6976  (ISO)
GTP  (ISO)
guanosine 5'-[beta,gamma-imido]triphosphate  (ISO)
haloperidol  (ISO)
hemin  (ISO)
hydrogen peroxide  (ISO)
idazoxan  (ISO)
imipramine  (ISO)
indometacin  (ISO)
ketamine  (ISO)
lidocaine  (ISO)
linsidomine  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mesoporphyrin IX  (ISO)
metamizole sodium  (ISO)
methamidophos  (ISO)
methamphetamine  (ISO)
methoxamine  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
monosodium L-glutamate  (ISO)
morphine  (EXP)
naloxone  (ISO)
naltrexone  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentobarbital  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
Phenelzine  (ISO)
phenytoin  (ISO)
pioglitazone  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
promazine  (ISO)
propranolol  (ISO)
quercetin  (ISO)
reserpine  (ISO)
rimonabant  (ISO)
risperidone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (ISO)
serotonin  (ISO)
sertraline  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
Soman  (ISO)
sphingosine  (ISO)
staurosporine  (ISO)
Sulpyrine  (ISO)
telmisartan  (ISO)
terbutaline  (ISO)
testosterone  (ISO)
tetraethylammonium  (ISO)
tetrodotoxin  (ISO)
thioridazine  (ISO)
toluene  (ISO)
trans-caffeic acid  (ISO)
trichloroethene  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
water  (ISO)
yohimbine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IMP)
associative learning  (ISO)
cellular response to cocaine  (ISO)
cellular response to dexamethasone stimulus  (ISO)
diterpenoid metabolic process  (ISO)
female pregnancy  (ISO)
glucocorticoid biosynthetic process  (IMP)
hormone-mediated apoptotic signaling pathway  (ISO)
hypothalamus development  (ISO)
inflammatory response  (IMP,ISO)
learning or memory  (ISO)
locomotory exploration behavior  (IGI)
long-term synaptic potentiation  (ISO)
lung development  (IMP)
monoatomic ion homeostasis  (ISO)
negative regulation of epinephrine secretion  (IBA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of glucagon secretion  (IBA,ISO)
negative regulation of luteinizing hormone secretion  (ISO)
negative regulation of norepinephrine secretion  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
neuron apoptotic process  (ISO)
positive regulation of behavioral fear response  (ISO)
positive regulation of calcium ion import  (ISO)
positive regulation of cAMP-mediated signaling  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular process  (ISO)
positive regulation of corticosterone secretion  (ISO)
positive regulation of corticotropin secretion  (ISO)
positive regulation of cortisol secretion  (IBA,ISO)
positive regulation of digestive system process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of protein phosphorylation  (ISO)
regulation of serotonin secretion  (ISO)
response to alcohol  (ISO)
response to aldosterone  (ISO)
response to cocaine  (ISO)
response to corticosterone  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to ether  (ISO)
response to immobilization stress  (ISO)
response to pain  (ISO)
response to xenobiotic stimulus  (ISO)
steroid metabolic process  (ISO)
synaptic transmission, dopaminergic  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adrenal gland morphology  (IAGP)
abnormal adrenal gland secretion  (IAGP)
abnormal adrenocorticotropin level  (IAGP)
abnormal anxiety-related response  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal body weight  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal cell-mediated immunity  (IAGP)
abnormal circulating adrenaline level  (IAGP)
abnormal circulating corticosterone level  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal circulating noradrenaline level  (IAGP)
abnormal club cell morphology  (IAGP)
abnormal corticosterone level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal fat cell morphology  (IAGP)
abnormal food intake  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal lung development  (IAGP)
abnormal lung morphology  (IAGP)
abnormal professional antigen presenting cell physiology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal solitary pulmonary neuroendocrine cell morphology  (IAGP)
abnormal surfactant composition  (IAGP)
abnormal urine homeostasis  (IAGP)
adrenal gland atrophy  (IAGP)
decreased adrenal gland weight  (IAGP)
decreased adrenal gland zona fasciculata size  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone ossification  (IAGP)
decreased circulating adrenaline level  (IAGP)
decreased circulating adrenocorticotropin level  (IAGP)
decreased circulating corticosterone level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating osteocalcin level  (IAGP)
decreased circulating parathyroid hormone level  (IAGP)
decreased inflammatory response  (IAGP)
decreased lean body mass  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased T cell proliferation  (IAGP)
hyperglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
increased adrenal gland weight  (IAGP)
increased adrenal gland zona fasciculata size  (IAGP)
increased blood uric acid level  (IAGP)
increased body weight  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating calcium level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating glucagon level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating total protein level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased mesenchymal cell proliferation involved in lung development  (IAGP)
increased splenocyte number  (IAGP)
increased total body fat amount  (IAGP)
increased urine calcium level  (IAGP)
increased urine corticosterone level  (IAGP)
increased urine glucose level  (IAGP)
increased urine protein level  (IAGP)
insulin resistance  (IAGP)
maternal effect  (IAGP)
no abnormal phenotype detected  (IEA)
obese  (IAGP)
polydipsia  (IAGP)
polyuria  (IAGP)
premature hair loss  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thin skin  (IAGP)
thin tail  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease. Behan DP, etal., Nature. 1995 Nov 16;378(6554):284-7.
2. Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders. Bravo JA, etal., Int J Neuropsychopharmacol. 2011 Jun;14(5):666-83. Epub 2010 Sep 22.
3. Abnormalities in corticotropin-releasing hormone (CRH) in Alzheimer's disease and other human disorders. De Souza EB, etal., Ann N Y Acad Sci. 1987;512:237-47.
4. Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic-pituitary-adrenal axis and induces anxiety-like behavior in adult male rat offspring. Fan JM, etal., Neuroscience. 2009 Apr 10;159(4):1363-73. Epub 2009 Feb 12.
5. Human neuronal changes in brain edema and increased intracranial pressure. Faragó N, etal., Acta Neuropathol Commun. 2016 Aug 4;4(1):78. doi: 10.1186/s40478-016-0356-x.
6. Role of corticotrophin-releasing hormone in the impairment of counterregulatory responses to hypoglycemia. Flanagan DE, etal., Diabetes 2003 Mar;52(3):605-13.
7. Corticotropin releasing hormone promoter polymorphisms in giant cell arteritis and polymyalgia rheumatica. Gonzalez-Gay MA, etal., Clin Exp Rheumatol. 2002 Mar-Apr;20(2):133-8.
8. Selective stimulatory actions of corticotropin-releasing factor ligands on correlates of energy balance. Heinrichs SC, etal., Physiol Behav. 2001 Sep 1-15;74(1-2):5-13.
9. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
10. Diurnal changes in corticotropin-releasing hormone messenger RNA in the rat thalamus. Hsu DT, etal., Neurosci Lett 2003 Feb 20;338(1):33-6.
11. Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults. Liu L, etal., PLoS One. 2011 May 12;6(5):e19498.
12. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
13. MGDs mouse GO annotations MGD data from the GO Consortium
14. Gene expression changes in the retina after systemic administration of aldosterone. Ono A, etal., Jpn J Ophthalmol. 2018 Jul;62(4):499-507. doi: 10.1007/s10384-018-0595-4. Epub 2018 Apr 30.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Intraventricular insulin potentiates the anorexic effect of corticotropin releasing hormone in rats. Richardson RD, etal., Am J Physiol Regul Integr Comp Physiol 2002 Dec;283(6):R1321-6.
20. Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence. Roberto M, etal., Biol Psychiatry. 2010 May 1;67(9):831-9. Epub 2010 Jan 8.
21. Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation. Roozendaal B, etal., Proc Natl Acad Sci U S A 2002 Oct 15;99(21):13908-13.
22. Experimental neuropathy increases limbic forebrain CRF. Rouwette T, etal., Eur J Pain. 2011 Jun 17.
23. Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotrophin-releasing hormone gene expression in diabetes. Schwartz MW, etal., Regul Pept. 1997 Oct 31;72(2-3):105-12.
24. Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilus. Smith MA, etal., Brain Res. 1997 Jan 16;745(1-2):248-56.
25. Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition. Smoller JW, etal., Biol Psychiatry 2003 Dec 15;54(12):1376-81.
26. Suppression of hypothalamic-pituitary-adrenal axis responsiveness to stress in a rat model of acute cholestasis. Swain MG, etal., J Clin Invest. 1993 May;91(5):1903-8.
