RGD Reference Report - Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation. - Rat Genome Database

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Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation.

Authors: Roozendaal, B  Brunson, KL  Holloway, BL  McGaugh, JL  Baram, TZ 
Citation: Roozendaal B, etal., Proc Natl Acad Sci U S A 2002 Oct 15;99(21):13908-13.
RGD ID: 625745
Pubmed: PMID:12361983   (View Abstract at PubMed)
PMCID: PMC129796   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.212504599   (Journal Full-text)

It is well established that adrenal stress hormone-induced activation of the basolateral complex of the amygdala (BLA) influences memory consolidation. The present experiments investigated the involvement of corticotropin-releasing hormone (CRH) in the BLA in modulating memory consolidation. Bilateral infusions of the CRH receptor antagonist [9-41]-alpha-helical CRH (0.3, 1.0, or 3.0 microg in 0.2 microl) administered into the BLA of male Sprague-Dawley rats immediately after aversively motivated inhibitory avoidance training produced dose-dependent impairment of 48-h retention performance. Because the CRH receptor antagonist infusions did not impair retention when administered into the BLA 3 h after training, the retention impairment selectively was due to time-dependent influences on memory consolidation. Furthermore, because immediate posttraining infusions of [9-41]-alpha-helical CRH into the adjacent central nucleus of the amygdala (CEA) were ineffective, the effect selectively involved the BLA. Immunocytochemistry showed that the aversive training stimulus of a single, brief footshock increased CRH levels in the CEA. These findings indicate that activation of CRH receptors in the BLA, likely by training-induced release of endogenous peptide originating from the CEA, participates in mediating stress effects on memory consolidation.

Objects referenced in this article
Gene CRH corticotropin releasing hormone Homo sapiens
Gene Crh corticotropin releasing hormone Mus musculus
Gene Crh corticotropin releasing hormone Rattus norvegicus

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