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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620505
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Crh
Name: corticotropin releasing hormone
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Crhincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of CRH mRNA; Lipopolysaccharides results in increased expression of CRH proteinPMID:21959975
Crhincreases secretionEXP 6480464CTDLipopolysaccharides results in increased secretion of CRH proteinPMID:11852909
Crhmultiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of CRH mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of CRH protein]; Dipyrone inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]; Indomethacin inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of CRH mRNA]PMID:11852909 PMID:21959975
Crhaffects expressionISOCrh (Mus musculus)6480464CTDLipopolysaccharides affects the expression of CRH mRNAPMID:15667454
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