27. The function of the adrenocortical axis in permanent middle cerebral artery occlusion: effect of glucocorticoids on the neurological outcome. Weidenfeld J, etal., Brain Res. 2011 Aug 17;1407:90-6. Epub 2011 Jun 23.
28. Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin. Wigger A, etal., Neuropsychopharmacology 2004 Jan;29(1):1-14.
29. Focal cerebral ischemia induces CRH mRNA in rat cerebral cortex and amygdala. Wong ML, etal., Neuroreport. 1995 Sep 11;6(13):1785-8.
30. Corticotrophin-releasing hormone (CRH) facilitates axon outgrowth. Yuan H, etal., Spinal Cord. 2010 Dec;48(12):850-6. Epub 2010 May 11.
31. [The relationship of ultrastructure and function of hypothalamus-pituitary-adrenal axis in early stage of sepsis in rats]. Zhang YX, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011 May;23(5):286-9.
32. Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine. Zhou Y, etal., Brain Res Mol Brain Res. 2003 May 26;114(1):73-9.
Additional References at PubMed
PMID:2981744   PMID:3871412   PMID:6267699   PMID:7704423   PMID:7830793   PMID:8090368   PMID:8182138   PMID:8194481   PMID:8211130   PMID:8268662   PMID:8543156   PMID:8889548  
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PMID:14988428   PMID:15033910   PMID:15159534   PMID:15331153   PMID:15469890   PMID:15567470   PMID:15582675   PMID:15591144   PMID:15623560   PMID:15664786   PMID:15833812   PMID:15843539  
PMID:15919058   PMID:16125539   PMID:16141072   PMID:16205360   PMID:16210362   PMID:16359808   PMID:16377004   PMID:16423327   PMID:16424218   PMID:16449297   PMID:16602821   PMID:16778399  
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PMID:19501082   PMID:19617649   PMID:19854866   PMID:20080794   PMID:20083850   PMID:20092567   PMID:20407282   PMID:20495559   PMID:20548294   PMID:20615973   PMID:20731720   PMID:20732324  
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PMID:21781958   PMID:21783178   PMID:21825133   PMID:21873635   PMID:21943598   PMID:22138165   PMID:22198557   PMID:22222439   PMID:22231481   PMID:22284183   PMID:22326386   PMID:22336193  
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PMID:23430746   PMID:23432085   PMID:23470617   PMID:23548689   PMID:23724107   PMID:23768074   PMID:23840363   PMID:24025224   PMID:24211652   PMID:24302625   PMID:24326400   PMID:24361598  
PMID:24411735   PMID:24473077   PMID:24487620   PMID:24490859   PMID:24704193   PMID:24899708   PMID:24946072   PMID:24952961   PMID:25057791   PMID:25071457   PMID:25094033   PMID:25125464  
PMID:25157144   PMID:25219790   PMID:25224546   PMID:25340785   PMID:25349575   PMID:25402857   PMID:25473847   PMID:25575243   PMID:25619114   PMID:25751534   PMID:25898242   PMID:25915476  
PMID:25964433   PMID:26212712   PMID:26338335   PMID:26402844   PMID:26657825   PMID:26987580   PMID:27001694   PMID:27060334   PMID:27080622   PMID:27267713   PMID:27306314   PMID:27385383  
PMID:27387482   PMID:27540587   PMID:27556938   PMID:27578785   PMID:27595593   PMID:27638512   PMID:27662084   PMID:27725087   PMID:28017470   PMID:28117439   PMID:28135239   PMID:28228269  
PMID:28334609   PMID:28460009   PMID:28514446   PMID:28614436   PMID:28625488   PMID:28706241   PMID:28744978   PMID:28758220   PMID:28786031   PMID:28912247   PMID:29043563   PMID:29056294  
PMID:29069304   PMID:29133846   PMID:29311741   PMID:29346425   PMID:29352046   PMID:29360543   PMID:29424419   PMID:29438518   PMID:29568676   PMID:29572434   PMID:29668880   PMID:29701827  
PMID:29749931   PMID:29751050   PMID:29786085   PMID:29844474   PMID:29934353   PMID:29981322   PMID:30038273   PMID:30104734   PMID:30170157   PMID:30186122   PMID:30209240   PMID:30266597  
PMID:30472090   PMID:30691514   PMID:30833699   PMID:30879785   PMID:31017816   PMID:31213976   PMID:31358754   PMID:31371721   PMID:31619956   PMID:31644914   PMID:31666704   PMID:31690636  
PMID:31712775   PMID:31754709   PMID:31827172   PMID:31836701   PMID:31969571   PMID:32003596   PMID:32093887   PMID:32094113   PMID:32101698   PMID:32206712   PMID:32218485   PMID:32224161  
