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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620505
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Crh
Name: corticotropin releasing hormone
Acc ID: CHEBI:10093
Term: yohimbine
Definition: An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina.
Chemical ID: MESH:D015016
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Crhmultiple interactionsEXP 6480464CTDYohimbine affects the reaction [Norepinephrine affects the expression of and affects the secretion of CRH protein]; Yohimbine inhibits the reaction [Nitroprusside results in increased expression of and results in increased secretion of CRH protein]PMID:3497798
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