PMID:32277042   PMID:32347794   PMID:32527376   PMID:32640184   PMID:32723474   PMID:32788592   PMID:32813270   PMID:32892351   PMID:33051356   PMID:33057013   PMID:33238113   PMID:33397711  
PMID:33413641   PMID:33443190   PMID:33504846   PMID:33543235   PMID:33649453   PMID:33858944   PMID:33887203   PMID:34004146   PMID:34127705   PMID:34194038   PMID:34281710   PMID:34350170  
PMID:34404890   PMID:34539345   PMID:34905510   PMID:34932943   PMID:35250437   PMID:35302583   PMID:35354026   PMID:35388122   PMID:35507386   PMID:35579999   PMID:35636458   PMID:35682965  
PMID:35750984   PMID:35770968   PMID:36245920   PMID:36317965   PMID:36442105   PMID:36623734   PMID:36732798   PMID:36774552   PMID:36841826   PMID:37168577   PMID:37246581   PMID:37400467  
PMID:37511494   PMID:37599997   PMID:37625400   PMID:37638323   PMID:37669667   PMID:37901949   PMID:37983249   PMID:38263350  


Genomics

Comparative Map Data
Crh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39319,747,565 - 19,749,560 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl319,747,565 - 19,749,560 (-)EnsemblGRCm39 Ensembl
GRCm38319,693,401 - 19,695,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl319,693,401 - 19,695,396 (-)EnsemblGRCm38mm10GRCm38
MGSCv37319,593,401 - 19,595,396 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36319,885,565 - 19,887,480 (-)NCBIMGSCv36mm8
Celera319,686,501 - 19,688,496 (-)NCBICelera
Cytogenetic Map3A2NCBI
cM Map35.75NCBI
CRH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38866,176,376 - 66,178,464 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl866,176,376 - 66,178,464 (-)EnsemblGRCh38hg38GRCh38
GRCh37867,088,611 - 67,090,699 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36867,251,173 - 67,253,252 (-)NCBINCBI36Build 36hg18NCBI36
Build 34867,251,172 - 67,253,252NCBI
Celera863,080,325 - 63,082,559 (-)NCBICelera
Cytogenetic Map8q13.1NCBI
HuRef862,578,767 - 62,581,001 (-)NCBIHuRef
CHM1_1867,143,265 - 67,145,499 (-)NCBICHM1_1
T2T-CHM13v2.0866,602,063 - 66,612,357 (-)NCBIT2T-CHM13v2.0
Crh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82104,059,184 - 104,061,048 (-)NCBIGRCr8
mRatBN7.22102,143,055 - 102,144,919 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2102,143,055 - 102,144,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2108,674,139 - 108,676,025 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02106,795,271 - 106,797,157 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02101,764,428 - 101,766,314 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02104,459,999 - 104,461,863 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2104,459,999 - 104,461,863 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02124,182,919 - 124,184,783 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42104,764,023 - 104,765,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12104,708,984 - 104,710,849 (-)NCBI
Celera297,536,796 - 97,538,660 (-)NCBICelera
Cytogenetic Map2q24NCBI
Crh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544412,989,210 - 12,991,300 (+)NCBIChiLan1.0ChiLan1.0
CRH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2781,908,836 - 81,919,149 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1857,548,461 - 57,558,776 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0862,714,721 - 62,716,979 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1864,382,912 - 64,385,175 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl864,383,419 - 64,384,009 (-)Ensemblpanpan1.1panPan2
CRH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12915,831,944 - 15,840,560 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2915,831,944 - 15,834,384 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2916,146,733 - 16,149,174 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02915,890,845 - 16,097,836 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2915,910,573 - 15,913,018 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12915,940,159 - 15,942,599 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02916,042,480 - 16,044,918 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02916,298,228 - 16,300,672 (-)NCBIUU_Cfam_GSD_1.0
Crh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530367,023,855 - 67,026,364 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364967,760,532 - 7,761,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364967,759,656 - 7,761,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl468,484,053 - 68,486,121 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1468,481,696 - 68,486,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2474,349,511 - 74,653,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1862,052,155 - 62,056,424 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl862,052,592 - 62,053,182 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603979,456,894 - 79,459,404 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474425,194,495 - 25,196,488 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474425,194,458 - 25,196,658 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crh
77 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:128
Interacting mature miRNAs:157
Transcripts:ENSMUST00000061294
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301256Skmw1_mskeletal muscle weight 1 (mouse)Not determined3125786432Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1300559Thypr3_mthymocyte proliferative response 3 (mouse)Not determined3452541938525519Mouse
12798540Scvg2_msubcutaneous vessel growth QTL 2 (mouse)3744981526249645Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
1301358Eae20_mexperimental allergic encephalomyelitis 20 (mouse)Not determined31163045345630591Mouse
12738410Lfibq2_mliver fibrosis QTL 2 (mouse)31206506020755242Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
4142092Tgq13_mtriglyceride QTL 13 (mouse)Not determined1828816852288168Mouse
25671383Hrsq1_mhost response to SARS QTL 1, vascular cuffing (mouse)31844095426823641Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000061294   ⟹   ENSMUSP00000061185
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl319,747,565 - 19,749,560 (-)Ensembl
GRCm38.p6 Ensembl319,693,401 - 19,695,396 (-)Ensembl
RefSeq Acc Id: NM_205769   ⟹   NP_991338
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39319,747,565 - 19,749,560 (-)NCBI
GRCm38319,693,401 - 19,695,396 (-)ENTREZGENE
MGSCv37319,593,401 - 19,595,396 (-)RGD
Celera319,686,501 - 19,688,496 (-)RGD
cM Map3 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_991338 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI16922 (Get FASTA)   NCBI Sequence Viewer  
  AAI19037 (Get FASTA)   NCBI Sequence Viewer  
  AAN07905 (Get FASTA)   NCBI Sequence Viewer  
  EDL34881 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000061185
  ENSMUSP00000061185.5
GenBank Protein Q8CIT0 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_991338   ⟸   NM_205769
- Peptide Label: preproprotein
- UniProtKB: Q14AA2 (UniProtKB/Swiss-Prot),   Q8CIT0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000061185   ⟸   ENSMUST00000061294

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CIT0-F1-model_v2 AlphaFold Q8CIT0 1-187 view protein structure

Promoters
RGD ID:6880312
Promoter ID:EPDNEW_M3607
Type:multiple initiation site
Name:Crh_1
Description:Mus musculus corticotropin releasing hormone , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38319,695,329 - 19,695,389EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88496 AgrOrtholog
Ensembl Genes ENSMUSG00000049796 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000061294 ENTREZGENE
  ENSMUST00000061294.5 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.1920 UniProtKB/Swiss-Prot
InterPro Corticotropin-releasing_fac_CS UniProtKB/Swiss-Prot
  CRF UniProtKB/Swiss-Prot
  Urocortin_CRF UniProtKB/Swiss-Prot
KEGG Report mmu:12918 UniProtKB/Swiss-Prot
MGD MGI:88496 ENTREZGENE
NCBI Gene 12918 ENTREZGENE
PANTHER CORTICOLIBERIN UniProtKB/Swiss-Prot
  PTHR15035 UniProtKB/Swiss-Prot
Pfam CRF UniProtKB/Swiss-Prot
PharmGKB CRH RGD
PhenoGen Crh PhenoGen
PRINTS CRFFAMILY UniProtKB/Swiss-Prot
PROSITE CRF UniProtKB/Swiss-Prot
SMART CRF UniProtKB/Swiss-Prot
UniProt CRF_MOUSE UniProtKB/Swiss-Prot
  Q14AA2 ENTREZGENE
  Q8CIT0 ENTREZGENE
UniProt Secondary Q14AA2 UniProtKB/Swiss-Prot